{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:03:09Z","timestamp":1789621389184,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006643","name":"Federation University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006643","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/05qbzwv83","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Pulmonary hypertension (PH) is a progressive and life-threatening disease characterised by elevated pulmonary arterial pressure, vascular remodelling and right ventricular dysfunction. Emerging evidence implicates circular RNAs (circRNAs) in the regulation of vascular remodelling and inflammation; however, their contribution to PH remains poorly understood. Here, we performed an in silico analysis using a multi-tool circRNA discovery pipeline across three publicly available transcriptomic datasets derived from experimental rat models of PH: H_PRN (PRJNA809145; pulmonary artery tissue from normoxic and hypoxia-induced PH rats; 21% vs. 10% O2; n = 7), H_GSE (GSE159668; right lung tissue from normoxic and hypoxia-induced PH rats; 21% vs. 10% O2; n = 6) and M_PRN (PRJNA732522; total lung tissue from control and monocrotaline-induced PH rats; n = 6). CircRNAs were detected in all datasets; however, robust differentially expressed candidates were identified primarily in the hypoxia-exposed pulmonary artery dataset (H_PRN). In this dataset, three circRNAs\u2014circCnot6l, circSmoc1 and circNtrk3\u2014met the differential expression criteria (Benjamini-Hochberg adjusted p-value (FDR q) &lt; 0.05, absolute log2 fold-change &gt; 1). Downstream network analysis from unpaired samples prioritised circCnot6l and circNtrk3 as potential regulators of circRNA\u2013microRNA (miRNA) and miRNA\u2013messenger RNA axes involving miR-204-5p and miR-205, respectively. The predicted target networks were enriched for genes associated with key PH-related processes, including cell proliferation, adhesion, migration, angiogenesis and vascular development. Collectively, these findings identify circCnot6l and circNtrk3 as promising circRNA candidates involved in hypoxia-induced pulmonary artery remodelling and provide a foundation for future experimental studies investigating circRNA-mediated mechanisms underlying PH pathogenesis.<\/jats:p>","DOI":"10.3390\/ijms27188195","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:16:48Z","timestamp":1789460208000},"page":"8195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Analysis of Rat Pulmonary Hypertension Datasets Identifies Candidate circRNA Networks in Hypoxia-Exposed Pulmonary Artery Tissue"],"prefix":"10.3390","volume":"27","author":[{"given":"Benjamin","family":"Atchison","sequence":"first","affiliation":[{"name":"Health Innovation and Transformation Centre (HITC), Institute of Innovation, Science and Sustainability (IISS), Federation University Australia, Ballarat, VIC 3350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Byars","sequence":"additional","affiliation":[{"name":"Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla R.","family":"Prestes","sequence":"additional","affiliation":[{"name":"Health Innovation and Transformation Centre (HITC), Institute of Innovation, Science and Sustainability (IISS), Federation University Australia, Ballarat, VIC 3350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-4795","authenticated-orcid":false,"given":"Mark","family":"Myers","sequence":"additional","affiliation":[{"name":"Health Innovation and Transformation Centre (HITC), Institute of Innovation, Science and Sustainability (IISS), Federation University Australia, Ballarat, VIC 3350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-6443","authenticated-orcid":false,"given":"Yutang","family":"Wang","sequence":"additional","affiliation":[{"name":"Health Innovation and Transformation Centre (HITC), Institute of Innovation, Science and Sustainability (IISS), Federation University Australia, Ballarat, VIC 3350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-9941","authenticated-orcid":false,"given":"Fadi J.","family":"Charchar","sequence":"additional","affiliation":[{"name":"Health Innovation and Transformation Centre (HITC), Institute of Innovation, Science and Sustainability (IISS), Federation University Australia, Ballarat, VIC 3350, Australia"},{"name":"Center for Active Living, Taylor\u2019s University, Subang Jaya 47500, Selangor, Malaysia"},{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12944-021-01614-6","article-title":"Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults","volume":"20","author":"Wang","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00210-011-0611-4","article-title":"Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice","volume":"383","author":"Jackman","year":"2011","journal-title":"Naunyn Schmiedeberg\u2019s Arch. 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