{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:03:20Z","timestamp":1790863400633,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Prostate cancer (PCa) is a highly heterogeneous disease, and the molecular features underlying differences in tumor aggressiveness remain incompletely understood. This study aimed to characterize the molecular differences between young aggressive (YA) and old indolence-associated (OI) prostate tumors using an integrative multi-omics approach. RNA sequencing, copy number alteration (CNA), and clinical data from The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) cohort were analyzed. YA tumors (age \u2264 58 years, Gleason score \u2265 8; n = 30) were compared with OI tumors (age \u2265 67 years, Gleason score \u2264 7; n = 41). YA tumors exhibited higher FGA and a greater nominal frequency of homozygous PTEN deletion, consistent with increased genomic instability. Transcriptomic analysis identified 1083 differentially expressed genes, whereas integrative RNA\u2013CNA analysis prioritized 40 exploratory concordant genes, 35 of which showed copy-number loss-associated downregulation. Sensitivity analyses showed that 8 of 40 genes retained both the predefined FDR and effect-size criteria after tumor-purity adjustment, whereas only one gene retained both criteria after additional adjustment for pT and N. Functional enrichment and network analyses identified metabolic and homeostatic programs and a central interaction module within the original prioritized gene set. These findings provide exploratory hypotheses regarding molecular differences between the two predefined extreme phenotypes.<\/jats:p>","DOI":"10.3390\/ijms27188316","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:18:26Z","timestamp":1790860706000},"page":"8316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Young Aggressive Prostate Tumors Exhibit Increased Genomic Instability and an Exploratory RNA\u2013CNA-Concordant Transcriptomic Pattern"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-5738","authenticated-orcid":false,"given":"Fernando","family":"Bergez-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-7683","authenticated-orcid":false,"given":"Alejandra","family":"Mart\u00ednez-Camberos","sequence":"additional","affiliation":[{"name":"Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-106X","authenticated-orcid":false,"given":"Geovanni","family":"Romero-Quintana","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Sinaloa, Ciudad Universitaria, Calz. de las Am\u00e9ricas Nte. 2771, Col. Bur\u00f3crata, Culiac\u00e1n Rosales C.P. 80030, Sinaloa, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-6879","authenticated-orcid":false,"given":"Jes\u00fas","family":"Parra-Unda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaciones en Salud P\u00fablica \u201cDra. Kaethe Willms\u201d, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Sinaloa, Ciudad Universitaria, Culiac\u00e1n Rosales C.P. 80013, Sinaloa, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennin","family":"Garrido-Palazuelos","sequence":"additional","affiliation":[{"name":"Unidad Regional Los Mochis, Departamento Acad\u00e9mico de Ciencias de la Salud, Universidad Aut\u00f3noma de Occidente, Blvd. Macario Gaxiola y Carretera Internacional M\u00e9xico 15, Los Mochis C.P. 81223, Sinaloa, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-7963","authenticated-orcid":false,"given":"Mart\u00edn","family":"Irigoyen Arredondo","sequence":"additional","affiliation":[{"name":"Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. 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