{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:09:24Z","timestamp":1788869364108,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interdisciplinary Center for Clinical Research (IZKF) Jena","award":["PROM-2024-26"],"award-info":[{"award-number":["PROM-2024-26"]}]},{"name":"Bundesministeriums f\u00fcr Forschung, Technologie und Raumfahrt research grant \u201cGender in Focus\u2014Young Talent\u201d","award":["01FP23G11"],"award-info":[{"award-number":["01FP23G11"]}]},{"award":["01FP23G11"],"award-info":[{"award-number":["01FP23G11"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) is a major age-associated metabolic disease, and aging substantially contributes to the increasing burden and progression of chronic complications, including diabetic kidney disease (DKD). However, the molecular mechanisms underlying changes in renal susceptibility during disease progression remain incompletely understood. We hypothesized that the scaffold protein mitogen-activated protein kinase organizer 1 (MORG1\/WDR83) contributes to stage-dependent differences in DKD and that these effects may vary according to biological sex. Heterozygous Morg1 deletion was introduced into the diabetic C57BLKS\/J db\/db mouse model, and male and female mice were analysed at early and later disease stages alongside non-diabetic controls. Renal fibrosis, albuminuria, HIF-1\u03b1 expression, mTORC1 and ERK1\/2 activity, and renal cortical gene expression were assessed. Morg1 haploinsufficiency was associated with reduced renal fibrosis and albuminuria during early diabetes, whereas these protective effects were less evident in later-stage diabetic animals. HIF-1\u03b1 expression decreased during progression in most groups but was relatively preserved in later-stage female Morg1 heterozygotes, whereas mTORC1 and ERK1\/2 signalling was altered in a genotype- and stage-dependent manner. These findings identify MORG1 as a context-dependent modifier of DKD whose renoprotective effects change across disease progression, linking MORG1-associated signalling to the evolving renal phenotype of an age-associated metabolic disease.<\/jats:p>","DOI":"10.3390\/ijms27187990","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:23:51Z","timestamp":1788866631000},"page":"7990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney Disease"],"prefix":"10.3390","volume":"27","author":[{"given":"Jonas Till","family":"Ihle","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-4741","authenticated-orcid":false,"given":"Nadja","family":"Ziller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Elflein","sequence":"additional","affiliation":[{"name":"Central Experimental Animal Facility, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Berndt","sequence":"additional","affiliation":[{"name":"Section Pathology, Institute of Forensic Medicine, Jena University Hospital Jena, 07747 Jena, Germany"},{"name":"Thuringian Center for Molecular Diagnostics and Prevention\u2013Center for Translational Medicine (ThIMEDOP-CeTraMed), Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Ga\u00dfler","sequence":"additional","affiliation":[{"name":"Section Pathology, Institute of Forensic Medicine, Jena University Hospital Jena, 07747 Jena, Germany"},{"name":"Thuringian Center for Molecular Diagnostics and Prevention\u2013Center for Translational Medicine (ThIMEDOP-CeTraMed), Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-0610","authenticated-orcid":false,"given":"Gunter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-5647","authenticated-orcid":false,"given":"Ivonne","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.kint.2022.08.012","article-title":"Diabetes management in chronic kidney disease: A consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"102","author":"Khunti","year":"2022","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/CM9.0000000000003428","article-title":"Epidemiological status, development trends, and risk factors of disability-adjusted life years due to diabetic kidney disease: A systematic analysis of Global Burden of Disease Study 2021","volume":"138","author":"Li","year":"2025","journal-title":"Chin. 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