{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:29:09Z","timestamp":1789658949779,"version":"4.0.1"},"reference-count":144,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173396"],"award-info":[{"award-number":["82173396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52572078"],"award-info":[{"award-number":["52572078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82173396"],"award-info":[{"award-number":["82173396"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["52572078"],"award-info":[{"award-number":["52572078"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Clinical Research Plan of SHDC","award":["SHDC22025306"],"award-info":[{"award-number":["SHDC22025306"]}]},{"name":"Development Project for Innovative Teams of Clinical Subspecialties, Shanghai Children\u2019s Medical Center","award":["SCMC-XEQ-202603"],"award-info":[{"award-number":["SCMC-XEQ-202603"]}],"id":[{"id":"https:\/\/ror.org\/00cd9s024","id-type":"ROR","asserted-by":"crossref"}]},{"award":["SCMC-XEQ-202603"],"award-info":[{"award-number":["SCMC-XEQ-202603"]}],"id":[{"id":"https:\/\/ror.org\/00cd9s024","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Scientific Research Program of Shanghai Pudong New Area Health Commission","award":["PW2026D-01"],"award-info":[{"award-number":["PW2026D-01"]}],"id":[{"id":"https:\/\/ror.org\/041s47w50","id-type":"ROR","asserted-by":"crossref"}]},{"award":["PW2026D-01"],"award-info":[{"award-number":["PW2026D-01"]}],"id":[{"id":"https:\/\/ror.org\/041s47w50","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Inflammatory skin diseases, including atopic dermatitis (AD), psoriasis, diabetic wounds, and photoaging, represent major public health challenges due to their high prevalence, chronic recurrence, and substantial disease burden. Current treatments, such as glucocorticoids, calcineurin inhibitors, and biologics, are often constrained by limited efficacy, long-term adverse effects, or high costs, highlighting the need for safer and more accessible therapeutic strategies. Cerium oxide nanoparticles (CeO2 NPs) have attracted increasing attention because of their reversible Ce3+\/Ce4+ redox cycling and multiple enzyme-mimetic activities. This review examines the synthesis strategies and structure\u2013activity relationships of CeO2 NPs, and discusses their antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, and proangiogenic mechanisms in inflammatory skin microenvironments. We further evaluate their applications in AD, psoriasis, diabetic wounds, and photoaging, and summarize advanced delivery approaches involving structural functionalization, biomimetic surface modification, and formulation hybridization. Key translational challenges, including long-term safety, degradability, manufacturing consistency, and disease-specific applicability, are also discussed. Finally, we propose a \u201c5D\u201d framework for next-generation CeO2-based nanomedicines, integrating disease-specific design, degradability, data-driven optimization, device integration, and digital health interfacing.<\/jats:p>","DOI":"10.3390\/ijms27188243","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:06:37Z","timestamp":1789549597000},"page":"8243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives"],"prefix":"10.3390","volume":"27","author":[{"given":"Zishang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-5619","authenticated-orcid":false,"given":"Fei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, ETH Z\u00fcrich, 8092 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Advanced High-Temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.anai.2025.05.003","article-title":"Current Updates in the Epidemiology and Comorbidities of Atopic Dermatitis","volume":"135","author":"Narla","year":"2025","journal-title":"Ann. 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