{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:06:10Z","timestamp":1789707970545,"version":"4.0.1"},"reference-count":142,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Toll-like receptors (TLRs) are critical components of the innate immune system, acting as pattern recognition receptors and interacting with oxidative stress. TLR2, TLR4, and TLR7 play distinct yet overlapping roles in immune regulation, contributing to both physiological processes and disease progression. Therefore, modulation of TLR signaling pathways represents a promising therapeutic strategy for a wide range of diseases. Natural antioxidants have attracted considerable interest as modulators of TLRs, with cinnamon-derived phytochemicals, particularly cinnamaldehyde, emerging as promising candidates for the treatment of TLR-mediated diseases. Experimental evidence, supported by molecular docking studies, demonstrates that cinnamaldehyde directly interacts with TLR2 and TLR4. Specifically, it inhibits ligand-induced heterodimerization of TLR2 with TLR1 and TLR6, while binding to MD-2 to prevent TLR4 oligomerization and subsequent receptor activation. Furthermore, emerging evidence suggests that cinnamaldehyde may also interact with TLR7 and suppress its downstream signaling. To improve the pharmacokinetic properties, bioavailability, and targeted delivery of cinnamon-derived compounds, nanoformulations and semi-synthetic derivatives have been developed and have shown potential to modulate TLR signaling pathways. However, despite the strong biological plausibility and experimental evidence supporting the parent cinnamaldehyde scaffold as a direct TLR modulator, direct interactions between TLRs and these advanced formulations or semi-synthetic derivatives remain insufficiently documented.<\/jats:p>","DOI":"10.3390\/ijms27188229","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:58:59Z","timestamp":1789545539000},"page":"8229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cinnamon and Derivatives as Modulators of Toll-like Receptors"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-4609","authenticated-orcid":false,"given":"Georges","family":"Maalouly","sequence":"first","affiliation":[{"name":"Laboratory of Research in Physiology and Pathophysiology, Faculty of Medicine, Saint Joseph University of Beirut, Beirut 1104 2020, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Gemayel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Saint Joseph University of Beirut, Beirut 1104 2020, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Khoury","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Saint Joseph University of Beirut, Beirut 1104 2020, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-2611","authenticated-orcid":false,"given":"Nassim","family":"Fares","sequence":"additional","affiliation":[{"name":"Laboratory of Research in Physiology and Pathophysiology, Faculty of Medicine, Saint Joseph University of Beirut, Beirut 1104 2020, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cavaillon, J.-M., and Singer, M. (2017). Pathogen-Associated Molecular Patterns. Inflammation: From Molecular and Cellular Mechanisms to the Clinic, Wiley.","DOI":"10.1002\/9783527692156"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1016\/j.molcel.2025.09.007","article-title":"DAMPs in the Immunogenicity of Cell Death","volume":"85","author":"Chen","year":"2025","journal-title":"Mol. Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2024.03.004","article-title":"Decoding Toll-like Receptors: Recent Insights and Perspectives in Innate Immunity","volume":"57","author":"Kawai","year":"2024","journal-title":"Immunity"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s43440-024-00613-5","article-title":"Mechanistic Insights on TLR-4 Mediated Inflammatory Pathway in Neurodegenerative Diseases","volume":"76","author":"Sharma","year":"2024","journal-title":"Pharmacol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1517\/14728221003642027","article-title":"Toll-like Receptors as Therapeutic Targets in Gastrointestinal Diseases","volume":"14","author":"Soares","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Savva, A., and Roger, T. (2013). Targeting Toll-like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00387"},{"key":"ref_7","first-page":"2859135","article-title":"Natural Products with Toll-Like Receptor 4 Antagonist Activity","volume":"2018","author":"Molteni","year":"2018","journal-title":"Int. J. Inflamm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107096","DOI":"10.1016\/j.intimp.2020.107096","article-title":"Toll-like Receptor 4, Toll-like Receptor 7 and Toll-like Receptor 9 Agonists Enhance Immune Responses against Blood-Stage Plasmodium Chabaudi Infection in BALB\/c Mice","volume":"89","author":"Gao","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Monserrat-Mesquida, M., Quetglas-Llabr\u00e9s, M., Cap\u00f3, X., Bouzas, C., Mateos, D., Pons, A., Tur, J.A., and Sureda, A. (2020). Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State. Antioxidants, 9.","DOI":"10.3390\/antiox9030236"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1286-4579(00)00303-8","article-title":"Toll-like Receptors","volume":"2","author":"Muzio","year":"2000","journal-title":"Microbes Infect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105400","DOI":"10.1016\/j.dci.2025.105400","article-title":"Toll-like Receptor-4 in the Fish Immune System","volume":"169","author":"Li","year":"2025","journal-title":"Dev. Comp. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"13466","DOI":"10.1021\/acs.jmedchem.0c01049","article-title":"Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists","volume":"63","author":"Federico","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e549","DOI":"10.1002\/mco2.549","article-title":"Toll-like Receptors in Health and Disease","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4161\/hv.5.6.8175","article-title":"Potential Adjuvantic Properties of Innate Immune Stimuli","volume":"5","author":"Warshakoon","year":"2009","journal-title":"Hum. Vaccines"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4067\/S0716-97602007000200001","article-title":"Toll-like Receptors Are Key Participants in Innate Immune Responses","volume":"40","author":"Arancibia","year":"2007","journal-title":"Biol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Manavalan, B., Basith, S., and Choi, S. (2011). Similar Structures but Different Roles\u2014An Updated Perspective on TLR Structures. Front. Physiol., 2.","DOI":"10.3389\/fphys.2011.00041"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9914854","DOI":"10.1155\/2021\/9914854","article-title":"Toll-Like Receptors: General Molecular and Structural Biology","volume":"2021","author":"Behzadi","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"RCR5189","DOI":"10.59761\/RCR5189","article-title":"Monocarbonyl Synthetic Curcumin Analogues with Antitumour Potential. Chemical and Biological Aspects","volume":"94","author":"Neganova","year":"2025","journal-title":"Russ. Chem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like Receptors and Innate Immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/MNH.0b013e32803fb767","article-title":"Toll-like Receptors: Emerging Concepts in Kidney Disease","volume":"16","author":"Anders","year":"2007","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/molbev\/msy050","article-title":"Evolutionary Origins of Toll-like Receptor Signaling","volume":"35","author":"Brennan","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000320801","article-title":"Toll-like Receptor 2 as Therapeutic Target in Lung Disease","volume":"Volume 39","author":"Hansel","year":"2010","journal-title":"New Drugs and Targets for Asthma and COPD"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.intimp.2009.10.002","article-title":"CD14 but Not MD2 Transmit Signals from DAMP","volume":"10","author":"Chun","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"119157","DOI":"10.1016\/j.ejmech.2026.119157","article-title":"Targeting MD2 in Diseases: From Structure and Function to Inhibitor Development","volume":"318","author":"Cheng","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.drudis.2018.01.015","article-title":"Recent Progress in the Discovery of Myeloid Differentiation 2 (MD2) Modulators for Inflammatory Diseases","volume":"23","author":"Chen","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1073\/pnas.0630495100","article-title":"The Role of Disulfide Bonds in the Assembly and Function of MD-2","volume":"100","author":"Mullen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e70031","DOI":"10.1002\/ddr.70031","article-title":"Structural Diversity and Mutational Challenges of Toll-Like Receptor 4 Antagonists as Inflammatory Pathway Blocker","volume":"86","author":"Nandi","year":"2025","journal-title":"Drug Dev. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2174\/0113894501316051240821060249","article-title":"Endogenous Ligands of TLR4 in Microglia: Potential Targets for Related Neurological Diseases","volume":"25","author":"Chen","year":"2024","journal-title":"Curr. Drug Targets"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"23653","DOI":"10.1073\/pnas.1915326116","article-title":"Identification of U11snRNA as an Endogenous Agonist of TLR7-Mediated Immune Pathogenesis","volume":"116","author":"Negishi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gaspari, A.A., and Tyring, S.K. (2008). Toll-like Receptors. Clinical and Basic Immunodermatology, Springer.","DOI":"10.1007\/978-1-84800-165-7"},{"key":"ref_31","first-page":"99","article-title":"Role of Toll-like receptor 7 in anti-infective immunity","volume":"40","author":"Yin","year":"2022","journal-title":"Chin. J. Parasitol. Parasit. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.chembiol.2013.05.010","article-title":"PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12\/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling","volume":"20","author":"Cai","year":"2013","journal-title":"Chem. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yesudhas, D., Gosu, V., Anwar, M.A., and Choi, S. (2014). Multiple Roles of Toll-like Receptor 4 in Colorectal Cancer. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00334"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1002\/jcp.26273","article-title":"Toll like Receptor Signaling Pathway as a Potential Therapeutic Target in Colorectal Cancer","volume":"233","author":"Hassanian","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.intimp.2011.04.027","article-title":"TLRs as Pharmacological Targets for Plant-Derived Compounds in Infectious and Inflammatory Diseases","volume":"11","author":"Liu","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Wu, J., Liu, X., Chen, X., and Wang, J. (2024). Decoding Nature: Multi-Target Anti-Inflammatory Mechanisms of Natural Products in the TLR4\/NF-\u03baB Pathway. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1467193"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-41342-6_1","article-title":"Cinnamon and Chronic Diseases","volume":"Volume 929","author":"Hariri","year":"2016","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"642942","DOI":"10.1155\/2014\/642942","article-title":"Cinnamon: A Multifaceted Medicinal Plant","volume":"2014","author":"Rao","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pasupuleti, V.R. (2021). Bioactive Compounds of Cinnamon (Cinnamomum Species). Reference Series in Phytochemistry, Springer Science and Business Media B.V.","DOI":"10.1007\/978-3-030-57415-4_25"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Singh, J., Meshram, V., and Gupta, M. (2020). Current Knowledge of Cinnamomum Species: A Review on the Bioactive Components, Pharmacological Properties, Analytical and Biotechnological Studies. Bioactive Natural Products in Drug Discovery, Springer.","DOI":"10.1007\/978-981-15-1394-7"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"B\u0142aszczyk, N., Rosiak, A., and Ka\u0142u\u017cna-Czapli\u0144ska, J. (2021). The Potential Role of Cinnamon in Human Health. Forests, 12.","DOI":"10.3390\/f12050648"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jfutfo.2022.03.010","article-title":"Ceylon Cinnamon: A Versatile Ingredient for Futuristic Diabetes Management","volume":"2","author":"Senevirathne","year":"2022","journal-title":"J. Future Foods"},{"key":"ref_43","first-page":"387","article-title":"A Review on Factors Influencing the Chemical Composition and Functional Activity of Cinnamon Essential Oil","volume":"47","author":"Bai","year":"2026","journal-title":"Food Sci."},{"key":"ref_44","first-page":"2237","article-title":"Cinnamon and Its Derivatives as Potential Ingredient in Functional Food\u2014A Review","volume":"20","author":"Muhammad","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5958\/0974-4479.2025.00002.4","article-title":"Therapeutic Uses of Cinnamon (Cinnamomum verum) in Human Health: A Review","volume":"38","author":"Katiyar","year":"2025","journal-title":"Indian J. Agric. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101336","DOI":"10.1016\/j.afres.2025.101336","article-title":"Optimized HPLC-DAD Method for Quantifying Coumarin and Cinnamaldehyde in Local Cinnamon Sample","volume":"5","author":"Tamim","year":"2025","journal-title":"Appl. Food Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1134\/S1068162024050108","article-title":"Synthesis and Importance of Coumarin Derivatives in Medicinal Chemistry: A Comprehensive Review","volume":"50","author":"Samanth","year":"2024","journal-title":"Russ. J. Bioorganic Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.33483\/jfpau.1762483","article-title":"Assessment of Coumarin Levels in Cinnamon Spices Available in the Turkish Market","volume":"50","author":"Diker","year":"2026","journal-title":"Ank. Univ. Eczaci. Fak. Derg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hong, J.-W., Yang, G.-E., Kim, Y.B., Eom, S.H., Lew, J.-H., and Kang, H. (2012). Anti-Inflammatory Activity of Cinnamon Water Extract in Vivo and in Vitro LPS-Induced Models. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-237"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s10068-023-01292-3","article-title":"Cinnamon (Cinnamomum cassia) Hot Water Extract Improves Inflammation and Tight Junctions in the Intestine In Vitro and In Vivo","volume":"32","author":"Park","year":"2023","journal-title":"Food Sci. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Maalouly, G., Saliba, Y., Hajal, J., Zein-El-Din, A., Fakhoury, L., Najem, R., Smayra, V., Nassereddine, H., and Fares, N. (2025). Cinnamomum cassia Alleviates Neuropsychiatric Lupus in a Murine Experimental Model. Nutrients, 17.","DOI":"10.3390\/nu17111820"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/07315724.2018.1460733","article-title":"Cinnamon Consumption Improves Clinical Symptoms and Inflammatory Markers in Women With Rheumatoid Arthritis","volume":"37","author":"Shishehbor","year":"2018","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"155651","DOI":"10.1016\/j.phymed.2024.155651","article-title":"Essential Oil from Cinnamomum cassia Presl Bark Regulates Macrophage Polarization and Ameliorates Lipopolysaccharide-Induced Acute Lung Injury through TLR4\/MyD88\/NF-\u03baB Pathway","volume":"129","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2016.10.017","article-title":"Cinnamaldehyde Ameliorates LPS-Induced Cardiac Dysfunction via TLR4-NOX4 Pathway: The Regulation of Autophagy and ROS Production","volume":"101","author":"Zhao","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jfda.2017.03.006","article-title":"Anti-Inflammatory Effect of Cinnamaldehyde and Linalool from the Leaf Essential Oil of Cinnamomum osmophloeum Kanehira in Endotoxin-Induced Mice","volume":"26","author":"Lee","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/JPER.17-0727","article-title":"Trans-Cinnamic Aldehyde Inhibits Aggregatibacter Actinomycetemcomitans-Induced Inflammation in THP-1-Derived Macrophages via Autophagy Activation","volume":"89","author":"Chung","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-3-030-71697-4_15","article-title":"Cinnamon: A Promising Natural Product Against COVID-19","volume":"Volume 1327","author":"Zareie","year":"2021","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lucas, K., Ackermann, M., Leifke, A.L., Li, W.W., P\u00f6schl, U., and Fr\u00f6hlich-Nowoisky, J. (2021). Ceylon Cinnamon and Its Major Compound Cinnamaldehyde Can Limit Overshooting Inflammatory Signaling and Angiogenesis In Vitro: Implications for COVID-19 Treatment. bioRxiv.","DOI":"10.1101\/2021.06.16.448642"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/jcmm.17148","article-title":"Cinnamic Aldehyde, the Main Monomer Component of Cinnamon, Exhibits Anti-Inflammatory Property in OA Synovial Fibroblasts via TLR4\/MyD88 Pathway","volume":"26","author":"Chen","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chen, P., Ruan, A., Zhou, J., Huang, L., Zhang, X., Ma, Y., and Wang, Q. (2020). Cinnamic Aldehyde Inhibits Lipopolysaccharide-Induced Chondrocyte Inflammation and Reduces Cartilage Degeneration by Blocking the Nuclear Factor-Kappa B Signaling Pathway. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00949"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Li, W., Wang, K., Liu, Y., Wu, H., He, Y., Li, C., Wang, Q., Su, X., Yan, S., and Su, W. (2022). A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4\/NF\u03baB\/NLRP3 Activation-Induced Pyroptosis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.912933"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/0118715230278980231212103709","article-title":"Cinnamic Acid Ameliorates Acetic Acid-Induced Inflammatory Response through Inhibition of TLR-4 in Colitis Rat Model","volume":"23","author":"Rezaei","year":"2024","journal-title":"Anti-Inflamm. Anti-Allergy Agents Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e202200089","DOI":"10.1002\/cbdv.202200089","article-title":"Cinnamaldehyde Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating TLR4\/NF-\u03baB Signaling Pathway and NLRP3 Inflammasome Activation","volume":"20","author":"Tan","year":"2023","journal-title":"Chem. Biodivers."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Maalouly, G., Itani, T., and Fares, N. (2025). Cinnamomum cassia Modulates Key Players of Gut-Liver Axis in Murine Lupus. Biomedicines, 14.","DOI":"10.20944\/preprints202511.0582.v1"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Maalouly, G., Martin, C.-M.-A., Baz, Y., Saliba, Y., Baramili, A.-M., and Fares, N. (2024). Antioxidant and Anti-Apoptotic Neuroprotective Effects of Cinnamon in Imiquimod-Induced Lupus. Antioxidants, 13.","DOI":"10.3390\/antiox13070880"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1034325","DOI":"10.1155\/2020\/1034325","article-title":"Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases","volume":"2020","author":"Hajinejad","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1111\/bph.13270","article-title":"Cinnamaldehyde Inhibits Inflammation and Brain Damage in a Mouse Model of Permanent Cerebral Ischaemia","volume":"172","author":"Zhao","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"111456","DOI":"10.1016\/j.brainresbull.2025.111456","article-title":"Trans-Cinnamaldehyde Ameliorates Neuroinflammation-Mediated Synaptic Plasticity and Memory Impairment by Blocking TLR4\/MyD88\/MAPKs Pathway in Global Cerebral Ischemia","volume":"229","author":"Liu","year":"2025","journal-title":"Brain Res. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11011-026-01817-9","article-title":"Mechanistic Study on the Alleviating Effects of Cinnamaldehyde on Aluminum Chloride-Induced Cognitive Impairment in Zebrafish through Modulating the TLR4\/NF-\u03baB Signaling Pathway","volume":"41","author":"Zhong","year":"2026","journal-title":"Metab. Brain Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"27460","DOI":"10.1038\/srep27460","article-title":"Cinnamaldehyde and Allopurinol Reduce Fructose-Induced Cardiac Inflammation and Fibrosis by Attenuating CD36-Mediated TLR4\/6-IRAK4\/1 Signaling to Suppress NLRP3 Inflammasome Activation","volume":"6","author":"Kang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_71","first-page":"188","article-title":"Investigation of the Effect of Cinnamon Extract on TLR4 Expression and Numerical Distribution of Mast Cells in the Experimental Diabetic Rat Kidney","volume":"36","year":"2022","journal-title":"Firat Univ. Saglik Bilim. Vet. Derg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.2147\/DDDT.S241410","article-title":"Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4","volume":"14","author":"Mei","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_73","first-page":"2420","article-title":"Cinnamaldehyde Causes Apoptosis of Myeloid-derived Suppressor Cells through the Activation of TLR4","volume":"18","author":"He","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11756-021-00725-w","article-title":"Cinnamaldehyde Targets TLR-4 and Inflammatory Mediators in Acetic-Acid Induced Ulcerative Colitis Model","volume":"76","author":"Momtaz","year":"2021","journal-title":"Biologia"},{"key":"ref_75","first-page":"2","article-title":"The Role and Mechanism of Cinnamaldehyde in Cancer","volume":"32","author":"Peng","year":"2024","journal-title":"J. Food Drug Anal."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1080\/03639045.2026.2678494","article-title":"Recent Advancements and Clinical Translation of Cinnamaldehyde Derivatives in Therapeutics","volume":"52","author":"Shakir","year":"2026","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"100237","DOI":"10.1016\/j.fochms.2024.100237","article-title":"Evaluation of Bioaccessibility, Metabolic Clearance and Interaction with Xenobiotic Receptors (PXR and AhR) of Cinnamaldehyde","volume":"10","author":"Husain","year":"2024","journal-title":"Food Chem. Mol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF03191384","article-title":"Pharmacokinetics and Bioavailability of Cinnamic Acid after Oral Administration of Ramulus Cinnamomi in Rats","volume":"34","author":"Chen","year":"2009","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpba.2013.10.044","article-title":"Pharmacokinetic Study of Cinnamaldehyde in Rats by GC-MS after Oral and Intravenous Administration","volume":"89","author":"Zhao","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e2200785","DOI":"10.1002\/mnfr.202200785","article-title":"Characterization and Pharmacokinetic Profile of Herbs and Spices\u2019 Phytochemicals over 24 h after Consumption in Overweight\/Obese Adults","volume":"67","author":"Huang","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0923-1811(02)00139-1","article-title":"Cinnamic Compound Metabolism in Human Skin and the Role Metabolism May Play in Determining Relative Sensitisation Potency","volume":"31","author":"Cheung","year":"2003","journal-title":"J. Dermatol. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.phrs.2017.05.019","article-title":"Cinnamaldehyde in Diabetes: A Review of Pharmacology, Pharmacokinetics and Safety","volume":"122","author":"Zhu","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4038\/jnsfsr.v51i1.10817","article-title":"Quantification of Metabolite Cinnamic Acid of Cinnamon (Cinnamomum zeylanicum) in Human Plasma","volume":"51","author":"Pigera","year":"2023","journal-title":"J. Natl. Sci. Found. Sri Lanka"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/08923973.2011.561861","article-title":"Immunomodulation of Experimental Allergic Encephalomyelitis by Cinnamon Metabolite Sodium Benzoate","volume":"33","author":"Pahan","year":"2011","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/mnfr.201000394","article-title":"Relative Bioavailability of Coumarin from Cinnamon and Cinnamon-Containing Foods Compared to Isolated Coumarin: A Four-Way Crossover Study in Human Volunteers","volume":"55","author":"Abraham","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Tjandrawinata, R.R., Rosari, B.P., Syahputra, R.A., Surya, R., and Nurkolis, F. (2026). Cinnamon-Derived Phytonutrients as Modulators of Ion Channels and G Protein-Coupled Receptor Signaling in Metabolic Diseases. Nutrients, 18.","DOI":"10.3390\/nu18030547"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3109\/19390211.2011.627783","article-title":"An Evidence-Based Systematic Review of Cinnamon (Cinnamomum Spp.) by the Natural Standard Research Collaboration","volume":"8","author":"Ulbricht","year":"2011","journal-title":"J. Diet. Suppl."},{"key":"ref_88","first-page":"370","article-title":"An Overview of the Therapeutic Applications of Cinnamon-Loaded in Nanosystems","volume":"12","author":"Asadi","year":"2025","journal-title":"Nanomed. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"150420","DOI":"10.1016\/j.foodchem.2026.150420","article-title":"Comparative Study of Antioxidant Activity and Chemical Composition of Alcoholic Extracts and Essential Oils from Cinnamomum verum and Cinnamomum cassia","volume":"525","author":"Gajewska","year":"2026","journal-title":"Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"95","DOI":"10.9734\/irjpac\/2025\/v26i3920","article-title":"Influence of Some Solvents and Solvent Mixtures on Polyphenol Content and Antioxidant Activity of Cinnamomum verum Extracts","volume":"26","year":"2025","journal-title":"Int. Res. J. Pure Appl. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Chen, X., Shang, S., Yan, F., Jiang, H., Zhao, G., Tian, S., Chen, R., Chen, D., and Dang, Y. (2023). Antioxidant Activities of Essential Oils and Their Major Components in Scavenging Free Radicals, Inhibiting Lipid Oxidation and Reducing Cellular Oxidative Stress. Molecules, 28.","DOI":"10.3390\/molecules28114559"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1080\/10942912.2019.1656232","article-title":"Anticholinergic, Antidiabetic and Antioxidant Activities of Cinnamon (Cinnamomum verum) Bark Extracts: Polyphenol Contents Analysis by LC-MS\/MS","volume":"22","author":"Gulcin","year":"2019","journal-title":"Int. J. Food Prop."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N.C., Bouyahya, A., and Vitalini, S. (2021). Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.600139"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/07315724.2009.10719756","article-title":"Antioxidant Effects of a Cinnamon Extract in People with Impaired Fasting Glucose That Are Overweight or Obese","volume":"28","author":"Roussel","year":"2009","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Bastos, M.S., Del Vesco, A.P., Santana, T.P., Santos, T.S., de Oliveira Junior, G.M., Fernandes, R.P.M., Barbosa, L.T., and Gasparino, E. (2017). The Role of Cinnamon as a Modulator of the Expression of Genes Related to Antioxidant Activity and Lipid Metabolism of Laying Quails. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189619"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Sharma, U.K., Sharma, A.K., and Pandey, A.K. (2016). Medicinal Attributes of Major Phenylpropanoids Present in Cinnamon. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1147-4"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1089\/jmf.2010.0197","article-title":"Antioxidant Activity of Eugenol: A Structure\u2013Activity Relationship Study","volume":"14","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.3390\/molecules15053338","article-title":"The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells","volume":"15","author":"Wondrak","year":"2010","journal-title":"Molecules"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s11094-010-0468-8","article-title":"Targeted Search for a Lead Compound in a Series of Cinnamic Acid Derivatives Possessing Antiradical Activity","volume":"44","author":"Agadzhanyan","year":"2010","journal-title":"Pharm. Chem. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4314\/tjpr.v12i6.22","article-title":"Antioxidative Activities of Natural Hydroxy-Bearing Cinnamaldehydes and Cinnamic Acids: A Comparative Study","volume":"12","author":"Jiang","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1248\/cpb.c17-00416","article-title":"Synthesis of Amide and Ester Derivatives of Cinnamic Acid and Its Analogs: Evaluation of Their Free Radical Scavenging and Monoamine Oxidase and Cholinesterase Inhibitory Activities","volume":"65","author":"Takao","year":"2017","journal-title":"Chem. Pharm. Bull."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cplett.2006.04.034","article-title":"QTAIM Charge Density Study of Natural Cinnamic Acids","volume":"424","author":"Mandado","year":"2006","journal-title":"Chem. Phys. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0006-2952(03)00458-1","article-title":"Antioxidant Protection of Low Density Lipoprotein by Procyanidins: Structure\/Activity Relationships","volume":"66","author":"Laranjinha","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"148067","DOI":"10.1016\/j.foodchem.2026.148067","article-title":"Proanthocyanidins in Food and Health: Structure\u2013Activity Relationships, Application Challenges, and Emerging Strategies","volume":"505","author":"Li","year":"2026","journal-title":"Food Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bcp.2007.08.033","article-title":"Cinnamaldehyde Suppresses Toll-like Receptor 4 Activation Mediated through the Inhibition of Receptor Oligomerization","volume":"75","author":"Youn","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1021\/jm401006s","article-title":"Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update","volume":"57","author":"Peri","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1039\/C8FO01286E","article-title":"Anti-Inflammatory Effects of Cinnamon Extract and Identification of Active Compounds Influencing the TLR2 and TLR4 Signaling Pathways","volume":"9","author":"Schink","year":"2018","journal-title":"Food Funct."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Ho, S.-C., Chang, Y.-H., and Chang, K.-S. (2018). Structural Moieties Required for Cinnamaldehyde-Related Compounds to Inhibit Canonical IL-1\u03b2 Secretion. Molecules, 23.","DOI":"10.3390\/molecules23123241"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1074\/jbc.M109.075127","article-title":"MD-2-Mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation","volume":"285","author":"Meng","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/cbic.200800769","article-title":"A Peptide Antagonist of the TLR4\u2013MD2 Interaction","volume":"10","author":"Slivka","year":"2009","journal-title":"Chembiochem"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1753-4887.2011.00394.x","article-title":"Inhibition of Pattern Recognition Receptor-Mediated Inflammation by Bioactive Phytochemicals: A Review of Recent Research","volume":"69","author":"Zhao","year":"2011","journal-title":"Nutr. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Wang, S., Song, X., Zhang, K., Deng, S., Jiao, P., Qi, M., Lian, Z., and Yao, Y. (2020). Overexpression of Toll-Like Receptor 4 Affects Autophagy, Oxidative Stress, and Inflammatory Responses in Monocytes of Transgenic Sheep. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00248"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"99","DOI":"10.61186\/phypha.28.2.99","article-title":"Antioxidant and Anti-Inflammatory Effects of Cinnamomum Species and Their Bioactive Compounds: An Updated Review of the Molecular Mechanisms","volume":"28","author":"Davoudi","year":"2024","journal-title":"Physiol. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.4049\/jimmunol.172.4.2522","article-title":"Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-\u03baB","volume":"172","author":"Asehnoune","year":"2004","journal-title":"J. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.yjmcc.2015.10.010","article-title":"Cardiac-Specific Overexpression of Catalase Prevents Diabetes-Induced Pathological Changes by Inhibiting NF-\u03baB Signaling Activation in the Heart","volume":"89","author":"Cong","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.freeradbiomed.2008.06.019","article-title":"The Non-Provitamin A Carotenoid, Lutein, Inhibits NF-\u03baB-Dependent Gene Expression through Redox-Based Regulation of the Phosphatidylinositol 3-Kinase\/PTEN\/Akt and NF-\u03baB-Inducing Kinase Pathways: Role of H2O2 in NF-\u03baB Activation","volume":"45","author":"Kim","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Su, Q., Yu, X.-J., Wang, X.-M., Li, H.-B., Li, Y., Bai, J., Qi, J., Zhang, N., Liu, K.-L., and Zhang, Y. (2021). Bilateral Paraventricular Nucleus Upregulation of Extracellular Superoxide Dismutase Decreases Blood Pressure by Regulation of the NLRP3 and Neurotransmitters in Salt-Induced Hypertensive Rats. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.756671"},{"key":"ref_118","first-page":"88","article-title":"Antiinflmmatory and Antihyperlipidemic Effect of Adjuvant Cinnamon in Type 2 Diabetic Patients","volume":"41","author":"Kadhim","year":"2016","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ajcn\/nqab331","article-title":"Four Weeks of Spice Consumption Lowers Plasma Proinflammatory Cytokines and Alters the Function of Monocytes in Adults at Risk of Cardiometabolic Disease: Secondary Outcome Analysis in a 3-Period, Randomized, Crossover, Controlled Feeding Trial","volume":"115","author":"Oh","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.numecd.2024.08.009","article-title":"Effect of Cinnamon Supplementation on Blood Pressure, Oxidative Stress, and Inflammatory Biomarkers in Adults: An Umbrella Review of the Meta-Analyses of Randomized Controlled Trials","volume":"34","author":"Zhang","year":"2024","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000374074","article-title":"Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2","volume":"36","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Londono, M.B.Z., Yunda, D.F.U., Osma, J.A., and Maldonado-Celis, M.E. (2022). Coffee, Ginger and Cinnamon: Molecular Mechanisms of Action on Human Health. Molecular Mechanisms of Functional Food, Wiley.","DOI":"10.1002\/9781119804055.ch12"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.freeradbiomed.2018.04.557","article-title":"Nrf2 Protects against Acute Lung Injury and Inflammation by Modulating TLR4 and Akt Signaling","volume":"121","author":"Yan","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/TP.0000000000000316","article-title":"Nuclear Factor Erythroid 2yrelated Factor 2 Regulates Toll-like Receptor 4 Innate Responses in Mouse Liver Ischemia-Reperfusion Injury through Akt-Forkhead Box Protein O1 Signaling Network","volume":"98","author":"Huang","year":"2014","journal-title":"Transplantation"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3748\/wjg.v17.i8.976","article-title":"Cinnamon Extract Suppresses Experimental Colitis through Modulation of Antigen-Presenting Cells","volume":"17","author":"Kwon","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Mondal, S., and Pahan, K. (2015). Cinnamon Ameliorates Experimental Allergic Encephalomyelitis in Mice via Regulatory T Cells: Implications for Multiple Sclerosis Therapy. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116566"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"365258","DOI":"10.1155\/2014\/365258","article-title":"Immunosuppressive Effects of A-Type Procyanidin Oligomers from Cinnamomum tamala","volume":"2014","author":"Chen","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"565","DOI":"10.56499\/jppres24.2045_13.2.565","article-title":"In Silico Prediction of Cinnamaldehyde on the PI3K\/AKT Pathway Activator of Anti-Apoptotic Potential","volume":"13","author":"Fukata","year":"2025","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Qureshi, K.A., Mohammed, S.A.A., Khan, O., Ali, H.M., El-Readi, M.Z., and Mohammed, H.A. (2022). Cinnamaldehyde-Based Self-Nanoemulsion (CA-SNEDDS) Accelerates Wound Healing and Exerts Antimicrobial, Antioxidant, and Anti-Inflammatory Effects in Rats\u2019 Skin Burn Model. Molecules, 27.","DOI":"10.3390\/molecules27165225"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Korbecki, J., Maruszewska, A., Bosiacki, M., Chlubek, D., and Baranowska-Bosiacka, I. (2022). The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010205"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2639773","DOI":"10.1080\/09712119.2026.2639773","article-title":"Effects of Cinnamon and Silver Nanoparticles Combination on Growth, Immune Function, Oxidative Status, Inflammation, and Cecal Microbiota in Broiler Chickens","volume":"54","author":"Fathi","year":"2026","journal-title":"J. Appl. Anim. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.oooo.2012.01.019","article-title":"Silver Nanoparticles Induce Apoptosis through the Toll-like Receptor 2 Pathway","volume":"113","author":"Kim","year":"2012","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"108658","DOI":"10.1016\/j.abb.2020.108658","article-title":"Suppression of Inflammatory Cascades via Novel Cinnamic Acid Nanoparticles in Acute Hepatitis Rat Model","volume":"696","author":"Ibrahim","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e2200191","DOI":"10.1002\/ardp.202200191","article-title":"Discovery of New Cinnamic Derivatives as Anti-Inflammatory Agents for Treating Acute Lung Injury in Mice","volume":"356","author":"Chen","year":"2023","journal-title":"Arch. Pharm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.freeradbiomed.2015.12.003","article-title":"A Low Toxicity Synthetic Cinnamaldehyde Derivative Ameliorates Renal Inflammation in Mice by Inhibiting NLRP3 Inflammasome and Its Related Signaling Pathways","volume":"91","author":"Ka","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/17568919.2024.2351293","article-title":"Exploring the Therapeutic Potential of Cinnamoyl Derivatives in Attenuating Inflammation in Lipopolysaccharide-Induced Caco-2 Cells","volume":"16","author":"Reale","year":"2024","journal-title":"Future Med. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.intimp.2012.06.007","article-title":"The Comparison of \u03b1-Bromo-4-Chlorocinnamaldehyde and Cinnamaldehyde on Coxsackie Virus B3-Induced Myocarditis and Their Mechanisms","volume":"14","author":"Zhang","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1021\/acsmedchemlett.3c00437","article-title":"Synthesis of 9-Cinnamyl-9H-Purine Derivatives as Novel TLR4\/MyD88\/NF-\u03baB Pathway Inhibitors for Anti-Inflammatory Effects","volume":"14","author":"Pham","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1021\/acs.jmedchem.5b01574","article-title":"Discovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury","volume":"59","author":"Chen","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Al Nasr, I.S., Koko, W.S., Khan, T.A., Schobert, R., and Biersack, B. (2024). Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances. Antibiotics, 13.","DOI":"10.3390\/antibiotics13121114"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Karimirad, R., Inbaraj, B.S., and Chen, B.-H. (2025). Recent Advances on the Analysis and Biological Functions of Cinnamaldehyde and Its Derivatives. Antioxidants, 14.","DOI":"10.3390\/antiox14070765"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Chun, Y.L., Park, K.-H., Pallavi, B., Eom, W.-J., Park, C., Huh, Y., Lee, Y., Lee, J., Kim, S.H., and Yeo, S.G. (2022). Novel Cinnamaldehyde Derivatives Inhibit Peripheral Nerve Degeneration by Targeting Schwann Cells. Antioxidants, 11.","DOI":"10.3390\/antiox11101846"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:26:16Z","timestamp":1789705576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":142,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27188229"],"URL":"https:\/\/doi.org\/10.3390\/ijms27188229","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]}}}