{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:16:35Z","timestamp":1788498995852,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"publisher","award":["grant numbers 2020\/39\/D\/NZ9\/01009; 2020\/39\/B\/NZ9\/01061."],"award-info":[{"award-number":["grant numbers 2020\/39\/D\/NZ9\/01009; 2020\/39\/B\/NZ9\/01061."]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"publisher"}]},{"award":["grant numbers 2020\/39\/D\/NZ9\/01009; 2020\/39\/B\/NZ9\/01061."],"award-info":[{"award-number":["grant numbers 2020\/39\/D\/NZ9\/01009; 2020\/39\/B\/NZ9\/01061."]}],"id":[{"id":"https:\/\/ror.org\/03ha2q922","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>In pigs, the establishment of pregnancy depends on tightly coordinated molecular interactions between the conceptus and the maternal endometrium during the peri-implantation period. Adipokines, peptide hormones produced by adipose tissue, function as endocrine mediators linking metabolic status with uterine function. Omentin-1, a hormone belonging to the adipokines group, is hypothesized to play a potential role in regulating female reproductive functions through its influence on uterine functions. Therefore, this study investigated the effects of omentin-1 on endometrial progesterone and oestradiol secretion using radioimmunoassay, on the abundance of key steroidogenic proteins and Akt phosphorylation using Western blot, and on endometrial cell proliferation and apoptosis using flow cytometry. Results showed that its actions are characterised by promotion of progesterone-dominant conditions, selective modulation of steroidogenic pathways, activation of Akt signalling, and cell-type-specific regulation of proliferation and apoptosis. This combination of effects positions omentin-1 as a previously unrecognised regulator of endometrial adaptation and suggests that adipokines may represent an important mechanistic link between metabolic status and reproductive success.<\/jats:p>","DOI":"10.3390\/ijms27177731","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:48:36Z","timestamp":1788256116000},"page":"7731","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Omentin-1 Modulates Porcine Endometrial Steroidogenesis and Tissue Remodelling During Early Pregnancy and the Oestrous Cycle"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2396-170X","authenticated-orcid":false,"given":"Oguzhan","family":"Koker","sequence":"first","affiliation":[{"name":"Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"},{"name":"Doctoral School, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Kopij","sequence":"additional","affiliation":[{"name":"InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-683 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-1328","authenticated-orcid":false,"given":"Marlena","family":"Gudelska","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-1833","authenticated-orcid":false,"given":"Katarzyna","family":"Kisielewska","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Dobrzyn","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Zaobidna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-6148","authenticated-orcid":false,"given":"Anna","family":"Nynca","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-026X","authenticated-orcid":false,"given":"Tadeusz","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-1387","authenticated-orcid":false,"given":"Nina","family":"Smolinska","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-5282","authenticated-orcid":false,"given":"Marta","family":"Kiezun","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.anireprosci.2004.04.014","article-title":"Conceptus Signals for Establishment and Maintenance of Pregnancy","volume":"82\u201383","author":"Spencer","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2049-1891-4-23","article-title":"Pregnancy Recognition Signaling Mechanisms in Ruminants and Pigs","volume":"4","author":"Bazer","year":"2013","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40104-018-0259-8","article-title":"Endometrial Response to Conceptus-Derived Estrogen and Interleukin-1\u03b2 at the Time of Implantation in Pigs","volume":"9","author":"Ka","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1439-0531.2011.01843.x","article-title":"Mechanisms for the Establishment of Pregnancy in the Pig","volume":"46","author":"Ziecik","year":"2011","journal-title":"Reprod. Domest. Anim."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1642-431X(12)60013-8","article-title":"Endometrial and Myometrial Secretion of Androgens and Estrone during Early Pregnancy and Luteolysis in Pigs","volume":"8","author":"Franczak","year":"2008","journal-title":"Reprod. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.theriogenology.2007.09.023","article-title":"Secretion of Estradiol-17\u03b2 by Porcine Endometrium and Myometrium during Early Pregnancy and Luteolysis","volume":"69","author":"Franczak","year":"2008","journal-title":"Theriogenology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1262\/jrd.2012-099","article-title":"The Activity and Localization of 3\u03b2-Hydroxysteroid Dehydrogenase\/\u03945-\u03944 Isomerase and Release of Androstenedione and Progesterone by Uterine Tissues during Early Pregnancy and the Estrous Cycle in Pigs","volume":"59","author":"Wojciechowicz","year":"2013","journal-title":"J. Reprod. Dev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kaczynski, P., Bauersachs, S., Baryla, M., Goryszewska, E., Muszak, J., Grzegorzewski, W.J., and Waclawik, A. (2020). Estradiol-17\u03b2-Induced Changes in the Porcine Endometrial Transcriptome In Vivo. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030890"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.physbeh.2004.02.007","article-title":"Energy Balance and Reproduction","volume":"81","author":"Schneider","year":"2004","journal-title":"Physiol. Behav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1515\/hmbci-2015-0034","article-title":"Adipokines in Human Reproduction","volume":"24","author":"Dupont","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Barbe, A., Bongrani, A., Mellouk, N., Estienne, A., Kurowska, P., Grandhaye, J., Elfassy, Y., Levy, R., Rak, A., and Froment, P. (2019). Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071526"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1017\/S175173112000097X","article-title":"The Expression of Chemerin and Its Receptors (CMKLR1, GPR1, CCRL2) in the Porcine Uterus during the Oestrous Cycle and Early Pregnancy and in Trophoblasts and Conceptuses","volume":"14","author":"Gudelska","year":"2020","journal-title":"Animal"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1515\/hmbci-2015-0031","article-title":"The Roles of Leptin and Adiponectin at the Fetal-Maternal Interface in Humans","volume":"24","author":"Santos","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.anireprosci.2014.02.001","article-title":"Expression of Adiponectin and Adiponectin Receptors 1 (AdipoR1) and 2 (AdipoR2) in the Porcine Uterus during the Oestrous Cycle","volume":"146","author":"Smolinska","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.anireprosci.2008.06.001","article-title":"Long Form of Leptin Receptor Gene and Protein Expression in the Porcine Trophoblast and Uterine Tissues during Early Pregnancy and the Oestrous Cycle","volume":"113","author":"Smolinska","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yu, M., Yang, Y., Huang, C., Ge, L., Xue, L., Xiao, Z., Xiao, T., Zhao, H., Ren, P., and Zhang, J.V. (2022). Chemerin: A Functional Adipokine in Reproductive Health and Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081910"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R267","DOI":"10.1530\/EC-21-0288","article-title":"Role of Adipokines in Embryo Implantation","volume":"10","author":"Oghbaei","year":"2021","journal-title":"Endocr. Connect."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mlyczy\u0144ska, E., Kie\u017cun, M., Kurowska, P., Dawid, M., Pich, K., Respekta, N., Daudon, M., Rytelewska, E., Dobrzy\u0144, K., and Kami\u0144ska, B. (2022). New Aspects of Corpus Luteum Regulation in Physiological and Pathological Conditions: Involvement of Adipokines and Neuropeptides. Cells, 11.","DOI":"10.3390\/cells11060957"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"RD24097","DOI":"10.1071\/RD24097","article-title":"Role of Resistin in the Porcine Uterus: Effects on Endometrial Steroidogenesis","volume":"37","author":"Gudelska","year":"2025","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gudelska, M., Dobrzyn, K., Kiezun, M., Kisielewska, K., Rytelewska, E., Kaminski, T., and Smolinska, N. (2022). Chemerin Affects P4 and E2 Synthesis in the Porcine Endometrium during Early Pregnancy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020945"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107067","DOI":"10.1016\/j.anireprosci.2022.107067","article-title":"Adiponectin Affects Uterine Steroidogenesis during Early Pregnancy and the Oestrous Cycle: An in Vitro Study","volume":"245","author":"Kiezun","year":"2022","journal-title":"Anim. Reprod. Sci."},{"key":"ref_22","first-page":"443","article-title":"Effect of Adiponectin on the Steroidogenic Acute Regulatory Protein, P450 Side Chain Cleavage Enzyme and 3\u0392-Hydroxysteroid Dehydrogenase Gene Expression, Progesterone and Androstenedione Production by the Porcine Uterus during Early Pregnancy","volume":"67","author":"Smolinska","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.ijo.0803719","article-title":"The \u2018Beneficial\u2019 Adipokines in Reproduction and Fertility","volume":"32","author":"Campos","year":"2008","journal-title":"Int. J. Obes."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/j.2040-4603.2017.tb00769.x","article-title":"Adipose Tissue-Derived Omentin-1 Function and Regulation","volume":"7","author":"Watanabe","year":"2017","journal-title":"Compr. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1515\/jpm-2014-0215","article-title":"Omentin, an Adipokine with Insulin-Sensitizing Properties, Is Negatively Associated with Insulin Resistance in Normal Gestation","volume":"43","author":"Brandt","year":"2015","journal-title":"J. Perinat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1080\/13813455.2023.2283685","article-title":"Omentin Roles in Physiology and Pathophysiology: An up-to-Date Comprehensive Review","volume":"130","author":"Hussein","year":"2024","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00125-019-05017-2","article-title":"Higher Circulating Omentin Is Associated with Increased Risk of Primary Cardiovascular Events in Individuals with Diabetes","volume":"63","author":"Niersmann","year":"2020","journal-title":"Diabetologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"368970","DOI":"10.1155\/2013\/368970","article-title":"Omentin-1 Stimulates Human Osteoblast Proliferation through PI3K\/Akt Signal Pathway","volume":"2013","author":"Wu","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Barker, G., Lim, R., Georgiou, H.M., and Lappas, M. (2012). Omentin-1 Is Decreased in Maternal Plasma, Placenta and Adipose Tissue of Women with Pre-Existing Obesity. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042943"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1095\/biolreprod.114.120410","article-title":"Expression and Regulation of INTELECTIN1 in Human Granulosa-Lutein Cells: Role in IGF-1-Induced Steroidogenesis Through NAMPT1","volume":"91","author":"Cloix","year":"2014","journal-title":"Biol. Reprod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pich, K., Respekta, N., Kurowska, P., Rame, C., Dobrzy\u0144, K., Smoli\u0144ska, N., Dupont, J., and Rak, A. (2024). Omentin Expression in the Ovarian Follicles of Large White and Meishan Sows during the Oestrous Cycle and in Vitro Effect of Gonadotropins and Steroids on Its Level: Role of ERK1\/2 and PI3K Signaling Pathways. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0297875"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"114722","DOI":"10.1016\/j.ygcen.2025.114722","article-title":"Intelectin-1 Promotes Granulosa Cells Proliferation and Modulates Apoptosis via ERK1\/2, AKT, and Insulin Receptor Signaling Pathways in Large White and Meishan Pigs","volume":"367","author":"Pich","year":"2025","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107783","DOI":"10.1016\/j.anireprosci.2025.107783","article-title":"In Vitro Effect of Omentin-1 on Level of Other Adipokines in Granulosa Cells from Ovaries of Large White and Meishan Pigs","volume":"274","author":"Pich","year":"2025","journal-title":"Anim. Reprod. Sci."},{"key":"ref_34","first-page":"577","article-title":"In Vitro Effect of Omentin-1 on Porcine Ovarian Follicular Steroidogenesis: Role of Insulin Receptor, Extracellular Signal-Regulated Kinase 1\/2 and Protein Kinase A Signaling Pathways","volume":"76","author":"Pich","year":"2025","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"19325","DOI":"10.1038\/s41598-023-46742-4","article-title":"Plasma Level of Omentin-1, Its Expression, and Its Regulation by Gonadotropin-Releasing Hormone and Gonadotropins in Porcine Anterior Pituitary Cells","volume":"13","author":"Respekta","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diff.2013.11.005","article-title":"Pig Blastocyst\u2013Uterine Interactions","volume":"87","author":"Bazer","year":"2014","journal-title":"Differentiation"},{"key":"ref_38","first-page":"411","article-title":"Endometrial Steroid Receptor Dysregulation and Its Association with Vitamin D AMH and Inflammation in Recurrent Implantation Failure: A Case-Control Study","volume":"19","author":"Rostami","year":"2025","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.xfss.2023.04.003","article-title":"An Integrative Analysis of Endometrial Steroid Metabolism and Transcriptome in Relation to Endometrial Receptivity in in Vitro Fertilization Patients","volume":"4","author":"Obukhova","year":"2023","journal-title":"F&S Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/REP-11-0033","article-title":"Novel Insights into the Mechanisms of Pregnancy Establishment: Regulation of Prostaglandin Synthesis and Signaling in the Pig","volume":"142","author":"Waclawik","year":"2011","journal-title":"Reproduction"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2527\/jas1986.633848x","article-title":"Intrauterine Migration of the Porcine Embryo: Coordination of Bead Migration with Estradiol","volume":"63","author":"Pope","year":"1986","journal-title":"J. Anim. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.12717\/DR.2025.29.3.63","article-title":"The Steroidogenic Acute Regulatory (STAR) Gene Anatomy, Expression, and Roles","volume":"29","author":"Lim","year":"2025","journal-title":"Dev. Reprod."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Bazer, F.W., Minela, T., and Johnson, G.A. (2025). Novel Aspects of the Physiology of Pregnancy in Domestic Ruminants. Animals, 15.","DOI":"10.3390\/ani15182672"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1095\/biolreprod.109.080929","article-title":"Cathepsin B, Cathepsin L, and Cystatin C in the Porcine Uterus and Placenta: Potential Roles in Endometrial\/Placental Remodeling and in Fluid-Phase Transport of Proteins Secreted by Uterine Epithelia Across Placental Areolae1","volume":"82","author":"Song","year":"2010","journal-title":"Biol. Reprod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12958-024-01215-9","article-title":"The Adipokines Progranulin and Omentin\u2014Novel Regulators of Basic Ovarian Cell Functions","volume":"22","author":"Sirotkin","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13287-017-0676-1","article-title":"Omentin-1 Effects on Mesenchymal Stem Cells: Proliferation, Apoptosis, and Angiogenesis in Vitro","volume":"8","author":"Yin","year":"2017","journal-title":"Stem. Cell Res. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/mrd.23567","article-title":"Novel Insights into Conceptus\u2013Maternal Signaling during Pregnancy Establishment in Pigs","volume":"90","author":"Kaczynski","year":"2023","journal-title":"Mol. Reprod. Devel."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-030-77360-1_5","article-title":"The Early Stages of Implantation and Placentation in the Pig","volume":"Volume 234","author":"Geisert","year":"2021","journal-title":"Placentation in Mammals"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2337\/db07-0990","article-title":"Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women with Polycystic Ovary Syndrome","volume":"57","author":"Tan","year":"2008","journal-title":"Diabetes"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1071\/RD15430","article-title":"Expression of 17\u03b2-Hydroxysteroid Dehydrogenase and the Effects of LH, FSH and Prolactin on Oestrone and 17\u03b2-Oestradiol Secretion in the Endometrium of Pigs during Early Pregnancy and the Oestrous Cycle","volume":"29","author":"Wojciechowicz","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1262\/jrd.2025-107","article-title":"The Role of Omentin-1 in Female Reproduction: A Critical Review","volume":"72","author":"Kubicka","year":"2026","journal-title":"J. Reprod. Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/rda.13280","article-title":"Annexin A8 (ANXA8) Regulates Proliferation of Porcine Endometrial Cells via Akt Signalling Pathway","volume":"54","author":"Jiang","year":"2019","journal-title":"Reprod. Domest. Anim."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.18632\/aging.102367","article-title":"Melatonin Induces Progesterone Production in Human Granulosa-Lutein Cells through Upregulation of StAR Expression","volume":"11","author":"Fang","year":"2019","journal-title":"Aging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"22286","DOI":"10.1038\/s41598-024-72720-5","article-title":"Expression of Intelectin-1, Also Known as Omentin-1, Is Related to Clinical Phenotypes Such as Overweight, Obesity, Insulin Resistance, and Changes after Bariatric Surgery","volume":"14","author":"Czechowski","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sperling, M., Grzelak, T., Pelczy\u0144ska, M., Bogda\u0144ski, P., Formanowicz, D., and Czy\u017cewska, K. (2023). Association of Serum Omentin-1 Concentration with the Content of Adipose Tissue and Glucose Tolerance in Subjects with Central Obesity. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020331"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11626-026-01187-7","article-title":"The Effects of Omentin on Estradiol and Progesterone Release in Human Granulosa Cell Culture","volume":"62","author":"Baba","year":"2026","journal-title":"In Vitro Cell. Dev. Biol.-Anim."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Gry, M., Rimini, R., Str\u00f6mberg, S., Asplund, A., Pont\u00e9n, F., Uhl\u00e9n, M., and Nilsson, P. (2009). Correlations between RNA and Protein Expression Profiles in 23 Human Cell Lines. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-365"},{"key":"ref_58","first-page":"1953","article-title":"Gross Ovarian Changes during Estrous Cycle of Swine","volume":"29","author":"Akins","year":"1968","journal-title":"Am. J. Vet. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ar.1091900112","article-title":"Growth, Protein Content and Distribution of Early Pig Embryos","volume":"190","author":"Anderson","year":"1978","journal-title":"Anat. Rec."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7731\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:27:34Z","timestamp":1788496054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":59,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177731"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177731","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}