{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:54:27Z","timestamp":1790862867293,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Artificial intelligence (AI) is increasingly being explored as a bridge between high-dimensional cardiovascular phenotyping and genomic interpretation in children with inherited and congenital heart disease. This review focuses specifically on where AI-assisted approaches in pediatric cardiovascular genetics have progressed beyond proof-of-concept, how the maturity of evidence differs between general genomic tools and pediatric cardiovascular applications, and what is required for responsible clinical translation. Inherited and rare cardiovascular disorders are characterized by genetic heterogeneity, incomplete penetrance, variable expressivity, and age-dependent phenotypes, while modern sequencing, imaging, and longitudinal monitoring generate data that are difficult to integrate using conventional approaches alone. AI-assisted methods are being investigated across diagnostic, prognostic, and therapeutic domains, including computational phenotyping, genomic variant prioritization, electrocardiographic and imaging analysis, multimodal risk prediction, and selection of candidates for precision therapies. The strongest pediatric cardiovascular evidence currently comes from externally evaluated ECG and echocardiographic models and from large outcome-prediction cohorts, whereas many genomic tools\u2014including variant callers and pathogenicity predictors\u2014remain general-purpose methods that have not been specifically validated in pediatric cardiovascular genetics. Recent disease-specific genomic models and automated reanalysis frameworks illustrate a shift toward more clinically contextualized interpretation, but current evidence remains limited by retrospective design, small or selectively assembled rare-disease cohorts, domain shift, population bias, incomplete calibration, and uncertain clinical utility. Accordingly, AI should be viewed as a governed decision-support layer rather than an autonomous authority. With external validation, transparent reporting, longitudinal monitoring, and multidisciplinary oversight, AI has the potential to augment specialist expertise and may support earlier diagnosis, improved risk stratification, and more individualized treatment.<\/jats:p>","DOI":"10.3390\/ijms27188284","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:50:58Z","timestamp":1790859058000},"page":"8284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial Intelligence in Pediatric Cardiovascular Genetics: From Multimodal Diagnosis to Risk Prediction and Precision Therapeutics"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-208X","authenticated-orcid":false,"given":"Nikola","family":"Ili\u0107","sequence":"first","affiliation":[{"name":"Clinical Genetics Outpatient Clinic, Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sta\u0161a","family":"Krasi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"},{"name":"Department of Pediatrics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav","family":"Vukomanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"},{"name":"Department of Pediatrics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-6737","authenticated-orcid":false,"given":"Adrijan","family":"Sarajlija","sequence":"additional","affiliation":[{"name":"Clinical Genetics Outpatient Clinic, Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"},{"name":"Department of Pediatrics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e000086","DOI":"10.1161\/HCG.0000000000000086","article-title":"Genetic testing for heritable cardiovascular diseases in pediatric patients: A scientific statement from the American Heart Association","volume":"14","author":"Landstrom","year":"2021","journal-title":"Circ. 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