{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:03:10Z","timestamp":1789534990890,"version":"build-2803163510"},"reference-count":71,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["zyyzdxk-2023120"],"award-info":[{"award-number":["zyyzdxk-2023120"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"award":["zyyzdxk-2023120"],"award-info":[{"award-number":["zyyzdxk-2023120"]}],"id":[{"id":"https:\/\/ror.org\/003cpqh10","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The mechanical cation channel Piezo1 has been confirmed as a key membrane mechanical protein that can convert physical forces into biological signals, serving as a molecular hub linking hemodynamic stimulation with thrombotic diseases. Studying mechanical sensitive channels in the cardiovascular system is helpful for understanding the working mechanism of these channels and providing new therapeutic targets for thrombotic diseases. This article systematically summarizes the expression and functional roles of the Piezo1 channel in cell types involved in thrombosis, including platelets, endothelial cells, red blood cells, immune cells, etc. This article also discusses the mechanical gating structural basis of Piezo1 and its activation mechanism and downstream signaling pathways in the thrombosis-related mechanical microenvironment. Based on the existing evidence, Piezo1 has significant pathological significance in the occurrence and development of thrombotic diseases, and targeting Piezo1 may provide new strategies for anti-thrombotic treatment. Future research needs to further clarify the differential regulatory mechanisms of the Piezo1 channel in different hemodynamic environments and evaluate its safety and efficacy as a drug target.<\/jats:p>","DOI":"10.3390\/ijms27188102","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:39:24Z","timestamp":1789137564000},"page":"8102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of Piezo1-Mediated Mechanotransduction in Thrombotic Diseases"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5513-7672","authenticated-orcid":false,"given":"Hanrong","family":"Dong","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlun","family":"Li","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine Innovation, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.advms.2022.10.002","article-title":"Venous thromboembolism: Why is it still a significant health problem?","volume":"68","author":"Lisowska","year":"2023","journal-title":"Adv. Med. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.2174\/0109298673324637240930140545","article-title":"Thrombosis in hypertension: Pathophysiology, biomarkers, and the effect of antihypertensive treatment","volume":"32","author":"Theofilis","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/ATVBAHA.124.320151","article-title":"Global health burden of venous thromboembolism","volume":"44","author":"Wendelboe","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jacbts.2024.12.004","article-title":"Recent pathophysiological insights are advancing the treatment of venous thromboembolism","volume":"10","author":"Singh","year":"2025","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13696998.2024.2436797","article-title":"The burden of venous thromboembolism in ten countries: A cost-of-illness markov model on surgical and ICU patients","volume":"28","author":"Seemann","year":"2025","journal-title":"J. Med. Econ."},{"key":"ref_6","unstructured":"Ashorobi, D., Ameer, M.A., and Fernandez, R. (2026). Thrombosis. StatPearls, StatPearls Publishing."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCRESAHA.123.322798","article-title":"PIEZO ion channels in cardiovascular functions and diseases","volume":"134","author":"Coste","year":"2024","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/labinvest.3700215","article-title":"The role of shear stress in the pathogenesis of atherosclerosis","volume":"85","author":"Cunningham","year":"2005","journal-title":"Lab. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rana, A., Westein, E., Niego, B., and Hagemeyer, C.E. (2019). Shear-dependent platelet aggregation: Mechanisms and therapeutic opportunities. Front. Cardiovasc. Med., 6.","DOI":"10.3389\/fcvm.2019.00141"},{"key":"ref_11","first-page":"235","article-title":"Research progress on biomechanopharmacology of traditional Chinese medicine based on mechanosensitive ion channel Piezo1","volume":"29","author":"Liu","year":"2023","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2933-1","article-title":"Discoveries in structure and physiology of mechanically activated ion channels","volume":"587","author":"Kefauver","year":"2020","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1016\/j.neuron.2024.08.009","article-title":"Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function","volume":"112","author":"Zhang","year":"2024","journal-title":"Neuron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100625","DOI":"10.1016\/j.cophys.2022.100625","article-title":"Advances and recent insights into the gating mechanisms of the mechanically activated ion channels PIEZO1 and PIEZO2","volume":"31","author":"Verkest","year":"2023","journal-title":"Curr. Opin. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/jcp.31001","article-title":"Regulation of PIEZO1 channels by lipids and the structural components of extracellular matrix\/cell cytoskeleton","volume":"238","author":"Vasileva","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12939","DOI":"10.1038\/ncomms12939","article-title":"Localized force application reveals mechanically sensitive domains of Piezo1","volume":"7","author":"Wu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1111\/bph.17434","article-title":"Involvement of piezo 1 in inhibition of shear-induced platelet activation and arterial thrombosis by ginsenoside Rb1","volume":"182","author":"Wang","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41467-018-03570-9","article-title":"A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_20","first-page":"1360","article-title":"Piezo1-mediated mechanical signaling in cardiovascular regulation","volume":"54","author":"Lou","year":"2024","journal-title":"Sci. Sin. Vitae"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102738","DOI":"10.1016\/j.ceca.2023.102738","article-title":"High-throughput assessment identifying major platelet Ca2+ entry pathways via tyrosine kinase-linked and G protein-coupled receptors","volume":"112","author":"Cheung","year":"2023","journal-title":"Cell Calcium"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mosevoll, K.A., Johansen, S., Wendelbo, \u00d8., Nepstad, I., Bruserud, \u00d8., and Reikvam, H. (2018). Cytokines, adhesion molecules, and matrix metalloproteases as predisposing, diagnostic, and prognostic factors in venous thrombosis. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00147"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1111\/jth.15504","article-title":"Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension","volume":"19","author":"Zhao","year":"2021","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zainal Abidin, N.A., Poon, E.K.W., Szydzik, C., Timofeeva, M., Akbaridoust, F., Brazilek, R.J., Tovar Lopez, F.J., Ma, X., Lav, C., and Marusic, I. (2022). An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients. BMC Biol., 20.","DOI":"10.1186\/s12915-022-01274-7"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MOH.0000000000000788","article-title":"Platelet mechanosensing as key to understanding platelet function","volume":"31","author":"Schoen","year":"2024","journal-title":"Curr. Opin. Hematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1160\/TH15-11-0891","article-title":"Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines","volume":"116","author":"Wright","year":"2016","journal-title":"Thromb. Haemost."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1182\/blood.2021014914","article-title":"Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI","volume":"140","author":"Kaiser","year":"2022","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.tips.2019.10.002","article-title":"Piezo ion channels in cardiovascular mechanobiology","volume":"40","author":"Douguet","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"103892","DOI":"10.1016\/j.redox.2025.103892","article-title":"Beyond energy: Mitochondrial control of platelet lifecycle through redox, calcium, and dynamics","volume":"87","author":"Wang","year":"2025","journal-title":"Redox Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41467-018-03430-6","article-title":"Compression force sensing regulates integrin \u03b1IIb\u03b23 adhesive function on diabetic platelets","volume":"9","author":"Ju","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1182\/bloodadvances.2025018019","article-title":"The clot thickens: Transverse cables under high shear flow","volume":"9","author":"Kreinin","year":"2025","journal-title":"Blood Adv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9204","DOI":"10.1074\/jbc.M116.766196","article-title":"Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line","volume":"292","author":"Ilkan","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1182\/blood.2021014614","article-title":"Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis","volume":"140","author":"Wang","year":"2022","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1016\/j.bpj.2025.03.021","article-title":"Flow-sensitive ion channels in vascular endothelial cells: Mechanisms of activation and roles in mechanotransduction","volume":"124","author":"Beverley","year":"2025","journal-title":"Biophys. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"H989","DOI":"10.1152\/ajpheart.00431.2024","article-title":"Integrating molecular and cellular components of endothelial shear stress mechanotransduction","volume":"327","author":"Power","year":"2024","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1002\/jcp.30056","article-title":"Analyzing the shear-induced sensitization of mechanosensitive ion channel piezo-1 in human aortic endothelial cells","volume":"236","author":"Lai","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.jtha.2023.05.022","article-title":"Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots","volume":"21","author":"Evtugina","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.niox.2013.09.004","article-title":"Nitric oxide, a protective molecule in the cardiovascular system","volume":"35","author":"Lei","year":"2013","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.gendis.2022.08.015","article-title":"The janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation","volume":"10","author":"Huang","year":"2023","journal-title":"Genes Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1182\/blood-2023-190267","article-title":"Piezo1 ca 2+ channel activation prevents inflammation-induced endothelial prothrombotic transformation by stimulating an antithrombotic pathway","volume":"142","author":"Sack","year":"2023","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/jth.14360","article-title":"Red blood cells: The forgotten player in hemostasis and thrombosis","volume":"17","author":"Weisel","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/jth.15407","article-title":"Pathologically stiff erythrocytes impede contraction of blood clots","volume":"19","author":"Tutwiler","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12933-018-0789-6","article-title":"Polyhedrocytes in blood clots of type 2 diabetic patients with high cardiovascular risk: Association with glycemia, oxidative stress and platelet activation","volume":"17","author":"Gajos","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/ajh.70086","article-title":"Targeting PIEZO1-TMEM16F coupling to mitigate sickle cell disease complications","volume":"100","author":"Liang","year":"2025","journal-title":"Am. J. Hematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1182\/blood.2023021465","article-title":"Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis","volume":"143","author":"Liang","year":"2024","journal-title":"Blood"},{"key":"ref_46","first-page":"312","article-title":"Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome","volume":"24","author":"Wang","year":"2004","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"117473","DOI":"10.1016\/j.atherosclerosis.2024.117473","article-title":"Low shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation","volume":"391","author":"Zhu","year":"2024","journal-title":"Atherosclerosis"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, X., Liu, J., Deng, X., and Bo, L. (2024). Understanding COVID-19-associated endothelial dysfunction: Role of PIEZO1 as a potential therapeutic target. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1281263"},{"key":"ref_49","first-page":"601","article-title":"Effect of astragaloside IV and salvianolic acid B on antioxidant stress and vascular endothelial protection in the treatment of atherosclerosis based on metabonomics","volume":"20","author":"Kong","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s12276-025-01616-9","article-title":"Piezo1 activation in endothelial cells aggravates microvascular ischemia\u2013reperfusion injury in limbs by enhancing ferroptosis","volume":"58","author":"Chen","year":"2026","journal-title":"Exp. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e70065","DOI":"10.1002\/bies.70065","article-title":"Shear stress as a danger signal: Inducing inflammation and thrombosis via mechanosensitive NETosis","volume":"47","author":"Baratchi","year":"2025","journal-title":"BioEssays"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1038\/s41467-024-51211-1","article-title":"Piezo1 expression in neutrophils regulates shear-induced NETosis","volume":"15","author":"Baratchi","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1182\/bloodadvances.2024014114","article-title":"Venous thrombosis unchained: Pandora\u2019s box of noninflammatory mechanisms","volume":"9","author":"Smith","year":"2025","journal-title":"Blood Adv."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/ATVBAHA.123.318341","article-title":"Platelet mechanotransduction: Regulatory cross talk between mechanosensitive receptors and calcium channels","volume":"43","author":"Gudermann","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1182\/blood-2024-208301","article-title":"Piezo1-mediated thromboprotection is markedly influenced by laminar shear forces in vitro and in vivo","volume":"144","author":"Sack","year":"2024","journal-title":"Blood"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jtha.2025.11.028","article-title":"Piezo1 gain of function induces a platelet preactivation state","volume":"24","author":"Marchelli","year":"2026","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13577-021-00600-5","article-title":"Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP\/TAZ activation","volume":"35","author":"Yang","year":"2022","journal-title":"Hum. Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ibd\/izac152","article-title":"The mechanosensitive ion channel PIEZO1 in intestinal epithelial cells mediates inflammation through the NOD-like receptor 3 pathway in crohn\u2019s disease","volume":"29","author":"Liu","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.biocel.2014.02.015","article-title":"Mitochondria: Biological roles in platelet physiology and pathology","volume":"50","author":"Oliveira","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"20110","DOI":"10.1038\/s41598-020-76979-2","article-title":"Yoda1 and phosphatidylserine exposure in red cells from patients with sickle cell anaemia","volume":"10","author":"Wadud","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Liu, L., Zhang, Q., Xiao, S., Sun, Z., Ding, S., Chen, Y., Wang, L., Yin, X., Liao, F., and Jiang, L.-H. (2021). Inhibition of shear-induced platelet aggregation by xueshuantong via targeting Piezo1 channel-mediated Ca2+ signaling pathway. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.606245"},{"key":"ref_62","first-page":"111","article-title":"Biomechanopharmacological analysis of panax notoginseng saponins in inhibiting shear-induced platelet aggregation and thrombosis","volume":"30","author":"Wang","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_63","first-page":"2446","article-title":"Inhibitory effect of xueshuantong for injection on thrombosis and its influence on hemodynamics","volume":"45","author":"Liu","year":"2020","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"114755","DOI":"10.1016\/j.biopha.2023.114755","article-title":"Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells","volume":"163","author":"Hong","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Liu, S., Pan, X., Cheng, W., Deng, B., He, Y., Zhang, L., Ning, Y., and Li, J. (2020). Tubeimoside I antagonizes Yoda1-evoked Piezo1 channel activation. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00768"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1111\/bph.15826","article-title":"Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B","volume":"179","author":"Pan","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/bph.14188","article-title":"Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation","volume":"175","author":"Evans","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbrc.2018.02.058","article-title":"Yoda1-induced phosphorylation of akt and ERK1\/2 does not require Piezo1 activation","volume":"497","author":"Frangos","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"eabk1707","DOI":"10.1126\/scitranslmed.abk1707","article-title":"PIEZO1 mediates a mechanothrombotic pathway in diabetes","volume":"14","author":"Zhu","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1111\/febs.70157","article-title":"Insulin facilitates entry of calcium ions into human and murine erythrocytes via Piezo1: A newly identified mechanism with implications for type 2 diabetes","volume":"292","author":"Kuck","year":"2025","journal-title":"FEBS J."},{"key":"ref_71","unstructured":"(2026, August 20). Isth. Available online: https:\/\/isth2024.eventscribe.net\/fsPopup.asp?PresentationID=1432540&mode=presInfo."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8102\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:21:56Z","timestamp":1789532516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":71,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27188102"],"URL":"https:\/\/doi.org\/10.3390\/ijms27188102","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}