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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>This study examined the effects of the trans-resveratrol (Res) and l-carnitine (l-Car) complex (RC) on mice genetically resistant to obesity. Male DBA\/2J mice received low (RCl, 25\/300 mg\/kg BW) or high (RCh, 50\/600 mg\/kg BW) doses of the RC for 64 days in a control diet (CD) or a high-fat-high-carbohydrate diet (HFCD). Differential expression (DE) of genes in the liver was analyzed using DNA microarrays. HFCD alone altered 471 genes (1.7%) versus CD. In CD-fed mice, RCl and RCh affected 170 (0.6%) and 321 (1.2%) genes, respectively. In HFCD-fed mice, RCl and RCh affected 109 (0.4%) and 223 (0.8%) genes. Opposite DE changes between HFCD and RC + HFCD occurred in immune recognition and fat-storage genes (Ccl24, Fabp7, Cd74, H2-Ab1, Srebf1, etc.). Uniform responses to HFCD and RC + CD were seen in Ppard, Irs-1, Tsku, Cyp26b1, Il1r1, Onecut1, Per1, Nlrd2, Rgs16, Grem2, Klf9, and Lpin1. RC effects were consistent with liver morphology. Key RC-targeted pathways included retinoid metabolism, PPAR signaling, and antigen presentation. In HFCD-fed mice, additional pathways were steroid biosynthesis, oxylipin metabolism, and Jak-STAT signaling. DBA\/2J mice may exhibit an innate compensatory response involving PPAR signaling, Srebf1, and Socs2, and the contribution of polymorphisms in these genes merits separate investigation in future studies of obesity resistance.<\/jats:p>","DOI":"10.3390\/ijms27177808","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:48:36Z","timestamp":1788256116000},"page":"7808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co-Administration of Trans-Resveratrol and L-Carnitine with a High-Fat and High-Carbohydrate Diet Modulates Liver Transcriptome in Obesity-Resistant DBA\/2J Mice"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-6508","authenticated-orcid":false,"given":"Ivan V.","family":"Gmoshinski","sequence":"first","affiliation":[{"name":"Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-9297","authenticated-orcid":false,"given":"Nikita V.","family":"Trusov","sequence":"additional","affiliation":[{"name":"Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, Russia"},{"name":"Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0015-8735","authenticated-orcid":false,"given":"Vladimir A.","family":"Shipelin","sequence":"additional","affiliation":[{"name":"Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Dmitriy B.","family":"Nikityuk","sequence":"additional","affiliation":[{"name":"Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, Russia"},{"name":"Department of Operative Surgery and Topographic Anatomy, I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia"},{"name":"Department of Ecology and Food Safety, Institute of Ecology, Peoples\u2019 Friendship University of Russia Named After Patrice Lumumba, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref_1","first-page":"46","article-title":"Promising Source of Micronutrients for Specialized Foods with Modified Carbohydrate Profile: Traditional Medicine Experience","volume":"84","author":"Tutelyan","year":"2016","journal-title":"Probl. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sun, N.N., Wu, T.Y., and Chau, C.F. (2016). Natural Dietary and Herbal Products in Anti-Obesity Treatment. 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