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Additionally, the CCND1 LD block (rs678653\/rs7177) also showed nominal associations (overdominant model: OR = 2.60; 95% CI = 1.01\u20136.71; p = 0.044). None of these associations remained statistically significant after Bonferroni correction for multiple testing (corrected \u03b1 = 0.000588). Patients with severe toxicity had lower 5-year overall survival than those without severe toxicity (70.2% vs. 90.5%; p = 0.0609), although the difference was not statistically significant. Variants in 5\u2032 and 3\u2032 UTRs regions were markedly enriched compared to coding sequences, underscoring the importance of regulatory region analysis.<\/jats:p>","DOI":"10.3390\/ijms27188131","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:09:51Z","timestamp":1789387791000},"page":"8131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Association of 5\u2032 and 3\u2032 UTRs Variants in TYMS and CCND1 with Severe Hematologic Toxicity in Pediatric Acute Lymphoblastic Leukemia"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1203-1085","authenticated-orcid":false,"given":"Daniela","family":"Rojo-Serrato","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico 11340, Mexico"},{"name":"UIM en Gen\u00e9tica Humana, Hospital de Pediatr\u00eda, 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