{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:05:37Z","timestamp":1792181137566,"version":"4.4.0"},"reference-count":73,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guizhou Provincial Basic Research Program (Natural Science) General Project","award":["Qian Ke He Basic MS [2026] 908"],"award-info":[{"award-number":["Qian Ke He Basic MS [2026] 908"]}]},{"name":"Zunyi Municipal Science and Technology Program","award":["ZSKH SYS (2025) 1"],"award-info":[{"award-number":["ZSKH SYS (2025) 1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Oral diseases represent a major global health burden, and non-coding RNAs (ncRNAs) have emerged as pivotal regulators in their pathogenesis, offering new avenues for diagnosis and therapy. This review synthesizes current knowledge on ncRNAs\u2014including miRNAs, lncRNAs, and circRNAs\u2014across a spectrum of oral conditions, encompassing periodontitis, oral squamous cell carcinoma, oral submucous fibrosis, oral lichen planus, oral leukoplakia, and chronic orofacial pain. Mechanistically, ncRNAs function through competing endogenous RNA networks, immune\u2013inflammatory cascades, metabolic reprogramming, and fibroblast activation; notably, recent discoveries have revealed that certain circRNAs and lncRNAs encode functional micropeptides, adding an additional layer of regulatory complexity in oral pathology. On the translational front, salivary and circulating ncRNAs have shown promise as non-invasive biomarkers. However, major bottlenecks remain, including insufficient longitudinal validation, marked technical heterogeneity across studies, and delivery challenges specific to the oral microenvironment. By critically evaluating mechanistic insights alongside these translational barriers, this review identifies critical knowledge gaps and proposes prioritized strategies to facilitate the clinical integration of ncRNA-based precision dentistry.<\/jats:p>","DOI":"10.3390\/ijms27177832","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:41:18Z","timestamp":1788266478000},"page":"7832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-Coding RNAs in Oral Diseases: From Pathogenesis to Clinical Translation"],"prefix":"10.3390","volume":"27","author":[{"given":"Letong","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Microbial Resources and Drug Development of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"An","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunli","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Oral Disease Research of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Key Laboratory of Microbial Resources and Drug Development of Guizhou Education Department, School of Stomatology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Adamouli, D., Marasli, C., and Bobetsis, Y.A. 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