{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:12Z","timestamp":1792789512519,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Padua","award":["ANDR_BIRD24_01"],"award-info":[{"award-number":["ANDR_BIRD24_01"]}],"id":[{"id":"https:\/\/ror.org\/00240q980","id-type":"ROR","asserted-by":"crossref"}]},{"award":["ANDR_BIRD24_01"],"award-info":[{"award-number":["ANDR_BIRD24_01"]}],"id":[{"id":"https:\/\/ror.org\/00240q980","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Chronic endometritis (CE) is a persistent inflammatory disorder of the endometrium that is histopathologically characterized by CD138-positive plasma cells within the endometrial stroma. This study evaluated components of the renin\u2013angiotensin\u2013aldosterone system (RAAS) and interleukin-6 (IL-6) in infertile women with CE. Thirty-nine infertile women undergoing diagnostic hysteroscopy with endometrial biopsy were included. A total of 21 women were classified as CE-positive and 18 as CE-negative. Fasting blood samples were collected 48 h before hysteroscopy (t1) and approximately 2.5 h before the procedure (t2) to assess plasma renin, serum aldosterone, the aldosterone-to-renin ratio (ARR), sodium, potassium, progesterone, thyroid-stimulating hormone (TSH), and IL-6. Exploratory analyses were performed according to the extent of CD138-positive plasma-cell infiltration (plasma-cell burden, stratified as &lt;20 or \u226520 cells\/high-power field) and persistence versus resolution of CE after antibiotic treatment. Baseline characteristics, including body mass index (BMI), infertility duration, and anti-M\u00fcllerian hormone (AMH), were comparable between groups. No significant differences in the parameters were observed between CE-positive and CE-negative women. No consistent RAAS or inflammatory differences emerged according to plasma-cell burden or CE persistence after treatment. These findings suggest that CE is not associated with measurable systemic RAAS activation or IL-6 changes, supporting the hypothesis of local CE alterations.<\/jats:p>","DOI":"10.3390\/ijms27188256","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:07:29Z","timestamp":1789574849000},"page":"8256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renin\u2013Angiotensin\u2013Aldosterone Axis Activity in Women with Chronic Endometritis: A Prospective Observational Study"],"prefix":"10.3390","volume":"27","author":[{"given":"Giulia","family":"Garbin","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, University of Padova, 35128 Padova, 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