{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:51Z","timestamp":1792789491951,"version":"4.5.0"},"reference-count":692,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroclaw Medical University","id":[{"id":"https:\/\/ror.org\/01qpw1b93","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01qpw1b93","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Crohn\u2019s disease and ulcerative colitis, the principal forms of inflammatory bowel disease (IBD), are chronic inflammatory disorders characterized by recurrent intestinal injury, impaired mucosal healing, and substantial disease burden. Despite significant therapeutic advances, many patients fail to achieve sustained remission, highlighting the need for a better understanding of the molecular mechanisms driving intestinal inflammation. Nitric oxide (NO) is a key regulator of intestinal homeostasis, influencing epithelial barrier integrity, vascular function, host defense, and immune responses. In IBD, dysregulated production of NO, largely attributable to inducible nitric oxide synthase (NOS2), has been associated with both protective and pathogenic effects. Accumulating evidence indicates that the biological consequences of NOS2 activation depend on the cellular source of NO, local microenvironmental signals, and disease context. This review summarizes current knowledge on the transcriptional, epigenetic, post-transcriptional, translational, and post-translational mechanisms regulating NOS2 expression and activity in the intestine. Particular emphasis is placed on cell-specific regulation in epithelial, stromal, endothelial, neural, and immune-cell populations, as well as emerging insights from single-cell and spatial transcriptomic studies. Collectively, available evidence supports a context-dependent role for NOS2 in IBD and highlights the importance of cell-specific approaches for future biomarker development and therapeutic targeting.<\/jats:p>","DOI":"10.3390\/ijms27188359","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:17:26Z","timestamp":1790158646000},"page":"8359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"given":"Ma\u0142gorzata","family":"Krzystek-Korpacka","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Korpacki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland"},{"name":"Department of Gastroenterology, Hepatology, and Internal Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"W\u0105sowicz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland"},{"name":"Department of Gastroenterology, Hepatology, and Internal Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Internal Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tips.2005.02.005","article-title":"Mitochondrial nitric oxide synthase","volume":"26","author":"Ghafourifar","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8288","DOI":"10.1021\/bi062130b","article-title":"Differential binding of calmodulin domains to constitutive and inducible nitric oxide synthase enzymes","volume":"46","author":"Spratt","year":"2007","journal-title":"Biochemistry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00726-004-0078-4","article-title":"Arginine pathways and the inflammatory response: Interregulation of nitric oxide and polyamines: Review article","volume":"26","author":"Satriano","year":"2004","journal-title":"Amino Acids"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/164_2020_382","article-title":"Nitric Oxide Synthase Inhibitors into the Clinic at Last","volume":"Volume 264","author":"Dao","year":"2021","journal-title":"Reactive Oxygen Species: Network Pharmacology and Therapeutic Applications"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1126\/science.279.5359.2121","article-title":"Structure of nitric oxide synthase oxygenase dimer with pterin and substrate","volume":"279","author":"Crane","year":"1998","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1021\/bi5003986","article-title":"Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase","volume":"53","author":"Chreifi","year":"2014","journal-title":"Biochemistry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e202211521","DOI":"10.1002\/anie.202211521","article-title":"The role of heme peroxo oxidants in the rational mechanistic modeling of nitric oxide synthase: Characterization of key intermediates and elucidation of the mechanism","volume":"61","author":"Mondal","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"A1046","DOI":"10.1016\/S0016-5085(98)84253-4","article-title":"INOS is expressed by unstimulated human duodenal enterocytes in vitro with increased expression in disease","volume":"114","author":"Murray","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1096\/fasebj.12.10.773","article-title":"Expressional control of the \u2019constitutive\u2019 isoforms of nitric oxide synthase (NOS I and NOS III)","volume":"12","author":"Boissel","year":"1998","journal-title":"FASEB J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/sj.bjp.0703471","article-title":"Bile acids increase intracellular Ca2+ concentration and nitric oxide production in vascular endothelial cells","volume":"130","author":"Nakajima","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","article-title":"Nitric oxide in inflammatory bowel disease: A universal messenger in an unsolved puzzle","volume":"113","author":"Kolios","year":"2004","journal-title":"Immunology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0002-9343(00)00480-0","article-title":"Nitric oxide and intestinal inflammation","volume":"109","author":"Kubes","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107781","DOI":"10.1016\/j.phrs.2025.107781","article-title":"Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms","volume":"216","author":"Farahani","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gut.47.1.6","article-title":"Inducible nitric oxide synthase: A little bit of good in all of us","volume":"47","author":"Kubes","year":"2000","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1080\/003655202760230919","article-title":"Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium","volume":"37","author":"Perner","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1172\/JCI119473","article-title":"Perspectives series: Host\/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity","volume":"99","author":"Fang","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/mi.2017.106","article-title":"iNOS- and NOX1-dependent ROS production maintains bacterial homeostasis in the ileum of mice","volume":"11","author":"Matziouridou","year":"2018","journal-title":"Mucosal Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/cs1000001","article-title":"Role of inducible nitric oxide synthase in the regulation of leucocyte recruitment","volume":"100","author":"Hickey","year":"2001","journal-title":"Clin. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1053\/j.gastro.2007.01.032","article-title":"Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation","volume":"132","author":"Beck","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/gast.1997.v112.pm9041266","article-title":"Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation","volume":"112","author":"McCafferty","year":"1997","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.celrep.2018.04.053","article-title":"Induction of nitric-oxide metabolism in enterocytes alleviates colitis and inflammation-associated colon cancer","volume":"23","author":"Stettner","year":"2018","journal-title":"Cell Rep."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hashimoto-Hill, S., Hunt, B., Cole, S., Negi, S., Waddell, A., Yang, Z.F., Wayman, J.A., Ollberding, N.J., Miraldi, E.R., and Lim, H.W. (2025). Epithelial-intrinsic nitric oxide synthase 2 sustains host-microbiota dynamics that promote colitis. bioRxiv.","DOI":"10.1101\/2025.09.23.677925"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF03401781","article-title":"Inducible nitric oxide synthase and inflammatory diseases","volume":"6","author":"Zamora","year":"2000","journal-title":"Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1515\/BC.2003.152","article-title":"Regulation of the expression of inducible nitric oxide synthase","volume":"384","author":"Kleinert","year":"2003","journal-title":"Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J. Med. Life"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jgh.14872","article-title":"The epidemiology of inflammatory bowel disease: East meets West","volume":"35","author":"Mak","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2021.12.282","article-title":"Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: Systematic review","volume":"162","author":"Kuenzig","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: A systematic analysis for the global burden of disease study 2017","volume":"5","author":"Alatab","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11894-019-0705-6","article-title":"Evolving epidemiology of IBD","volume":"21","author":"Windsor","year":"2019","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S2468-1253(19)30173-6","article-title":"Comorbidities in inflammatory bowel disease: A call for action","volume":"4","author":"Argollo","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10151-019-1926-2","article-title":"Colorectal cancer in inflammatory bowel disease: Review of the evidence","volume":"23","author":"Keller","year":"2019","journal-title":"Tech. Coloproctol."},{"key":"ref_35","first-page":"165","article-title":"Inflammatory bowel diseases and work disability: A systematic review of predictive factors","volume":"25","author":"Leso","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7247238","DOI":"10.1155\/2019\/7247238","article-title":"A comprehensive review and update on the pathogenesis of inflammatory bowel disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gao, F., Lucke-Wold, B.P., Li, X., Logsdon, A.F., Xu, L.C., Xu, S., LaPenna, K.B., Wang, H., Talukder, M.A.H., and Siedlecki, C.A. (2018). Reduction of endothelial nitric oxide increases the adhesiveness of constitutive endothelial membrane ICAM-1 through Src-mediated phosphorylation. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.01124"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Krzystek-Korpacka, M., Fleszar, M.G., Bednarz-Misa, I., Lewandowski, \u0141., Szczuka, I., Kempi\u0144ski, R., and Neubauer, K. (2020). Transcriptional and metabolomic analysis of L-arginine\/nitric oxide pathway in inflammatory bowel disease and its association with local inflammatory and angiogenic response: Preliminary findings. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051641"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1002\/ibd.22957","article-title":"Immune markers and differential signaling networks in ulcerative colitis and Crohn\u2019s disease","volume":"18","author":"Christophi","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1053\/j.gastro.2008.07.068","article-title":"MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2\u03b1","volume":"135","author":"Wu","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_42","first-page":"S124","article-title":"Inducible nitric oxide synthase as a potential blood-based biomarker in inflammatory bowel diseases","volume":"11","author":"Baranipour","year":"2018","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0016-5085(96)70055-0","article-title":"Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease","volume":"111","author":"Singer","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/(SICI)1096-9896(199812)186:4<416::AID-PATH201>3.0.CO;2-U","article-title":"Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease","volume":"186","author":"Dijkstra","year":"1998","journal-title":"J. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1038\/ctg.2013.17","article-title":"Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease","volume":"5","author":"Dhillon","year":"2014","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s007260050020","article-title":"Inducible nitric oxide synthase activity in colon biopsies from inflammatory areas: Correlation with inflammation intensity in patients with ulcerative colitis but not with Crohn\u2019s disease","volume":"18","author":"Guihot","year":"2000","journal-title":"Amino Acids"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1572-0241.2000.02047.x","article-title":"Inducible nitric oxide synthase activity is expressed not only in inflamed but also in normal colonic mucosa in patients with ulcerative colitis: A potential prognostic marker","volume":"95","author":"Lizasoain","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0022-3565(24)29482-9","article-title":"Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine","volume":"298","author":"Kankuri","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s43556-025-00395-z","article-title":"Inflammatory bowel diseases: Pathological mechanisms and therapeutic perspectives","volume":"7","author":"Yang","year":"2026","journal-title":"Mol. Biomed."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Alarfaj, S.J., Mostafa, S.A., Negm, W.A., El-Masry, T.A., Kamal, M., Elsaeed, M., and El Nakib, A.M. (2023). Mucosal genes expression in inflammatory bowel disease patients: New insights. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020324"},{"key":"ref_51","first-page":"437","article-title":"5-Aminosalicylic acid inhibits iNOS transcription in human intestinal epithelial cells","volume":"4","author":"Kennedy","year":"1999","journal-title":"Int. J. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.lfs.2006.01.015","article-title":"Inhibition of inducible nitric oxide synthesis by azathioprine in a macrophage cell line","volume":"79","author":"Moeslinger","year":"2006","journal-title":"Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"G1290","DOI":"10.1152\/ajpgi.1997.273.6.G1290","article-title":"Dexamethasone suppresses iNOS gene expression by upregulating I-\u03baB\u03b1 and inhibiting NF-\u03baB","volume":"273","author":"Taylor","year":"1997","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1083\/jcb.150.5.1199","article-title":"Glucocorticoids antagonize AP-1 by inhibiting the activation\/phosphorylation of Jnk without affecting its subcellular distribution","volume":"150","author":"Berciano","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"G261","DOI":"10.1152\/ajpgi.00336.2004","article-title":"Effect of corticosteroids on nitric oxide production in inflammatory bowel disease: Are leukocytes the site of action?","volume":"288","author":"Linehan","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1136\/jcp.51.10.750","article-title":"Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment","volume":"51","author":"Leonard","year":"1998","journal-title":"J. Clin. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.gastha.2022.09.004","article-title":"A20 restricts NOS2 expression and intestinal tumorigenesis in a mouse model of colitis-associated cancer","volume":"2","author":"Basta","year":"2023","journal-title":"Gastro Hep Adv."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Bj\u00f6rner, K., Chen, W.N., Gannavarapu, V.R., Axling, F., Gulyas, M., Halim, M.A., Webb, D.L., and Hellstr\u00f6m, P.M. (2023). High iNOS and IL-1\u03b2 immunoreactivity are features of colitis-associated colorectal cancer tumors, but fail to predict 5-year survival. Upsala J. Med. Sci., 128.","DOI":"10.48101\/ujms.v128.10241"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Krzystek-Korpacka, M., Kempi\u0144ski, R., Bromke, M.A., and Neubauer, K. (2020). Oxidative stress markers in inflammatory bowel diseases: Systematic review. Diagnostics, 10.","DOI":"10.3390\/diagnostics10080601"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40001-022-00720-0","article-title":"Prognostic and tumor immunity implication of inflammatory bowel disease-associated genes in colorectal cancer","volume":"27","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Caligiuri, A., Becatti, M., Porro, N., Borghi, S., Marra, F., Pastore, M., Taddei, N., Fiorillo, C., and Gentilini, A. (2024). Oxidative stress and redox-dependent pathways in cholangiocarcinoma. Antioxidants, 13.","DOI":"10.3390\/antiox13010028"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"0300060520905985","DOI":"10.1177\/0300060520905985","article-title":"The regulation of nitric oxide in tumor progression and therapy","volume":"48","author":"Hu","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wang, H., Wang, L., Xie, Z., Zhou, S., Li, Y., Zhou, Y., and Sun, M. (2020). Nitric oxide (NO) and NO synthases (NOS)-based targeted therapy for colon cancer. Cancers, 12.","DOI":"10.3390\/cancers12071881"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1158\/1541-7786.MCR-22-0509","article-title":"Downregulation of iNOS\/NO promotes epithelial-mesenchymal transition and metastasis in colorectal cancer","volume":"21","author":"Du","year":"2023","journal-title":"Mol. Cancer Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1016\/S0021-9258(17)37441-0","article-title":"Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene","volume":"269","author":"Chartrain","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-022-00855-x","article-title":"A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types","volume":"20","author":"Gather","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1006\/bbrc.1994.1522","article-title":"Promoter analysis of human inducible nitric oxide synthase gene associated with cardiovascular homeostasis","volume":"200","author":"Nunokawa","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jlb.59.4.575","article-title":"Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide\/interferon-\u03b3","volume":"59","author":"Zhang","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1073\/pnas.93.3.1054","article-title":"Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: Initial analysis of the human NOS2 promoter","volume":"93","author":"Shapiro","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"G1499","DOI":"10.1152\/ajpgi.1997.272.6.G1499","article-title":"Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line","volume":"272","author":"Linn","year":"1997","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0167-4781(96)06909-6","article-title":"Analysis of expression and promoter function of the human inducible nitric oxide synthase gene in DLD-1 cells and monkey hepatocytes","volume":"1351","author":"Laubach","year":"1997","journal-title":"Biochim. Biophys. Acta (BBA)-Gene Struct. Expr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15148","DOI":"10.1074\/jbc.273.24.15148","article-title":"Multiple NF-\u03baB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene","volume":"273","author":"Taylor","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jmb.2009.05.036","article-title":"A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric oxide synthase gene","volume":"390","author":"Park","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1158\/0008-5472.CAN-05-4110","article-title":"Regulation of human nitric oxide synthase 2 expression by Wnt \u03b2-catenin signaling","volume":"66","author":"Du","year":"2006","journal-title":"Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"36837","DOI":"10.1074\/jbc.M706909200","article-title":"Negative regulation of inducible nitric oxide synthase expression mediated through transforming growth factor-\u03b2-dependent modulation of transcription factor TCF11","volume":"282","author":"Berg","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2018.10.441","article-title":"Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1","volume":"130","author":"Lee","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1006\/bbrc.1998.9062","article-title":"Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: Characterization of differences between human and mouse iNOS promoters","volume":"248","author":"Chu","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"22201","DOI":"10.1074\/jbc.273.35.22201","article-title":"Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor \u03baB-binding sites","volume":"273","author":"Chu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1074\/jbc.M009563200","article-title":"Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation","volume":"276","author":"Kristof","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.1073\/pnas.151239498","article-title":"Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-\u03baB","volume":"98","author":"Ganster","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1096\/fj.01-0450fje","article-title":"A repressor in the proximal human inducible nitric oxide synthase promoter modulates transcriptional activation","volume":"16","author":"Pance","year":"2002","journal-title":"FASEB J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"14212","DOI":"10.1073\/pnas.212306199","article-title":"Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-\u03baB-repressing factor (NRF) in basal repression of the hiNOS gene","volume":"99","author":"Feng","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1096\/fj.02-1172fje","article-title":"A critical role for C\/EBP\u03b2 binding to the AABS promoter response element in the human iNOS gene","volume":"17","author":"Guo","year":"2003","journal-title":"FASEB J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"14812","DOI":"10.1074\/jbc.M300787200","article-title":"Transcriptional activation of the human inducible nitric oxide synthase promoter by Kruppel-like factor 6","volume":"278","author":"Warke","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/gut.45.3.367","article-title":"Potentiation of cytokine-induced iNOS expression in the human intestinal epithelial cell line, DLD-1, by cyclic AMP","volume":"45","author":"Cavicchi","year":"1999","journal-title":"Gut"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/gut.42.4.477","article-title":"Activation of nuclear factor \u03baB in inflammatory bowel disease","volume":"42","author":"Schreiber","year":"1998","journal-title":"Gut"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1128\/IAI.68.12.7010-7017.2000","article-title":"Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease","volume":"68","author":"Cario","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: New insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u03baB in inflammation and cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"108810","DOI":"10.1016\/j.pharmthera.2025.108810","article-title":"Targeting TAK1: Evolution of inhibitors, challenges, and future directions","volume":"267","author":"Benedik","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Xu, H., Li, D., Liang, J., Adamson, N., Scherl, A., Zou, L., Hu, C., Storm, E.E., Cox, C.B., and Johnson, A. (2026). Noncanonical NF-\u03baB pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel disease. Front. Immunol., 17.","DOI":"10.3389\/fimmu.2026.1825442"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/bbrc.1996.0897","article-title":"Human inducible nitric oxide synthase gene is transcriptionally regulated by nuclear factor-\u03baB dependent mechanism","volume":"223","author":"Nunokawa","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF03402216","article-title":"Transcriptional regulation of the human iNOS gene by IL-1\u03b2 in endothelial cells","volume":"7","author":"Kolyada","year":"2001","journal-title":"Mol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2707","article-title":"Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function","volume":"10","author":"Abreu","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.phrs.2017.11.017","article-title":"Role of toll-like receptors in inflammatory bowel disease","volume":"129","author":"Kordjazy","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/cei.12732","article-title":"Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn\u2019s disease: A role for Tollip and peroxisome proliferator-activated receptor gamma?","volume":"183","author":"Fernandes","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","article-title":"NOD1 and NOD2: Signaling, host defense, and inflammatory disease","volume":"41","author":"Caruso","year":"2014","journal-title":"Immunity"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1097\/MIB.0000000000000151","article-title":"Emerging significance of NLRs in inflammatory bowel disease","volume":"20","author":"Davis","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/sj.emboj.7601962","article-title":"A critical role of RICK\/RIP2 polyubiquitination in Nod-induced NF-\u03baB activation","volume":"27","author":"Hasegawa","year":"2008","journal-title":"EMBO J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.4049\/jimmunol.176.8.4804","article-title":"IFN-\u03b3 enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2","volume":"176","author":"Sheppard","year":"2006","journal-title":"J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"32087","DOI":"10.1074\/jbc.M110.124297","article-title":"A novel pathway for inducible nitric oxide synthase activation through inflammasomes","volume":"285","author":"Buzzo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"41686","DOI":"10.1038\/srep41686","article-title":"Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage","volume":"7","author":"Buzzo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/intimm\/dxu051","article-title":"Pleiotropic functions of TNF-\u03b1 in the regulation of the intestinal epithelial response to inflammation","volume":"26","author":"Leppkes","year":"2014","journal-title":"Int. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1111\/j.1476-5381.1995.tb15938.x","article-title":"Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29","volume":"116","author":"Kolios","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Parisio, L., Cuccia, G., Giudice, A., Carrabetta, F., Del Gaudio, A., Privitera, G., Carbone, L., Spagnuolo, R., and Pugliese, D. (2025). Interleukin 23: Pathogenetic involvement and therapeutic target for ulcerative colitis. J. Clin. Med., 14.","DOI":"10.3390\/jcm14134590"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.4049\/jimmunol.162.9.5337","article-title":"NF-\u03baB-inducing kinase is a common mediator of IL-17-, TNF-\u03b1-, and IL-1\u03b2-induced chemokine promoter activation in intestinal epithelial cells","volume":"162","author":"Awane","year":"1999","journal-title":"J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"297645","DOI":"10.1155\/2009\/297645","article-title":"Interleukin-23 and Th17 cells in the control of gut inflammation","volume":"2009","author":"Monteleone","year":"2009","journal-title":"Mediat. Inflamm."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/jir.2012.0063","article-title":"IL-23\/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: Immunomodulatory effect of retinoic acid","volume":"33","author":"Rafa","year":"2013","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI21404","article-title":"IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6","volume":"116","author":"Yen","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"111051","DOI":"10.1016\/j.celrep.2022.111051","article-title":"B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation","volume":"40","author":"Melcher","year":"2022","journal-title":"Cell Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1021\/bi002239y","article-title":"Inhibition of NF-\u03baB by S-nitrosylation","volume":"40","author":"Marshall","year":"2001","journal-title":"Biochemistry"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"30667","DOI":"10.1074\/jbc.M705929200","article-title":"NOS2 regulation of NF-\u03baB by S-nitrosylation of p65","volume":"282","author":"Kelleher","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0016-5085(98)70202-1","article-title":"Nuclear factor \u03baB is activated in macrophages and epithelial cells of inflamed intestinal mucosa","volume":"115","author":"Rogler","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2249.2007.03531.x","article-title":"Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease","volume":"151","author":"Szebeni","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1369\/jhc.7A7303.2007","article-title":"Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: Upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis","volume":"56","author":"Frolova","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/1753425909339231","article-title":"Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: A comprehensive analysis","volume":"16","author":"Vamadevan","year":"2010","journal-title":"Innate Immun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Cheng, Y., Zhu, Y., Huang, X., Zhang, W., Han, Z., and Liu, S. (2015). Association between TLR2 and TLR4 gene polymorphisms and the susceptibility to inflammatory bowel disease: A meta-analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126803"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1744-313X.2005.00546.x","article-title":"A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis","volume":"32","author":"Borm","year":"2005","journal-title":"Int. J. Immunogenet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/039463200501800116","article-title":"Increased levels of NF-\u03baB inhibitors (I\u03baB\u03b1 and I\u03baB\u03b3) in the intestinal mucosa of Crohn\u2019s disease patients during infliximab treatment","volume":"18","author":"Guidi","year":"2005","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e00578","DOI":"10.14309\/ctg.0000000000000578","article-title":"Mirikizumab regulates genes involved in ulcerative colitis disease activity and anti-TNF resistance: Results from a phase 2 study","volume":"14","author":"Steere","year":"2023","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Rath, T., Billmeier, U., Ferrazzi, F., Vieth, M., Ekici, A., Neurath, M.F., and Atreya, R. (2018). Effects of anti-integrin treatment with vedolizumab on immune pathways and cytokines in inflammatory bowel diseases. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01700"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.bjp.0706847","article-title":"Protection from experimental colitis by theaflavin-3,3\u2032-digallate correlates with inhibition of IKK and NF-\u03baB activation","volume":"149","author":"Ukil","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/gut.2006.096487","article-title":"Non-viral delivery of nuclear factor-\u03baB decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis","volume":"56","author":"Prasad","year":"2007","journal-title":"Gut"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.07.013","article-title":"IKK\u03b2 links inflammation and tumorigenesis in a mouse model of colitis-associated cancer","volume":"118","author":"Greten","year":"2004","journal-title":"Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/jbmr.3759","article-title":"Attenuation of NF-\u03baB in intestinal epithelial cells is sufficient to mitigate the bone loss comorbidity of experimental mouse colitis","volume":"34","author":"Ke","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Abou El Hassan, M., Huang, K., Eswara, M.B., Xu, Z., Yu, T., Aubry, A., Ni, Z., Livne-Bar, I., Sangwan, M., and Ahmad, M. (2017). Properties of STAT1 and IRF1 enhancers and the influence of SNPs. BMC Mol. Biol., 18.","DOI":"10.1186\/s12867-017-0084-1"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1101\/gad.257592.114","article-title":"A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages","volume":"29","author":"Mancino","year":"2015","journal-title":"Genes Dev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"108891","DOI":"10.1016\/j.celrep.2021.108891","article-title":"IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility","volume":"34","author":"Song","year":"2021","journal-title":"Cell Rep."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Simon, P.S., Sharman, S.K., Lu, C., Yang, D., Paschall, A.V., Tulachan, S.S., and Liu, K. (2015). The NF-\u03baB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1808-6"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Feng, H., Zhang, Y.B., Gui, J.F., Lemon, S.M., and Yamane, D. (2021). Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009220"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)80047-1","article-title":"SOCS1 is a critical inhibitor of interferon \u03b3 signaling and prevents the potentially fatal neonatal actions of this cytokine","volume":"98","author":"Alexander","year":"1999","journal-title":"Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/ni1104","article-title":"PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity","volume":"5","author":"Liu","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1128\/MCB.22.16.5662-5668.2002","article-title":"Identification of a nuclear Stat1 protein tyrosine phosphatase","volume":"22","author":"Fu","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/jir.2010.0012","article-title":"Involvement of interferon-\u03b3 in bowel disease pathogenesis by nitric oxide pathway: A study in Algerian patients","volume":"30","author":"Rafa","year":"2010","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1084\/jem.20060436","article-title":"IFN\u03b3-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice","volume":"203","author":"Hanada","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/10935266241265767","article-title":"Interferon \u03b3 expressing mucosal cells in pediatric chronic inflammatory bowel disease","volume":"27","author":"Terry","year":"2024","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"G1405","DOI":"10.1152\/ajpgi.00543.2011","article-title":"Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells","volume":"302","author":"Zimmerman","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/s41467-024-45665-6","article-title":"Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis","volume":"15","author":"Mennillo","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.immuni.2023.01.002","article-title":"The landscape of immune dysregulation in Crohn\u2019s disease revealed through single-cell transcriptomic profiling in the ileum and colon","volume":"56","author":"Kong","year":"2023","journal-title":"Immunity"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41588-026-02634-7","article-title":"Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn\u2019s disease pathogenesis","volume":"58","author":"Krzak","year":"2026","journal-title":"Nat. Genet."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.20151764","article-title":"The macrophage IRF8\/IRF1 regulome is required for protection against infections and is associated with chronic inflammation","volume":"213","author":"Langlais","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3748\/wjg.v22.i3.1034","article-title":"Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease","volume":"22","author":"Spalinger","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1053\/j.gastro.2020.07.040","article-title":"Immunobiota Study Group. Loss-of-function mutation in PTPN2 causes aberrant activation of JAK signaling via STAT and very early onset intestinal inflammation","volume":"159","author":"Parlato","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(00)81288-X","article-title":"Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway","volume":"84","author":"Meraz","year":"1996","journal-title":"Cell"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1126\/science.7510419","article-title":"Requirement for transcription factor IRF-1 in NO synthase induction in macrophages","volume":"263","author":"Kamijo","year":"1994","journal-title":"Science"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.180.3.977","article-title":"Role of interferon regulatory factor 1 in induction of nitric oxide synthase","volume":"180","author":"Martin","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"L137","DOI":"10.1152\/ajplung.00441.2002","article-title":"STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation","volume":"285","author":"Xu","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Guo, Z., Zheng, L., Liao, X., and Geller, D. (2016). Up-regulation of human inducible nitric oxide synthase by p300 transcriptional complex. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146640"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/BSR20120055","article-title":"Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases","volume":"32","author":"Correa","year":"2012","journal-title":"Biosci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2567.2004.01991.x","article-title":"Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis","volume":"113","author":"Zingarelli","year":"2004","journal-title":"Immunology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.4049\/jimmunol.168.10.5342","article-title":"P38 mitogen-activated protein kinase is activated and linked to TNF-\u03b1 signaling in inflammatory bowel disease","volume":"168","author":"Waetzig","year":"2002","journal-title":"J. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"9208274","DOI":"10.1155\/2018\/9208274","article-title":"Differential intestinal mucosa transcriptomic biomarkers for Crohn\u2019s disease and ulcerative colitis","volume":"2018","author":"Dobre","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/labinvest.2008.38","article-title":"Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis","volume":"88","author":"Moriyama","year":"2008","journal-title":"Lab. Investig."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1038\/onc.2008.211","article-title":"The role of the transcription factor AP-1 in colitis-associated and \u03b2-catenin-dependent intestinal tumorigenesis in mice","volume":"27","author":"Hasselblatt","year":"2008","journal-title":"Oncogene"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrgastro.2010.39","article-title":"Hypoxia: An alarm signal during intestinal inflammation","volume":"7","author":"Colgan","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"goae030","DOI":"10.1093\/gastro\/goae030","article-title":"Hypoxia, hypoxia-inducible factors and inflammatory bowel diseases","volume":"12","author":"Hou","year":"2024","journal-title":"Gastroenterol. Rep."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/jir.2005.25.707","article-title":"Differential effects of TNF-\u03b1 and IFN-\u03b3 on gene transcription mediated by NF-\u03baB\u2013Stat1 interactions","volume":"25","author":"Ganster","year":"2005","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"G98","DOI":"10.1152\/ajpgi.00081.2019","article-title":"Temporal induction of intestinal epithelial hypoxia-inducible factor-2\u03b1 is sufficient to drive colitis","volume":"317","author":"Solanki","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"18154","DOI":"10.1073\/pnas.0602235103","article-title":"Prolyl hydroxylase-1 negatively regulates I\u03baB kinase-\u03b2, giving insight into hypoxia-induced NF-\u03baB activity","volume":"103","author":"Cummins","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/jcp.56.3.209","article-title":"Hypoxia inducible factor 1\u03b1 and 2\u03b1 overexpression in inflammatory bowel disease","volume":"56","author":"Giatromanolaki","year":"2003","journal-title":"J. Clin. Pathol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Knyazev, E., Maltseva, D., Raygorodskaya, M., and Shkurnikov, M. (2021). HIF-dependent NFATC1 activation upregulates ITGA5 and PLAUR in intestinal epithelium in inflammatory bowel disease. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.791640"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Kim, Y.I., Yi, E.J., Kim, Y.D., Lee, A.R., Chung, J., Ha, H.C., Cho, J.M., Kim, S.R., Ko, H.J., and Cheon, J.H. (2021). Local stabilization of hypoxia-inducible factor-1\u03b1 controls intestinal inflammation via enhanced gut barrier function and immune regulation. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.609689"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kr\u00fcppel-like factors in health and diseases","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.gene.2017.02.025","article-title":"Kr\u00fcppel-like factor 4 (KLF4): What we currently know","volume":"611","author":"Ghaleb","year":"2017","journal-title":"Gene"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"38247","DOI":"10.1074\/jbc.M509378200","article-title":"Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages","volume":"280","author":"Feinberg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1172\/JCI45444","article-title":"Kr\u00fcppel-like factor 4 regulates macrophage polarization","volume":"121","author":"Liao","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/mi.2016.1","article-title":"KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation","volume":"9","author":"Goodman","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00018-024-05514-7","article-title":"Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease","volume":"81","author":"Zhu","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e1199","DOI":"10.1002\/iid3.1199","article-title":"KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling","volume":"12","author":"Chen","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/MIB.0000000000000022","article-title":"Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-\u03baB pathway inflammatory response","volume":"20","author":"Ghaleb","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.7150\/ijbs.28576","article-title":"SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression","volume":"14","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"23958","DOI":"10.1074\/jbc.M513918200","article-title":"Phosphatidylinositol 3-kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1","volume":"281","author":"Kristof","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1038\/s41388-018-0348-3","article-title":"The dynamic and stress-adaptive signaling hub of 14-3-3: Emerging mechanisms of regulation and context-dependent protein\u2013protein interactions","volume":"37","author":"Pennington","year":"2018","journal-title":"Oncogene"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/labinvest.2009.66","article-title":"Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation","volume":"89","author":"Snoeks","year":"2009","journal-title":"Lab. Investig."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cell.2013.08.034","article-title":"Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway","volume":"155","author":"Lee","year":"2013","journal-title":"Cell"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jcmgh.2018.10.003","article-title":"Loss of forkhead box O3 facilitates inflammatory colon cancer: Transcriptome profiling of the immune landscape and novel targets","volume":"7","author":"Penrose","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1128\/IAI.00227-08","article-title":"Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells","volume":"76","author":"Snoeks","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"G844","DOI":"10.1152\/ajpgi.00407.2015","article-title":"Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets","volume":"310","author":"Heller","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0092-8674(04)00302-2","article-title":"I\u03baB kinase promotes tumorigenesis through Inhibition of forkhead FOXO3a","volume":"117","author":"Hu","year":"2004","journal-title":"Cell"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"e1445942","DOI":"10.1080\/23723556.2018.1445942","article-title":"Complex role of SIRT6 in NF-\u03baB pathway regulation","volume":"5","author":"Vaquero","year":"2018","journal-title":"Mol. Cell. Oncol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"G247","DOI":"10.1152\/ajpgi.00201.2023","article-title":"FOXO3: At the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon","volume":"326","author":"Snarski","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Iftikhar, R., Penrose, H.M., King, A.N., Kim, Y., Ruiz, E., Kandil, E., Machado, H.L., and Savkovic, S.D. (2022). FOXO3 expression in macrophages is lowered by a high-fat diet and regulates colonic inflammation and tumorigenesis. Metabolites, 12.","DOI":"10.3390\/metabo12030250"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Ghimire, J., Iftikhar, R., Penrose, H.M., Snarski, P., Ruiz, E., and Savkovic, S.D. (2023). FOXO3 deficiency in neutrophils drives colonic inflammation and tumorigenesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119730"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbrc.2015.11.119","article-title":"Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3\/Sirtuin6","volume":"469","author":"Penrose","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Lavudi, K., Nuguri, S.M., Olverson, Z., Dhanabalan, A.K., Patnaik, S., and Kokkanti, R.R. (2023). Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1254612"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2007.01.178","article-title":"Retinoic acid activates human inducible nitric oxide synthase gene through binding of RAR\u03b1\/RXR\u03b1 heterodimer to a novel retinoic acid response element in the promoter","volume":"355","author":"Zou","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.molimm.2004.12.009","article-title":"A novel PPAR response element in the murine iNOS promoter","volume":"42","author":"Crosby","year":"2005","journal-title":"Mol. Immunol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/1523-1747.ep12347939","article-title":"CD23-mediated nitric oxide synthase pathway induction in human keratinocytes is inhibited by retinoic acid derivatives","volume":"106","author":"Ktorza","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jlb.55.3.336","article-title":"Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages","volume":"55","author":"Mehta","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1006\/bbrc.2000.2535","article-title":"Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-\u03b1","volume":"270","author":"Olsson","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1145697","article-title":"Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid","volume":"317","author":"Mucida","year":"2007","journal-title":"Science"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1053\/j.gastro.2014.01.057","article-title":"Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn\u2019s disease","volume":"146","author":"Sanders","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ibd\/izaa121","article-title":"Retinoic acid is elevated in the mucosa of patients with active ulcerative colitis and displays a proinflammatory role by augmenting IL-17 and IFN\u03b3 production","volume":"27","author":"Rampal","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1189\/jlb.3VMA1015-476R","article-title":"Retinoic acid-primed human dendritic cells inhibit Th9 cells and induce Th1\/Th17 cell differentiation","volume":"100","author":"Rampal","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Yang, Y., Han, X., Sun, L., Shao, F., Yin, Y., and Zhang, W. (2024). ETS transcription factors in immune cells and immune-related diseases. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810004"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1074\/jbc.M006507200","article-title":"ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-\u03baB to regulate the inducible nitric oxide synthase gene","volume":"276","author":"Rudders","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3724\/abbs.2022020","article-title":"Propofol protects against high glucose-mediated endothelial injury via inhibition of COX2 and iNOS expressions","volume":"54","author":"Shao","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"39572","DOI":"10.1074\/jbc.M308179200","article-title":"Elk-3 is a transcriptional repressor of nitric-oxide synthase 2","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Cao, M., Chen, P., Peng, B., Cheng, Y., Xie, J., Hou, Z., Chen, H., Ye, L., Li, H., and Wang, H. (2023). The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1270411"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41586-024-07501-1","article-title":"A disease-associated gene desert directs macrophage inflammation through ETS2","volume":"630","author":"Stankey","year":"2024","journal-title":"Nature"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41590-021-00984-4","article-title":"Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation","volume":"22","author":"Tyler","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s10875-023-01453-3","article-title":"A multicenter cohort study of immune dysregulation disorders caused by ELF4 variants in China","volume":"43","author":"Sun","year":"2023","journal-title":"J. Clin. Immunol."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Starkova, T.Y., Polyanichko, A.M., Artamonova, T.O., Tsimokha, A.S., Tomilin, A.N., and Chikhirzhina, E.V. (2023). Structural characteristics of high-mobility group proteins HMGB1 and HMGB2 and their interaction with DNA. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043577"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2014.05.001","article-title":"HMGB1 in health and disease","volume":"40","author":"Kang","year":"2014","journal-title":"Mol. Asp. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0006-291X(03)00184-0","article-title":"HMGB1 interacts differentially with members of the Rel family of transcription factors","volume":"302","author":"Agresti","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"150118","DOI":"10.1098\/rsob.150118","article-title":"The human parasite Leishmania amazonensis downregulates iNOS expression via NF-\u03baB p50\/p50 homodimer: Role of the PI3K\/Akt pathway","volume":"5","author":"Vivarini","year":"2015","journal-title":"Open Biol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/eji.201747257","article-title":"Leishmania amazonensis downregulates macrophage iNOS expression via histone deacetylase 1 (HDAC1): A novel parasite evasion mechanism","volume":"48","author":"Vivarini","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B0-12-370879-6\/00161-7","article-title":"Gene regulation","volume":"Volume 1","author":"Perrella","year":"2006","journal-title":"Encyclopedia of Respiratory Medicine"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.febslet.2008.02.008","article-title":"High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression","volume":"582","author":"Takamiya","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"5741948","DOI":"10.1155\/2017\/5741948","article-title":"Identification of candidate genes related to inflammatory bowel disease using minimum redundancy maximum relevance, incremental feature selection, and the shortest-path approach","volume":"2017","author":"Yuan","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbagrm.2016.02.007","article-title":"The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks","volume":"1859","author":"Tantin","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA)-Gene Regul. Mech."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1007\/s00018-012-0939-z","article-title":"Oct-1 cooperates with the TATA-binding initiation complex to control rapid transcription of human iNOS","volume":"69","author":"Reveneau","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/hmg\/11.11.1281","article-title":"Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF-\u03baB transcription factors","volume":"11","author":"Udalova","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"V\u00e1zquez-Arregu\u00edn, K., Bensard, C., Schell, J.C., Swanson, E., Chen, X., Rutter, J., and Tantin, D. (2019). Oct1\/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy. PLoS Genet., 15.","DOI":"10.1371\/journal.pgen.1007687"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13287-025-04280-y","article-title":"Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: Insights from transcriptomic, histological, and microbiome analyses","volume":"16","author":"Janeckova","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.4049\/jimmunol.179.5.3109","article-title":"The Paneth cell \u03b1-defensin deficiency of ileal Crohn\u2019s disease is linked to Wnt\/Tcf-4","volume":"179","author":"Wehkamp","year":"2007","journal-title":"J. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"115938","DOI":"10.1016\/j.biopha.2023.115938","article-title":"C\/EBP\u03b2: The structure, regulation, and its roles in inflammation-related diseases","volume":"169","author":"Ren","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_223","first-page":"3964","article-title":"Functional and physical associations between NF-\u03baB and C\/EBP family members: A Rel domain\u2013bZIP interaction","volume":"13","author":"Stein","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.cellsig.2010.07.006","article-title":"XBP1U inhibits the XBP1S-mediated upregulation of the iNOS gene expression in mammalian ER stress response","volume":"22","author":"Guo","year":"2010","journal-title":"Cell. Signal."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","article-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","volume":"134","author":"Kaser","year":"2008","journal-title":"Cell"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/ecco-jcc\/jjac033","article-title":"Characterisation of the circulating transcriptomic landscape in inflammatory bowel disease provides evidence for dysregulation of multiple transcription factors including NFE2, SPI1, CEBPB, and IRF2","volume":"16","author":"Nowak","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"e174198","DOI":"10.1172\/JCI174198","article-title":"The IRE1\u03b1\/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease","volume":"134","author":"Cao","year":"2024","journal-title":"J. Clin. Investig."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s10753-021-01552-6","article-title":"Short-chain fatty acid decreases the expression of CEBPB to inhibit miR-145-mediated DUSP6 and thus further suppresses intestinal inflammation","volume":"45","author":"Liu","year":"2022","journal-title":"Inflammation"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1111\/j.1742-4658.2012.08676.x","article-title":"P2Y2 receptor expression is regulated by C\/EBP\u03b2 during inflammation in intestinal epithelial cells","volume":"279","author":"Turgeon","year":"2012","journal-title":"FEBS J."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"18131","DOI":"10.1074\/jbc.RA119.009591","article-title":"Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells","volume":"294","author":"Liu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"119606","DOI":"10.1016\/j.bbamcr.2023.119606","article-title":"NRF2 interacts with a distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells","volume":"1871","author":"Cortolezzis","year":"2024","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Rapozzi, V., Comuzzi, C., Di Giorgio, E., and Xodo, L.E. (2025). KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: The influence of oxidative and nitrosative stress. Front. Cell Dev. Biol., 13, Erratum in Front. Cell Dev. Biol. 2025, 13, 1661525.","DOI":"10.3389\/fcell.2025.1547582"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1038\/mi.2008.55","article-title":"TGF-\u03b21 and Smad7 in the regulation of IBD","volume":"1","author":"Monteleone","year":"2008","journal-title":"Mucosal Immunol."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Troncone, E., Marafini, I., Stolfi, C., and Monteleone, G. (2018). Transforming growth factor-\u03b21\/Smad7 in intestinal immunity, inflammation, and cancer. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01407"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Stolfi, C., Troncone, E., Marafini, I., and Monteleone, G. (2021). Role of TGF-beta and Smad7 in gut inflammation, fibrosis and cancer. Biomolecules, 11.","DOI":"10.3390\/biom11010017"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/intimm\/dxr126","article-title":"Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways","volume":"24","author":"Sugiyama","year":"2012","journal-title":"Int. Immunol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1172\/JCI12821","article-title":"Blocking Smad7 restores TGF-\u03b21 signaling in chronic inflammatory bowel disease","volume":"108","author":"Monteleone","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12967-020-02558-8","article-title":"High Smad7 in the early post-operative recurrence of Crohn\u2019s disease","volume":"18","author":"Zorzi","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa1407250","article-title":"Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn\u2019s disease","volume":"372","author":"Monteleone","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40291-022-00606-1","article-title":"Smad7 antisense oligonucleotide-based therapy in Crohn\u2019s disease: Is it time to re-evaluate?","volume":"26","author":"Monteleone","year":"2022","journal-title":"Mol. Diagn. Ther."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.188.10.1929","article-title":"Oxazolone colitis: A murine model of T helper cell type 2 colitis treated with treatable with antibodies to interleukin 4","volume":"188","author":"Boirivant","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1084\/jem.192.2.151","article-title":"Blockade of transforming growth factor-\u03b2\/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity","volume":"192","author":"Nakao","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.4049\/jimmunol.175.6.3846","article-title":"Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells","volume":"175","author":"Chan","year":"2005","journal-title":"J. Immunol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.4049\/jimmunol.1301758","article-title":"Epigenetic silencing of the human NOS2 gene: Rethinking the role of nitric oxide in human macrophage inflammatory responses","volume":"192","author":"Gross","year":"2014","journal-title":"J. Immunol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41588-020-00736-4","article-title":"Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation","volume":"52","author":"Morgan","year":"2020","journal-title":"Nat. Genet."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"102153","DOI":"10.1016\/j.gde.2024.102153","article-title":"Role of H3K4 monomethylation in gene regulation","volume":"84","author":"Wang","year":"2024","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ygeno.2016.02.002","article-title":"Epigenetic suppression of iNOS expression in human endothelial cells: A potential role of Ezh2-mediated H3K27me3","volume":"107","author":"Dreger","year":"2016","journal-title":"Genomics"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1007\/s10620-019-05705-4","article-title":"EZH2 regulates intestinal inflammation and necroptosis through the JNK signaling pathway in intestinal epithelial cells","volume":"64","author":"Lou","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1172\/JCI200421854","article-title":"Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice","volume":"114","author":"Herceg","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Del Moral-Mart\u00ednez, M., S\u00e1nchez-Uceta, P., Clemente-Gonz\u00e1lez, R., Moreno-SanJuan, S., Puentes-Pardo, J.D., Khaldy, H., L\u00f3pez-P\u00e9rez, D., Arnedo, J., Casado, J., and Mart\u00ednez-Heredia, L. (2025). iNOS-produced nitric oxide from cancer cells as an intermediate of stemness regulation by PARP-1 in colorectal cancer. Biomolecules, 15.","DOI":"10.3390\/biom15010125"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/carcin\/bgw042","article-title":"The epigenetic effects of aspirin: The modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane-and dextran sulfate sodium-treated CF-1 mice","volume":"37","author":"Guo","year":"2016","journal-title":"Carcinogenesis"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1073\/pnas.1614958114","article-title":"Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications","volume":"114","author":"Hardbower","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"108510","DOI":"10.1016\/j.celrep.2020.108510","article-title":"Hypusination orchestrates the antimicrobial response of macrophages","volume":"33","author":"Gobert","year":"2020","journal-title":"Cell Rep."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1074\/jbc.C400498200","article-title":"Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation","volume":"280","author":"Chaturvedi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"115118","DOI":"10.1016\/j.addr.2023.115118","article-title":"Transflammation in tissue regeneration and response to injury: How cell-autonomous inflammatory signaling mediates cell plasticity","volume":"203","author":"Cooke","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"2251646","DOI":"10.1080\/19490976.2023.2251646","article-title":"Ring1a protects against colitis through regulating mucosal immune system and colonic microbial ecology","volume":"15","author":"Wang","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"10625","DOI":"10.1074\/jbc.270.18.10625","article-title":"Structural diversity in the 5\u2032-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA","volume":"270","author":"Chu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"27184","DOI":"10.1074\/jbc.271.43.27184","article-title":"Alternative splicing of human inducible nitric-oxide synthase mRNA: Tissue-specific regulation and induction by cytokines","volume":"271","author":"Eissa","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cbin.11717","article-title":"Knockdown of the inducible nitric oxide synthase (NOS2) splicing variant S3 promotes autophagic cell death from nitrosative stress in SW480 human colon cancer cells","volume":"46","author":"Castro","year":"2022","journal-title":"Cell Biol. Int."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1073\/pnas.95.13.7625","article-title":"Cloning and characterization of human inducible nitric oxide synthase splice variants: A domain, encoded by exons 8 and 9, is critical for dimerization","volume":"95","author":"Eissa","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1165\/ajrcmb.24.5.4324","article-title":"Identification of residues critical for enzymatic activity in the domain encoded by exons 8 and 9 of the human inducible nitric oxide synthase","volume":"24","author":"Eissa","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"27403","DOI":"10.1074\/jbc.270.46.27403","article-title":"Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants","volume":"270","author":"Lee","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/sj.leu.2403169","article-title":"Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions","volume":"18","author":"Tiscornia","year":"2004","journal-title":"Leukemia"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/bbrc.1997.6471","article-title":"Expression of human inducible nitric oxide synthase is regulated by both promoter and 3\u2032-regions","volume":"233","author":"Nunokawa","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1432-1033.1994.tb19972.x","article-title":"Inducible nitric-oxide-synthase mRNA is transiently expressed and destroyed by a cycloheximide-sensitive process","volume":"219","author":"Evans","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1073\/pnas.83.6.1670","article-title":"Identification of a common nucleotide sequence in the 3\u2032-untranslated region of mRNA molecules specifying inflammatory mediators","volume":"83","author":"Caput","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"26040","DOI":"10.1074\/jbc.M910460199","article-title":"Complex contribution of the 3\u2032-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene: Involvement of the RNA-binding protein HuR","volume":"275","author":"Hausding","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/nar\/gki797","article-title":"Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR","volume":"33","author":"Linker","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Mauri\u00f1o, S.M., Rivero-Rodr\u00edguez, F., Vel\u00e1zquez-Cruz, A., Hern\u00e1ndez-Vellisca, M., D\u00edaz-Quintana, A., De la Rosa, M.A., and D\u00edaz-Moreno, I. (2017). RNA binding protein regulation and cross-talk in the control of AU-rich mRNA fate. Front. Mol. Biosci., 4.","DOI":"10.3389\/fmolb.2017.00071"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1124\/mol.104.008763","article-title":"Tristetraprolin regulates the expression of the human inducible nitric oxide synthase gene","volume":"67","author":"Fechir","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"14413","DOI":"10.1038\/s41598-019-50957-9","article-title":"Tristetraprolin targets Nos2 expression in the colonic epithelium","volume":"9","author":"Eshelman","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_274","first-page":"299","article-title":"The RNA binding protein TIAR is involved in the regulation of human iNOS expression","volume":"51","author":"Fechir","year":"2005","journal-title":"Cell Mol. Biol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"32294","DOI":"10.1074\/jbc.M603915200","article-title":"The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression","volume":"281","author":"Pautz","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.niox.2013.05.002","article-title":"Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP)","volume":"33","author":"Casper","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.niox.2013.02.083","article-title":"Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport","volume":"30","author":"Bollmann","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13578-021-00733-y","article-title":"The eukaryotic initiation factor 5A (eIF5A1): The molecule, mechanisms and recent insights into the pathophysiological roles","volume":"11","author":"Tauc","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"119849","DOI":"10.1016\/j.bbamcr.2024.119849","article-title":"Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis","volume":"1871","author":"Guo","year":"2024","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.tcb.2022.03.006","article-title":"Moonlighting translation factors: Multifunctionality drives diverse gene regulation","volume":"32","author":"Farache","year":"2022","journal-title":"Trends Cell Biol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1261\/rna.060137.116","article-title":"A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery","volume":"23","author":"Volpon","year":"2017","journal-title":"RNA"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.cmet.2021.08.003","article-title":"Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype","volume":"33","author":"Kulkarni","year":"2021","journal-title":"Cell Metab."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"36226","DOI":"10.1074\/jbc.M113.473942","article-title":"Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes","volume":"288","author":"Colvin","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1172\/JCI38924","article-title":"The unique hypusine modification of eIF5A promotes islet \u03b2 cell inflammation and dysfunction in mice","volume":"120","author":"Maier","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"11952","DOI":"10.1038\/ncomms11952","article-title":"Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A","volume":"7","author":"Aksu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00432-013-1372-x","article-title":"Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients","volume":"139","author":"Tunca","year":"2013","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Nazari, M.H.D., Ghorbaninejad, M., Shahrokh, S., and Meyfour, A. (2025). Biomarker discovery for non-invasive diagnosis of inflammatory bowel disease using blood transcriptomics. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1570374"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1053\/j.gastro.2023.05.041","article-title":"Hypusination maintains intestinal homeostasis and prevents colitis and carcinogenesis by enhancing aldehyde detoxification","volume":"165","author":"Gobert","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"e33838","DOI":"10.1016\/j.heliyon.2024.e33838","article-title":"Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer","volume":"10","author":"Gobert","year":"2024","journal-title":"Heliyon"},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Sokal-Dembowska, A., Jarmakiewicz-Czaja, S., Helma, K., and Filip, R. (2025). The role of microRNAs in inflammatory bowel disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26104750"},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"Ortega Moreno, L., Chaparro, M., and Gisbert, J.P. (2024). Long non-coding RNAs and their potential role as biomarkers in inflammatory bowel disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25168808"},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Fasseu, M., Tr\u00e9ton, X., Guichard, C., Pedruzzi, E., Cazals-Hatem, D., Richard, C., Aparicio, T., Daniel, F., Soul\u00e9, J.C., and Moreau, R. (2010). Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013160"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1186\/s12935-021-02272-5","article-title":"Long non-coding RNA HEIH: A novel tumor activator in multiple cancers","volume":"21","author":"Sun","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"W409","DOI":"10.1093\/nar\/gkab297","article-title":"MiRTargetLink 2.0\u2014Interactive miRNA target gene and target pathway networks","volume":"49","author":"Kern","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"MiRTarBase 2025: Updates to the collection of experimentally validated microRNA-target interactions","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"e243173","DOI":"10.1001\/jamanetworkopen.2024.3173","article-title":"Citations of microRNA biomarker articles that were retracted: A systematic review","volume":"7","author":"Zhu","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"103124","DOI":"10.1016\/j.critrevonc.2020.103124","article-title":"MiR-26 family and its target genes in tumorigenesis and development","volume":"157","author":"Li","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/path.4171","article-title":"NPM-ALK up-regulates iNOS expression through a STAT3\/microRNA-26a-dependent mechanism","volume":"230","author":"Zhu","year":"2013","journal-title":"J. Pathol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2016.02.003","article-title":"MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of the NF-\u03baB pathway in human osteoarthritis chondrocytes","volume":"594","author":"Rasheed","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1158\/0008-5472.CAN-16-2964","article-title":"TET-mediated sequestration of miR-26 drives EZH2 expression and gastric carcinogenesis","volume":"77","author":"Deng","year":"2017","journal-title":"Cancer Res."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1073\/pnas.1118118109","article-title":"MiRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes","volume":"109","author":"Guo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"11381","DOI":"10.1111\/jcmm.15740","article-title":"Differentially expressed lnc-NOS2P3-miR-939-5p axis in chronic heart failure inhibits myocardial and endothelial cells apoptosis via the iNOS\/TNF\u03b1 pathway","volume":"24","author":"Chen","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.4081\/ejh.2022.3316","article-title":"Effects of miR-939 and miR-376A on ulcerative colitis using a decoy strategy to inhibit NF-\u03baB and NFAT expression","volume":"66","author":"Lin","year":"2022","journal-title":"Eur. J. Histochem."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10585-016-9810-1","article-title":"Prognostic value of 5-microRNA-based signature in T2\u2013T3N0 colon cancer","volume":"33","author":"Bobowicz","year":"2016","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1002\/jcp.30234","article-title":"LncRNA HEIH\/miR-939-5p interplay modulates triple-negative breast cancer progression through NOS2-induced nitric oxide production","volume":"236","author":"Nafea","year":"2021","journal-title":"J. Cell Physiol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4143\/crt.2017.226","article-title":"Long noncoding RNA HEIH promotes colorectal cancer tumorigenesis via counteracting miR-939-mediated transcriptional repression of Bcl-xL","volume":"50","author":"Cui","year":"2018","journal-title":"Cancer Res. Treat."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"109916","DOI":"10.1016\/j.biopha.2020.109916","article-title":"LncRNA HEIH promotes cell proliferation, migration and invasion in cholangiocarcinoma by modulating the miR-98-5p\/HECTD4","volume":"125","author":"Wan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.2353\/ajpath.2010.091111","article-title":"Loss of inducible nitric oxide synthase expression in the mouse renal cell carcinoma cell line RENCA is mediated by MicroRNA miR-146a","volume":"177","author":"Perske","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"28556","DOI":"10.18632\/oncotarget.5597","article-title":"MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis","volume":"6","author":"Runtsch","year":"2015","journal-title":"Oncotarget"},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Simanovich, E., Brod, V., Rahat, M.M., and Rahat, M.A. (2018). Function of miR-146a-5p in tumor cells as a regulatory switch between cell death and angiogenesis: Macrophage therapy revisited. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01931"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1038\/ncomms8321","article-title":"Exosome-delivered microRNAs modulate the inflammatory response to endotoxin","volume":"6","author":"Alexander","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.dld.2016.12.022","article-title":"Altered mucosal expression of microRNAs in pediatric patients with inflammatory bowel disease","volume":"49","author":"Kiss","year":"2017","journal-title":"Dig. Liver Dis."},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Zhu, F., Yang, T., Ning, M., Liu, Y., Xia, W., Fu, Y., Wen, T., Zheng, M., Xia, R., and Qian, R. (2024). MiR-146a alleviates inflammatory bowel disease in mice through systematic regulation of multiple genetic networks. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1366319"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-\u03baB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3892\/ijmm.2022.5210","article-title":"Mechanisms and application strategies of miRNA-146a regulating inflammation and fibrosis at molecular and cellular levels (Review)","volume":"51","author":"Liao","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1038\/s41467-021-22641-y","article-title":"MicroRNA-146a limits tumorigenic inflammation in colorectal cancer","volume":"12","author":"Garo","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Schaefer, J.S., Attumi, T., Opekun, A.R., Abraham, B., Hou, J., Shelby, H., Graham, D.Y., Streckfus, C., and Klein, J.R. (2015). MicroRNA signatures differentiate Crohn\u2019s disease from ulcerative colitis. BMC Immunol., 16.","DOI":"10.1186\/s12865-015-0069-0"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1111\/j.1440-1746.2009.06216.x","article-title":"Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis","volume":"25","author":"Takagi","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/carcin\/bgs408","article-title":"Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases","volume":"34","author":"Svrcek","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/MIB.0000000000000009","article-title":"MicroRNA-155 is involved in the pathogenesis of ulcerative colitis by targeting FOXO3a","volume":"20","author":"Min","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/MIB.0000000000000687","article-title":"Role of altered expression of miR-146a, miR-155, and miR-122 in pediatric patients with inflammatory bowel disease","volume":"22","author":"Kocsis","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"140134","DOI":"10.1016\/j.ijbiomac.2025.140134","article-title":"MiRNA-155: A double-edged sword in colorectal cancer progression and drug resistance mechanisms","volume":"299","author":"Hussen","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_323","doi-asserted-by":"crossref","unstructured":"Yao, R., Ma, Y.L., Liang, W., Li, H.H., Ma, Z.J., Yu, X., and Liao, Y.H. (2012). MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046082"},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Jablonski, K.A., Gaudet, A.D., Amici, S.A., Popovich, P.G., and Guerau-de-Arellano, M. (2016). Control of the inflammatory macrophage transcriptional signature by miR-155. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159724"},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s11033-025-10934-0","article-title":"MiR-155 aggravates inflammation in MRSA pneumonia by modulating macrophage polarization","volume":"52","author":"Shi","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jmcb\/mjs044","article-title":"Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155","volume":"4","author":"Cai","year":"2012","journal-title":"J. Mol. Cell Biol."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.crohns.2012.02.006","article-title":"Circulating microRNA in inflammatory bowel disease","volume":"6","author":"Paraskevi","year":"2012","journal-title":"J. Crohns Colitis"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/imm.12328","article-title":"MiR-155 deficiency protects mice from experimental colitis by reducing T helper type 1\/type 17 responses","volume":"143","author":"Singh","year":"2014","journal-title":"Immunology"},{"key":"ref_329","doi-asserted-by":"crossref","unstructured":"Qin, Y., Wang, Q., Zhou, Y., Duan, Y., and Gao, Q. (2016). Inhibition of IFN-\u03b3-induced nitric oxide dependent antimycobacterial activity by miR-155 and C\/EBP\u03b2. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040535"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.febslet.2010.02.063","article-title":"Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation","volume":"584","author":"Tang","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1074\/jbc.M112.414862","article-title":"MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2","volume":"288","author":"Xu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1038\/s41598-020-75358-1","article-title":"MiR-155\/GSK-3\u03b2 mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-\u03baB signaling pathway in LPS-induced RAW264.7 cell","volume":"10","author":"Xin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cyto.2010.10.009","article-title":"Glycogen synthase kinase-3: A point of convergence for the host inflammatory response","volume":"53","author":"Wang","year":"2011","journal-title":"Cytokine"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"41328","DOI":"10.1074\/jbc.M110.146852","article-title":"MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-\u03b2","volume":"285","author":"Louafi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1172\/JCI61716","article-title":"MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages","volume":"122","author":"Wei","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_336","doi-asserted-by":"crossref","unstructured":"Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I.B., and Kurowska-Stolarska, M. (2018). MicroRNA-155\u2014at the critical interface of innate and adaptive immunity in arthritis. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01932"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.bbadis.2015.04.012","article-title":"MiR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells","volume":"1852","author":"Yang","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1161\/CIRCULATIONAHA.112.000736","article-title":"The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis","volume":"127","author":"Wei","year":"2013","journal-title":"Circulation"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"220070","DOI":"10.1098\/rsob.220070","article-title":"MiR-155-3p: Processing by-product or rising star in immunity and cancer?","volume":"12","author":"Dawson","year":"2022","journal-title":"Open Biol."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.immuni.2013.08.035","article-title":"The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release","volume":"39","author":"Brain","year":"2013","journal-title":"Immunity"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"eaau6571","DOI":"10.1126\/sciimmunol.aau6571","article-title":"IL-23-producing IL-10R\u03b1-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial response","volume":"4","author":"Bernshtein","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/ecco-jcc\/jjac034","article-title":"Interleukin-23 in the pathogenesis of inflammatory bowel disease and implications for therapeutic intervention","volume":"16","author":"Sewell","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yexcr.2019.02.005","article-title":"TRAF6-p38\/JNK-ATF2 axis promotes microglial inflammatory activation","volume":"376","author":"Li","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"109957","DOI":"10.1016\/j.cellsig.2021.109957","article-title":"Mechanisms of HuR in regulation of epithelial cell apoptosis in rat ulcerative colitis","volume":"82","author":"Guo","year":"2021","journal-title":"Cell. Signal."},{"key":"ref_345","doi-asserted-by":"crossref","unstructured":"Sheedy, F.J. (2015). Turning 21: Induction of miR-21 as a key switch in the inflammatory response. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00019"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/MIB.0000000000001086","article-title":"Expression and localization of miR-21 and miR-126 in mucosal tissue from patients with inflammatory bowel disease","volume":"23","author":"Andersen","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"izaf120","DOI":"10.1093\/ibd\/izaf120","article-title":"Tissue microRNA expression signatures as diagnostic biomarkers and predictors of residual disease activity and relapse in treatment-na\u00efve pediatric inflammatory bowel disease","volume":"31","author":"Deissova","year":"2025","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/ecco-jcc\/jjy010","article-title":"Differential expression of microRNAs in peripheral blood mononuclear cells identifies autophagy- and TGF-\u03b2-related signatures aberrantly expressed in inflammatory bowel disease","volume":"12","author":"Mohammadi","year":"2018","journal-title":"J. Crohns Colitis"},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ni.1828","article-title":"Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by microRNA miR-21","volume":"11","author":"Sheedy","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/1873-3468.13438","article-title":"MiR-21-5p regulates mycobacterial survival and inflammatory responses by targeting Bcl-2 and TLR4 in Mycobacterium tuberculosis-infected macrophages","volume":"593","author":"Zhao","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.celrep.2019.12.015","article-title":"Mycobacterium tuberculosis limits host glycolysis and IL-1\u03b2 by restriction of PFK-M via microRNA-21","volume":"30","author":"Hackett","year":"2020","journal-title":"Cell Rep."},{"key":"ref_352","doi-asserted-by":"crossref","unstructured":"Correia de Sousa, M., Calo, N., Sobolewski, C., Gjorgjieva, M., Cl\u00e9ment, S., Maeder, C., Dolicka, D., Fournier, M., Vinet, L., and Montet, X. (2021). Mir-21 suppression promotes mouse hepatocarcinogenesis. Cancers, 13.","DOI":"10.3390\/cancers13194983"},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Pereira, M., and Gazzinelli, R.T. (2023). Regulation of innate immune signaling by IRAK proteins. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1133354"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"e29630","DOI":"10.7554\/eLife.29630","article-title":"IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs","volume":"6","author":"Zhou","year":"2017","journal-title":"eLife"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.canlet.2008.06.034","article-title":"MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G","volume":"272","author":"Chen","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"e2311674120","DOI":"10.1073\/pnas.2311674120","article-title":"SERS analysis of cancer cell-secreted purines reveals a unique paracrine crosstalk in MTAP-deficient tumors","volume":"120","author":"Valera","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/j.devcel.2024.08.003","article-title":"Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression","volume":"59","author":"Zhang","year":"2024","journal-title":"Dev. Cell"},{"key":"ref_358","doi-asserted-by":"crossref","unstructured":"Feng, X., Wang, H., Ye, S., Guan, J., Tan, W., Cheng, S., Wei, G., Wu, W., Wu, F., and Zhou, Y. (2012). Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor I\u03baB\u03b1. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052782"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm.3487","article-title":"MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1","volume":"20","author":"Schober","year":"2014","journal-title":"Nat. Med."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vph.2016.12.002","article-title":"MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic conditions by targeting HMGB1","volume":"88","author":"Tang","year":"2017","journal-title":"Vasc. Pharmacol."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.3748\/wjg.v19.i27.4289","article-title":"MiR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis","volume":"19","author":"Coskun","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_362","first-page":"157","article-title":"MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease","volume":"67","author":"Peng","year":"2020","journal-title":"Acta Biochim. Pol."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s10753-020-01400-z","article-title":"Long non-coding RNA MEG3 alleviated ulcerative colitis through up-regulating miR-98-5p-sponged IL-10","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.4049\/jimmunol.1500209","article-title":"MicroRNA-9 regulates the differentiation and function of myeloid-derived suppressor cells via targeting Runx1","volume":"195","author":"Tian","year":"2015","journal-title":"J. Immunol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1007\/s10528-024-10917-z","article-title":"Identification and validation of biomarkers to predict early diagnosis of inflammatory bowel disease and its progression to colorectal cancer","volume":"63","author":"Khan","year":"2025","journal-title":"Biochem. Genet."},{"key":"ref_366","doi-asserted-by":"crossref","unstructured":"Ebihara, T., and Taniuchi, I. (2019). Transcription factors in the development and function of group 2 innate lymphoid cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061377"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.immuni.2009.09.003","article-title":"Indispensable role of the Runx1\u2013Cbf\u03b2 transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells","volume":"31","author":"Kitoh","year":"2009","journal-title":"Immunity"},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.4049\/jimmunol.1102991","article-title":"Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells","volume":"188","author":"Wong","year":"2012","journal-title":"J. Immunol."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/eji.201444726","article-title":"TGF-\u03b2 converts Th1 cells into Th17 cells through stimulation of Runx1 expression","volume":"45","author":"Liu","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"ref_370","doi-asserted-by":"crossref","unstructured":"Liu, Y., Chen, J., Li, A., Wu, Y., Ge, J., Yuan, M., Xu, B., Zheng, X., Chen, L., and Jiang, J. (2024). Novel biomarkers: The RUNX family as prognostic predictors in colorectal cancer. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1430136"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1038\/s41598-020-72991-8","article-title":"MiR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory responses","volume":"10","author":"Scalavino","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"e1801390","DOI":"10.1002\/mnfr.201801390","article-title":"Quercetin-induced miR-369-3p suppresses chronic inflammatory response targeting C\/EBP-\u03b2","volume":"63","author":"Galleggiante","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_373","doi-asserted-by":"crossref","unstructured":"Guo, H., Zhang, N., Huang, T., and Shen, N. (2025). MicroRNA-200c in cancer generation, invasion, and metastasis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26020710"},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.15252\/embj.201488641","article-title":"Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion","volume":"33","author":"Bracken","year":"2014","journal-title":"EMBO J."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41467-024-44703-7","article-title":"ROCK1\/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease","volume":"15","author":"Stell","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1182\/blood-2006-03-012898","article-title":"Dual role for RhoA in suppression and induction of cytokines in the human neutrophil","volume":"109","author":"Fessler","year":"2007","journal-title":"Blood"},{"key":"ref_377","doi-asserted-by":"crossref","unstructured":"Glotfelty, E.J., Tovar-Y-Romo, L.B., Hsueh, S.C., Tweedie, D., Li, Y., Harvey, B.K., Hoffer, B.J., Karlsson, T.E., Olson, L., and Greig, N.H. (2023). The RhoA\u2013ROCK1\/ROCK2 pathway exacerbates inflammatory signaling in immortalized and primary microglia. Cells, 12.","DOI":"10.3390\/cells12101367"},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ajpath.2017.10.023","article-title":"MicroRNA-31-3p is involved in substance P (SP)\u2013associated inflammation in human colonic epithelial cells and experimental colitis","volume":"188","author":"Fang","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejphar.2013.11.027","article-title":"Contribution of RhoA\/Rho-kinase\/MEK1\/ERK1\/2\/iNOS pathway to ischemia\/reperfusion-induced oxidative\/nitrosative stress and inflammation leading to distant and target organ injury in rats","volume":"723","author":"Sari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s00417-016-3456-1","article-title":"Role of RhoA\/MEK1\/ERK1\/2\/iNOS signaling in ocular ischemic syndrome","volume":"254","author":"Du","year":"2016","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(03)00459-3","article-title":"Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: Negative regulation of IKK\u03b1","volume":"35","author":"Rattan","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"ref_382","first-page":"6310","article-title":"Circulating miRNA-16 in inflammatory bowel disease and some clinical correlations\u2014A cohort study in Bulgarian patients","volume":"26","author":"Atanassova","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_383","doi-asserted-by":"crossref","unstructured":"Vuerich, M., Nguyen, D.H., Ferrari, D., and Longhi, M.S. (2024). Adenosine-mediated immune responses in inflammatory bowel disease. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1429736"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-5793(98)00556-0","article-title":"Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells","volume":"429","author":"Brodie","year":"1998","journal-title":"FEBS Lett."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.gastro.2005.05.032","article-title":"Activation of the A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease","volume":"129","author":"Odashima","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"30824","DOI":"10.1038\/srep30824","article-title":"MicroRNA-16 is putatively involved in the NF-\u03baB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting","volume":"6","author":"Tian","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1053\/j.gastro.2013.07.001","article-title":"MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis","volume":"145","author":"Koukos","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/phar.70088","article-title":"Therapeutic modulation of IL-6\/STAT-3 and nitric oxide by fenofibrate in patients with ulcerative colitis: A randomized controlled pilot study","volume":"45","author":"Aldossary","year":"2025","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"e21615","DOI":"10.1016\/j.heliyon.2023.e21615","article-title":"The potential role of miRNA in regulating macrophage polarization","volume":"9","author":"Khayati","year":"2023","journal-title":"Heliyon"},{"key":"ref_390","first-page":"2227","article-title":"Mechanism underlying the significant role of the miR-4262\/SIRT1 axis in children with inflammatory bowel disease","volume":"20","author":"Deng","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_391","doi-asserted-by":"crossref","unstructured":"Yang, Y., Liu, Y., Wang, Y., Chao, Y., Zhang, J., Jia, Y., Tie, J., and Hu, D. (2022). Regulation of SIRT1 and its roles in inflammation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.831168"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_393","doi-asserted-by":"crossref","unstructured":"Leija Montoya, G., Gonz\u00e1lez Ram\u00edrez, J., Sandoval Basilio, J., Seraf\u00edn Higuera, I., Isiordia Espinoza, M., Gonz\u00e1lez Gonz\u00e1lez, R., and Seraf\u00edn Higuera, N. (2019). Long non-coding RNAs: Regulators of the activity of myeloid-derived suppressor cells. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01734"},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1158\/2326-6066.CIR-18-0108","article-title":"Lnc-C\/EBP\u03b2 negatively regulates the suppressive function of myeloid-derived suppressor cells","volume":"6","author":"Gao","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.4049\/jimmunol.1701721","article-title":"Lnc-chop promotes immunosuppressive function of myeloid-derived suppressor cells in tumor and inflammatory environments","volume":"200","author":"Gao","year":"2018","journal-title":"J. Immunol."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"111754","DOI":"10.18632\/oncotarget.22906","article-title":"LncRNA RNCR3 promotes Chop expression by sponging miR-185-5p during MDSC differentiation","volume":"8","author":"Shang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/ibd\/izy381","article-title":"CCAT1 lncRNA promotes inflammatory bowel disease malignancy by destroying intestinal barrier via downregulating miR-185-3p","volume":"25","author":"Ma","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_398","doi-asserted-by":"crossref","unstructured":"Kr\u0161ul, D., Prenc, E., Po\u017egaj, L., \u0160tefok, D., Pongrac, P., Podolski, M., Radi\u010devi\u0107, A.P., Karlovi\u0107, D., Jerkovi\u0107, A., and Gol\u010di\u0107, M. (2025). Diagnostic relevance of miR-185, miR-141, and miR-21 in colon carcinoma: Insights into tumor sidedness and reference gene selection. Biomedicines, 13.","DOI":"10.3390\/biomedicines13102460"},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1158\/2326-6066.CIR-18-0443","article-title":"The pseudogene Olfr29-ps1 promotes suppressive function and differentiation of monocytic MDSCs","volume":"7","author":"Shang","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"bae013","DOI":"10.1093\/pcmedi\/pbae013","article-title":"Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis","volume":"7","author":"Li","year":"2024","journal-title":"Precis. Clin. Med."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1128\/IAI.72.4.2400-2404.2004","article-title":"MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression","volume":"72","author":"Scanga","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s13258-024-01598-4","article-title":"MiR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells","volume":"47","author":"Zhao","year":"2025","journal-title":"Genes Genom."},{"key":"ref_403","first-page":"8524972","article-title":"Downregulation of miR-214-3p may contribute to pathogenesis of ulcerative colitis via targeting STAT6","volume":"2017","author":"Li","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.4049\/jimmunol.166.4.2173","article-title":"Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production","volume":"166","author":"Rutschman","year":"2001","journal-title":"J. Immunol."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/s41388-018-0551-2","article-title":"Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis","volume":"38","author":"Ramakrishnan","year":"2019","journal-title":"Oncogene"},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3892\/ol.2014.2746","article-title":"MicroRNA-214 functions as a tumor suppressor in human colon cancer via the suppression of ADP-ribosylation factor-like protein 2","volume":"9","author":"Long","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"169764","DOI":"10.1016\/j.jmb.2026.169764","article-title":"Regulation of eukaryotic gene expression through functional coupling between alternative splicing and nonsense-mediated decay","volume":"438","author":"Yap","year":"2026","journal-title":"J. Mol. Biol."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.niox.2019.04.008","article-title":"Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame","volume":"88","author":"Gather","year":"2019","journal-title":"Nitric Oxide"},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0163-7258(99)00030-3","article-title":"Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors","volume":"84","author":"Bryk","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"31020","DOI":"10.1074\/jbc.M203749200","article-title":"Distinct dimer interaction and regulation in nitric oxide synthase types I, II, and III","volume":"277","author":"Panda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1096\/fj.10-180554","article-title":"Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process","volume":"25","author":"Ghosh","year":"2011","journal-title":"FASEB J."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1074\/jbc.271.10.5414","article-title":"Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability","volume":"271","author":"Albakri","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1021\/bi011877t","article-title":"Control of nitric oxide synthase dimer assembly by a heme-NO-dependent mechanism","volume":"41","author":"Chen","year":"2002","journal-title":"Biochemistry"},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/bj20020339","article-title":"Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: Implications for enzymic activity","volume":"366","author":"Lanone","year":"2002","journal-title":"Biochem. J."},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1021\/bi0474463","article-title":"S-nitrosation and regulation of inducible nitric oxide synthase","volume":"44","author":"Mitchell","year":"2005","journal-title":"Biochemistry"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1074\/jbc.274.2.930","article-title":"Antifungal imidazoles block assembly of inducible NO synthase into an active dimer","volume":"274","author":"Sennequier","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"19685","DOI":"10.1074\/jbc.M112.446542","article-title":"Mechanism of inducible nitric oxide synthase dimerization inhibition by novel pyrimidine imidazoles","volume":"288","author":"Nagpal","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1124\/jpet.108.141887","article-title":"Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-\u03baB-dependent manner","volume":"327","author":"Thapa","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"30250","DOI":"10.1074\/jbc.274.42.30250","article-title":"An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity","volume":"274","author":"Ratovitski","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"13854","DOI":"10.1073\/pnas.0913495107","article-title":"Regulation of NF-\u03baB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13)","volume":"107","author":"Mazumdar","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1074\/jbc.274.2.993","article-title":"Kalirin inhibition of inducible nitric oxide synthase","volume":"274","author":"Ratovitski","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"17736","DOI":"10.1074\/jbc.M601896200","article-title":"Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: Critical dimerization of inducible nitric-oxide synthase","volume":"281","author":"Sakai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_423","doi-asserted-by":"crossref","unstructured":"Banjarnahor, S., Rodionov, R.N., K\u00f6nig, J., and Maas, R. (2020). Transport of L-arginine-related cardiovascular risk markers. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123975"},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1152\/physrev.00018.2006","article-title":"Amino acid transport across mammalian intestinal and renal epithelia","volume":"88","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_425","first-page":"343","article-title":"Amino acid transport across the mammalian intestine","volume":"9","author":"Fairweather","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"G1061","DOI":"10.1152\/ajpgi.00544.2011","article-title":"L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution","volume":"302","author":"Singh","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_427","doi-asserted-by":"crossref","unstructured":"Franceschelli, S., Gatta, D.M.P., Pesce, M., Ferrone, A., Quiles, J.L., Genovese, S., Epifano, F., Fiorito, S., Taddeo, V.A., and Patruno, A. (2019). Modulation of CAT-2B-mediated L-arginine uptake and nitric oxide biosynthesis in HCT116 cell line through biological activity of 4\u2032-geranyloxyferulic acid extract from quinoa seeds. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133262"},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"G225","DOI":"10.1152\/ajpgi.00091.2013","article-title":"Deletion of cationic amino acid transporter-2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response","volume":"305","author":"Singh","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_429","doi-asserted-by":"crossref","unstructured":"Singh, K., Al-Greene, N.T., Verriere, T.G., Coburn, L.A., Asim, M., Barry, D.P., Allaman, M.M., Hardbower, D.M., Delgado, A.G., and Piazuelo, M.B. (2016). The L-arginine transporter solute carrier family 7 member 2 mediates immunopathogenesis of attaching and effacing bacteria. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005984"},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbadis.2005.04.002","article-title":"Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans","volume":"1741","author":"Gupta","year":"2005","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_431","doi-asserted-by":"crossref","unstructured":"Eriksson, A., Flach, C.F., Lindgren, A., Kvifors, E., and Lange, S. (2008). Five mucosal transcripts of interest in ulcerative colitis identified by quantitative real-time PCR: A prospective study. BMC Gastroenterol., 8.","DOI":"10.1186\/1471-230X-8-34"},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/MEG.0b013e3282f3557c","article-title":"Real-time PCR quantification analysis of five mucosal transcripts in patients with Crohn\u2019s disease","volume":"20","author":"Eriksson","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1053\/j.gastro.2010.06.060","article-title":"Polyamines impair immunity to Helicobacter pylori by inhibiting L-arginine uptake required for nitric oxide production","volume":"139","author":"Chaturvedi","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_434","first-page":"318087","article-title":"Arginine-based inhibitors of nitric oxide synthase: Therapeutic potential and challenges","volume":"2012","author":"Lojek","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00726-019-02719-0","article-title":"The role of polyamines in the regulation of macrophage polarization and function","volume":"52","author":"Latour","year":"2020","journal-title":"Amino Acids"},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"2820S","DOI":"10.1093\/jn\/134.10.2820S","article-title":"Arginine metabolic enzymes, nitric oxide and infection","volume":"134","author":"Mori","year":"2004","journal-title":"J. Nutr."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/nm.2544","article-title":"Requirement of argininosuccinate lyase for systemic nitric oxide production","volume":"17","author":"Erez","year":"2011","journal-title":"Nat. Med."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"2579S","DOI":"10.3945\/jn.115.226621","article-title":"Arginine metabolism revisited","volume":"146","author":"Morris","year":"2016","journal-title":"J. Nutr."},{"key":"ref_439","doi-asserted-by":"crossref","unstructured":"Rath, M., M\u00fcller, I., Kropf, P., Closs, E.I., and Munder, M. (2014). Metabolism via arginase or nitric oxide synthase: Two competing arginine pathways in macrophages. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00532"},{"key":"ref_440","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/19490976.2018.1494466","article-title":"Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome","volume":"10","author":"Nakamura","year":"2019","journal-title":"Gut Microbes"},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s42003-018-0178-4","article-title":"Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction","volume":"1","author":"Cheng","year":"2018","journal-title":"Commun. Biol."},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3892\/or.2016.5221","article-title":"Silencing of argininosuccinate lyase inhibits colorectal cancer formation","volume":"37","author":"Huang","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_443","doi-asserted-by":"crossref","unstructured":"Bednarz-Misa, I., Fleszar, M.G., Zawadzki, M., Kapturkiewicz, B., Kubiak, A., Neubauer, K., Witkiewicz, W., and Krzystek-Korpacka, M. (2020). L-arginine\/NO pathway metabolites in colorectal cancer: Relevance as disease biomarkers and predictors of adverse clinical outcomes following surgery. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061782"},{"key":"ref_444","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/cvr\/cvr087","article-title":"Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology","volume":"91","author":"Nishijima","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.4049\/jimmunol.171.6.3225","article-title":"Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with \u03b1-actinin 4","volume":"171","author":"Daniliuc","year":"2003","journal-title":"J. Immunol."},{"key":"ref_446","doi-asserted-by":"crossref","first-page":"F326","DOI":"10.1152\/ajprenal.2001.281.2.F326","article-title":"Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages","volume":"281","author":"Kuncewicz","year":"2001","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_447","doi-asserted-by":"crossref","first-page":"25437","DOI":"10.1074\/jbc.272.41.25437","article-title":"Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: Functional significance of the NOS caveolin binding domainin vivo","volume":"272","author":"Martasek","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_448","doi-asserted-by":"crossref","first-page":"14334","DOI":"10.1073\/pnas.250406797","article-title":"Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells","volume":"97","author":"Bender","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1042\/bj3140889","article-title":"Tyrosine phosphorylation of inducible nitric oxide synthase: Implications for potential post-translational regulation","volume":"314","author":"Pan","year":"1996","journal-title":"Biochem. J."},{"key":"ref_450","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/sj.onc.1209030","article-title":"Src-mediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase","volume":"25","author":"Hausel","year":"2006","journal-title":"Oncogene"},{"key":"ref_451","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1074\/jbc.M109.055038","article-title":"Src kinase-mediated phosphorylation stabilizes inducible nitric oxide synthase in normal cells and cancer cells","volume":"285","author":"Tyryshkin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_452","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cell.2014.09.032","article-title":"Target-selective protein S-nitrosylation by sequence motif recognition","volume":"159","author":"Jia","year":"2014","journal-title":"Cell"},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.molcel.2017.12.019","article-title":"Evidence against stable protein S-nitrosylation as a widespread mechanism of post-translational regulation","volume":"69","author":"Wolhuter","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"55682","DOI":"10.1074\/jbc.M406621200","article-title":"Palmitoylation of inducible nitric oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis","volume":"279","author":"Corvi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_455","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1128\/IAI.69.10.6391-6400.2001","article-title":"Macrophage nitric oxide synthase associates with cortical actin but is not recruited to phagosomes","volume":"69","author":"Webb","year":"2001","journal-title":"Infect. Immun."},{"key":"ref_456","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1189\/jlb.0605320","article-title":"Nitric oxide synthase localization in the rat neutrophils: Immunocytochemical, molecular, and biochemical studies","volume":"79","author":"Saini","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1073\/pnas.0500485102","article-title":"Regulation of inducible nitric oxide synthase by aggresome formation","volume":"102","author":"Kolodziejska","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_458","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1074\/jbc.M205764200","article-title":"Epithelial inducible nitric oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output","volume":"277","author":"Glynne","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_459","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1742-4658.2004.04484.x","article-title":"Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells","volume":"272","author":"Rumbo","year":"2005","journal-title":"FEBS J."},{"key":"ref_460","doi-asserted-by":"crossref","first-page":"H2634","DOI":"10.1152\/ajpheart.01247.2006","article-title":"iNOS regulation by calcium\/calmodulin-dependent protein kinase II in vascular smooth muscle","volume":"292","author":"Jones","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_461","doi-asserted-by":"crossref","first-page":"24268","DOI":"10.1074\/jbc.M100725200","article-title":"Inducible nitric oxide synthase is regulated by the proteasome degradation pathway","volume":"276","author":"Musial","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_462","doi-asserted-by":"crossref","first-page":"12315","DOI":"10.1073\/pnas.192345199","article-title":"Ubiquitination of inducible nitric oxide synthase is required for its degradation","volume":"99","author":"Kolodziejski","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_463","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cellimm.2009.03.009","article-title":"CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation","volume":"258","author":"Chen","year":"2009","journal-title":"Cell. Immunol."},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.200912087","article-title":"The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation","volume":"190","author":"Kuang","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_465","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2013.02.079","article-title":"Proteomic analysis of the NOS2 interactome in human airway epithelial cells","volume":"34","author":"Foster","year":"2013","journal-title":"Nitric Oxide"},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"9009","DOI":"10.1074\/jbc.M110.190678","article-title":"Regulation of inducible nitric oxide synthase by the SPRY domain- and SOCS box-containing proteins","volume":"286","author":"Nishiya","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_467","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.01.021","article-title":"Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2","volume":"117","author":"Wang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_468","first-page":"5870","article-title":"Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity","volume":"60","author":"Bender","year":"2000","journal-title":"Cancer Res."},{"key":"ref_469","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1073\/pnas.0810968106","article-title":"The physiologic aggresome mediates cellular inactivation of iNOS","volume":"106","author":"Pandit","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_470","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1128\/MCB.00829-08","article-title":"A critical role for CHIP in the aggresome pathway","volume":"29","author":"Sha","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_471","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbrc.2012.08.099","article-title":"Inducible nitric oxide synthase aggresome formation is mediated by nitric oxide","volume":"426","author":"Wang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_472","unstructured":"Atlas, P. (2025, December 25). NOS2 Tissue Expression Profile. Available online: https:\/\/www.proteinatlas.org\/ENSG00000007171-NOS2\/tissue."},{"key":"ref_473","first-page":"G564","article-title":"Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells","volume":"275","author":"Eckmann","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_474","doi-asserted-by":"crossref","first-page":"G178","DOI":"10.1152\/ajpgi.1998.274.1.G178","article-title":"Synergistic regulation of NOS II expression by IL-1\u03b2 and TNF-\u03b1 in cultured rat colonic smooth muscle cells","volume":"274","author":"Kuemmerle","year":"1998","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_475","doi-asserted-by":"crossref","first-page":"G592","DOI":"10.1152\/ajpgi.1998.275.3.G592","article-title":"iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion","volume":"275","author":"Binion","year":"1998","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_476","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0891-5849(00)00391-9","article-title":"Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion","volume":"29","author":"Binion","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_477","doi-asserted-by":"crossref","unstructured":"Loscalzo, J., and Vita, J.A. (2000). The Fibroblast and Nitric Oxide. Nitric Oxide and the Cardiovascular System, Humana Press. Contemporary Cardiology.","DOI":"10.1385\/1592590020"},{"key":"ref_478","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/jcp.24164","article-title":"Intestinal myofibroblasts produce nitric oxide in response to combinatorial cytokine stimulation","volume":"228","author":"Wu","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref_479","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/JLB.4RU0418-161R","article-title":"Inducible nitric oxide synthase: An asset to neutrophils","volume":"105","author":"Saini","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_480","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_481","doi-asserted-by":"crossref","unstructured":"Albert-Bayo, M., Paracuellos, I., Gonz\u00e1lez-Castro, A.M., Rodr\u00edguez-Urrutia, A., Rodr\u00edguez-Lagunas, M.J., Alonso-Cotoner, C., Santos, J., and Vicario, M. (2019). Intestinal mucosal mast cells: Key modulators of barrier function and homeostasis. Cells, 8.","DOI":"10.3390\/cells8020135"},{"key":"ref_482","doi-asserted-by":"crossref","first-page":"74834","DOI":"10.18632\/oncotarget.11361","article-title":"Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells","volume":"7","author":"Si","year":"2016","journal-title":"Oncotarget"},{"key":"ref_483","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S1567-5769(01)00095-9","article-title":"Natural killer cells and nitric oxide","volume":"1","author":"Cifone","year":"2001","journal-title":"Int. Immunopharmacol."},{"key":"ref_484","doi-asserted-by":"crossref","unstructured":"Douguet, L., Cherfils-Vicini, J., Bod, L., Lengagne, R., Gilson, E., and Pr\u00e9vost-Blondel, A. (2016). Nitric oxide synthase 2 improves proliferation and glycolysis of peripheral \u03b3\u03b4 T cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165639"},{"key":"ref_485","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ni.2806","article-title":"Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells","volume":"15","author":"Saini","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_486","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cellimm.2009.11.009","article-title":"B1 cells produce nitric oxide in response to a series of toll-like receptor ligands","volume":"261","author":"Tumurkhuu","year":"2010","journal-title":"Cell. Immunol."},{"key":"ref_487","doi-asserted-by":"crossref","unstructured":"Mattila, J.T., and Thomas, A.C. (2014). Nitric oxide synthase: Non-canonical expression patterns. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00478"},{"key":"ref_488","unstructured":"(2025, December 25). The Cell Line Mutation Encyclopedia (CCLE). Available online: https:\/\/www.gtexportal.org\/home\/multiGeneQueryPage\/NOS2."},{"key":"ref_489","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bcp.2005.06.027","article-title":"NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells","volume":"70","author":"Spiegel","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_490","unstructured":"(2025, December 25). The COSMIC Cell Line Gene Mutation Profiles. Available online: https:\/\/maayanlab.cloud\/Harmonizome\/gene\/NOS2."},{"key":"ref_491","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.bjp.0702827","article-title":"Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: Influence of cell differentiation","volume":"128","author":"Cavicchi","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref_492","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/bjc.1994.409","article-title":"Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation","volume":"70","author":"Jenkins","year":"1994","journal-title":"Br. J. Cancer"},{"key":"ref_493","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/sj.bjc.6600224","article-title":"Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion","volume":"86","author":"Siegert","year":"2002","journal-title":"Br. J. Cancer"},{"key":"ref_494","unstructured":"(2025, December 25). Available online: https:\/\/www.proteinatlas.org\/ENSG00000007171-NOS2\/cell+line."},{"key":"ref_495","unstructured":"(2025, December 25). Available online: https:\/\/sites.broadinstitute.org\/ccle\/datasets\/\/sites.broadinstitute.org\/ccle\/datasets."},{"key":"ref_496","first-page":"261","article-title":"Decreased activity of inducible nitric oxide synthase type 2 and modulation of the expression of glutathione S-transferase alpha, bcl-2, and metallothioneins during the differentiation of CaCo-2 cells","volume":"8","author":"Vecchini","year":"1997","journal-title":"Cell Growth Differ."},{"key":"ref_497","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4049\/jimmunol.158.1.226","article-title":"Evidence for altered regulation of I kappa B \u03b1 degradation in human colonic epithelial cells","volume":"158","author":"Jobin","year":"1997","journal-title":"J. Immunol."},{"key":"ref_498","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2019.06.029","article-title":"Intra- and inter-cellular rewiring of the human colon during ulcerative colitis","volume":"178","author":"Smillie","year":"2019","journal-title":"Cell"},{"key":"ref_499","doi-asserted-by":"crossref","first-page":"e0265189","DOI":"10.1371\/journal.pone.0265189","article-title":"Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn\u2019s disease","volume":"17","author":"Bakke","year":"2022","journal-title":"PLoS One."},{"key":"ref_500","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.1038\/s41467-024-51580-7","article-title":"Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn\u2019s disease","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_501","doi-asserted-by":"crossref","first-page":"eadh1641","DOI":"10.1126\/scisignal.adh1641","article-title":"The NF-\u03baB signaling system in the immunopathogenesis of inflammatory bowel disease","volume":"17","author":"Mukherjee","year":"2024","journal-title":"Sci. Signal."},{"key":"ref_502","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cbi.2010.08.007","article-title":"Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium","volume":"188","author":"Sergent","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"ref_503","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1074\/jbc.M609426200","article-title":"Essential role of the JAK\/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate","volume":"282","author":"Stempelj","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_504","doi-asserted-by":"crossref","first-page":"C1133","DOI":"10.1152\/ajpcell.00293.2002","article-title":"Interferon-\u03b3 induces C\/EBP\u03b2 expression and activity through MEK\/ERK and p38 in T84 colon epithelial cells","volume":"284","author":"Hukkanen","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_505","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.4049\/jimmunol.178.7.4284","article-title":"TGF-\u03b2suppresses IFN-\u03b3-STAT1-dependent gene transcription by enhancing STAT1-PIAS1 interactions in epithelia but not monocytes\/macrophages","volume":"178","author":"Reardon","year":"2007","journal-title":"J. Immunol."},{"key":"ref_506","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.aam9949","article-title":"Microbiota-activated PPAR-\u03b3 signaling inhibits dysbiotic Enterobacteriaceae expansion","volume":"357","author":"Byndloss","year":"2017","journal-title":"Science"},{"key":"ref_507","doi-asserted-by":"crossref","unstructured":"Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., and Mao, Z. (2024). The emerging role of oxidative stress in inflammatory bowel disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1390351"},{"key":"ref_508","doi-asserted-by":"crossref","first-page":"e13181","DOI":"10.14814\/phy2.13181","article-title":"Activation of TGF-\u03b2-activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease","volume":"5","author":"Liu","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_509","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature05698","article-title":"Epithelial NEMO links innate immunity to chronic intestinal inflammation","volume":"446","author":"Nenci","year":"2007","journal-title":"Nature"},{"key":"ref_510","doi-asserted-by":"crossref","unstructured":"Zong, W., Gong, Y., Sun, W., Li, T., and Wang, Z.Q. (2022). PARP1: Liaison of chromatin remodeling and transcription. Cancers, 14.","DOI":"10.3390\/cancers14174162"},{"key":"ref_511","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1007\/s00210-024-03164-x","article-title":"Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies","volume":"397","author":"Ali","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_512","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/gast.2002.35391","article-title":"HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice","volume":"123","author":"Sappington","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_513","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00011-015-0841-x","article-title":"Role of high-mobility group box-1 protein in inflammatory bowel disease","volume":"64","author":"Hu","year":"2015","journal-title":"Inflamm. Res."},{"key":"ref_514","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1161\/01.CIR.0000143082.63063.33","article-title":"Heat shock protein 70 confers cardiovascular protection during endotoxemia via inhibition of nuclear factor-\u03baB activation and inducible nitric oxide synthase expression in the rostral ventrolateral medulla","volume":"110","author":"Chan","year":"2004","journal-title":"Circulation"},{"key":"ref_515","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/MIB.0000000000000858","article-title":"Emerging roles for noncanonical NF-\u03baB signaling in the modulation inflammatory bowel disease pathobiology","volume":"22","author":"McDaniel","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_516","doi-asserted-by":"crossref","first-page":"e2024828118","DOI":"10.1073\/pnas.2024828118","article-title":"An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-\u03baB module","volume":"118","author":"Chawla","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_517","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/74697","article-title":"HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine","volume":"6","author":"Asea","year":"2000","journal-title":"Nat. Med."},{"key":"ref_518","doi-asserted-by":"crossref","first-page":"249205","DOI":"10.1155\/2015\/249205","article-title":"The chaperone balance hypothesis: The importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management","volume":"2015","author":"Krause","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_519","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1023\/A:1026616221950","article-title":"Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel diseases","volume":"44","author":"Ludwig","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"ref_520","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.4081\/ejh.2011.e38","article-title":"Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy","volume":"55","author":"Tomasello","year":"2011","journal-title":"Eur. J. Histochem."},{"key":"ref_521","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2006.07.028","article-title":"Role of heat shock proteins (molecular chaperones) in intestinal mucosal protection","volume":"348","author":"Otaka","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_522","doi-asserted-by":"crossref","first-page":"G177","DOI":"10.1152\/ajpgi.00307.2002","article-title":"Amelioration of dextran sulfate colitis by butyrate: Role of heat shock protein 70 and NF-\u03baB","volume":"285","author":"Venkatraman","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_523","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1136\/gut.2006.093484","article-title":"PPAR-\u03b3 as a new therapeutic target in inflammatory bowel diseases","volume":"55","author":"Dubuquoy","year":"2006","journal-title":"Gut"},{"key":"ref_524","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_525","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2005.06.071","article-title":"Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts","volume":"129","author":"Andoh","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_526","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1074\/jbc.M611040200","article-title":"The interleukin-22\/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells","volume":"282","author":"Bachmann","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_527","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.bjp.0702039","article-title":"Cytokine induction of NO synthase II in human DLD-1 cells: Roles of the JAK-STAT, AP-1 and NF-\u03baB-signaling pathways","volume":"125","author":"Kleinert","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"ref_528","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.180.4.2659","article-title":"Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP","volume":"180","author":"Grbic","year":"2008","journal-title":"J. Immunol."},{"key":"ref_529","doi-asserted-by":"crossref","unstructured":"Salarpour, F., and S\u00e9vigny, J. (2025). P2Y2 receptor signaling in health and disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26199815"},{"key":"ref_530","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1172\/JCI83585","article-title":"EGFR regulates macrophage activation and function in bacterial infection","volume":"126","author":"Hardbower","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_531","doi-asserted-by":"crossref","first-page":"e135923","DOI":"10.1172\/jci.insight.135923","article-title":"Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration","volume":"5","author":"Zhang","year":"2020","journal-title":"JCI Insight"},{"key":"ref_532","first-page":"90","article-title":"Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway","volume":"130","author":"Miguel","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_533","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/niox.2001.0393","article-title":"Heparin-binding EGF-like growth factor down regulates proinflammatory cytokine-induced nitric oxide and inducible nitric oxide synthase production in intestinal epithelial cells","volume":"6","author":"Mehta","year":"2002","journal-title":"Nitric Oxide"},{"key":"ref_534","doi-asserted-by":"crossref","unstructured":"Tremblay, \u00c9., Thibault, M.P., Ferretti, E., Babakissa, C., Bertelle, V., Bettolli, M., Burghardt, K.M., Colombani, J.F., Grynspan, D., and Levy, E. (2016). Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn\u2019s disease. BMC Med. Genom., 9.","DOI":"10.1186\/s12920-016-0166-9"},{"key":"ref_535","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.niox.2017.03.003","article-title":"The nitric oxide synthase 2 pathway is targeted by both pro- and anti-inflammatory treatments in the immature human intestine","volume":"66","author":"Ferretti","year":"2017","journal-title":"Nitric Oxide"},{"key":"ref_536","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.lfs.2006.09.016","article-title":"Role of endogenous nitric oxide (NO) and NO synthases in healing of indomethacin-induced intestinal ulcers in rats","volume":"80","author":"Takeuchi","year":"2007","journal-title":"Life Sci."},{"key":"ref_537","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1158\/1078-0432.CCR-03-0192","article-title":"Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer","volume":"10","author":"Cianchi","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_538","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ccr.2005.05.007","article-title":"Nuclear interaction of EGFR and STAT3 in the activation of the iNOS\/NO pathway","volume":"7","author":"Lo","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_539","doi-asserted-by":"crossref","first-page":"114050","DOI":"10.1016\/j.ygcen.2022.114050","article-title":"The biological activity and signaling profile of EGF\/EGFR were affected under heat stress conditions in IEC6 cells","volume":"325","author":"Wang","year":"2022","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_540","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2008.11.034","article-title":"P38 MAP kinase controls EGF receptor down-regulation via phosphorylation at Ser1046\/1047","volume":"277","author":"Adachi","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_541","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/MCB.00375-09","article-title":"TAK1-mediated serine\/threonine phosphorylation of epidermal growth factor receptor via p38\/extracellular signal-regulated kinase: NF-\u03baB-independent survival pathways in tumor necrosis factor alpha signaling","volume":"29","author":"Nishimura","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_542","doi-asserted-by":"crossref","first-page":"2364121","DOI":"10.1155\/2023\/2364121","article-title":"Amphiregulin induces iNOS and COX-2 expression through NF-\u03baB and MAPK signaling in hepatic inflammation","volume":"2023","author":"Heo","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"ref_543","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcdb.2015.10.040","article-title":"The role of the calcium-sensing receptor in gastrointestinal inflammation","volume":"49","author":"Owen","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_544","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1016\/j.febslet.2014.05.007","article-title":"Epithelial CaSR deficiency alters intestinal integrity and promotes pro-inflammatory immune responses","volume":"588","author":"Cheng","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_545","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbadis.2014.12.023","article-title":"\u03b3-Glutamyl cysteine and \u03b3-glutamyl valine inhibit TNF-\u03b1 signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor","volume":"1852","author":"Zhang","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_546","doi-asserted-by":"crossref","unstructured":"Piatek, K., Gushchina, V., Kleinw\u00e4chter, A., Kupper, N., Mesteri, I., Elajnaf, T., Iamartino, L., Salzmann, M., M\u00fcller, C., and Manhardt, T. (2024). Targeting the calcium-sensing receptor in chemically induced medium-grade colitis in female BALB\/C mice. Nutrients, 16.","DOI":"10.3390\/nu16244362"},{"key":"ref_547","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diff.2017.08.003","article-title":"Extrinsic control of Wnt signaling in the intestine","volume":"97","author":"Koch","year":"2017","journal-title":"Differentiation"},{"key":"ref_548","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1158\/0008-5472.CAN-09-0014","article-title":"Wnt\/\u03b2-catenin signaling regulates cytokine-induced human inducible nitric oxide synthase expression by inhibiting nuclear factor-\u03baB activation in cancer cells","volume":"69","author":"Du","year":"2009","journal-title":"Cancer Res."},{"key":"ref_549","doi-asserted-by":"crossref","first-page":"116337","DOI":"10.1016\/j.ecoenv.2024.116337","article-title":"Cadmium modulates intestinal Wnt\/\u03b2-catenin signaling ensuing intestinal barrier disruption and systemic inflammation","volume":"277","author":"Verma","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_550","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI80997","article-title":"Rho-A prenylation and signaling links epithelial homeostasis to intestinal inflammation","volume":"126","author":"Becker","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_551","doi-asserted-by":"crossref","first-page":"H1762","DOI":"10.1152\/ajpheart.2000.278.6.H1762","article-title":"Inhibition of Rho protein stimulates iNOS expression in rat vascular smooth muscle cells","volume":"278","author":"Muniyappa","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_552","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.bjp.0703607","article-title":"Inhibition of small G proteins of the Rho family by statins or Clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II","volume":"131","author":"Hausding","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"ref_553","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0014-4827(03)00129-0","article-title":"Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression","volume":"287","author":"Witteck","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_554","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1172\/JCI119812","article-title":"Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages","volume":"100","author":"Pahan","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_555","doi-asserted-by":"crossref","first-page":"G886","DOI":"10.1152\/ajpgi.2000.278.6.G886","article-title":"Intraepithelial lymphocytes coinduce nitric oxide synthase in intestinal epithelial cells","volume":"278","author":"Hoffman","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_556","doi-asserted-by":"crossref","unstructured":"Ke, B.J., Dragoni, G., and Matteoli, G. (2024). Fibroblast heterogeneity in inflammatory bowel disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313008"},{"key":"ref_557","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/intimm\/dxaf015","article-title":"Roles of fibroblasts in the pathogenesis of inflammatory bowel diseases and IBD-associated fibrosis","volume":"37","author":"Ito","year":"2025","journal-title":"Int. Immunol."},{"key":"ref_558","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/ecco-jcc\/jjaa009","article-title":"Stromal cells in the pathogenesis of inflammatory bowel disease","volume":"14","author":"Barnhoorn","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_559","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/1751-2980.12852","article-title":"The fate of myofibroblasts during the development of fibrosis in Crohn\u2019s disease","volume":"21","author":"Li","year":"2020","journal-title":"J. Dig. Dis."},{"key":"ref_560","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1158\/0008-5472.CAN-13-2740","article-title":"Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties","volume":"74","author":"Augsten","year":"2014","journal-title":"Cancer Res."},{"key":"ref_561","first-page":"2749","article-title":"SMAD3 promotes ELK3 expression following transforming growth factor \u03b2-mediated stimulation of MDA-MB231 cells","volume":"19","author":"Park","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_562","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fertnstert.2007.11.059","article-title":"Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through NF-\u03baB activation","volume":"91","author":"Jiang","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_563","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/2050640614548096","article-title":"Colonic motility in ulcerative colitis","volume":"2","author":"Bassotti","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_564","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1748-1716.2006.01576.x","article-title":"Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis","volume":"187","author":"Lundberg","year":"2006","journal-title":"Acta Physiol."},{"key":"ref_565","doi-asserted-by":"crossref","first-page":"G1187","DOI":"10.1152\/ajpgi.00452.2009","article-title":"Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages","volume":"299","author":"Wehner","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_566","doi-asserted-by":"crossref","unstructured":"Lin, Y.M., Li, F., and Shi, X.Z. (2014). Mechanical stress is a pro-inflammatory stimulus in the gut: In vitro, in vivo and ex vivo evidence. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106242"},{"key":"ref_567","doi-asserted-by":"crossref","first-page":"16388","DOI":"10.1074\/jbc.M309664200","article-title":"Transforming growth factor-\u03b21 inhibition of vascular smooth muscle cell activation is mediated via Smad3","volume":"279","author":"Feinberg","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_568","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1074\/jbc.M008170200","article-title":"Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-\u03b21","volume":"276","author":"Pellacani","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_569","doi-asserted-by":"crossref","unstructured":"Mih\u0103ilu\u021b\u0103, F., Chioa\u0219c\u0103, T.P., Onofrei Popa, A., Chelmu Vod\u0103, C., Balt\u0103, A.A.\u0218., Arghir, O.C., and Voinescu, D.C. (2025). The vulnerable vascular network: Endothelial dysfunction as a central driver of intestinal inflammation\u2014A systematic review. Biomedicines, 13.","DOI":"10.3390\/biomedicines13112690"},{"key":"ref_570","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cyto.2011.01.015","article-title":"Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells","volume":"54","author":"Wang","year":"2011","journal-title":"Cytokine"},{"key":"ref_571","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1291\/hypres.27.93","article-title":"Laminar shear stress up-regulates inducible nitric oxide synthase in the endothelium","volume":"27","author":"Ozawa","year":"2004","journal-title":"Hypertens. Res."},{"key":"ref_572","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1128\/IAI.00248-06","article-title":"Intestinal microvascular endothelium and innate immunity in inflammatory bowel disease: A second line of defense?","volume":"74","author":"Heidemann","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_573","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1093\/nar\/gkh906","article-title":"Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors","volume":"32","author":"Hollenhorst","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_574","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/j.gastro.2015.04.007","article-title":"Inhibiting inducible nitric oxide synthase in enteric glia restores electrogenic ion transport in mice with colitis","volume":"149","author":"MacEachern","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_575","doi-asserted-by":"crossref","first-page":"e13198","DOI":"10.1111\/nmo.13198","article-title":"Modulation of VIPergic phenotype of enteric neurons by colonic biopsy supernatants from patients with inflammatory bowel disease: Involvement of IL-6 in Crohn\u2019s disease","volume":"30","author":"Soufflet","year":"2018","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_576","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/gidisord6020025","article-title":"Enteric nervous system alterations in inflammatory bowel disease: Perspectives and implications","volume":"6","author":"Suman","year":"2024","journal-title":"Gastrointest. Disord."},{"key":"ref_577","doi-asserted-by":"crossref","first-page":"goag005","DOI":"10.1093\/gastro\/goag005","article-title":"Enteric nervous system and inflammatory bowel disease","volume":"14","author":"Wang","year":"2026","journal-title":"Gastroenterol. Rep."},{"key":"ref_578","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00011-026-02195-9","article-title":"Inflammatory bowel disease and extracellular matrix: When victim becomes double agent","volume":"75","author":"Sferra","year":"2026","journal-title":"Inflamm. Res."},{"key":"ref_579","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-021-00543-0","article-title":"Revisiting fibrosis in inflammatory bowel disease: The gut thickens","volume":"19","author":"Ungaro","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_580","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1074\/jbc.M310859200","article-title":"Hyaluronan fragments stimulate endothelial recognition of injury through TLR4","volume":"279","author":"Taylor","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_581","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1315","article-title":"Regulation of lung injury and repair by Toll-like receptors and hyaluronan","volume":"11","author":"Jiang","year":"2005","journal-title":"Nat. Med."},{"key":"ref_582","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0002-9440(10)63636-X","article-title":"Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: Inter-\u03b1-trypsin inhibitor is crucial to structure and function","volume":"163","author":"Hascall","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_583","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.matbio.2018.03.011","article-title":"Hyaluronan in inflammatory bowel disease: Cross-linking inflammation and coagulation","volume":"78\u201379","author":"Petrey","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_584","first-page":"132","article-title":"Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation","volume":"16","author":"Oller","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"ref_585","doi-asserted-by":"crossref","first-page":"a021907","DOI":"10.1101\/cshperspect.a021907","article-title":"Regulation of the bioavailability of TGF-\u03b2 and TGF-\u03b2-related proteins","volume":"8","author":"Robertson","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_586","doi-asserted-by":"crossref","first-page":"L862","DOI":"10.1152\/ajplung.1995.268.5.L862","article-title":"TGF-beta regulates production of NO in pulmonary artery smooth muscle cells by inhibiting expression of NOS","volume":"268","author":"Finder","year":"1995","journal-title":"Am. J. Physiol. Lung. Cell. Mol. Physiol."},{"key":"ref_587","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5217\/ir.2015.13.2.105","article-title":"Myeloid-derived suppressor cells in inflammatory bowel disease","volume":"13","author":"Kim","year":"2015","journal-title":"Intest. Res."},{"key":"ref_588","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1038\/s41467-023-40156-6","article-title":"Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease","volume":"14","author":"Corraliza","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_589","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/ibd\/izab029","article-title":"Human intestinal macrophages are involved in the pathology of both ulcerative colitis and Crohn\u2019s disease","volume":"27","author":"Dharmasiri","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_590","doi-asserted-by":"crossref","unstructured":"Kang, J.H., Kim, J.H., Gim, J.A., and Lee, M.Y. (2025). iNOS in macrophage polarization: Pharmacological and regulatory insights. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262412056"},{"key":"ref_591","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1155\/S0962935195000135","article-title":"Modulation of nitric oxide synthase activity in macrophages","volume":"4","author":"Jorens","year":"1995","journal-title":"Mediat. Inflamm."},{"key":"ref_592","doi-asserted-by":"crossref","first-page":"e08670","DOI":"10.1016\/j.heliyon.2021.e08670","article-title":"Production of NOS2 and inflammatory cytokines is reduced by selected protein kinase inhibitors with partial repolarization of HL-60 derived and human blood macrophages","volume":"8","author":"Szokol","year":"2022","journal-title":"Heliyon"},{"key":"ref_593","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/1547691X.2012.686929","article-title":"Role of AP-1 family proteins in regulation of inducible nitric oxide synthase (iNOS) in human neutrophils","volume":"10","author":"Jablonska","year":"2013","journal-title":"J. Immunotoxicol."},{"key":"ref_594","doi-asserted-by":"crossref","unstructured":"Santana, P.T., de Lima, I.S., Silva E Souza, K.C.D., Barbosa, P.H.S., and de Souza, H.S.P. (2024). Persistent activation of the P2X7 receptor underlies chronic inflammation and carcinogenic changes in the intestine. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252010874"},{"key":"ref_595","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/01.MIB.0000441201.10454.06","article-title":"Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn\u2019s disease","volume":"20","author":"Neves","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_596","doi-asserted-by":"crossref","first-page":"102137","DOI":"10.1016\/j.redox.2021.102137","article-title":"Purinergic signaling in the modulation of redox biology","volume":"47","author":"Savio","year":"2021","journal-title":"Redox Biol."},{"key":"ref_597","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.phrs.2013.08.002","article-title":"A1 and A3 adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes","volume":"76","author":"Gessi","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_598","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/sj.bjp.0703375","article-title":"Pyrimidinoceptor potentiation of macrophage PGE2 release involved in the induction of nitric oxide synthase","volume":"130","author":"Chen","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"ref_599","doi-asserted-by":"crossref","first-page":"11322","DOI":"10.1038\/ncomms11322","article-title":"Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution","volume":"7","author":"Lee","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_600","doi-asserted-by":"crossref","unstructured":"Veremeyko, T., Yung, A.W.Y., Anthony, D.C., Strekalova, T., and Ponomarev, E.D. (2018). Early growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription factor CEBP\u03b2. Front. Immunol., 9, Erratum in Front. Immunol. 2018, 9, 2923.","DOI":"10.3389\/fimmu.2018.02515"},{"key":"ref_601","doi-asserted-by":"crossref","first-page":"49304","DOI":"10.1074\/jbc.M205030200","article-title":"Salicylate suppresses macrophage nitric-oxide synthase-2 and cyclo-oxygenase-2 expression by inhibiting CCAAT\/enhancer-binding protein-\u03b2 binding via a common signaling pathway","volume":"277","author":"Cieslik","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_602","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: Enabling diversity with identity","volume":"11","author":"Lawrence","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_603","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1172\/JCI76289","article-title":"TGR5 reduces macrophage migration through mTOR-induced C\/EBP\u03b2 differential translation","volume":"124","author":"Perino","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_604","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1038\/onc.2017.23","article-title":"EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis","volume":"36","author":"Hardbower","year":"2017","journal-title":"Oncogene"},{"key":"ref_605","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.1881410","article-title":"Differential activation and antagonistic functions of HIF-\u03b1 isoforms in macrophages are essential for NO homeostasis","volume":"24","author":"Takeda","year":"2010","journal-title":"Genes Dev."},{"key":"ref_606","doi-asserted-by":"crossref","first-page":"e17167","DOI":"10.1016\/j.heliyon.2023.e17167","article-title":"Hypoxia-inducible factor-1\u03b1 is an important regulator of macrophage biology","volume":"9","author":"Qiu","year":"2023","journal-title":"Heliyon"},{"key":"ref_607","doi-asserted-by":"crossref","unstructured":"Sun, B., Long, Y., Xu, G., Chen, J., Wu, G., Liu, B., and Gao, Y. (2025). Acute hypoxia modulate macrophage phenotype accompanied with transcriptome re-programming and metabolic re-modeling. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1534009"},{"key":"ref_608","doi-asserted-by":"crossref","unstructured":"Platanitis, E., and Decker, T. (2018). Regulatory networks involving STATs, IRFs, and NF-\u03baB in inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02542"},{"key":"ref_609","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.celrep.2016.04.001","article-title":"TNF-mediated restriction of arginase 1 expression in myeloid cells triggers type 2 NO synthase activity at the site of infection","volume":"15","author":"Schleicher","year":"2016","journal-title":"Cell Rep."},{"key":"ref_610","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.niox.2005.05.001","article-title":"TGF-\u03b21 enhances degradation of IFN-\u03b3-induced iNOS protein via proteasomes in RAW 264.7 cells","volume":"13","author":"Mitani","year":"2005","journal-title":"Nitric Oxide"},{"key":"ref_611","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1365-2443.2006.00988.x","article-title":"TGF-\u03b21 enhances degradation of IFN-\u03b3-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation","volume":"11","author":"Takaki","year":"2006","journal-title":"Genes Cells"},{"key":"ref_612","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/17826","article-title":"Inhibition of transforming growth factor-\u03b2\/SMAD signalling by the interferon-\u03b3\/STAT pathway","volume":"397","author":"Ulloa","year":"1999","journal-title":"Nature"},{"key":"ref_613","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/jir.2022.0132","article-title":"IFN-\u03b3 and TGF-\u03b2, crucial players in immune responses: A tribute to Howard Young","volume":"42","author":"Gauthier","year":"2022","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_614","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1084\/jem.178.2.605","article-title":"Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta","volume":"178","author":"Vodovotz","year":"1993","journal-title":"J. Exp. Med."},{"key":"ref_615","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.4049\/jimmunol.162.10.6184","article-title":"Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages","volume":"162","author":"Castrillo","year":"1999","journal-title":"J. Immunol."},{"key":"ref_616","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1073\/pnas.1119038109","article-title":"Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization","volume":"109","author":"Arranz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_617","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/IAI.01235-10","article-title":"Protective role of Akt2 in Salmonella enterica serovar Typhimurium-induced gastroenterocolitis","volume":"79","author":"Kum","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_618","doi-asserted-by":"crossref","first-page":"4629495","DOI":"10.1155\/2017\/4629495","article-title":"Multifaceted roles of GSK-3 in cancer and autophagy-related diseases","volume":"2017","author":"Mancinelli","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_619","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tibs.2016.10.009","article-title":"Stressed and inflamed, can GSK3 be blamed?","volume":"42","author":"Jope","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"ref_620","doi-asserted-by":"crossref","unstructured":"Hoffmeister, L., Diekmann, M., Brand, K., and Huber, R. (2020). GSK3: A kinase balancing promotion and resolution of inflammation. Cells, 9.","DOI":"10.3390\/cells9040820"},{"key":"ref_621","doi-asserted-by":"crossref","first-page":"210563","DOI":"10.1155\/2013\/210563","article-title":"Carbon monoxide attenuates dextran sulfate sodium-induced colitis via inhibition of GSK-3\u03b2 signaling","volume":"2013","author":"Uddin","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_622","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt signaling pathway in macrophage activation and M1\/M2 polarization","volume":"198","author":"Vergadi","year":"2017","journal-title":"J. Immunol."},{"key":"ref_623","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00018-024-05133-2","article-title":"FAM76B regulates PI3K\/Akt\/NF-\u03baB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA","volume":"81","author":"Wang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_624","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-\u03b3 is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"key":"ref_625","doi-asserted-by":"crossref","first-page":"979","DOI":"10.4049\/jimmunol.171.2.979","article-title":"Inhibition of IFN-\u03b3-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor \u03b3 agonist, 15-deoxy-\u039412, 14-prostaglandin J2, involves inhibition of the upstream Janus kinase\/STAT1 signaling pathway","volume":"171","author":"Chen","year":"2003","journal-title":"J. Immunol."},{"key":"ref_626","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.bjp.0707477","article-title":"PPAR-\u03b1 agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages","volume":"152","author":"Paukkeri","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_627","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0016-5085(03)00271-3","article-title":"Impaired expression of peroxisome proliferator-activated receptor \u03b3 in ulcerative colitis","volume":"124","author":"Dubuquoy","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_628","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1084\/jem.20041948","article-title":"Intestinal anti-inflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator\u2013activated receptor-\u03b3","volume":"201","author":"Rousseaux","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_629","doi-asserted-by":"crossref","first-page":"iii68","DOI":"10.1136\/ard.60.90003.iii68","article-title":"The atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages","volume":"60","author":"Kiemer","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"ref_630","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0026-895X(24)12602-8","article-title":"Induction of L-arginine transport is inhibited by atrial natriuretic peptide: A peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability","volume":"60","author":"Kiemer","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"ref_631","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: A potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_632","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/003655202317316105","article-title":"Butyrate inhibits NF-\u03baB activation in lamina propria macrophages of patients with ulcerative colitis","volume":"37","author":"Gerke","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_633","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","article-title":"A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis","volume":"63","author":"Machiels","year":"2014","journal-title":"Gut"},{"key":"ref_634","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.180.3.969","article-title":"Iron regulates nitric oxide synthase activity by controlling nuclear transcription","volume":"180","author":"Weiss","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_635","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.4049\/jimmunol.162.10.6171","article-title":"Central role of transcription factor NF-IL6 for cytokine- and iron-mediated regulation of murine inducible nitric oxide synthase expression","volume":"162","author":"Dlaska","year":"1999","journal-title":"J. Immunol."},{"key":"ref_636","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.3324\/haematol.2010.023879","article-title":"Polarization dictates iron handling by inflammatory and alternatively activated macrophages","volume":"95","author":"Corna","year":"2010","journal-title":"Haematologica"},{"key":"ref_637","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cellimm.2018.12.008","article-title":"Endoplasmic reticulum stress regulates macrophage polarization via EIF-2\u03b1 kinase","volume":"336","author":"Yang","year":"2019","journal-title":"Cell. Immunol."},{"key":"ref_638","doi-asserted-by":"crossref","first-page":"1621334","DOI":"10.3389\/fimmu.2025.1621334","article-title":"Systems biology to unravel Western diet-associated triggers in inflammatory bowel disease","volume":"16","author":"Konjar","year":"2025","journal-title":"Front. Immunol."},{"key":"ref_639","doi-asserted-by":"crossref","unstructured":"Yang, Y., Wang, L., Peugnet-Gonz\u00e1lez, I., Parada-Venegas, D., Dijkstra, G., and Faber, K.N. (2023). cGAS\u2013STING signaling pathway in intestinal homeostasis and disease. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1239142"},{"key":"ref_640","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/eji.202048777","article-title":"The role of cGAS\u2013STING in intestinal immunity","volume":"51","author":"Wottawa","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_641","doi-asserted-by":"crossref","unstructured":"Gomes, M.T.R., Guimar\u00e3es, E.S., Marinho, F.V., Macedo, I., Aguiar, E.R.G.R., Barber, G.N., Moraes-Vieira, P.M.M., Alves-Filho, J.C., and Oliveira, S.C. (2021). STING regulates metabolic reprogramming in macrophages via HIF-1\u03b1 during Brucella infection. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009597"},{"key":"ref_642","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000328636","article-title":"Neuropeptides as pleiotropic modulators of the immune responses","volume":"94","author":"Caro","year":"2011","journal-title":"Neuroendocrinology"},{"key":"ref_643","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1189\/jlb.3A0116-032RR","article-title":"VIP impairs acquisition of the macrophage proinflammatory polarization profile","volume":"100","author":"Juarranz","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_644","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3892\/ijo.2015.3126","article-title":"Vasoactive intestinal peptide represses activation of tumor-associated macrophages in gastric cancer via regulation of TNF\u03b1, IL-6, IL-12 and iNOS","volume":"47","author":"Chen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_645","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41598-023-28073-6","article-title":"Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice","volume":"13","author":"Kittikulsuth","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_646","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bbi.2008.06.001","article-title":"Anti-inflammatory neuropeptides: Endogenous immunoregulatory agents","volume":"22","author":"Delgado","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"ref_647","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1093\/emboj\/18.16.4446","article-title":"Resistance to endotoxic shock as a consequence of defective NF-\u03baB activation in poly (ADP-ribose) polymerase-1 deficient mice","volume":"18","author":"Oliver","year":"1999","journal-title":"EMBO J."},{"key":"ref_648","doi-asserted-by":"crossref","first-page":"45145","DOI":"10.1074\/jbc.M307957200","article-title":"Transcriptional Coactivation of Nuclear Factor-\u03baB-dependent Gene Expression by p300 Is Regulated by Poly(ADP)-ribose Polymerase-1","volume":"278","author":"Hassa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_649","doi-asserted-by":"crossref","first-page":"40450","DOI":"10.1074\/jbc.M507553200","article-title":"Acetylation of poly (ADP-ribose) polymerase-1 by p300\/CREB-binding protein regulates coactivation of NF-\u03baB-dependent transcription","volume":"280","author":"Hassa","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_650","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1006\/bbrc.1998.8113","article-title":"Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF-\u03baB activation","volume":"243","author":"Sanceau","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_651","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1074\/jbc.M116.714386","article-title":"Transcriptional reprogramming and resistance to colonic mucosal injury in poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice","volume":"291","author":"Larmonier","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_652","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1038\/s41467-024-48708-0","article-title":"Disruption of the TIGAR\u2013TAK1 axis alleviates immunopathology in a murine model of sepsis","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_653","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.bbrc.2020.10.007","article-title":"WNK1\u2013TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages","volume":"533","author":"Arai","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_654","doi-asserted-by":"crossref","unstructured":"Park, Y.J., Yoo, S.A., Kim, M., and Kim, W.U. (2020). The role of calcium\u2013calcineurin\u2013NFAT signaling pathway in health and autoimmune diseases. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00195"},{"key":"ref_655","doi-asserted-by":"crossref","first-page":"7025634","DOI":"10.1155\/2022\/7025634","article-title":"Emerging role of dendritic cell intervention in the treatment of inflammatory bowel disease","volume":"2022","author":"Sun","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_656","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-2249.2011.04439.x","article-title":"Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn\u2019s disease and ulcerative colitis","volume":"166","author":"Baumgart","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"ref_657","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.canlet.2017.10.032","article-title":"The role of nitric oxide in metabolic regulation of dendritic cell immune function","volume":"412","author":"Thwe","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_658","doi-asserted-by":"crossref","first-page":"27263","DOI":"10.1038\/srep27263","article-title":"Triggering through NOD-2 differentiates bone marrow precursors to dendritic cells with potent bactericidal activity","volume":"6","author":"Khan","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_659","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nm.4260","article-title":"JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression","volume":"23","author":"Zhao","year":"2017","journal-title":"Nat. Med."},{"key":"ref_660","doi-asserted-by":"crossref","unstructured":"Tang, J., Lin, G., Langdon, W.Y., Tao, L., and Zhang, J. (2018). Regulation of C-type lectin receptor-mediated antifungal immunity. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00123"},{"key":"ref_661","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12602-023-10058-6","article-title":"The effect of Akkermansia muciniphila and its outer membrane vesicles on microRNAs expression of inflammatory and anti-inflammatory pathways in human dendritic cells","volume":"16","author":"Mofrad","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_662","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood-2012-03-419747","article-title":"Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells","volume":"120","author":"Everts","year":"2012","journal-title":"Blood"},{"key":"ref_663","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00281-025-01062-9","article-title":"Crosstalk between the microbiota and intestinal dendritic cells in IBD","volume":"47","author":"Letz","year":"2025","journal-title":"Semin. Immunopathol."},{"key":"ref_664","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1189\/jlb.3RU0914-443R","article-title":"Role of gamma-delta (\u03b3\u03b4) T cells in autoimmunity","volume":"97","author":"Paul","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_665","doi-asserted-by":"crossref","unstructured":"Shiromizu, C.M., and Jancic, C.C. (2018). \u03b3\u03b4 T lymphocytes: An effector cell in autoimmunity and infection. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02389"},{"key":"ref_666","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1038\/s41467-021-23042-x","article-title":"EGFR-HIF1\u03b1 signaling positively regulates the differentiation of IL-9 producing T helper cells","volume":"12","author":"Roy","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_667","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/intimm\/dxl082","article-title":"TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells","volume":"18","author":"Sato","year":"2006","journal-title":"Int. Immunol."},{"key":"ref_668","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1096\/fj.11-186924","article-title":"Kr\u00fcppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation","volume":"25","author":"An","year":"2011","journal-title":"FASEB J."},{"key":"ref_669","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-5793(00)01764-6","article-title":"Up-regulation of gut-enriched kr\u00fcppel-like factor by interferon-\u03b3 in human colon carcinoma cells","volume":"477","author":"Chen","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_670","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1182\/blood.V93.11.3876","article-title":"Interleukin-2-activated rat natural killer cells express inducible nitric oxide synthase that contributes to cytotoxic function and interferon-\u03b3 production","volume":"93","author":"Cifone","year":"1999","journal-title":"Blood"},{"key":"ref_671","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1126\/science.284.5416.951","article-title":"Requirement for type 2 NO synthase for IL-12 signaling in innate immunity","volume":"284","author":"Diefenbach","year":"1999","journal-title":"Science"},{"key":"ref_672","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1182\/blood.V92.6.2093","article-title":"The induction of nitric oxide by interleukin-12 and tumor necrosis factor-alpha in human natural killer cells: Relationship with the regulation of lytic activity","volume":"92","author":"Salvucci","year":"1998","journal-title":"Blood"},{"key":"ref_673","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.163.3.1473","article-title":"Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-\u03b1","volume":"163","author":"Furuke","year":"1999","journal-title":"J. Immunol."},{"key":"ref_674","doi-asserted-by":"crossref","unstructured":"Poggi, A., Benelli, R., Ven\u00e8, R., Costa, D., Ferrari, N., Tosetti, F., and Zocchi, M.R. (2019). Human gut-associated natural killer cells in health and disease. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00961"},{"key":"ref_675","doi-asserted-by":"crossref","first-page":"e000609","DOI":"10.1136\/jitc-2020-000609","article-title":"Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer","volume":"8","author":"Wang","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_676","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/08916934.2017.1283405","article-title":"Aberrant function of myeloid-derived suppressor cells (MDSCs) in experimental colitis and in inflammatory bowel disease (IBD) immune responses","volume":"50","author":"Kontaki","year":"2017","journal-title":"Autoimmunity"},{"key":"ref_677","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1053\/j.gastro.2008.06.032","article-title":"Myeloid-derived suppressor cells in inflammatory bowel disease: A new immunoregulatory pathway","volume":"135","author":"Haile","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_678","doi-asserted-by":"crossref","unstructured":"Zhu, Y., and Cao, S. (2025). Unraveling the complexities of myeloid-derived suppressor cells in inflammatory bowel disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073291"},{"key":"ref_679","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.4049\/jimmunol.181.7.4666","article-title":"Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells","volume":"181","author":"Sinha","year":"2008","journal-title":"J. Immunol."},{"key":"ref_680","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20080132","article-title":"Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein","volume":"205","author":"Cheng","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_681","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2003-08-2990","article-title":"Expression, localization, and regulation of NOS in human mast cell lines: Effects on leukotriene production","volume":"104","author":"Gilchrist","year":"2004","journal-title":"Blood"},{"key":"ref_682","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1034\/j.1600-0463.2003.1111008.x","article-title":"Inducible nitric oxide synthase (NOS II) is constitutive in human neutrophils","volume":"111","author":"Cedergren","year":"2003","journal-title":"APMIS"},{"key":"ref_683","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1172\/JCI119121","article-title":"Bacterial infection induces nitric oxide synthase in human neutrophils","volume":"99","author":"Wheeler","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_684","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1089\/ars.2012.4970","article-title":"Interaction of inducible nitric oxide synthase with Rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: Implication in microbial killing","volume":"20","author":"Jyoti","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_685","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.niox.2016.06.002","article-title":"High oxidative stress adversely affects NF\u03baB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia","volume":"58","author":"Singh","year":"2016","journal-title":"Nitric Oxide"},{"key":"ref_686","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.4049\/jimmunol.0902958","article-title":"Constitutive association of TGF-\u03b2\u2013activated kinase 1 with the I\u03baB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes","volume":"184","author":"Ear","year":"2010","journal-title":"J. Immunol."},{"key":"ref_687","doi-asserted-by":"crossref","first-page":"e1739","DOI":"10.1002\/ctm2.1739","article-title":"Neutrophils: Old cells in IBD, new actors in interactions with the gut microbiota","volume":"14","author":"Danne","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"ref_688","doi-asserted-by":"crossref","unstructured":"W\u00e9ra, O., Lancellotti, P., and Oury, C. (2016). The dual role of neutrophils in inflammatory bowel diseases. J. Clin. Med., 5.","DOI":"10.3390\/jcm5120118"},{"key":"ref_689","doi-asserted-by":"crossref","unstructured":"Putro, E., Carnevale, A., Marangio, C., Fulci, V., Paolini, R., and Molfetta, R. (2024). New insight into intestinal mast cells revealed by single-cell RNA sequencing. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202404.0537.v1"},{"key":"ref_690","first-page":"G222","article-title":"Nitric oxide synthesis inhibition increases epithelial permeability via mast cells","volume":"266","author":"Kanwar","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_691","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10620-006-9409-5","article-title":"Modulatory effect of nitric oxide on mast cells during induction of dextran sulfate sodium colitis","volume":"52","author":"Videla","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref_692","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1097\/MIB.0000000000000142","article-title":"The multifaceted mast cell in inflammatory bowel disease","volume":"20","author":"Hamilton","year":"2014","journal-title":"Inflamm. Bowel Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8359\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:29:55Z","timestamp":1790864995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":692,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27188359"],"URL":"https:\/\/doi.org\/10.3390\/ijms27188359","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]}}}