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Sci.","IJMS"],"abstract":"<jats:p>Chemotherapy-induced cardiotoxicity is a serious consequence of chemotherapy during cancer treatment that can affect any patient. The purpose of this review is to highlight the development of cardiotoxicity associated with the use of anthracyclines or trastuzumab and to examine prevention and treatment methods using polyphenols, biologically active substances that hold significant therapeutic potential. The main mechanisms of this pathology, modern biomarkers for detection, and the classification and biological activity of polyphenols are discussed. 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Statistics at a Glance. Available online: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/900-world-fact-sheet.pdf."},{"key":"ref_2","unstructured":"(2026, August 31). GCO Cancer Today. GLOBOCAN 2024. Available online: https:\/\/gco.iarc.who.int\/today\/en\/dataviz\/pie?mode=population&group_populations=0&cancers=20&types=0."},{"key":"ref_3","first-page":"9","article-title":"Epidemiology of Breast Cancer in Kazakhstan: The Analysis of Morbidity, Mortality, and Disease Staging in 2015\u20132024","volume":"76","author":"Aidarov","year":"2025","journal-title":"Eur. J. Onc. Rad."},{"key":"ref_4","unstructured":"Ministry of Health of the Republic of Kazakhstan (2026, August 17). Up to 5,000 Cases of Breast Cancer Are Diagnosed in Kazakhstan Annually, Available online: https:\/\/www.gov.kz\/memleket\/entities\/dsm\/press\/news\/details\/439582?lang=ru."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","article-title":"Global Patterns and Trends in Breast Cancer Incidence and Mortality across 185 Countries","volume":"31","author":"Kim","year":"2025","journal-title":"Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1080\/21645515.2015.1125056","article-title":"Trastuzumab and Target-Therapy Side Effects: Is Still Valid to Differentiate Anthracycline Type I from Type II Cardiomyopathies?","volume":"12","author":"Riccio","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/157340311799960645","article-title":"Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment","volume":"7","author":"Volkova","year":"2011","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1158\/0008-5472.CAN-07-1649","article-title":"Topoisomerase II\u03b2\u2013Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane","volume":"67","author":"Yi","year":"2007","journal-title":"Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nm.2919","article-title":"Identification of the Molecular Basis of Doxorubicin-Induced Cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2004.08.066","article-title":"Inhibition of ErbB2 Causes Mitochondrial Dysfunction in Cardiomyocytes: Implications for Herceptin-Induced Cardiomyopathy","volume":"44","author":"Grazette","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e132747","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-Dependent Ferroptosis Plays a Pivotal Role in Doxorubicin Cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"eabn8017","DOI":"10.1126\/scisignal.abn8017","article-title":"Doxorubicin Causes Ferroptosis and Cardiotoxicity by Intercalating into Mitochondrial DNA and Disrupting Alas1-Dependent Heme Synthesis","volume":"15","author":"Abe","year":"2022","journal-title":"Sci. Signal."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1042\/BCJ20160385","article-title":"Doxorubicin Impairs Cardiomyocyte Viability by Suppressing Transcription Factor EB Expression and Disrupting Autophagy","volume":"473","author":"Bartlett","year":"2016","journal-title":"Biochem. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.phrs.2013.08.003","article-title":"The Sulphydryl Containing ACE Inhibitor Zofenoprilat Protects Coronary Endothelium from Doxorubicin-Induced Apoptosis","volume":"76","author":"Monti","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1056\/NEJMoa052306","article-title":"Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer","volume":"353","author":"Procter","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nm0502-459","article-title":"ErbB2 Is Essential in the Prevention of Dilated Cardiomyopathy","volume":"8","author":"Crone","year":"2002","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1161\/CIRCULATIONAHA.118.037357","article-title":"Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients with Breast Cancer","volume":"139","author":"Kitani","year":"2019","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1158\/1535-7163.MCT-15-0741","article-title":"Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes","volume":"15","author":"Mohan","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/CIRCULATIONAHA.114.013777","article-title":"Early Detection of Anthracycline Cardiotoxicity and Improvement with Heart Failure Therapy","volume":"131","author":"Cardinale","year":"2015","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.18632\/oncotarget.23543","article-title":"Type IIB DNA Topoisomerase Is Downregulated by Trastuzumab and Doxorubicin to Synergize Cardiotoxicity","volume":"9","author":"Jiang","year":"2018","journal-title":"Oncotarget"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0735-1097(00)00748-8","article-title":"Left Ventricular Dysfunction Predicted by Early Troponin I Release after High-Dose Chemotherapy","volume":"36","author":"Cardinale","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e014708","DOI":"10.1161\/JAHA.119.014708","article-title":"Changes in Cardiovascular Biomarkers With Breast Cancer Therapy and Associations with Cardiac Dysfunction","volume":"9","author":"Demissei","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jacc.2013.10.061","article-title":"Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients with Breast Cancer Treated with Doxorubicin, Taxanes, and Trastuzumab","volume":"63","author":"Ky","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10549-012-2039-z","article-title":"High-Sensitivity C-Reactive Protein (Hs-CRP) as a Biomarker for Trastuzumab-Induced Cardiotoxicity in HER2-Positive Early-Stage Breast Cancer: A Pilot Study","volume":"134","author":"Onitilo","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116896","DOI":"10.1016\/j.envres.2023.116896","article-title":"Protection against Cancer Therapy-Induced Cardiovascular Injury by Planed-Derived Polyphenols and Nanomaterials","volume":"238","author":"Liao","year":"2023","journal-title":"Environ. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Khan, J., Deb, P.K., Priya, S., Medina, K.D., Devi, R., Walode, S.G., and Rudrapal, M. (2021). Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns. Molecules, 26.","DOI":"10.20944\/preprints202106.0305.v1"},{"key":"ref_28","first-page":"7425","article-title":"Cardioprotective and Nephroprotective Effects of Quercetin against Different Toxic Agents","volume":"25","author":"Alasmari","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_29","first-page":"1147","article-title":"Cardioprotective Effect of Maternal Supplementation with Resveratrol on Toxicity Induced by Doxorubicin in Offspring Cardiomyocytes","volume":"117","author":"Brito","year":"2021","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"14720","DOI":"10.1038\/s41598-020-71827-9","article-title":"Cardioprotective Effect of Grape Polyphenol Extract against Doxorubicin Induced Cardiotoxicity","volume":"10","author":"Sergazy","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhang, X.Y., Yang, K.L., Li, Y., Zhao, Y., Jiang, K.W., Wang, Q., and Liu, X.N. (2022). Can Dietary Nutrients Prevent Cancer Chemotherapy-Induced Cardiotoxicity? An Evidence Mapping of Human Studies and Animal Models. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.921609"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2174\/0929867324666170920144130","article-title":"Nutraceuticals and \u201cRepurposed\u201d Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Diseases and Cancer","volume":"26","author":"Albini","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jff.2016.09.009","article-title":"Potential Chemopreventive Activities of a Polyphenol Rich Purified Extract from Olive Mill Wastewater on Colon Cancer Cells","volume":"27","author":"Bassani","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jakobu\u0161i\u0107 Brala, C., Karkovi\u0107 Markovi\u0107, A., Kugi\u0107, A., Tori\u0107, J., and Barbari\u0107, M. (2023). Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies\u2014An Update Overview. Molecules, 28.","DOI":"10.3390\/molecules28093746"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Atale, N., Yadav, D., Rani, V., and Jin, J.O. (2020). Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols. Front. Nutr., 7.","DOI":"10.3389\/fnut.2020.564352"},{"key":"ref_36","first-page":"e66215","article-title":"Cardio-Oncology\u2019s Modern Approaches to Prevent Doxorubicin-Induced Cardiotoxicity: A Systematic Review","volume":"16","author":"Palvia","year":"2024","journal-title":"Cureus"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Aldayel, T.S., Kilany, O.E., El-Hak, H.N.G., Abdelrazek, H.M.A., Abdallah, O., and Omar, D.E. (2024). Clinicopathological Studies on the Impact of Grape Seed Extract and L-Carnitine as Cardioprotective Agents Against Doxorubicin-Induced Toxicity in Rats. Life, 14.","DOI":"10.3390\/life14121656"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00059-019-04888-w","article-title":"Effects of Grapeseed Extract on Doxorubicin-Induced Cardiotoxicity in Rats","volume":"46","author":"Karahan","year":"2021","journal-title":"Herz"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"423","DOI":"10.15171\/apb.2016.055","article-title":"Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats","volume":"6","author":"Razmaraii","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12012-012-9155-1","article-title":"Grape Seed and Skin Extract Protects Against Acute Chemotherapy Toxicity Induced by Doxorubicin in Rat Heart","volume":"12","author":"Mokni","year":"2012","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10238-011-0165-2","article-title":"Catechin Protects against Oxidative Stress and Inflammatory-Mediated Cardiotoxicity in Adriamycin-Treated Rats","volume":"12","author":"Mohamed","year":"2012","journal-title":"Clin. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/13880209.2012.729065","article-title":"Cardioprotective Effect of Grape-Seed Proanthocyanidins on Doxorubicin-Induced Cardiac Toxicity in Rats","volume":"51","author":"Ammar","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Dulf, P.L., Coad\u0103, C.A., Florea, A., Moldovan, R., Baldea, I., Dulf, D.V., Blendea, D., and Filip, A.G. (2024). Mitigating Doxorubicin-Induced Cardiotoxicity through Quercetin Intervention: An Experimental Study in Rats. Antioxidants, 13.","DOI":"10.3390\/antiox13091068"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2008.06.068","article-title":"Catechin and Proanthocyanidin B4 from Grape Seeds Prevent Doxorubicin-Induced Toxicity in Cardiomyocytes","volume":"591","author":"Du","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111702","DOI":"10.1016\/j.biopha.2021.111702","article-title":"Resveratrol Significantly Improves Cell Survival in Comparison to Dexrazoxane and Carvedilol in a H9c2 Model of Doxorubicin Induced Cardiotoxicity","volume":"140","author":"Monahan","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1002\/fsn3.3525","article-title":"Effects of Resveratrol on Tolerance to Ischemia\/Reperfusion Injury in Aged Male Mice: Role of Autophagy and Apoptosis","volume":"11","author":"Song","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ma, M., Jiang, X., Liu, W., Xue, J., Yuan, Y., Zhi, X., Feng, J., Long, Y., Li, Y., and Zhang, Z. (2025). Quercetin Reverses \u03b21-Adrenoceptor Autoantibody-Induced Heart Failure by Promoting MDM2-Mediated Ubiquitination and Degradation of P53 in Cardiomyocytes. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1674507"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Pop, R.M., Boarescu, P.M., Bocsan, C.I., Gherman, M.L., Chedea, V.S., Jianu, E.M., Ro\u0219ian, \u0218.H., Boarescu, I., Ranga, F., and Tomoiag\u0103, L.L. (2025). Anti-Inflammatory and Antioxidant Effects of White Grape Pomace Polyphenols on Isoproterenol-Induced Myocardial Infarction. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052035"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"BR326","DOI":"10.12659\/MSM.882042","article-title":"Proanthocyanidin Prevents Myocardial Ischemic Injury in Adult Rats","volume":"17","author":"Guler","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0891-5849(01)00626-8","article-title":"Grape Seed Proanthocyanidin Reduces Cardiomyocyte Apoptosis by Inhibiting Ischemia\/Reperfusion-Induced Activation of JNK-1 and C-JUN","volume":"31","author":"Sato","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1874070702115010164","article-title":"Polyphenols: A Comprehensive Review of Their Nutritional Properties","volume":"15","author":"Ebrahimi","year":"2021","journal-title":"Open Biotechnol. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10586","DOI":"10.1021\/jf202438d","article-title":"Survey of Polyphenol Constituents in Grapes and Grape-Derived Products","volume":"59","author":"Xu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tifs.2021.03.060","article-title":"Stilbenes in Grape Berries and Wine and Their Potential Role as Anti-Obesity Agents: A Review","volume":"112","author":"Benbouguerra","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"19651","DOI":"10.3390\/ijms141019651","article-title":"Advanced Knowledge of Three Important Classes of Grape Phenolics: Anthocyanins, Stilbenes and Flavonols","volume":"14","author":"Flamini","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"120265","DOI":"10.1016\/j.lfs.2021.120265","article-title":"Resveratrol Alleviates Cardiac Apoptosis Following Exposure to Fenitrothion by Modulating the Sirtuin1\/c-Jun N-Terminal Kinases\/P53 Pathway through pro-Oxidant and Inflammatory Response Improvements: In Vivo and In Silico Studies","volume":"290","author":"Ibrahim","year":"2022","journal-title":"Life Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.13492","article-title":"Antioxidant Effects of Resveratrol in the Cardiovascular System","volume":"174","author":"Xia","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"100149","DOI":"10.1016\/j.fochx.2021.100149","article-title":"Grape Bioactive Molecules, and the Potential Health Benefits in Reducing the Risk of Heart Diseases","volume":"12","author":"Sabra","year":"2021","journal-title":"Food Chem. X"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Karastergiou, A., Gancel, A.L., Jourdes, M., and Teissedre, P.L. (2024). Valorization of Grape Pomace: A Review of Phenolic Composition, Bioactivity, and Therapeutic Potential. Antioxidants, 13.","DOI":"10.3390\/antiox13091131"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sova, M., and Saso, L. (2020). Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites. Nutrients, 12.","DOI":"10.3390\/nu12082190"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Monteiro Esp\u00edndola, K.M., Ferreira, R.G., Mosquera Narvaez, L.E., Rocha Silva Rosario, A.C., Machado Da Silva, A.H., Bispo Silva, A.G., Oliveira Vieira, A.P., and Chagas Monteiro, M. (2019). Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00541"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3892\/or.2016.4804","article-title":"Ferulic Acid Exerts Antitumor Activity and Inhibits Metastasis in Breast Cancer Cells by Regulating Epithelial to Mesenchymal Transition","volume":"36","author":"Zhang","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"108571","DOI":"10.1016\/j.biotechadv.2025.108571","article-title":"Hydroxybenzoic Acids: Microbial Metabolism, Pathway Engineering and Products","volume":"81","author":"Kutraite","year":"2025","journal-title":"Biotechnol. Adv."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Nicolescu, C.M., Bumbac, M., Radulescu, C., Buruleanu, C.L., Olteanu, R.L., Stanescu, S.G., Gorghiu, L.M., Serban, B.C., and Buiu, O. (2023). Phytochemical Statistical Mapping of Red Grape Varieties Cultivated in Romanian Organic and Conventional Vineyards. Plants, 12.","DOI":"10.3390\/plants12244179"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Milin\u010di\u0107, D.D., Stanisavljevi\u0107, N.S., Pe\u0161i\u0107, M.M., Kosti\u0107, A., Stanojevi\u0107, S.P., and Pe\u0161i\u0107, M.B. (2025). The Bioaccessibility of Grape-Derived Phenolic Compounds: An Overview. Foods, 14.","DOI":"10.3390\/foods14040607"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s43088-023-00387-4","article-title":"Natural Flavonols: Actions, Mechanisms, and Potential Therapeutic Utility for Various Diseases","volume":"12","author":"Mahmud","year":"2023","journal-title":"Beni. Suef. Univ. J. Basic Appl. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Mattioli, R., Francioso, A., Mosca, L., and Silva, P. (2020). Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases. Molecules, 25.","DOI":"10.3390\/molecules25173809"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ma, X., Jin, Z., Rao, Z., and Zheng, L. (2025). Health Benefits of Anthocyanins against Age-Related Diseases. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1618072"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bu, H., Gu, G., Hu, Y., Yang, Y., Yang, L., Yuan, H., and Yu, W. (2025). Research Advances in the Synthesis and Regulation of Apple Anthocyanins. Biology, 14.","DOI":"10.3390\/biology14101322"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1159\/000520645","article-title":"Anthocyanins Inhibit Airway Inflammation by Downregulating the NF-\u039aB Pathway via the MiR-138-5p\/SIRT1 Axis in Asthmatic Mice","volume":"183","author":"Liu","year":"2022","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Sadowska-Bartosz, I., and Bartosz, G. (2024). Antioxidant Activity of Anthocyanins and Anthocyanidins: A Critical Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212001"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., and Restani, P. (2021). Polyphenols and Human Health: The Role of Bioavailability. Nutrients, 13.","DOI":"10.3390\/nu13010273"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","article-title":"Anthocyanidins and Anthocyanins: Colored Pigments as Food, Pharmaceutical Ingredients, and the Potential Health Benefits","volume":"61","author":"Khoo","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Luo, Y., Jian, Y., Liu, Y., Jiang, S., Muhammad, D., and Wang, W. (2022). Flavanols from Nature: A Phytochemistry and Biological Activity Review. Molecules, 27.","DOI":"10.3390\/molecules27030719"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Jawhara, S. (2024). How Do Polyphenol-Rich Foods Prevent Oxidative Stress and Maintain Gut Health?. Microorganisms, 12.","DOI":"10.3390\/microorganisms12081570"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e71259","DOI":"10.1002\/fsn3.71259","article-title":"Antioxidant Potential of Polyphenolic Compounds, Sources, Extraction, Purification and Characterization Techniques: A Focused Review","volume":"13","author":"Ahmad","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12986-025-01047-3","article-title":"From Molecular Mechanisms to Translational Applications: A Parallel Assessment of Green and Black Tea Modulation of Oxidative Stress","volume":"22","author":"Zhao","year":"2025","journal-title":"Nutr. Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s44187-025-00637-7","article-title":"A Review on Exploring the Health Benefits and Antioxidant Properties of Bioactive Polyphenols","volume":"5","author":"Jain","year":"2025","journal-title":"Discov. Food"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/ptr.70268","article-title":"Redox Paradox of Polyphenols: Bioavailability, Hormesis, and Safety Concerns","volume":"40","author":"Vrankova","year":"2026","journal-title":"Phytother. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3390\/i8090950","article-title":"Dietary Polyphenols and Their Biological Significance","volume":"8","author":"Han","year":"2007","journal-title":"Int. J. Mol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"890","DOI":"10.21037\/atm-22-3789","article-title":"Activation of AMPK\/P38\/Nrf2 Is Involved in Resveratrol Alleviating Myocardial Ischemia-Reperfusion Injury in Diabetic Rats as an Endogenous Antioxidant Stress Feedback","volume":"10","author":"Xu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7432797","DOI":"10.1155\/2016\/7432797","article-title":"Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Farhan, M. (2023). Insights on the Role of Polyphenols in Combating Cancer Drug Resistance. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061709"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.21037\/tcr-20-2359","article-title":"Functions of Polyphenols and Its Anticancer Properties in Biomedical Research: A Narrative Review","volume":"9","author":"Bhosale","year":"2020","journal-title":"Transl. Cancer Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Saman, H., Raza, S.S., Uddin, S., and Rasul, K. (2020). Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches. Cancers, 12.","DOI":"10.20944\/preprints202004.0400.v1"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40364-025-00779-x","article-title":"Decoding Tumor Angiogenesis: Pathways, Mechanisms, and Future Directions in Anti-Cancer Strategies","volume":"13","author":"Liu","year":"2025","journal-title":"Biomark. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"117585","DOI":"10.1016\/j.biopha.2024.117585","article-title":"Physiological and Tumor-Associated Angiogenesis: Key Factors and Therapy Targeting VEGF\/VEGFR Pathway","volume":"180","author":"Lorenc","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0955-2863(02)00204-8","article-title":"Antiangiogenic Mechanisms of Diet-Derived Polyphenols","volume":"13","author":"Cao","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_88","first-page":"843","article-title":"Antiangiogenic Potential of Grape Stem Extract through Inhibition of Vascular Endothelial Growth Factor Expression","volume":"65","author":"Stagos","year":"2014","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Singaravelan, N., and Tollefsbol, T.O. (2025). Polyphenol-Based Prevention and Treatment of Cancer Through Epigenetic and Combinatorial Mechanisms. Nutrients, 17.","DOI":"10.3390\/nu17040616"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5564312","DOI":"10.1155\/2021\/5564312","article-title":"Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF-\u03b2 Signaling Pathway","volume":"2021","author":"Yang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Quero, J., Jim\u00e9nez-Moreno, N., Esparza, I., Osada, J., Cerrada, E., Anc\u00edn-Azpilicueta, C., and Rodr\u00edguez-Yoldi, M.J. (2021). Grape Stem Extracts with Potential Anticancer and Antioxidant Properties. Antioxidants, 10.","DOI":"10.3390\/antiox10020243"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"672416","DOI":"10.1155\/2012\/672416","article-title":"Antiproliferative and Anti-Invasive Effect of Piceatannol, a Polyphenol Present in Grapes and Wine, against Hepatoma AH109A Cells","volume":"2012","author":"Kita","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Tsantila, E.M., Esslinger, N., Christou, M., Papageorgis, P., and Neophytou, C.M. (2024). Antioxidant and Anticancer Activity of Vitis Vinifera Extracts in Breast Cell Lines. Life, 14.","DOI":"10.3390\/life14020228"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Sun, S., Liu, Z., Lin, M., Gao, N., and Wang, X. (2024). Polyphenols in Health and Food Processing: Antibacterial, Anti-Inflammatory, and Antioxidant Insights. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1456730"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Sangiovanni, E., and Dell\u2019Agli, M. (2020). Special Issue: Anti-Inflammatory Activity of Plant Polyphenols. Biomedicines, 8.","DOI":"10.3390\/biomedicines8030064"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/odi.13290","article-title":"Catechins Reduce Inflammation in Lipopolysaccharide-Stimulated Dental Pulp Cells by Inhibiting Activation of the NF-\u039aB Pathway","volume":"26","author":"Wang","year":"2020","journal-title":"Oral Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11033-024-09245-7","article-title":"Quercetin Inhibits NF-KB and JAK\/STAT Signaling via Modulating TLR in Thymocytes and Splenocytes during MSG-Induced Immunotoxicity: An In Vitro Approach","volume":"51","author":"Das","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"22859","DOI":"10.1038\/srep22859","article-title":"Inhibition of Pancreatic Oxidative Damage by Stilbene Derivative Dihydro-Resveratrol: Implication for Treatment of Acute Pancreatitis","volume":"6","author":"Tsang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Saad, A.M., Mohammed, D.M., Alkafaas, S.S., Ghosh, S., Negm, S.H., Salem, H.M., Fahmy, M.A., Semary, H.E., Ibrahim, E.H., and AbuQamar, S.F. (2025). Dietary Polyphenols and Human Health: Sources, Biological Activities, Nutritional and Immunological Aspects, and Bioavailability\u2014A Comprehensive Review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1653378"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Shakoor, H., Feehan, J., Apostolopoulos, V., Platat, C., Al Dhaheri, A.S., Ali, H.I., Ismail, L.C., Bosevski, M., and Stojanovska, L. (2021). Immunomodulatory Effects of Dietary Polyphenols. Nutrients, 13.","DOI":"10.3390\/nu13030728"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e202302065","DOI":"10.1002\/cbdv.202302065","article-title":"Grape Pomace Polyphenols Reduce Acute Inflammatory Response Induced by Carrageenan in a Murine Model","volume":"21","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_103","first-page":"0851_7836","article-title":"Anti-Inflammatory Effects of Grape Pomace as a Novel Source of Dietary Fibre and Polyphenols and Sex-Based Differences Explored in Wistar Rats","volume":"212","author":"Clarke","year":"2024","journal-title":"J. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sajb.2019.06.026","article-title":"Anti-Inflammatory Effect of Grape (Vitis vinifera L.) Seed Extract through the Downregulation of NF-\u039aB and MAPK Pathways in LPS-Induced RAW264.7 Macrophages","volume":"125","author":"Harbeoui","year":"2019","journal-title":"S. Afr. J. Bot."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5086541","DOI":"10.1155\/2024\/5086541","article-title":"The Effects of Grape\/Grape Products on Inflammatory and Oxidative Stress Markers: Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"2024","author":"Dehghani","year":"2024","journal-title":"J. Food Biochem."},{"key":"ref_106","first-page":"251","article-title":"Effect of Grape Polyphenols on Selected Inflammatory Mediators: A Systematic Review and Meta-Analysis Randomized Clinical Trials","volume":"19","author":"Haghighatdoost","year":"2020","journal-title":"EXCLI J."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Stankovic, S., Mutavdzin Krneta, S., Djuric, D., Milosevic, V., and Milenkovic, D. (2025). Plant Polyphenols as Heart\u2019s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26030915"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11033-014-3737-x","article-title":"Resveratrol Affects Histone 3 Lysine 27 Methylation of Vessels and Blood Biomarkers in DOCA Salt-Induced Hypertension","volume":"42","author":"Han","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"ref_109","first-page":"5312","article-title":"Homocysteine-Induced Proliferation of Vascular Smooth Muscle Cells Occurs via PTEN Hypermethylation and Is Mitigated by Resveratrol","volume":"17","author":"Ma","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_110","first-page":"6381380","article-title":"Role of Polyphenols and Carotenoids in Endothelial Dysfunction: An Overview from Classic to Innovative Biomarkers","volume":"2020","author":"Baldassarre","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Iqbal, I., Wilairatana, P., Saqib, F., Nasir, B., Wahid, M., Latif, M.F., Iqbal, A., Naz, R., and Mubarak, M.S. (2023). Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review. Molecules, 28.","DOI":"10.3390\/molecules28176403"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Rodriguez, L., Mu\u00f1oz-Bernal, \u00d3.A., Fuentes, E., Alvarez-Parrilla, E., and Palomo, I. (2024). Antiplatelet Activity of Phenolic Compounds-Fortified Merlot Wine and Pure Phenolic Compounds. Appl. Sci., 14.","DOI":"10.3390\/app14135707"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"101246","DOI":"10.37349\/ec.2025.101246","article-title":"Oxidized Low-Density Lipoproteins and Their Contribution to Atherosclerosis","volume":"3","author":"Babakr","year":"2025","journal-title":"Explor. Cardiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4103\/hm.HM-D-24-00106","article-title":"Effects of a Diet Rich in Polyphenols on Lipid Metabolism: An Updated Narrative Review","volume":"9","author":"Scavuzzi","year":"2025","journal-title":"Heart Mind"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Arfaoui, L. (2021). Dietary Plant Polyphenols: Effects of Food Processing on Their Content and Bioavailability. Molecules, 26.","DOI":"10.3390\/molecules26102959"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e70252","DOI":"10.1002\/mco2.70252","article-title":"Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects","volume":"6","author":"Ren","year":"2025","journal-title":"MedComm"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00280-010-1525-4","article-title":"Pharmacokinetics, Oral Bioavailability, and Metabolic Profile of Resveratrol and Its Dimethylether Analog, Pterostilbene, in Rats","volume":"68","author":"Kapetanovic","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0009-9120(02)00397-1","article-title":"Absorption of Three Wine-Related Polyphenols in Three Different Matrices by Healthy Subjects","volume":"36","author":"Goldberg","year":"2003","journal-title":"Clin. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"102622","DOI":"10.1016\/j.redox.2023.102622","article-title":"Targeting the Aryl Hydrocarbon Receptor by Gut Phenolic Metabolites: A Strategy towards Gut Inflammation","volume":"61","author":"Pinto","year":"2023","journal-title":"Redox Biol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Be\u0161lo, D., Golubi\u0107, N., Rastija, V., Agi\u0107, D., Karna\u0161, M., \u0160ubari\u0107, D., and Lu\u010di\u0107, B. (2023). Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals. Antioxidants, 12.","DOI":"10.3390\/antiox12061141"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Nazzaro, F., Coppola, F., Fratianni, F., Abdalrazeq, M., Ombra, M.N., De Giulio, B., Coppola, R., and Zengin, G. (2025). Polyphenols Bioactive Metabolites, and Their Anti-Biofilm and Neuroprotective Potential. Foods, 14.","DOI":"10.3390\/foods14223976"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Rudrapal, M., de Oliveira, A.M., and Singh, R.P. (2026). Dietary Polyphenols Maintain Human Health through Modulation of Gut Microbiota. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1710088"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Ma, Z.F., Liu, S., Fu, C., Zhou, S., and Lee, Y.Y. (2026). Functional Foods in Health Promotion and Disease Prevention: Innovations, Evidence and Challenges. Foods, 15.","DOI":"10.3390\/foods15040764"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Nikou, T., Sakavitsi, M.E., Kalampokis, E., and Halabalaki, M. (2022). Metabolism and Bioavailability of Olive Bioactive Constituents Based on In Vitro, In Vivo and Human Studies. Nutrients, 14.","DOI":"10.3390\/nu14183773"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1096\/fj.14-269043","article-title":"Translating Dosages from Animal Models to Human Clinical Trials-Revisiting Body Surface Area Scaling","volume":"29","author":"Blanchard","year":"2015","journal-title":"FASEB J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"113136","DOI":"10.1016\/j.biopha.2022.113136","article-title":"Interactions of Resveratrol and Its Metabolites (Resveratrol-3-Sulfate, Resveratrol-3-Glucuronide, and Dihydroresveratrol) with Serum Albumin, Cytochrome P450 Enzymes, and OATP Transporters","volume":"151","author":"Kaci","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1788S","DOI":"10.3945\/jn.109.107474","article-title":"Grapes and Cardiovascular Disease","volume":"139","author":"Dohadwala","year":"2009","journal-title":"J. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Petrozziello, M., Piano, F., Bonello, F., Ragkousi, V., Meleddu, F., Ronco, M., and Asproudi, A. (2026). Climate Change Effect on Polyphenols of Grignolino Grapes (Vitis vinifera L.) in Hilly Environment. Horticulturae, 12.","DOI":"10.3390\/horticulturae12020206"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Berretta, M., Bignucolo, A., Di Francia, R., Comello, F., Facchini, G., Ceccarelli, M., Iaffaioli, R.V., Quagliariello, V., and Maurea, N. (2020). Resveratrol in Cancer Patients: From Bench to Bedside. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082945"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"8157640","DOI":"10.1155\/2020\/8157640","article-title":"Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity","volume":"2020","author":"Henidi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s11694-025-03852-z","article-title":"Valorization of Polyphenolic Compounds via Encapsulation: A Review","volume":"20","author":"Kalita","year":"2026","journal-title":"J. Food Meas. Charact."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Marino, M., Del Bo, C., Martini, D., Porrini, M., and Riso, P. (2020). A Review of Registered Clinical Trials on Dietary (Poly)Phenols: Past Efforts and Possible Future Directions. Foods, 9.","DOI":"10.3390\/foods9111606"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Perrone, P., De Rosa, C., and D\u2019Angelo, S. (2025). Polyphenols and Bone Health: A Comprehensive Review of Their Role in Osteoporosis Prevention and Treatment. Molecules, 30.","DOI":"10.3390\/molecules30214154"},{"key":"ref_135","unstructured":"WHO (2026, August 27). Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants. Available online: https:\/\/www.who.int\/publications\/i\/item\/9241546271."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.2147\/IJN.S572417","article-title":"Plant-Derived Exosome-Like Nanoparticles: A Promising Therapeutic for Neurological Disorders and Drug Delivery","volume":"20","author":"Zheng","year":"2025","journal-title":"Int. J. Nanomed."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8095\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:25:49Z","timestamp":1789129549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":136,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27188095"],"URL":"https:\/\/doi.org\/10.3390\/ijms27188095","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}