{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:17:21Z","timestamp":1788499041785,"version":"build-2803163510"},"reference-count":430,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005289","name":"Provincial Secretariat for Science and Technological Development","doi-asserted-by":"crossref","award":["003877177 2025 09418 003 000 000 001"],"award-info":[{"award-number":["003877177 2025 09418 003 000 000 001"]}],"id":[{"id":"10.13039\/501100005289","id-type":"DOI","asserted-by":"crossref"}]},{"award":["003877177 2025 09418 003 000 000 001"],"award-info":[{"award-number":["003877177 2025 09418 003 000 000 001"]}],"id":[{"id":"https:\/\/ror.org\/0279n3m18","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Cancer therapy-related cardiotoxicity has emerged as a major challenge in contemporary oncology, particularly in long-term survivors of childhood malignancies. Oxidative stress (OS)-induced cardiotoxicity represents a key mechanistic pathway underlying myocardial injury caused by numerous anti-neoplastic drugs, most notably anthracycline-based chemotherapy, while OS also critically contributes to radiotherapy-induced cardiotoxicity. Excessive reactive oxygen and nitrogen species generation promotes mitochondrial dysfunction, impaired calcium homeostasis, lipid peroxidation, endothelial injury, inflammatory activation, and cardiomyocyte apoptosis, ultimately leading to progressive cardiac remodeling and ventricular dysfunction. These processes are of particular concern in pediatric cancer survivors, especially children treated for leukemia, who face a substantially elevated lifetime risk of cardiovascular disease following treatment exposure. Increasing attention has, therefore, been directed toward nutritional strategies capable of modulating redox homeostasis and attenuating treatment-associated myocardial injury. Experimental and translational evidence suggests that selected dietary compounds and nutraceuticals, including polyphenols, omega-3 fatty acids, coenzyme Q10, selenium, antioxidant vitamins, nutrition-based epigenetic interventions and intestinal microbiota composition modulations may exert cardioprotective effects through preservation of mitochondrial integrity, enhancement of endogenous antioxidant defenses, and suppression of oxidative and inflammatory signaling pathways. Nevertheless, clinical implementation remains limited by insufficient standardization, heterogeneous study designs, and incomplete understanding of long-term efficacy and safety. This narrative review critically examines the molecular basis of the OS-induced cardiotoxicity and radiotherapy-induced cardiotoxicity and evaluates current evidence supporting nutrition-based cardioprotective interventions, with particular emphasis on pediatric leukemia survivors and the prevention of long-term cardiovascular complications following anticancer therapy.<\/jats:p>","DOI":"10.3390\/ijms27177863","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:35:29Z","timestamp":1788359729000},"page":"7863","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional Prevention of Oxidative Stress-Induced Cardiotoxicity in Pediatric Cardio-Oncology: Molecular Mechanisms and Translational Perspectives\u2014A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-3473","authenticated-orcid":false,"given":"Karmen","family":"Stankov","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-3182","authenticated-orcid":false,"given":"Bojan","family":"Stanimirov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Ninkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"\u0110ani\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavica","family":"Lazarevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-3212","authenticated-orcid":false,"given":"Dragana","family":"Zaklan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-5830","authenticated-orcid":false,"given":"Neboj\u0161a","family":"Pavlovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40348-025-00196-y","article-title":"A systematic review of long-term cardiotoxic effects of treatment in survivors of childhood acute lymphoblastic leukemia","volume":"12","author":"Johnson","year":"2025","journal-title":"Mol. Cell. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e926","DOI":"10.1161\/CIR.0000000000001308","article-title":"Cardiovascular Toxicity in Patients Treated for Childhood Cancer: A Scientific Statement From the American Heart Association","volume":"151","author":"Ryan","year":"2025","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1158\/1055-9965.EPI-25-1472","article-title":"Cancer Treatment-Related Cardiotoxicity among Survivors of Childhood Cancer: A Comparative and Integrated View of Multiple Measures of Biological Age Acceleration","volume":"35","author":"Meng","year":"2026","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0113816128410093251006160508","article-title":"Doxorubicin-Induced Cardiotoxicity: Exploration of Molecular Pathogenesis and Phytocompound-Based Therapeutic Strategies","volume":"32","author":"Pawar","year":"2025","journal-title":"Curr. Pharm. Des."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.31083\/j.rcm2405148","article-title":"Anthracyclines-Induced Cardiac Dysfunction: What Every Clinician Should Know","volume":"24","author":"Ferrera","year":"2023","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jaccao.2024.07.017","article-title":"Cardiovascular Considerations Before Cancer Therapy: Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations","volume":"6","author":"Murphy","year":"2024","journal-title":"JACC CardioOncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sun, Y., Zheng, C., Li, L., Zhang, S., Guo, J., and Lv, J. (2025). Research progress in the prevention and treatment of radiation-induced heart disease. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1745302"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Beke, N., Jockers, X., Hern\u00e1df\u0151i, M., K\u00f3i, T., Lakatos, K., P\u00e1rniczky, A., Hegyi, P., and Garami, M. (2025). Cardiotoxicity in pediatric oncology: A systematic review and meta-analysis. Pediatr. Res.","DOI":"10.1038\/s41390-025-04601-0"},{"key":"ref_9","first-page":"e85670","article-title":"Long-Term Cardiovascular Outcomes in Childhood Cancer Survivors: A Systematic Review","volume":"17","author":"Fahmi","year":"2025","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11864-025-01367-9","article-title":"Cardiovascular Care in Pediatric Cancer Survivors: Updates on Risk, Prevention, and Therapies","volume":"27","author":"Lim","year":"2025","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e065776","DOI":"10.1136\/bmjopen-2022-065776","article-title":"Preventive strategies of cancer therapeutics-related cardiotoxicity in childhood cancer survivors: A protocol of systematic review","volume":"12","author":"Zhang","year":"2022","journal-title":"BMJ Open"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Correra, A., Cetoretta, V., Maratea, A.C., Ferrara, S., Di Sarno, I., Russo, V., Guerra, F., Mauriello, A., and D\u2019Andrea, A. (2026). Pediatric Cardio-Oncology: From Gap in Evidence to Future Perspectives. Diagnostics, 16.","DOI":"10.3390\/diagnostics16020268"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41571-018-0136-6","article-title":"Somatic and germline genomics in paediatric acute lymphoblastic leukaemia","volume":"16","author":"Pui","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Migliari, M., Fazzini, L., Campana, N., Deidda, M., Dess\u00ec, M., and Cadeddu Dessalvi, C. (2025). Current strategies for prevention of cancer therapy-related cardiotoxicity: Pharmacological, non-pharmacological and emerging approaches. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1668308"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"117745","DOI":"10.1016\/j.bcp.2026.117745","article-title":"Cellular crosstalk in doxorubicin-induced cardiotoxicity: Underlying mechanisms and therapeutic strategies","volume":"247","author":"Wei","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"ref_16","first-page":"71","article-title":"Cardioprotection strategies for anthracycline cardiotoxicity","volume":"120","year":"2025","journal-title":"Basic Res. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1470-2045(24)00001-9","article-title":"Secondary prevention of anthracycline cardiotoxicity in childhood cancer survivors","volume":"25","author":"Leerink","year":"2024","journal-title":"Lancet Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11886-025-02283-y","article-title":"Evolving Cardioprotective Strategies in Cardio-Oncology: A Narrative Review","volume":"27","author":"Wadden","year":"2025","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_19","first-page":"66","article-title":"Prevention and treatment of anthracycline-induced cardiotoxicity: A systematic review and network meta-analysis of randomized controlled trials","volume":"11","author":"Li","year":"2025","journal-title":"Cardiooncology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Konstantinidis, I., Tsokkou, S., Gavriilaki, E., Delis, G., and Papamitsou, T. (2025). Protective Role of Key Micronutrients in Chemotherapy-Induced Organ Toxicity: A Comprehensive Review of Mechanistic Insights and Clinical Implications. Nutrients, 17.","DOI":"10.3390\/nu17172838"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhang, X.-Y., Yang, K.-L., Li, Y., Zhao, Y., Jiang, K.-W., Wang, Q., and Liu, X.-N. (2022). Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.921609"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Stephenson, E., McLaughlin, M., Bray, J.W., Saxton, J.M., and Vince, R.V. (2024). Nutrition Modulation of Cardiotoxicity in Breast Cancer: A Scoping Review. Nutrients, 16.","DOI":"10.3390\/nu16213777"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Szponar, J., Nizi\u0144ski, P., Dudka, J., Kasprzak-Drozd, K., and Oniszczuk, A. (2024). Natural Products for Preventing and Managing Anthracycline-Induced Cardiotoxicity: A Comprehensive Review. Cells, 13.","DOI":"10.3390\/cells13131151"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pulliero, A., Marengo, B., Ferrante, O., Khalid, Z., Vernazza, S., Ruzzarin, N., Domenicotti, C., and Izzotti, A. (2025). Antioxidant Food Supplementation in Cancer: Lessons from Clinical Trials and Insights from Preclinical Studies. Antioxidants, 14.","DOI":"10.3390\/antiox14101261"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102710","DOI":"10.1016\/j.redox.2023.102710","article-title":"Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors","volume":"62","author":"Malcomson","year":"2023","journal-title":"Redox Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114591","DOI":"10.1016\/j.biopha.2023.114591","article-title":"Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1\/Nrf2 pathway","volume":"162","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Li, D., Liu, X., Pi, W., Zhang, Y., Yu, L., Xu, C., Sun, Z., and Jiang, J. (2021). Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1\/Nrf2 Signaling Pathway Activation. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.808480"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s11864-024-01203-6","article-title":"Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods","volume":"25","author":"Kuang","year":"2024","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41397-025-00369-y","article-title":"Influence of genetic biomarkers on cardiac diseases in childhood cancer survivors: A systematic review","volume":"25","author":"Aba","year":"2025","journal-title":"Pharmacogenom. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12263-025-00790-9","article-title":"Nutrigenomics meets multi-omics: Integrating genetic, metabolic, and microbiome data for personalized nutrition strategies","volume":"20","author":"Nourazarain","year":"2025","journal-title":"Genes Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Woldeselassie, M., and Tamene, A. (2024). Therapeutic controversies over use of antioxidant supplements during cancer treatment: A scoping review. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1480780"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/2211-5463.70139","article-title":"Dietary nitrate and nitrite protect against doxorubicin-induced cardiac fibrosis and oxidative protein damage in tumor-bearing mice","volume":"16","author":"Yammani","year":"2026","journal-title":"FEBS Open Bio"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"32664","DOI":"10.1038\/s41598-025-19853-3","article-title":"Comparative study on the protective effect of dexrazoxane and blueberry extract against doxorubicin-induced cardiotoxicity in rats","volume":"15","author":"Shaker","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1038\/s41598-025-87442-5","article-title":"Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: Transcriptomic and epigenetic profiling","volume":"15","author":"Kelly","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_35","first-page":"e39375","article-title":"Chemotherapy-Induced Atrial Fibrillation with Rapid Ventricular Response in a Patient with Pleomorphic Rhabdomyosarcoma: A Case Report and Approach to Management","volume":"15","author":"Hassan","year":"2023","journal-title":"Cureus"},{"key":"ref_36","first-page":"CD014638","article-title":"Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines","volume":"9","author":"Mulder","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCRESAHA.122.321667","article-title":"Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets","volume":"132","author":"Sawicki","year":"2023","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jaccao.2024.02.004","article-title":"Dexrazoxane to Prevent Cardiotoxicity in Adults Treated with Anthracyclines: JACC: CardioOncology Controversies in Cardio-Oncology","volume":"6","author":"Upshaw","year":"2024","journal-title":"JACC CardioOncol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Quintero-Martinez, J.A., Cordova-Madera, S.N., and Villarraga, H.R. (2021). Radiation-Induced Heart Disease. J. Clin. Med., 11.","DOI":"10.3390\/jcm11010146"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3579143","DOI":"10.1155\/2020\/3579143","article-title":"Oxidative Stress in Radiation-Induced Cardiotoxicity","volume":"2020","author":"Ping","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Daher, J., Rizza, A., Tonacci, A., and Borghini, A. (2025). A Comprehensive Review of Radiotherapy-Induced Coronary Artery Disease-Epidemiology, Biological Mechanisms, and Preventive Strategies. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26115401"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1667\/RR14075.1","article-title":"Atorvastatin Ameliorates Radiation-Induced Cardiac Fibrosis in Rats","volume":"184","author":"Zhang","year":"2015","journal-title":"Radiat. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijrobp.2008.04.042","article-title":"Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol","volume":"72","author":"Boerma","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00392-021-01809-y","article-title":"Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: From bench to bedside","volume":"110","author":"Varga","year":"2021","journal-title":"Clin. Res. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ortiz de Choudens, S., Sparapani, R., Narayanan, J., Lohr, N., Gao, F., Fish, B.L., Zielonka, M., Gasperetti, T., Veley, D., and Beyer, A. (2022). Lisinopril Mitigates Radiation-Induced Mitochondrial Defects in Rat Heart and Blood Cells. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.828177"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Merino, T., Pinto, M.P., Orellana, M.P., Martinez, G., And\u00eda, M., Munoz-Schuffenegger, P., Acevedo, F., Gabrielli, L., Sanchez, C., and Pereira, J. (2021). Multimodal assessment of acute cardiac toxicity induced by thoracic radiotherapy in cancer patients. Study protocol. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08823-3"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cstres.2024.09.001","article-title":"The mechanism and therapeutic strategies in doxorubicin-induced cardiotoxicity: Role of programmed cell death","volume":"29","author":"Li","year":"2024","journal-title":"Cell Stress Chaperones"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Contaldi, C., D\u2019Aniello, C., Panico, D., Zito, A., Calabr\u00f2, P., Di Lorenzo, E., Golino, P., and Montesarchio, V. (2025). Cancer-Therapy-Related Cardiac Dysfunction: Latest Advances in Prevention and Treatment. Life, 15.","DOI":"10.3390\/life15030471"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Saha, S., Singh, P.K., Roy, P., Vemuri, V., Ratajczak, M.Z., Singh, M., and Kakar, S.S. (2025). Cancer-Induced Cardiac Dysfunction: Mechanisms, Diagnostics, and Emerging Therapeutics in the Era of Onco-Cardiology. Cancers, 17.","DOI":"10.3390\/cancers17193225"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Meshrkey, F., Ibrahim, S.Y., Bagchi, R.A., and Richardson, W.J. (2025). Temporal Dynamics of Extracellular Matrix Remodeling in Anthracycline-Induced Cardiotoxicity. Cells, 14.","DOI":"10.3390\/cells14181471"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3892\/ijmm.2025.5624","article-title":"Alteration of cardiac energetics and mitochondrial function in doxorubicin-induced cardiotoxicity: Molecular mechanism and prospective implications (Review)","volume":"56","author":"Qing","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Guo, Y., Tang, Y., Lu, G., and Gu, J. (2023). p53 at the Crossroads between Doxorubicin-Induced Cardiotoxicity and Resistance: A Nutritional Balancing Act. Nutrients, 15.","DOI":"10.3390\/nu15102259"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s12012-025-10006-6","article-title":"Radiation-Induced Cardiac Remodeling: Mechanisms and Therapeutic Approaches","volume":"25","author":"Ghnim","year":"2025","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10557-024-07574-0","article-title":"A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms","volume":"39","author":"Nagy","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jacbts.2023.10.009","article-title":"Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity","volume":"9","author":"Wu","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"106632","DOI":"10.1016\/j.biocel.2024.106632","article-title":"Iron metabolism in doxorubicin-induced cardiotoxicity: From mechanisms to therapies","volume":"174","author":"Ye","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"117217","DOI":"10.1016\/j.biopha.2024.117217","article-title":"Ferroptosis: A novel therapeutic target of natural products against doxorubicin-induced cardiotoxicity","volume":"178","author":"Yi","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jat.4670","article-title":"Ferroptosis: Latest evidence and perspectives on plant-derived natural active compounds mitigating doxorubicin-induced cardiotoxicity","volume":"45","author":"Wang","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/cvr\/cvag019","article-title":"Ferroptosis in heart failure: From molecular insights to therapeutic implications","volume":"122","author":"Karampinos","year":"2026","journal-title":"Cardiovasc. Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhao, X.P., Duan, L., Zhao, Q.R., Lv, X., Tian, N.Y., Yang, S.L., and Dong, K. (2025). NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: Role of phytochemicals. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1567312"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"84","DOI":"10.21037\/cdt-23-142","article-title":"NOX4 aggravates doxorubicin-induced cardiomyocyte pyroptosis by increasing reactive oxygen species content and activating the NLRP3 inflammasome","volume":"14","author":"Zeng","year":"2024","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"117455","DOI":"10.1016\/j.taap.2025.117455","article-title":"NLRP3 inflammasome regulates doxorubicin-induced cardiotoxicity by modulating the abundance of gut microbiota","volume":"502","author":"Yin","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.trsl.2022.05.001","article-title":"Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage","volume":"248","author":"Ye","year":"2022","journal-title":"Transl. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1186\/s12967-025-07377-3","article-title":"Radiation meets inflammation: NLRP3 inflammasome at the core of radiation-induced cardiac injury","volume":"23","author":"Boncompagni","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"154922","DOI":"10.1016\/j.phymed.2023.154922","article-title":"Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING\/NLRP3 signalling pathway","volume":"117","author":"Fang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1142\/S0192415X24500198","article-title":"Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1\/NLRP3 Pathway","volume":"52","author":"Tian","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/tox.24075","article-title":"Bardoxolone methyl attenuates doxorubicin-induced cardiotoxicity by inhibiting the TXNIP-NLRP3 pathway through Nrf2 activation","volume":"39","author":"Zhang","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Qianqian, R., Peng, Z., Licai, Z., Ruizhi, Z., Tianhe, Y., Xiangwen, X., Chuansheng, Z., and Fan, Y. (2024). A longitudinal evaluation of oxidative stress-mitochondrial dysfunction-ferroptosis genes in anthracycline-induced cardiotoxicity. BMC Cardiovasc. Disord., 24.","DOI":"10.1186\/s12872-024-03967-z"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Huang, J., Wu, R., Chen, L., Yang, Z., Yan, D., and Li, M. (2022). Understanding Anthracycline Cardiotoxicity From Mitochondrial Aspect. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.811406"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Murabito, A., Hirsch, E., and Ghigo, A. (2020). Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?. Front. Cardiovasc. Med., 7.","DOI":"10.3389\/fcvm.2020.00035"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/CIRCRESAHA.119.314681","article-title":"Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy","volume":"126","author":"Wallace","year":"2020","journal-title":"Circ. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaccao.2024.02.005","article-title":"Anthracycline Cardiotoxicity Induces Progressive Changes in Myocardial Metabolism and Mitochondrial Quality Control: Novel Therapeutic Target","volume":"6","author":"Oliver","year":"2024","journal-title":"JACC CardioOncol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Dudek, J. (2017). Role of Cardiolipin in Mitochondrial Signaling Pathways. Front. Cell Dev. Biol., 5.","DOI":"10.3389\/fcell.2017.00090"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"32114","DOI":"10.1038\/s41598-025-17253-1","article-title":"Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats","volume":"15","author":"He","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/CIRCULATIONAHA.115.017443","article-title":"Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11096","DOI":"10.1096\/fj.201802663R","article-title":"Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy","volume":"33","author":"Catanzaro","year":"2019","journal-title":"FASEB J."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Chen, R., Niu, M., Hu, X., and He, Y. (2023). Targeting mitochondrial dynamics proteins for the treatment of doxorubicin-induced cardiotoxicity. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1241225"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"507","DOI":"10.7150\/ijbs.103810","article-title":"New insights into mitochondrial quality control in anthracycline-induced cardiotoxicity: Molecular mechanisms, therapeutic targets, and natural products","volume":"21","author":"Li","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jjcc.2022.01.001","article-title":"The effects of doxorubicin on cardiac calcium homeostasis and contractile function","volume":"80","author":"Shinlapawittayatorn","year":"2022","journal-title":"J. Cardiol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Vitale, R., Mazzone, M., Di Marcantonio, M.C., Marzocco, S., Mincione, G., and Popolo, A. (2025). Cardioprotective Effects of Simvastatin in Doxorubicin-Induced Acute Cardiomyocyte Injury. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199440"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kong, Y., Yang, C., Xie, L., Zhao, Y., Rong, Z., Zhou, X., and Mao, W. (2025). Cardiac toxicity and intervention strategies during thoracic cancer radiotherapy. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1638035"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2340\/1651-226X.2025.43654","article-title":"Heart failure in long-term survivors of childhood cancer\u2014A systematic review and meta-analysis of population-based studies","volume":"64","author":"Berg","year":"2025","journal-title":"Acta Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/S1470-2045(14)70409-7","article-title":"Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group","volume":"16","author":"Armenian","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ppedcard.2014.09.003","article-title":"Late Cardiotoxicity in Aging Adult Survivors of Childhood Cancer","volume":"36","author":"Armstrong","year":"2014","journal-title":"Prog. Pediatr. Cardiol."},{"key":"ref_85","first-page":"87","article-title":"Anthracycline-induced cardiomyopathy in childhood cancer survivors is associated with gene signatures of mitochondrial dysfunction-a COG ALTE03N1 report","volume":"11","author":"Trainor","year":"2025","journal-title":"Cardiooncology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1038\/s41598-023-39357-2","article-title":"Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy","volume":"13","author":"Singh","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e65299","DOI":"10.2196\/65299","article-title":"Cardiotoxicity in Pediatric Cancer Survivorship: Retrospective Cohort Study","volume":"6","author":"Mansoor","year":"2025","journal-title":"JMIRx Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1200\/JCO.21.02944","article-title":"Risk Factors for Heart Failure Among Pan-European Childhood Cancer Survivors: A PanCareSurFup and ProCardio Cohort and Nested Case-Control Study","volume":"41","author":"Feijen","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Guida, F., Fabi, M., Balducci, A., Zama, D., Masetti, R., Mercolini, F., Belotti, T., Cantarini, M.E., Facchini, E., and Legnani, E.L. (2025). Risk Stratification for Cardiotoxicity in Childhood Cancer Survivors: State-of-the-Art Review and a Novel Two-Step Approach. Cancers, 17.","DOI":"10.3390\/cancers17233740"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5818612","DOI":"10.1155\/2022\/5818612","article-title":"Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity","volume":"2022","author":"Ding","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Muggeo, P., Scicchitano, P., Muggeo, V.M.R., Novielli, C., Giordano, P., Ciccone, M.M., Faienza, M.F., and Santoro, N. (2022). Assessment of Cardiovascular Function in Childhood Leukemia Survivors: The Role of the Right Heart. Children, 9.","DOI":"10.3390\/children9111731"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"S4282","DOI":"10.21037\/jtd.2018.08.15","article-title":"Biomarkers for the detection of apparent and subclinical cancer therapy-related cardiotoxicity","volume":"10","author":"Michel","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_94","first-page":"e37308","article-title":"Efficacy of Dexrazoxane in Cardiac Protection in Pediatric Patients Treated with Anthracyclines","volume":"15","author":"Rahimi","year":"2023","journal-title":"Cureus"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Zhao, Y., He, R., Oerther, S., Zhou, W., Vosough, M., and Hassan, M. (2022). Cardiovascular Complications in Hematopoietic Stem Cell Transplanted Patients. J. Pers. Med., 12.","DOI":"10.3390\/jpm12111797"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jnci\/djz108","article-title":"Traditional Cardiovascular Risk Factors and Individual Prediction of Cardiovascular Events in Childhood Cancer Survivors","volume":"112","author":"Chen","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000495698","article-title":"Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer","volume":"91","author":"Friedman","year":"2019","journal-title":"Horm. Res. Paediatr."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Mainieri, F., Giannini, C., and Chiarelli, F. (2022). Cardiovascular Risk in Childhood Cancer Survivors. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123098"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaccao.2023.12.008","article-title":"Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer: JACC: CardioOncology State-of-the-Art Review","volume":"6","author":"Hammoud","year":"2024","journal-title":"JACC CardioOncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41568-024-00768-6","article-title":"Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy","volume":"25","author":"Wang","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/bph.13792","article-title":"The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system","volume":"174","author":"Kietzmann","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Gonzalez Acevedo, M.K., Powers, M., and Cucullo, L. (2026). Oxidative Stress, Environmental Pollutants, Aging, and Epigenetic Regulation: Mechanistic Insights and Biomarker Advances. Antioxidants, 15.","DOI":"10.20944\/preprints202604.0051.v1"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.freeradbiomed.2025.04.004","article-title":"Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response","volume":"233","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41392-024-02095-6","article-title":"Redox regulation: Mechanisms, biology and therapeutic targets in diseases","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e70774","DOI":"10.1002\/mco2.70774","article-title":"Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets","volume":"7","author":"Zhang","year":"2026","journal-title":"MedComm"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: Mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Maida, C.D., Pacinella, G., Daidone, M., Bona, M.M., Scaglione, S., Malfitano, R., Norrito, R., Cassataro, G., Dell\u2019Ajra, L., and Ferrantelli, S. (2026). Molecular Mechanisms and Multi-Omics Integration in Heart Failure: From Pathophysiology to Precision Medicine. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27114814"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/2211-5463.13252","article-title":"Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes","volume":"11","author":"Fang","year":"2021","journal-title":"FEBS Open Bio"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13148-021-01077-7","article-title":"The role of DNA methylation in syndromic and non-syndromic congenital heart disease","volume":"13","author":"Cao","year":"2021","journal-title":"Clin. Epigenet."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"168394","DOI":"10.1016\/j.jmb.2023.168394","article-title":"Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation","volume":"436","author":"Tibben","year":"2024","journal-title":"J. Mol. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"108106","DOI":"10.1016\/j.phrs.2026.108106","article-title":"Mitochondrial semi-autonomous inheritance in cardiovascular pathology: Emerging mechanisms and therapeutic opportunities","volume":"224","author":"Xie","year":"2026","journal-title":"Pharmacol. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13059-019-1805-1","article-title":"Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation","volume":"20","author":"Price","year":"2019","journal-title":"Genome Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev-genom-090413-025437","article-title":"Non-CG Methylation in the Human Genome","volume":"16","author":"He","year":"2015","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature14465","article-title":"Human body epigenome maps reveal noncanonical DNA methylation variation","volume":"523","author":"Schultz","year":"2015","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Nejati-Koshki, K., Roberts, C.T., Babaei, G., and Rastegar, M. (2023). The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology. Cancers, 15.","DOI":"10.3390\/cancers15102683"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"11204","DOI":"10.1038\/srep11204","article-title":"Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias","volume":"5","author":"Hara","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbrc.2010.08.064","article-title":"Epigenetic regulation of neonatal cardiomyocytes differentiation","volume":"400","author":"Kou","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"147487","DOI":"10.1016\/j.gene.2023.147487","article-title":"Mechanisms of human DNA methylation, alteration of methylation patterns in physiological processes and oncology","volume":"875","author":"Sergeeva","year":"2023","journal-title":"Gene"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00335-020-09844-2","article-title":"Diversification of CpG-Island Promoters Revealed by Comparative Analysis Between Human and Rhesus Monkey Genomes","volume":"31","author":"Aoto","year":"2020","journal-title":"Mamm. Genome"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"100465","DOI":"10.1016\/j.crmeth.2023.100465","article-title":"Engineering CpG island DNA methylation in pluripotent cells through synthetic CpG-free ssDNA insertion","volume":"3","author":"Tompkins","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e70101","DOI":"10.1111\/eva.70101","article-title":"The CpG Landscape of Protein Coding DNA in Vertebrates","volume":"18","author":"Wilcox","year":"2025","journal-title":"Evol. Appl."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1042\/BST20200695","article-title":"Sequence determinants, function, and evolution of CpG islands","volume":"49","author":"Angeloni","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-022-05580-6","article-title":"A DNA methylation atlas of normal human cell types","volume":"613","author":"Loyfer","year":"2023","journal-title":"Nature"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Ladisa, G., Montenegro, F., Picerno, A., Nigro, A., Cicirelli, A., Stasi, A., Fiorentino, M., Pontrelli, P., Gesualdo, L., and Sallustio, F. (2026). A New Complexity Layer: DNA Methylation and the Predictive Impact of Epigenetic Tests. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27031611"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"101328","DOI":"10.1016\/j.crmeth.2026.101328","article-title":"Ontology-aware DNA methylation classification with a curated atlas of human tissues and cell types","volume":"6","author":"Kim","year":"2026","journal-title":"Cell Rep. Methods"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Wang, J., Ma, X., Zhang, Q., Chen, Y., Wu, D., Zhao, P., and Yu, Y. (2021). The Interaction Analysis of SNP Variants and DNA Methylation Identifies Novel Methylated Pathogenesis Genes in Congenital Heart Diseases. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.665514"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"25-00073","DOI":"10.1266\/ggs.25-00073","article-title":"Molecular mechanisms of maintenance DNA methylation","volume":"100","author":"Mulholland","year":"2025","journal-title":"Genes Genet. Syst."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"46194","DOI":"10.31083\/RCM46194","article-title":"DNA Methylation: A Key Epigenetic Regulator of Cardiovascular Diseases","volume":"27","author":"Chen","year":"2026","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"102820","DOI":"10.1016\/j.redox.2023.102820","article-title":"Crosstalk between oxidative stress and epigenetic marks: New roles and therapeutic implications in cardiac fibrosis","volume":"65","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41374-020-0402-y","article-title":"Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin","volume":"100","author":"Wu","year":"2020","journal-title":"Lab. Investig."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"38696","DOI":"10.31083\/RCM38696","article-title":"Epigenetic Mechanisms in Heart Diseases","volume":"26","author":"Yildiz","year":"2025","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Xiang, M., Yang, M., Zhang, L., Ouyang, X., Sarapultsev, A., Luo, S., and Hu, D. (2025). Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target. Antioxidants, 14.","DOI":"10.3390\/antiox14091138"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Rabkin, S.W., and Wong, C.N. (2023). Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction. Biomedicines, 11.","DOI":"10.3390\/biomedicines11102815"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1161\/CIRCULATIONAHA.119.044444","article-title":"An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility","volume":"142","author":"Madsen","year":"2020","journal-title":"Circulation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yjmcc.2015.03.007","article-title":"Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B","volume":"82","author":"Vujic","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"12418","DOI":"10.1038\/ncomms12418","article-title":"DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy","volume":"7","author":"Greco","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Davletgildeeva, A.T., and Kuznetsov, N.A. (2024). The Role of DNMT Methyltransferases and TET Dioxygenases in the Maintenance of the DNA Methylation Level. Biomolecules, 14.","DOI":"10.3390\/biom14091117"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41392-023-01537-x","article-title":"TET (Ten-eleven translocation) family proteins: Structure, biological functions and applications","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"123915","DOI":"10.1016\/j.lfs.2025.123915","article-title":"The dioxygenase TET2 regulates pathological cardiac hypertrophy","volume":"379","author":"Hong","year":"2025","journal-title":"Life Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13148-024-01719-6","article-title":"Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response","volume":"16","author":"Rath","year":"2024","journal-title":"Clin. Epigenet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e70600","DOI":"10.1002\/mco2.70600","article-title":"Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets","volume":"7","author":"Qin","year":"2026","journal-title":"MedComm"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e70065","DOI":"10.1002\/mog2.70065","article-title":"Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics","volume":"5","author":"Yang","year":"2026","journal-title":"MedComm\u2013Oncology"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Szponar, J., Ciechanski, E., Ciechanska, M., Dudka, J., and Mandziuk, S. (2024). Evolution of Theories on Doxorubicin-Induced Late Cardiotoxicity-Role of Topoisomerase. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413567"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Lin, Y., Zhang, H., Jiang, Y., and Tian, W. (2025). Oxidative stress and its related epigenetic modifications in vascular calcification: Mechanisms and advances. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1662989"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"14078","DOI":"10.1074\/jbc.M112.355206","article-title":"SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status","volume":"287","author":"Yu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Robinson, E.L., Ameri, P., Delrue, L., Vanderheyden, M., Bartunek, J., Altieri, P., Heymans, S., and Heggermont, W.A. (2023). Differential expression of epigenetic modifiers in early and late cardiotoxic heart failure reveals DNA methylation as a key regulator of cardiotoxicity. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.884174"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/19491034.2022.2143106","article-title":"Chromatin accessibility: Methods, mechanisms, and biological insights","volume":"13","author":"Mansisidor","year":"2022","journal-title":"Nucleus"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"103301","DOI":"10.1016\/j.dnarep.2022.103301","article-title":"Histone variants: The unsung guardians of the genome","volume":"112","author":"Phillips","year":"2022","journal-title":"DNA Repair."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.7150\/ijbs.95954","article-title":"CHHM: A Manually Curated Catalogue of Human Histone Modifications Revealing Hotspot Regions and Unique Distribution Patterns","volume":"20","author":"Ma","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1002\/mco2.292","article-title":"Post-translational modifications of histones: Mechanisms, biological functions, and therapeutic targets","volume":"4","author":"Liu","year":"2023","journal-title":"MedComm"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"147964","DOI":"10.1016\/j.ijbiomac.2025.147964","article-title":"Recent progress in histone post-translational modifications as regulators of metabolic diseases: A review","volume":"330","author":"Zhu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13059-026-04011-3","article-title":"Unraveling the complexity of the histone code: Implications for gene regulation and disease","volume":"27","author":"Malone","year":"2026","journal-title":"Genome Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e70765","DOI":"10.1002\/mco2.70765","article-title":"Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities","volume":"7","author":"Zheng","year":"2026","journal-title":"MedComm"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13148-020-00895-5","article-title":"H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts","volume":"12","author":"Pei","year":"2020","journal-title":"Clin. Epigenet."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Yang, S., Sun, Y., and Yu, W. (2025). HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease. Cells, 14.","DOI":"10.3390\/cells14141116"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13148-024-01709-8","article-title":"H3K27ac acts as a molecular switch for doxorubicin-induced activation of cardiotoxic genes","volume":"16","author":"Hong","year":"2024","journal-title":"Clin. Epigenet."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Han, Y., Nie, J., Wang, D.W., and Ni, L. (2022). Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.931475"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"102089","DOI":"10.1016\/j.redox.2021.102089","article-title":"Role of acetylation in doxorubicin-induced cardiotoxicity","volume":"46","author":"Li","year":"2021","journal-title":"Redox Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yjmcc.2019.08.009","article-title":"Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3","volume":"136","author":"Meng","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Krekora, J., Matuszewska-Brycht, O., Wranicz, J.K., Krejca, M., Kaczmarek, K., Merks, P., and Dro\u017cd\u017c, J. (2026). Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases. Biomolecules, 16.","DOI":"10.3390\/biom16060793"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10565-021-09649-2","article-title":"Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53\/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms","volume":"39","author":"Wu","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"153119","DOI":"10.1016\/j.tox.2022.153119","article-title":"SIRT4 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the AKT\/mTOR\/Autophagy Pathway","volume":"469","author":"He","year":"2022","journal-title":"Toxicology"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41586-023-05780-8","article-title":"H3K4me3 regulates RNA polymerase II promoter-proximal pause-release","volume":"615","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/jat.70131","article-title":"Doxorubicin-Induced Cardiotoxicity: Comprehensive Pathway Insights and Advanced Preclinical Therapeutics","volume":"46","author":"Sharma","year":"2026","journal-title":"J. Appl. Toxicol."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Wang, P., Lan, R., Guo, Z., Cai, S., Wang, J., Wang, Q., Li, Z., Li, Z., Wang, Q., and Li, J. (2020). Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.548605"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"108834","DOI":"10.1016\/j.cbi.2019.108834","article-title":"The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes","volume":"313","author":"Hanf","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Dubey, A.K., Kumar, A., Nurbekova, Z., and Kumar, N. (2026). Long Non-Coding RNAs in Human Disease: An Overview of Biogenesis, Molecular Mechanism and Therapeutic Opportunities. Curr. Issues Mol. Biol., 48.","DOI":"10.3390\/cimb48040414"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Be\u0148a\u010dka, R., Szab\u00f3ov\u00e1, D., Gu\u013ea\u0161ov\u00e1, Z., Hertelyov\u00e1, Z., and Rado\u0148ak, J. (2023). Non-Coding RNAs in Human Cancer and Other Diseases: Overview of the Diagnostic Potential. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216213"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"101652","DOI":"10.1016\/j.gendis.2025.101652","article-title":"Unveiling the regulatory potential of the non-coding genome: Insights from the human genome project to precision medicine","volume":"12","author":"Ruffo","year":"2025","journal-title":"Genes Dis."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Diamantopoulos, M.A., Boti, M.A., Sarri, T., and Scorilas, A. (2025). Non-Coding RNAs in Health and Disease: From Biomarkers to Therapeutic Targets. LabMed, 2.","DOI":"10.3390\/labmed2030017"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Gaggi, G., Hausman, C., Cho, S., Badalamenti, B.C., Trinh, B.Q., Di Ruscio, A., and Ummarino, S. (2025). LncRNAs Ride the Storm of Epigenetic Marks. Genes, 16.","DOI":"10.3390\/genes16030313"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Good, D.J. (2023). Non-Coding RNAs in Human Health and Diseases. Genes, 14.","DOI":"10.3390\/genes14071429"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"100829","DOI":"10.1016\/j.cophys.2025.100829","article-title":"Impact of microRNAs and long noncoding RNAs in skeletal and cardiac muscles","volume":"44","author":"Diniz","year":"2025","journal-title":"Curr. Opin. Physiol."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"M\u0142ynarska, E., Bojdo, K., Bulicz, A., Hossa, K., Lisi\u0144ska, W., Stasiak, P., Rysz, J., and Franczyk, B. (2026). Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases: A Review of Recent Advances and Therapeutic Implications. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020983"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Kraus, L., Fredericks, S., and Scheeler, K. (2025). The epigenetic regulation of crosstalk between cardiac fibroblasts and other cardiac cell types during stress. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1539826"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1093\/nar\/gkv518","article-title":"Small RNA-mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation","volume":"43","author":"Zhang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nrcardio.2015.71","article-title":"Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure","volume":"12","author":"Greco","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Ren, Y., Zhao, B., Lv, L., Yang, J., Nan, X., Li, B., and Yang, B. (2025). Non-coding RNAs in heart failure: Epigenetic regulatory mechanisms and therapeutic potential. Front. Genet., 16, Correction in Front. Genet. 2025, 16, 1746339. https:\/\/doi.org\/10.3389\/fgene.2025.1746339.","DOI":"10.3389\/fgene.2025.1746339"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s11357-023-00929-9","article-title":"Bleomycin-treated myoblasts undergo p21-associated cellular senescence and have severely impaired differentiation","volume":"46","author":"Kamal","year":"2024","journal-title":"Geroscience"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Zivalj, D., Schleicher, L.M., Krsek, A., Diamee, H.J., Raljevic, D., and Baticic, L. (2026). MicroRNAs in Heart Failure Pathogenesis and Progression: Mechanistic Control, Biomarker Potential, and Translational Perspectives. Life, 16.","DOI":"10.3390\/life16030400"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Sun, M., Kim, I.-M., and Yang, L. (2025). Non-Coding RNAs in the Regulation of Doxorubicin-Induced Cardiotoxicity. Biomolecules, 15.","DOI":"10.3390\/biom15060800"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.redox.2017.12.013","article-title":"MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2","volume":"15","author":"Zhao","year":"2018","journal-title":"Redox Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"e1677","DOI":"10.1038\/cddis.2015.41","article-title":"MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity","volume":"6","author":"Wang","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_184","first-page":"3600","article-title":"MiR-378 modulates energy imbalance and apoptosis of mitochondria induced by doxorubicin","volume":"10","author":"Wang","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s12276-023-01050-9","article-title":"MicroRNA: Trends in clinical trials of cancer diagnosis and therapy strategies","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3892\/ijmm.2021.4958","article-title":"MicroRNA-133b alleviates doxorubicin-induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2","volume":"48","author":"Li","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/cvr\/cvw174","article-title":"Identifying circulating microRNAs as biomarkers of cardiovascular disease: A systematic review","volume":"111","author":"Navickas","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Bhutani, V., Varzideh, F., Wilson, S., Kansakar, U., Jankauskas, S.S., and Santulli, G. (2025). Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update. J. Cardiovasc. Dev. Dis., 12, Correction in J. Cardiovasc. Dev. Dis. 2025, 12, 242. https:\/\/doi.org\/10.3390\/jcdd12070242.","DOI":"10.3390\/jcdd12070242"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Kura, B., Kalocayova, B., Devaux, Y., and Bartekova, M. (2020). Potential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030700"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijcard.2017.06.054","article-title":"Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction\u2014The SITAGRAMI-miR analysis","volume":"244","author":"Grabmaier","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.18632\/oncotarget.14355","article-title":"Circulating miR-1 as a potential biomarker of doxorubicin-induced cardiotoxicity in breast cancer patients","volume":"8","author":"Rigaud","year":"2017","journal-title":"Oncotarget"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3892\/mi.2025.268","article-title":"Exosomal miRNAs as biomarkers in predicting chemotherapy-induced cardiotoxicity in patients with cancer (Review)","volume":"5","author":"Shah","year":"2025","journal-title":"Med. Int."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"14511","DOI":"10.3390\/ijms160714511","article-title":"MiR-21 Protected Cardiomyocytes against Doxorubicin-Induced Apoptosis by Targeting BTG2","volume":"16","author":"Tong","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"e15451","DOI":"10.1016\/j.heliyon.2023.e15451","article-title":"miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Kawano, I., and Adamcova, M. (2022). MicroRNAs in doxorubicin-induced cardiotoxicity: The DNA damage response. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1055911"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Wan, Q., Xu, T., Ding, W., Zhang, X., Ji, X., Yu, T., Yu, W., Lin, Z., and Wang, J. (2019). miR-499-5p Attenuates Mitochondrial Fission and Cell Apoptosis via p21 in Doxorubicin Cardiotoxicity. Front. Genet., 9.","DOI":"10.3389\/fgene.2018.00734"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"153587","DOI":"10.1016\/j.tox.2023.153587","article-title":"The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity","volume":"494","author":"Guan","year":"2023","journal-title":"Toxicology"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Stankovic, S., Mutavdzin Krneta, S., Djuric, D., Milosevic, V., and Milenkovic, D. (2025). Plant Polyphenols as Heart\u2019s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26030915"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/ptr.8215","article-title":"The interplay of exercise and polyphenols in cancer treatment: A focus on oxidative stress and antioxidant mechanisms","volume":"38","author":"Wang","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/cvr\/cvr022","article-title":"Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53","volume":"90","author":"Zhang","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Abdelgawad, I.Y., Grant, M.K.O., and Zordoky, B.N. (2019). Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology. Nutrients, 11.","DOI":"10.3390\/nu11030627"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Auwerx","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Lu, G., Liu, Q., Gao, T., Li, J., Zhang, J., Chen, O., Cao, C., Mao, M., Xiao, M., and Zhang, X. (2022). Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway. Nutrients, 14.","DOI":"10.3390\/nu14194017"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41420-023-01565-0","article-title":"Nrf2: A dark horse in doxorubicin-induced cardiotoxicity","volume":"9","author":"Zhao","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"116794","DOI":"10.1016\/j.taap.2023.116794","article-title":"Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway","volume":"482","author":"Chen","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1142\/S0192415X22500902","article-title":"Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol","volume":"50","author":"Yu","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bcp.2018.02.025","article-title":"Resveratrol suppresses doxorubicin-induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion","volume":"150","author":"Gu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.2147\/IJN.S211130","article-title":"Resveratrol solid lipid nanoparticles to trigger credible inhibition of doxorubicin cardiotoxicity","volume":"14","author":"Zhang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"111702","DOI":"10.1016\/j.biopha.2021.111702","article-title":"Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity","volume":"140","author":"Monahan","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Shoukry, H.S., Ammar, H.I., Rashed, L.A., Zikri, M.B., Shamaa, A.A., Abou Elfadl, S.G., Rub, E.A., Saravanan, S., and Dhingra, S. (2017). Prophylactic supplementation of resveratrol is more effective than its therapeutic use against doxorubicin induced cardiotoxicity. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0181535"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Ferenczyova, K., Kalocayova, B., and Bartekova, M. (2020). Potential Implications of Quercetin and its Derivatives in Cardioprotection. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051585"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.biopha.2014.10.013","article-title":"The flavonoid quercetin: Possible solution for anthracycline-induced cardiotoxicity and multidrug resistance","volume":"68","author":"Czepas","year":"2014","journal-title":"Biomed. Pharmacother."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1111\/bph.12795","article-title":"Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression","volume":"171","author":"Dong","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Dulf, P.L., Coad\u0103, C.A., Florea, A., Moldovan, R., Baldea, I., Dulf, D.V., Blendea, D., and Filip, A.G. (2024). Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats. Antioxidants, 13.","DOI":"10.3390\/antiox13091068"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.bbadis.2007.05.002","article-title":"Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase","volume":"1772","author":"Bast","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2147\/VHRM.S381485","article-title":"Evaluation of Ameliorative Effect of Quercetin and Candesartan in Doxorubicin-Induced Cardiotoxicity","volume":"18","author":"Majhi","year":"2022","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Voycheva, C., Popova, T., Slavkova, M., Tzankova, V., Stefanova, D., Tzankova, D., Spassova, I., Kovacheva, D., and Tzankov, B. (2023). Doxorubicin and Quercetin Double Loading in Modified MCM-41 Lowered Cardiotoxicity in H9c2 Cardioblast Cells In Vitro. Bioengineering, 10.","DOI":"10.3390\/bioengineering10060637"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Dorostkar, H., Haghiralsadat, B.F., Hemati, M., Safari, F., Hassanpour, A., Naghib, S.M., Roozbahani, M.H., Mozafari, M.R., and Moradi, A. (2023). Reduction of Doxorubicin-Induced Cardiotoxicity by Co-Administration of Smart Liposomal Doxorubicin and Free Quercetin: In Vitro and In Vivo Studies. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15071920"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1002\/jat.70044","article-title":"Cardiac-Targeted Quercetin-Loaded PLGA Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity via Nrf2\/HO-1 Pathway Activation in Mice","volume":"46","author":"Chahardori","year":"2026","journal-title":"J. Appl. Toxicol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"157357","DOI":"10.1016\/j.phymed.2025.157357","article-title":"Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux","volume":"148","author":"Bian","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12012-026-10127-6","article-title":"Quercetin Antagonizes Doxorubicin-Induced Cardiotoxicity via HO-1\/PGC-1\u03b1-ALOX5 Axis: Arachidonic Acid Metabolism-Ferroptosis Crosstalk as a Therapeutic Target","volume":"26","author":"Duan","year":"2026","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.biopha.2018.02.055","article-title":"Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it","volume":"100","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Iqbal, M.O., Wang, Q., Manzoor, M., Ahmad Khan, I., Gu, Y., Chen, J., and Wu, X. (2025). Evaluation of the protective effect of aqueous-methanolic leaf extract of Jatropha mollissima (Pohl.) Baill. on doxorubicin-induced cardiotoxicity in rats via modulating inflammatory markers and oxidative stress. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1634378"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"e27164","DOI":"10.1016\/j.heliyon.2024.e27164","article-title":"Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative Stress, preventing inflammation and apoptosis: Ultrastructural and computational approaches","volume":"10","author":"Shati","year":"2024","journal-title":"Heliyon"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"e22030","DOI":"10.1002\/jbt.22030","article-title":"Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats","volume":"32","author":"Benzer","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12012-021-09710-w","article-title":"Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-\u03baB, and TNF-\u03b1 in Rats","volume":"22","author":"Ahmed","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e36593","DOI":"10.1097\/MD.0000000000036593","article-title":"Exploring the mechanism of curcumin in the treatment of doxorubicin-induced cardiotoxicity based on network pharmacology and molecular docking technology","volume":"103","author":"Hu","year":"2024","journal-title":"Medicine"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"e22829","DOI":"10.1002\/jbt.22829","article-title":"Unraveling the biomechanistic role of Rac1\/TWEAK\/Fn14\/NF-\u03baB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin","volume":"35","author":"Soliman","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Akca, B., Disli, O.M., Erdil, N., Cigremis, Y., Ozen, H., Durhan, M., Tunc, S., Ozhan, O., Ulutas, Z., and Erdil, F.A. (2025). Curcumin Alleviates Doxorubicin-Induced Cardiotoxicity by Modulating Apelin Expression. Biomolecules, 15.","DOI":"10.3390\/biom15101416"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"752","DOI":"10.21037\/cdt-19-707","article-title":"Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K\/Akt\/mTOR-dependent manner","volume":"10","author":"Yu","year":"2020","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s12013-025-01723-4","article-title":"Targeting the NLRP3 by Natural Compounds: Therapeutic Strategies to Mitigate Doxorubicin-Induced Cardiotoxicity","volume":"83","author":"Shackebaei","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/s11033-026-12096-z","article-title":"Targeting NLRP3 inflammasome to mitigate chemotherapy-induced cardiotoxicity: Advances in selective inhibitors and natural modulators","volume":"53","author":"Dhondsekar","year":"2026","journal-title":"Mol. Biol. Rep."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1039\/C8FO00466H","article-title":"Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3\u03b3","volume":"9","author":"He","year":"2018","journal-title":"Food Funct."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Arruda, F.S., Tom\u00e9, F.D., Milhomem, A.C., Franco, P.I.R., Justino, A.B., Franco, R.R., Campos, E.C., Espindola, F.S., Soave, D.F., and Celes, M.R.N. (2024). Curcumin Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Increases Survival in Mice. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16081105"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"165665","DOI":"10.1016\/j.bbadis.2020.165665","article-title":"Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat","volume":"1866","author":"Mohammed","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/1440-1681.13579","article-title":"Curcumin-coated gold nanoparticles attenuate doxorubicin-induced cardiotoxicity via regulating apoptosis in a mouse model","volume":"49","author":"Sharifiaghdam","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_238","first-page":"378","article-title":"Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2\/HO-1 pathway","volume":"49","author":"Guan","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.2147\/IJN.S170067","article-title":"A complex micellar system co-delivering curcumin with doxorubicin against cardiotoxicity and tumor growth","volume":"13","author":"Zhang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"12533","DOI":"10.1039\/C7NR03611F","article-title":"pH-Responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin into tumor cells","volume":"9","author":"Gao","year":"2017","journal-title":"Nanoscale"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1080\/1061186X.2017.1315687","article-title":"One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin","volume":"25","author":"Peng","year":"2017","journal-title":"J. Drug Target."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1039\/C9FO01034C","article-title":"Zn(ii)-Curcumin supplementation alleviates gut dysbiosis and zinc dyshomeostasis during doxorubicin-induced cardiotoxicity in rats","volume":"10","author":"Wu","year":"2019","journal-title":"Food Funct."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11010-017-3195-6","article-title":"Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts","volume":"442","author":"Jain","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1177\/10781552241277958","article-title":"\u201cThe protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial\u201d","volume":"31","author":"Tohidi","year":"2025","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_245","first-page":"3868","article-title":"Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer","volume":"62","author":"Somasundaram","year":"2002","journal-title":"Cancer Res."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/1874471011666180831101459","article-title":"Evaluating the Radioprotective Effect of Curcumin on Rat\u2019s Heart Tissues","volume":"12","author":"Kolivand","year":"2019","journal-title":"Curr. Radiopharm."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00210-018-1506-4","article-title":"Cardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats","volume":"391","author":"Soliman","year":"2018","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12986-025-01044-6","article-title":"Omega-3 fatty acids and chemotherapy-induced toxicities: Mechanisms and emerging evidence with a pediatric focus","volume":"22","year":"2025","journal-title":"Nutr. Metab."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/0960327113493304","article-title":"Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats","volume":"33","author":"Uygur","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12929-014-0101-3","article-title":"N-3 polyunsaturated fatty acids decrease levels of doxorubicin-induced reactive oxygen species in cardiomyocytes -- involvement of uncoupling protein UCP2","volume":"21","author":"Hsu","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/FJC.0000000000000350","article-title":"Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-\u03baB\/iNOS\/NO Signaling Pathway Activation in H9C2 Cardiac Cells","volume":"67","author":"Wang","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"9198","DOI":"10.1002\/fsn3.4492","article-title":"Omega-3 supplementation attenuates doxorubicin-induced cardiotoxicity but is not related to the ceramide pathway","volume":"12","author":"Monte","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"102056","DOI":"10.1016\/j.toxrep.2025.102056","article-title":"Protective effect of omega-3 on reducing doxorubicin toxicity in preclinical trials","volume":"14","author":"Garcia","year":"2025","journal-title":"Toxicol. Rep."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Saleh, D., Abdelbaset, M., Hassan, A., Sharaf, O., Mahmoud, S., and Hegazy, R. (2020). Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0242175"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/0748233713483203","article-title":"The protective effects of \u03c9-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats","volume":"31","author":"Tulubas","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"114188","DOI":"10.1016\/j.bcp.2020.114188","article-title":"Resolvin E1 protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress, autophagy and apoptosis by targeting AKT\/mTOR signaling","volume":"180","author":"Zhang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"166525","DOI":"10.1016\/j.bbadis.2022.166525","article-title":"Resolvin E1 attenuates doxorubicin-induced cardiac fibroblast senescence: A key role for IL-1\u03b2","volume":"1868","author":"Shamoon","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"e29496","DOI":"10.1002\/pbc.29496","article-title":"Omega 3 fatty acids can reduce early doxorubicin-induced cardiotoxicity in children with acute lymphoblastic leukemia","volume":"69","author":"Khedr","year":"2022","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Barbosa-Cortes, L., Atilano-Miguel, S., Martin-Trejo, J.A., Jim\u00e9nez-Aguayo, E., Mart\u00ednez-Becerril, F.I., L\u00f3pez-Alarc\u00f3n, M., Mej\u00eda Arangur\u00e9, J.M., Maldonado-Hern\u00e1ndez, J., Delgadillo-Portillo, S., and Guzm\u00e1n-Castro, B. (2023). Effect of long-chain omega-3 polyunsaturated fatty acids on cardiometabolic factors in children with acute lymphoblastic leukemia undergoing treatment: A secondary analysis of a randomized controlled trial. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1120364"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.clnu.2023.06.022","article-title":"Pilot study on the effect of supplementation with long-chain \u03c9-3 polyunsaturated fatty acids on body composition in children with acute lymphoblastic leukemia: Randomized clinical trial","volume":"42","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1043-6618(02)00287-6","article-title":"Anthracycline-induced cardiac toxicity is not increased by dietary omega-3 fatty acids","volume":"47","author":"Germain","year":"2003","journal-title":"Pharmacol. Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"101882","DOI":"10.1016\/j.jsps.2023.101882","article-title":"Protective effect of coenzyme Q10 against doxorubicin-induced cardiotoxicity: Scoping review article","volume":"32","year":"2024","journal-title":"Saudi Pharm. J."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/1534735405276191","article-title":"Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity","volume":"4","author":"Conklin","year":"2005","journal-title":"Integr. Cancer Ther."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"s207","DOI":"10.1016\/0098-2997(94)90030-2","article-title":"Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: Control study in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma","volume":"15","author":"Iarussi","year":"1994","journal-title":"Mol. Asp. Med."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"15347354251388014","DOI":"10.1177\/15347354251388014","article-title":"Phase I Randomized, Placebo-Controlled, Cross-Over Dose-Finding Study of Coenzyme Q10 on Doxorubicin Pharmacokinetics during Breast Cancer Treatment","volume":"24","author":"Greenlee","year":"2025","journal-title":"Integr. Cancer Ther."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Sacks, B., Onal, H., Martorana, R., Sehgal, A., Harvey, A., Wastella, C., Ahmad, H., Ross, E., Pjetergjoka, A., and Prasad, S. (2021). Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: Pretreatment vs. co-treatment. BMC Pharmacol. Toxicol., 22.","DOI":"10.1186\/s40360-021-00518-6"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jaccao.2020.06.010","article-title":"Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment","volume":"2","author":"Clayton","year":"2020","journal-title":"JACC CardioOncol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"H1154","DOI":"10.1152\/ajpheart.00568.2025","article-title":"MitoQ reduces senescence burden in doxorubicin-treated endothelial cells by reducing mitochondrial ROS and DNA damage","volume":"329","author":"Abdeahad","year":"2025","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.2147\/IJN.S245170","article-title":"Nano-Encapsulation of Coenzyme Q10 in Secondary and Tertiary Nano-Emulsions for Enhanced Cardioprotection and Hepatoprotection in Human Cardiomyocytes and Hepatocytes During Exposure to Anthracyclines and Trastuzumab","volume":"15","author":"Quagliariello","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1039\/d0mt00225a","article-title":"Selenium supplementation protects against oxidative stress-induced cardiomyocyte cell cycle arrest through activation of PI3K\/AKT","volume":"12","author":"Sun","year":"2020","journal-title":"Metallomics"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1007\/s12011-021-02891-z","article-title":"Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway","volume":"200","author":"Yang","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0891-5849(94)90154-6","article-title":"Protective effect of dietary selenium supplementation on delayed cardiotoxicity of adriamycin in rat: Is PHGPX but not GPX involved?","volume":"16","author":"Jotti","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/21691401.2018.1452250","article-title":"Se@SiO2 nanocomposites attenuate doxorubicin-induced cardiotoxicity through combatting oxidative damage","volume":"46","author":"Deng","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/jpp\/rgaf079","article-title":"Selenium and iron oxide nanoparticles mitigate doxorubicin-induced cardiomyopathy in rats via Nox1\/p53 pathway inhibition","volume":"77","author":"Hassan","year":"2025","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"120792","DOI":"10.1016\/j.lfs.2022.120792","article-title":"Protective effect of green synthesized Selenium Nanoparticles against Doxorubicin induced multiple adverse effects in Swiss albino mice","volume":"305","author":"Khan","year":"2022","journal-title":"Life Sci."},{"key":"ref_276","first-page":"393","article-title":"Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease","volume":"37","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"651630","DOI":"10.1155\/2012\/651630","article-title":"Selenium in the prevention of anthracycline-induced cardiac toxicity in children with cancer","volume":"2012","author":"Tacyildiz","year":"2012","journal-title":"J. Oncol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"103095","DOI":"10.1016\/j.ctim.2024.103095","article-title":"A systematic review of Selenium as a complementary treatment in cancer patients","volume":"86","author":"Krannich","year":"2024","journal-title":"Complement. Ther. Med."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1080\/10715762.2019.1641602","article-title":"Modulation of selenium-dependent glutathione peroxidase activity enhances doxorubicin-induced apoptosis, tumour cell killing and hydroxyl radical production in human NCI\/ADR-RES cancer cells despite high-level P-glycoprotein expression","volume":"53","author":"Doroshow","year":"2019","journal-title":"Free Radic. Res."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2025.03.049","article-title":"Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite","volume":"233","author":"Gencheva","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"e042534","DOI":"10.1161\/JAHA.125.042534","article-title":"Vitamin C as a Cardioprotective Agent Against Doxorubicin-Induced Cardiotoxicity","volume":"14","author":"Nsairat","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Ludke, A., Akolkar, G., Ayyappan, P., Sharma, A.K., and Singal, P.K. (2017). Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179452"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4103\/0253-7613.84952","article-title":"Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats","volume":"43","author":"Wangikar","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"H795","DOI":"10.1152\/ajpheart.00253.2017","article-title":"Vitamin C mitigates oxidative\/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy","volume":"313","author":"Akolkar","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-011-1059-z","article-title":"Subcellular basis of vitamin C protection against doxorubicin-induced changes in rat cardiomyocytes","volume":"360","author":"Ludke","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0304-3835(96)04212-7","article-title":"Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro","volume":"103","author":"Kurbacher","year":"1996","journal-title":"Cancer Lett."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00432-016-2259-4","article-title":"Proteomic analysis of the vitamin C effect on the doxorubicin cytotoxicity in the MCF-7 breast cancer cell line","volume":"143","author":"Bober","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_288","doi-asserted-by":"crossref","unstructured":"Perveen, F., Arshad, N., Qureshi, R., Nowsherwan, J., Sultan, A., Nosheen, B., and Rafique, H. (2018). Electrochemical, spectroscopic and theoretical monitoring of anthracyclines\u2019 interactions with DNA and ascorbic acid by adopting two routes: Cancer cell line studies. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205764"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"152311","DOI":"10.1016\/j.bbrc.2025.152311","article-title":"Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model","volume":"777","author":"Takruri","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1536\/ihj.37.353","article-title":"Cardioprotection in patients undergoing chemo- and\/or radiotherapy for neoplastic disease. A pilot study","volume":"37","author":"Wagdi","year":"1996","journal-title":"Jpn. Heart J."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"110265","DOI":"10.1016\/j.jnutbio.2026.110265","article-title":"Vitamin E and related tocols in cancer: Unraveling the paradox of antioxidant and pro-oxidant roles","volume":"151","author":"Xiao","year":"2026","journal-title":"J. Nutr. Biochem."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S0954422423000112","article-title":"Vitamin E and cardiovascular diseases: An interest to public health?","volume":"37","year":"2024","journal-title":"Nutr. Res. Rev."},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Moabedi, M., and Milajerdi, A. (2025). The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1547888"},{"key":"ref_294","first-page":"94","article-title":"Alpha-tocopherol reduces doxorubicin-induced toxicity in rats--histological and biochemical evidences","volume":"34","author":"Geetha","year":"1990","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-2005-872923","article-title":"Electrocardiographic and biochemical evidence for the cardioprotective effect of vitamin E in doxorubicin-induced acute cardiotoxicity in rats","volume":"15","author":"Puri","year":"2005","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_296","doi-asserted-by":"crossref","unstructured":"Hadi, N., Yousif, N.G., Al-amran, F.G., Huntei, N.K., Mohammad, B.I., and Ali, S.J. (2012). Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response. BMC Cardiovasc. Disord., 12.","DOI":"10.1186\/1471-2261-12-63"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1385\/CT:5:3:257","article-title":"Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction","volume":"5","author":"Berthiaume","year":"2005","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1742-7843.2005.pto_166.x","article-title":"Activity of d,l-alpha-tocopherol (vitamin E) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice","volume":"97","author":"Bjelogrlic","year":"2005","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1177\/10781552221078284","article-title":"Vitamin E and levocarnitine as prophylaxis against doxorubicin-induced cardio toxicity in the adult cancer patient: A review","volume":"28","author":"Moustafa","year":"2022","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/10781552231171114","article-title":"A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients","volume":"30","author":"Moustafa","year":"2024","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/acsptsci.2c00091","article-title":"Rational Drug Design of Targeted and Enzyme-Cleavable Vitamin E Analogs as a Neoadjuvant to Chemotherapy: In Vitro and In Vivo Evaluation on Reduction of the Cardiotoxicity Side Effect of Doxorubicin","volume":"6","author":"Pandurangi","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jbm.a.32734","article-title":"Doxorubicin conjugated to D-alpha-tocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy","volume":"94","author":"Anbharasi","year":"2010","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"105205","DOI":"10.1016\/j.ejps.2019.105205","article-title":"Alpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomes","volume":"144","author":"Boratto","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"112373","DOI":"10.1016\/j.biopha.2021.112373","article-title":"pH-sensitive doxorubicin-tocopherol succinate prodrug encapsulated in docosahexaenoic acid-based nanostructured lipid carriers: An effective strategy to improve pharmacokinetics and reduce toxic effects","volume":"144","author":"Lages","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.biopha.2017.09.006","article-title":"Mixed micelles for encapsulation of doxorubicin with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines versus Doxil\u00ae","volume":"95","author":"Cagel","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_306","doi-asserted-by":"crossref","unstructured":"Metwally, A.A., Ganguly, S., Biomi, N., Yao, M., and Elbayoumi, T. (2024). Cationic Vitamin E-TPGS Mixed Micelles of Berberine to Neutralize Doxorubicin-Induced Cardiotoxicity via Amelioration of Mitochondrial Dysfunction and Impeding Apoptosis. Molecules, 29.","DOI":"10.3390\/molecules29051155"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"201","DOI":"10.31557\/APJCP.2022.23.1.201","article-title":"Effects of Vitamin E on Doxorubicin Cytotoxicity in Human Breast Cancer Cells in Vitro","volume":"23","author":"Ahmadi","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/15287394.2023.2168224","article-title":"\u03b1-tocopherol as a selective modulator of toxicogenic damage induced by antineoplastic agents cyclophosphamide and doxorubicin","volume":"86","author":"Pereira","year":"2023","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_309","first-page":"2710","article-title":"Vitamin E promotes breast cancer cell proliferation by reducing ROS production and p53 expression","volume":"20","author":"Diao","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_310","first-page":"508","article-title":"The effect of magnesium and vitamin E pre-treatments on irradiation-induced oxidative injury of cardiac and pulmonary tissues in rats: A randomized experimental study","volume":"12","author":"Atasoy","year":"2012","journal-title":"Anadolu Kardiyol. Derg."},{"key":"ref_311","doi-asserted-by":"crossref","unstructured":"Varzideh, F., Mone, P., Kansakar, U., and Santulli, G. (2026). Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation. Nutrients, 18.","DOI":"10.3390\/nu18030499"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"123062","DOI":"10.1016\/j.lfs.2024.123062","article-title":"Vitamin D as a modulator of molecular pathways involved in CVDs: Evidence from preclinical studies","volume":"357","author":"Anilkumar","year":"2024","journal-title":"Life Sci."},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Lee, K.J., Wright, G., Bryant, H., Wiggins, L.A., Dal Zotto, V.L., Schuler, M., Malozzi, C., Cohen, M.V., and Gassman, N.R. (2021). Cytoprotective Effect of Vitamin D on Doxorubicin-Induced Cardiac Toxicity in Triple Negative Breast Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147439"},{"key":"ref_314","doi-asserted-by":"crossref","unstructured":"Vitale, R., Marzocco, S., and Popolo, A. (2024). Role of Oxidative Stress and Inflammation in Doxorubicin-Induced Cardiotoxicity: A Brief Account. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202405.1681.v1"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.clbc.2022.01.008","article-title":"The Cardioprotective Effect of Vitamin D in Breast Cancer Patients Receiving Adjuvant Doxorubicin Based Chemotherapy","volume":"22","author":"Helmy","year":"2022","journal-title":"Clin. Breast Cancer"},{"key":"ref_316","doi-asserted-by":"crossref","unstructured":"Tsai, T.H., Lin, C.J., Hang, C.L., and Chen, W.Y. (2019). Calcitriol Attenuates Doxorubicin-Induced Cardiac Dysfunction and Inhibits Endothelial-to-Mesenchymal Transition in Mice. Cells, 8.","DOI":"10.3390\/cells8080865"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3892\/etm.2023.12112","article-title":"1,25(OH)(2)D(3) ameliorates doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome and oxidative stress","volume":"26","author":"Gu","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref_318","first-page":"281","article-title":"Electrocardiographic, biochemical, and scintigraphic evidence for the cardioprotective effect of paricalcitol and vitamin D3 on doxorubicin-induced acute cardiotoxicity in rats","volume":"125","author":"Koroglu","year":"2024","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1007\/s00210-024-02998-9","article-title":"Vitamin D ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model via enhancement of the antioxidant defense and minimizing mitochondrial dysfunction","volume":"397","author":"Azizian","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"111679","DOI":"10.1016\/j.biopha.2021.111679","article-title":"Comparative study on beneficial effects of vitamins B and D in attenuating doxorubicin induced cardiotoxicity in rats: Emphasis on calcium homeostasis","volume":"140","author":"Awad","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1007\/s00277-020-04200-5","article-title":"The prognostic value of 25-hydroxy vitamin D deficiency and its interaction with c-Myc expression in diffuse large B cell lymphoma","volume":"99","author":"Wang","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clnu.2020.04.040","article-title":"Bioavailable 25(OH)D level is associated with clinical outcomes of patients with diffuse large B-cell lymphoma: An exploratory study","volume":"40","author":"Chen","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1200\/JCO.2014.57.5092","article-title":"Low Serum Vitamin D Levels Are Associated with Inferior Survival in Follicular Lymphoma: A Prospective Evaluation in SWOG and LYSA Studies","volume":"33","author":"Kelly","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/cam4.1166","article-title":"Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy","volume":"7","author":"Hohaus","year":"2018","journal-title":"Cancer Med."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1111\/jcmm.15224","article-title":"Calcitriol enhances Doxorubicin-induced apoptosis in papillary thyroid carcinoma cells via regulating VDR\/PTPN2\/p-STAT3 pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_326","first-page":"862","article-title":"1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage","volume":"59","author":"Ravid","year":"1999","journal-title":"Cancer Res."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/hmbci-2020-0045","article-title":"Evaluation of the potential anticancer activity of different vitamin D metabolites on colorectal and breast cancer cell lines","volume":"42","author":"Khriesha","year":"2021","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"117733","DOI":"10.1016\/j.lfs.2020.117733","article-title":"Crosstalk between aldehyde dehydrogenase-1 and chemoresistance in breast cancer: Insights into the role of vitamin D3","volume":"253","author":"Attia","year":"2020","journal-title":"Life Sci."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1124\/dmd.118.081612","article-title":"Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells","volume":"46","author":"Tan","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s13318-020-00632-6","article-title":"Gender Differences in the Effect of Calcitriol on the Body Disposition and Excretion of Doxorubicin in Mice","volume":"45","author":"Uney","year":"2020","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/01635581.2017.1339820","article-title":"Vitamin D-Loaded Nanostructured Lipid Carrier (NLC): A New Strategy for Enhancing Efficacy of Doxorubicin in Breast Cancer Treatment","volume":"69","author":"Sabzichi","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1208\/s12249-017-0885-z","article-title":"Cholecalciferol-PEG Conjugate Based Nanomicelles of Doxorubicin for Treatment of Triple-Negative Breast Cancer","volume":"19","author":"Kutlehria","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"108706","DOI":"10.1016\/j.carres.2022.108706","article-title":"Hyaluronic acid and cholecalciferol conjugate based nanomicelles: Synthesis, characterization, and cytotoxicity against MCF-7 breast cancer cells","volume":"522","author":"Gao","year":"2022","journal-title":"Carbohydr. Res."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.21873\/anticanres.17608","article-title":"In Vitro Evaluation of the Dual Pharmacological Action of Vitamin D(3) as Cardio-protectant and Anti-cancer Agent","volume":"45","author":"Franco","year":"2025","journal-title":"Anticancer Res."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1172\/JCI110328","article-title":"Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine","volume":"68","author":"Doroshow","year":"1981","journal-title":"J. Clin. Investig."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/0960327112467043","article-title":"N-acetylcysteine prevents doxorubucine-induced cardiotoxicity in rats","volume":"32","author":"Arica","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_337","doi-asserted-by":"crossref","unstructured":"Tola, H.T., and K\u0131l\u0131\u00e7, S. (2026). Experimental evaluation of N-acetylcysteine against doxorubicin cardiotoxicity in rats. BMC Pharmacol. Toxicol., 27.","DOI":"10.1186\/s40360-025-01073-0"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.tiv.2010.06.009","article-title":"Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I\/II null mice","volume":"24","author":"Fu","year":"2010","journal-title":"Toxicol. Vitr."},{"key":"ref_339","doi-asserted-by":"crossref","unstructured":"Shi, R., Huang, C.C., Aronstam, R.S., Ercal, N., Martin, A., and Huang, Y.W. (2009). N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes. BMC Pharmacol., 9.","DOI":"10.1186\/1471-2210-9-7"},{"key":"ref_340","first-page":"1513","article-title":"The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab-Mediated Cardiac Dysfunction","volume":"32","author":"Goyal","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2024.04.212","article-title":"Doxorubicin induces phosphorylation of lamin A\/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity","volume":"218","author":"Tiwari","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"167692","DOI":"10.1016\/j.bbadis.2025.167692","article-title":"Doxorubicin-induced phosphorylation of lamin A\/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart","volume":"1871","author":"Tiwari","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4070\/kcj.2013.43.3.174","article-title":"Evaluation of Short-Term Use of N-Acetylcysteine as a Strategy for Prevention of Anthracycline-Induced Cardiomyopathy: EPOCH Trial\u2014A Prospective Randomized Study","volume":"43","author":"Jo","year":"2013","journal-title":"Korean Circ. J."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"117173","DOI":"10.1016\/j.lfs.2019.117173","article-title":"The role of melatonin on doxorubicin-induced cardiotoxicity: A systematic review","volume":"241","author":"Najafi","year":"2020","journal-title":"Life Sci."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2018.08.032","article-title":"AMPK\/PGC1\u03b1 activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis","volume":"129","author":"Liu","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1038\/s12276-020-00541-3","article-title":"Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPK\u03b12-dependent mitochondrial damage","volume":"52","author":"Yang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/s12276-021-00675-y","article-title":"Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPK\u03b11 transcription in human breast cancer cells","volume":"53","author":"Tran","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"115902","DOI":"10.1016\/j.taap.2022.115902","article-title":"Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression","volume":"437","author":"Sun","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_349","doi-asserted-by":"crossref","unstructured":"Attachaipanich, T., Chattipakorn, S.C., and Chattipakorn, N. (2023). Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030785"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"102818","DOI":"10.1016\/j.arr.2025.102818","article-title":"Targeting autophagy in doxorubicin-induced cardiotoxicity: A comprehensive review of scientific landscapes and therapeutic innovations","volume":"110","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"e12884","DOI":"10.1111\/jpi.12884","article-title":"Effects of melatonin on cardiac metabolic reprogramming in doxorubicin-induced heart failure rats: A metabolomics study for potential therapeutic targets","volume":"75","author":"Thonusin","year":"2023","journal-title":"J. Pineal Res."},{"key":"ref_352","doi-asserted-by":"crossref","unstructured":"Park, S., Khan, Z.A., Hong, Y., Shin, J., Lkhagvasuren, T., Lee, S., and Hong, Y. (2025). Synergistic benefits of melatonin and therapeutic exercise as a unified strategy for managing stroke and doxorubicin-induced cardiotoxicity. Front. Neurol., 16.","DOI":"10.3389\/fneur.2025.1567263"},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Hanna, M., Seddiek, H., Aboulhoda, B.E., Morcos, G.N.B., Akabawy, A.M.A., Elbaset, M.A., Ibrahim, A.A., Khalifa, M.M., Khalifah, I.M., and Fadel, M.S. (2022). Synergistic cardioprotective effects of melatonin and deferoxamine through the improvement of ferritinophagy in doxorubicin-induced acute cardiotoxicity. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.1050598"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-079X.2010.00818.x","article-title":"Efficacy of melatonin, mercaptoethylguanidine and 1400W in doxorubicin- and trastuzumab-induced cardiotoxicity","volume":"50","author":"Ozturk","year":"2011","journal-title":"J. Pineal Res."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12012-020-09625-y","article-title":"Effects of Melatonin and Adrenomedullin in Reducing the Cardiotoxic Effects of Doxorubicin in Rats","volume":"21","author":"Durdagi","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"114743","DOI":"10.1016\/j.bcp.2021.114743","article-title":"Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics","volume":"192","author":"Arinno","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"e162962","DOI":"10.5812\/ijpr-162962","article-title":"Evaluating the Cardioprotective Effects of Melatonin in Non-metastatic Breast Cancer Patients Receiving Doxorubicin Plus Cyclophosphamide: A Triple-Blind, Placebo-Controlled Randomized Controlled Trial","volume":"24","author":"Mousavinia","year":"2025","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/S0959-8049(99)00159-8","article-title":"Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status","volume":"35","author":"Lissoni","year":"1999","journal-title":"Eur. J. Cancer"},{"key":"ref_359","doi-asserted-by":"crossref","unstructured":"Koss-Miko\u0142ajczyk, I., Todorovic, V., Sobajic, S., Mahajna, J., Geri\u0107, M., Tur, J.A., and Bartoszek, A. (2021). Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810037"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.biopha.2017.04.033","article-title":"Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity","volume":"90","author":"Abushouk","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_361","first-page":"243","article-title":"Reversal of Doxorubicin-induced Cardiotoxicity by Using Phytotherapy: A Review","volume":"20","author":"Hosseini","year":"2017","journal-title":"J. Pharmacopunct."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/01635589409514341","article-title":"Protective effects of an aged garlic extract on doxorubicin-induced cardiotoxicity in the mouse","volume":"22","author":"Kojima","year":"1994","journal-title":"Nutr. Cancer"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/1534735411426726","article-title":"Mechanisms of cardioprotective effect of aged garlic extract against Doxorubicin-induced cardiotoxicity","volume":"11","author":"Alkreathy","year":"2012","journal-title":"Integr. Cancer Ther."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.fct.2010.01.005","article-title":"Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats","volume":"48","author":"Alkreathy","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.fct.2010.02.008","article-title":"Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats","volume":"48","author":"Elberry","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"133792","DOI":"10.1016\/j.ijbiomac.2024.133792","article-title":"Fucoidan alleviates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via Nrf2\/GPX4 pathway","volume":"276","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bcp.2015.02.006","article-title":"Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study","volume":"95","author":"Saeed","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.lfs.2016.12.004","article-title":"(-)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice","volume":"180","author":"Yao","year":"2017","journal-title":"Life Sci."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1142\/S0192415X10008068","article-title":"Grape seed proanthocyanidins ameliorate Doxorubicin-induced cardiotoxicity","volume":"38","author":"Li","year":"2010","journal-title":"Am. J. Chin. Med."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"14720","DOI":"10.1038\/s41598-020-71827-9","article-title":"Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity","volume":"10","author":"Sergazy","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"423","DOI":"10.15171\/apb.2016.055","article-title":"Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats","volume":"6","author":"Razmaraii","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ptr.1746","article-title":"Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity","volume":"19","author":"Karimi","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tox.2005.10.015","article-title":"Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity","volume":"218","author":"Yilmaz","year":"2006","journal-title":"Toxicology"},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-7843.2007.00070.x","article-title":"Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment","volume":"101","author":"Russell","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/08982104.2019.1580720","article-title":"Enhanced antitumor efficacy and attenuated cardiotoxicity of doxorubicin in combination with lycopene liposomes","volume":"30","author":"Zhu","year":"2020","journal-title":"J. Liposome Res."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3892\/ijmm.2015.2199","article-title":"Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells","volume":"36","author":"Li","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"e12277","DOI":"10.1111\/1755-5922.12277","article-title":"Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation","volume":"35","author":"Bai","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"ref_378","doi-asserted-by":"crossref","unstructured":"Bose, C., Awasthi, S., Sharma, R., Bene\u0161, H., Hauer-Jensen, M., Boerma, M., and Singh, S.P. (2018). Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193918"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1615\/JEnvironPatholToxicolOncol.2014010625","article-title":"Protective role of naringenin against doxorubicin-induced cardiotoxicity in a rat model: Histopathology and mRNA expression profile studies","volume":"33","author":"Subburaman","year":"2014","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1016\/j.fct.2008.06.086","article-title":"Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes","volume":"46","author":"Han","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.3892\/mmr.2017.7823","article-title":"Naringin protects myocardial cells from doxorubicin-induced apoptosis partially by inhibiting the p38MAPK pathway","volume":"16","author":"Jian","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_382","doi-asserted-by":"crossref","unstructured":"B\u00e9rard, S., Morel, S., Teasdale, E., Shivappa, N., Hebert, J.R., Laverdi\u00e8re, C., Sinnett, D., Levy, E., and Marcil, V. (2020). Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia. Nutrients, 12.","DOI":"10.3390\/nu12072137"},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/01635581.2013.770042","article-title":"Dietary quality, caloric intake, and adiposity of childhood cancer survivors and their siblings: An analysis from the cardiac risk factors in childhood cancer survivors study","volume":"65","author":"Landy","year":"2013","journal-title":"Nutr. Cancer"},{"key":"ref_384","first-page":"631","article-title":"Food insecurity, dietary quality, and cardiovascular risk among early childhood cancer survivors","volume":"34","author":"Paul","year":"2026","journal-title":"Support. Care Cancer"},{"key":"ref_385","doi-asserted-by":"crossref","unstructured":"Grundherr, J.V., Elmers, S., Samland, L., M\u00fchlberg, R., Dwinger, S., Baumann, J., Koch, B., Wolters, F., Hail, L.A., and Escherich, G. (2026). Dietary intervention among young cancer survivors within the CARE for CAYA program. J. Cancer Surviv., 20.","DOI":"10.1007\/s11764-026-01997-4"},{"key":"ref_386","doi-asserted-by":"crossref","unstructured":"Ranbhise, J.S., Singh, M.K., Ju, S., Han, S., Yun, H.R., Kim, S.S., and Kang, I. (2025). The Redox Paradox: Cancer\u2019s Double-Edged Sword for Malignancy and Therapy. Antioxidants, 14.","DOI":"10.20944\/preprints202508.1909.v1"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3109\/10715769109145859","article-title":"Doxorubicin resistance conferred by selective enhancement of intracellular glutathione peroxidase or superoxide dismutase content in human MCF-7 breast cancer cells","volume":"13","author":"Doroshow","year":"1991","journal-title":"Free Radic. Res. Commun."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1073\/pnas.0506390102","article-title":"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1073\/pnas.0702854104","article-title":"Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1158\/0008-5472.CAN-19-3094","article-title":"Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity","volume":"80","author":"Gibson","year":"2020","journal-title":"Cancer Res."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"221ra215","DOI":"10.1126\/scitranslmed.3007653","article-title":"Antioxidants accelerate lung cancer progression in mice","volume":"6","author":"Sayin","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1200\/JCO.19.01203","article-title":"Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients with Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221)","volume":"38","author":"Ambrosone","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ajcn\/nqy223","article-title":"Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy","volume":"109","author":"Jung","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_394","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Iglesias, O., Naidoo, V., Carrera, I., Corzo, L., and Cacabelos, R. (2025). Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders. Genes, 16.","DOI":"10.3390\/genes16050566"},{"key":"ref_395","doi-asserted-by":"crossref","unstructured":"Xiong, Z., Liao, Y., Zhang, Z., Wan, Z., Liang, S., and Guo, J. (2025). Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies. Biomolecules, 15.","DOI":"10.3390\/biom15050670"},{"key":"ref_396","doi-asserted-by":"crossref","unstructured":"Hussain, S.A., Sarker, M.I., Liu, Y., and Jin, T.Z. (2026). DNA Methylation and Its Role in Personalized Nutrition: Mechanisms, Clinical Insights, and Future Perspectives. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020566"},{"key":"ref_397","doi-asserted-by":"crossref","unstructured":"Divyajanani, S., Harithpriya, K., Ganesan, K., and Ramkumar, K.M. (2023). Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease. Nutrients, 15.","DOI":"10.3390\/nu15153347"},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"113699","DOI":"10.1016\/j.bcp.2019.113699","article-title":"(\u2212)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation","volume":"173","author":"Milenkovic","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_399","doi-asserted-by":"crossref","unstructured":"Mattera, R., Benvenuto, M., Giganti, M.G., Tresoldi, I., Pluchinotta, F.R., Bergante, S., Tettamanti, G., Masuelli, L., Manzari, V., and Modesti, A. (2017). Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes. Nutrients, 9.","DOI":"10.3390\/nu9050523"},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1536\/ihj.24-546","article-title":"Sirtuin-3 Regulates the Mechanism of Doxorubicin-induced Cardiotoxicity","volume":"66","author":"Zhang","year":"2025","journal-title":"Int. Heart J."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/CIRCRESAHA.124.325440","article-title":"Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics","volume":"136","author":"Ding","year":"2025","journal-title":"Circ. Res."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1016\/j.apsb.2023.03.019","article-title":"Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling","volume":"13","author":"Peng","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_403","doi-asserted-by":"crossref","unstructured":"DeLucas, M., S\u00e1nchez, J., Palou, A., and Serra, F. (2024). The Impact of Diet on miRNA Regulation and Its Implications for Health: A Systematic Review. Nutrients, 16.","DOI":"10.3390\/nu16060770"},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"1921457","DOI":"10.1155\/2021\/1921457","article-title":"Ferulic Acid Alleviates Oxidative Stress-Induced Cardiomyocyte Injury by the Regulation of miR-499-5p\/p21 Signal Cascade","volume":"2021","author":"Sun","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"11879","DOI":"10.1038\/s41598-017-12192-y","article-title":"Activation of miR-34a-5p\/Sirt1\/p66shc pathway contributes to doxorubicin-induced cardiotoxicity","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"118315","DOI":"10.1016\/j.biopha.2025.118315","article-title":"Cardioprotective strategies against doxorubicin-induced cardiotoxicity: A review from standard therapies to emerging mitochondrial transplantation","volume":"189","author":"Hagiwara","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1111\/jcmm.13231","article-title":"Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase","volume":"21","author":"Octavia","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_408","doi-asserted-by":"crossref","unstructured":"Fan, R., Wang, Y., Zhang, J., An, X., Liu, S., Bai, J., Li, J., Lin, Q., Xie, Y., and Liao, J. (2023). Hyperhomocysteinaemia Promotes Doxorubicin-Induced Cardiotoxicity in Mice. Pharmaceuticals, 16.","DOI":"10.3390\/ph16091212"},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.freeradbiomed.2025.02.044","article-title":"Methionine is an essential amino acid in doxorubicin-induced cardiotoxicity through modulating mitophagy","volume":"232","author":"Xin","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10735-026-10824-0","article-title":"The possible effects of folic acid and postbiotic yeast on doxorubicin-induced cardiotoxicity in rats: Interactions among the gut microbiota, antioxidants, and NLrp3 activities","volume":"57","author":"Galal","year":"2026","journal-title":"J. Mol. Histol."},{"key":"ref_411","first-page":"65","article-title":"Effects of S-adenosylmethionine (SAMe) on doxorubicin-induced cardiotoxicity in the rat","volume":"25","author":"Russo","year":"1994","journal-title":"J. Med."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1042\/CS20181022","article-title":"Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity","volume":"133","author":"Zheng","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_413","doi-asserted-by":"crossref","unstructured":"Margier, M., Kuehnemann, C., Hulo, N., Morales, J., Ashok Kumaar, P.V., Cros, C., Cannelle, H., Charmetant, J., Verdin, E., and Canault, M. (2023). Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice. Cells, 12.","DOI":"10.3390\/cells12010108"},{"key":"ref_414","doi-asserted-by":"crossref","unstructured":"Wen, F., Xu, A., Wei, W., Yang, S., Xi, Z., Ge, Y., Wu, S., and Ju, Z. (2024). Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105303"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"e70075","DOI":"10.1002\/mco2.70075","article-title":"Histidine triad nucleotide-binding protein 2 attenuates doxorubicin-induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice","volume":"6","author":"Jiang","year":"2025","journal-title":"MedComm"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"103957","DOI":"10.1016\/j.redox.2025.103957","article-title":"Reprogramming of the kynurenine pathway impairs NAD(+) homeostasis and mediates doxorubicin-induced cardiotoxicity in mice","volume":"89","author":"Li","year":"2026","journal-title":"Redox Biol."},{"key":"ref_417","doi-asserted-by":"crossref","unstructured":"Tonon, C.R., Pereira, A.G., Ferreira, N.F., Monte, M.G., Vieira, N.M., Fujimori, A.S.S., Ballin, P.D.S., Paiva, S.A.R., Zornoff, L.A.M., and Minicucci, M.F. (2025). The Gut-Heart Axis and Its Role in Doxorubicin-Induced Cardiotoxicity: A Narrative Review. Microorganisms, 13.","DOI":"10.3390\/microorganisms13040855"},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"105977","DOI":"10.1016\/j.ejps.2021.105977","article-title":"Microbiota modulate Doxorubicin induced cardiotoxicity","volume":"166","author":"An","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_419","doi-asserted-by":"crossref","unstructured":"Huang, J., Wei, S., Jiang, C., Xiao, Z., Liu, J., Peng, W., Zhang, B., and Li, W. (2022). Involvement of Abnormal Gut Microbiota Composition and Function in Doxorubicin-Induced Cardiotoxicity. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.808837"},{"key":"ref_420","doi-asserted-by":"crossref","unstructured":"Fan, Y., Liang, L., Tang, X., Zhu, J., Mu, L., Wang, M., Huang, X., Gong, S., Xu, J., and Liu, T. (2023). Changes in the gut microbiota structure and function in rats with doxorubicin-induced heart failure. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1135428"},{"key":"ref_421","doi-asserted-by":"crossref","unstructured":"Huang, K., Liu, Y., Tang, H., Qiu, M., Li, C., Duan, C., Wang, C., Yang, J., and Zhou, X. (2019). Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00107"},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"e008220","DOI":"10.1161\/CIRCHEARTFAILURE.120.008220","article-title":"Yellow Wine Polyphenolic Compound Protects Against Doxorubicin-Induced Cardiotoxicity by Modulating the Composition and Metabolic Function of the Gut Microbiota","volume":"14","author":"Lin","year":"2021","journal-title":"Circ. Heart Fail."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"153815","DOI":"10.1016\/j.phymed.2021.153815","article-title":"Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT\/Bcl-2 signaling pathway","volume":"94","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_424","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Jiang, S., Fan, Q., Xu, K., Xu, Y., Wu, F., Zhang, X., Wang, T., and Xia, Z. (2023). Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity by regulating organic acid metabolism in gut microbiota. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1286210"},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2023.0355","article-title":"Fecal Microbiota Transplantation in Mice Exerts a Protective Effect Against Doxorubicin-Induced Cardiac Toxicity by Regulating Nrf2-Mediated Cardiac Mitochondrial Fission and Fusion","volume":"41","author":"Zhou","year":"2024","journal-title":"Antioxid. Redox Signal."},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10557-024-07665-y","article-title":"Novel Protective Role for Gut Microbiota-derived Metabolite PAGln in Doxorubicin-induced Cardiotoxicity","volume":"40","author":"Huang","year":"2026","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ejhf.1439","article-title":"The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity","volume":"21","author":"Russo","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"C161","DOI":"10.1152\/ajpcell.00477.2023","article-title":"Emodin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through the remodeling of gut microbiota composition","volume":"326","author":"Hu","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S2352-4642(22)00239-5","article-title":"Primary cardioprotection with dexrazoxane in patients with childhood cancer who are expected to receive anthracyclines: Recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group","volume":"6","author":"Mulder","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1016\/S1470-2045(23)00012-8","article-title":"Systematic review and updated recommendations for cardiomyopathy surveillance for survivors of childhood, adolescent, and young adult cancer from the International Late Effects of Childhood Cancer Guideline Harmonization Group","volume":"24","author":"Ehrhardt","year":"2023","journal-title":"Lancet Oncol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7863\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:30:36Z","timestamp":1788496236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":430,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177863"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177863","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}