{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:08:11Z","timestamp":1789034891602,"version":"build-2803163510"},"reference-count":76,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Cadmium is a persistent toxic metal that promotes oxidative stress, inflammation, and epigenetic dysregulation; however, the research landscape and recurrent microRNA (miRNA)-mediated responses associated with cadmium exposure remain incompletely characterized. This study integrated bibliometric, structured content, and bioinformatics analyses to identify major research trends and recurrent miRNA signals. PubMed\/MEDLINE, Scopus, and Web of Science Core Collection were searched using predefined cadmium- and miRNA-related search terms, yielding 1511 source records. After language\/document-type filtering and cross-database deduplication, 817 unique records remained for screening, of which 286 publications formed the final bibliometric corpus. Author-keyword co-occurrence analysis was performed using a minimum occurrence threshold of \u22653, with \u22655 used as a sensitivity analysis. Cadmium and microRNA remained the dominant thematic core, while heavy-metal toxicity, apoptosis, and cadmium-stress responses represented the most recurrent secondary themes. In the final human-relevant biological evidence corpus (n = 32 studies), recurrent miRNAs showed substantial directional heterogeneity rather than a uniformly replicated response: miR-155 was reported in four studies with an equal number of increases and decreases, whereas the let-7 and miR-30 families showed modest downward tendencies, and miR-146b and miR-222 showed modest upward tendencies. These small study counts preclude strong claims of directional reproducibility. The miRNA\u2013target network component should therefore be interpreted as exploratory and hypothesis-generating rather than as evidence of cadmium-specific pathway convergence. Overall, this synthesis supports a broader and more reproducible literature map while emphasizing the need for standardized exposure assessment, miRNA measurement, and independent validation of candidate regulatory signals.<\/jats:p>","DOI":"10.3390\/ijms27188051","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:13:03Z","timestamp":1789031583000},"page":"8051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the MicroRNA Landscape of Cadmium Exposure: A Bibliometric and Bioinformatics Analysis of Molecular Targets and Regulatory Pathways"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-2557","authenticated-orcid":false,"given":"Muhammet","family":"Kesin","sequence":"first","affiliation":[{"name":"Safranbolu State Hospital, Safranbolu, Karab\u00fck 78600, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-1834","authenticated-orcid":false,"given":"G\u00f6zde","family":"Oztan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-706X","authenticated-orcid":false,"given":"Halim","family":"I\u015fsever","sequence":"additional","affiliation":[{"name":"Department of Public Health, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10661-019-7528-7","article-title":"The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: An overview","volume":"191","author":"Rahman","year":"2019","journal-title":"Environ. 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