{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:54:31Z","timestamp":1790916871098,"version":"4.1.0"},"reference-count":173,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R00NS134965"],"award-info":[{"award-number":["R00NS134965"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Chronic pain is maintained by persistent, maladaptive molecular processes, many of which converge on ion channels. In sensory neurons, these processes include transcriptional reprogramming, altered trafficking, and remodeling of the channel complexes that set membrane excitability. Accumulating evidence indicates that the major ion channel changes driving chronification of neuropathic pain are not restricted to injured sensory neurons but also arise within the adjacent population of spared neurons. Here we review the ion channel alterations that sustain chronic pain states, the mechanisms by which neurons modulate expression of these channels, and the electrophysiological and functional consequences of these shifts in expression profile. We close by examining existing therapeutics directed at these channels and their regulatory mechanisms, which may offer means of interrupting the maintenance of neuropathic pain.<\/jats:p>","DOI":"10.3390\/ijms27188365","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:23:56Z","timestamp":1790864636000},"page":"8365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spared but Not Silent: Ion Channel Plasticity in Uninjured Sensory Neurons in Neuropathic Pain"],"prefix":"10.3390","volume":"27","author":[{"given":"Andrew","family":"Speidell","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University, Dallas, TX 75246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1867-5041","authenticated-orcid":false,"given":"Kimberly","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Texas A&M University, Dallas, TX 75246, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: Aetiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroscience.2004.12.036","article-title":"Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy","volume":"132","author":"Shim","year":"2005","journal-title":"Neuroscience"},{"key":"ref_4","unstructured":"Wall, P., and Melzack, R. (1999). Pathophysiology of damaged nerves in relation to chronic pain. Textbook of Pain, Churchill Livingstone. [4th ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: A maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbi.2018.04.016","article-title":"Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury","volume":"71","author":"Yang","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neures.2018.04.002","article-title":"Upregulation of Cav3.2 T-type calcium channels in adjacent intact L4 dorsal root ganglion neurons in neuropathic pain rats with L5 spinal nerve ligation","volume":"142","author":"Liu","year":"2019","journal-title":"Neurosci. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, W., Chi, Y.N., Kang, X.J., Liu, Q.Y., Zhang, H.L., Li, Z.H., Zhao, Z.F., Yang, Y., Su, L., and Cai, J. (2018). Accumulation of Cav3.2 T-type Calcium Channels in the Uninjured Sural Nerve Contributes to Neuropathic Pain in Rats with Spared Nerve Injury. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00024"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1523\/JNEUROSCI.0181-19.2019","article-title":"Cdk5-Dependent Phosphorylation of CaV3.2 T-Type Channels: Possible Role in Nerve Ligation-Induced Neuropathic Allodynia and the Compound Action Potential in Primary Afferent C Fibers","volume":"40","author":"Gomez","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuroscience.2021.07.013","article-title":"L5-6 Spinal Nerve Ligation-induced Neuropathy Changes the Location and Function of Ca2+ Channels and Cdk5 and Affects the Compound Action Potential in Adjacent Intact L4 Afferent Fibers","volume":"471","author":"Gomez","year":"2021","journal-title":"Neuroscience"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"173587","DOI":"10.1016\/j.ejphar.2020.173587","article-title":"Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain","volume":"888","author":"Tomita","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pain.2010.06.005","article-title":"TNF-\u03b1 contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury","volume":"151","author":"He","year":"2010","journal-title":"Pain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pain.2006.03.011","article-title":"The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat","volume":"123","author":"Xu","year":"2006","journal-title":"Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1073\/pnas.96.14.7640","article-title":"A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3\/SNS and NaN\/SNS2, in rat models of chronic pain","volume":"96","author":"Porreca","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1523\/JNEUROSCI.23-01-00158.2003","article-title":"Redistribution of NaV1.8 in uninjured axons enables neuropathic pain","volume":"23","author":"Gold","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.brainres.2004.02.057","article-title":"Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury","volume":"1009","author":"Zhang","year":"2004","journal-title":"Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1046\/j.0953-816x.2001.01591.x","article-title":"VR1 protein expression increases in undamaged DRG neurons after partial nerve injury","volume":"13","author":"Hudson","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10211","DOI":"10.1523\/JNEUROSCI.3388-04.2004","article-title":"Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation","volume":"24","author":"Obata","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"170910","DOI":"10.1155\/2013\/170910","article-title":"Low Frequency Electroacupuncture Alleviated Spinal Nerve Ligation Induced Mechanical Allodynia by Inhibiting TRPV1 Upregulation in Ipsilateral Undamaged Dorsal Root Ganglia in Rats","volume":"2013","author":"Jiang","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1002\/cne.24884","article-title":"Perineural application of resiniferatoxin on uninjured L3 and L4 nerves completely alleviates thermal and mechanical hypersensitivity following L5 nerve injury in rats","volume":"528","author":"Javed","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00001756-200403010-00015","article-title":"Spinal nerve injury increases the percentage of cold-responsive DRG neurons","volume":"15","author":"Djouhri","year":"2004","journal-title":"Neuroreport"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1172\/JCI25437","article-title":"TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury","volume":"115","author":"Obata","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.expneurol.2006.01.031","article-title":"Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats","volume":"200","author":"Katsura","year":"2006","journal-title":"Exp. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/j.pain.0000000000002402","article-title":"Genetic and functional evidence for gp130\/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain","volume":"163","author":"Kalpachidou","year":"2022","journal-title":"Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/kjm2.12088","article-title":"Voltage-gated sodium channel 1.7 expression decreases in dorsal root ganglia in a spinal nerve ligation neuropathic pain model","volume":"35","author":"Li","year":"2019","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1523\/JNEUROSCI.3066-05.2005","article-title":"Upregulation of the voltage-gated sodium channel \u03b22 subunit in neuropathic pain models: Characterization of expression in injured and non-injured primary sensory neurons","volume":"25","author":"Pertin","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2018.06.001","article-title":"Blockade of anoctamin-1 in injured and uninjured nerves reduces neuropathic pain","volume":"1696","author":"Garcia","year":"2018","journal-title":"Brain Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jpain.2022.12.005","article-title":"Bestrophin-1 Participates in Neuropathic Pain Induced by Spinal Nerve Transection but not Spinal Nerve Ligation","volume":"24","author":"Garcia","year":"2023","journal-title":"J. Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1744806919847810","DOI":"10.1177\/1744806919847810","article-title":"Electroacupuncture downregulates P2X3 receptor expression in dorsal root ganglia of the spinal nerve-ligated rat","volume":"15","author":"Liang","year":"2019","journal-title":"Mol. Pain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/310501a0","article-title":"A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones","volume":"310","author":"Carbone","year":"1984","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/316440a0","article-title":"Three types of neuronal calcium channel with different calcium agonist sensitivity","volume":"316","author":"Nowycky","year":"1985","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1113\/jphysiol.1987.sp016864","article-title":"Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones","volume":"394","author":"Fox","year":"1987","journal-title":"J. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(91)90073-9","article-title":"Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS","volume":"7","author":"Snutch","year":"1991","journal-title":"Neuron"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","article-title":"Nomenclature of voltage-gated calcium channels","volume":"25","author":"Ertel","year":"2000","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1126\/science.1321501","article-title":"Structure and functional expression of an \u03c9-conotoxin-sensitive human N-type calcium channel","volume":"257","author":"Williams","year":"1992","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1523\/JNEUROSCI.15-10-06403.1995","article-title":"Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels","volume":"15","author":"Westenbroek","year":"1995","journal-title":"J. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1113\/jphysiol.2006.115030","article-title":"Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels","volume":"576","author":"Castiglioni","year":"2006","journal-title":"J. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0896-6273(03)00801-8","article-title":"Cell-specific alternative splicing increases calcium channel current density in the pain pathway","volume":"41","author":"Bell","year":"2004","journal-title":"Neuron"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e2305215120","DOI":"10.1073\/pnas.2305215120","article-title":"A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain","volume":"120","author":"Gomez","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","first-page":"E12043","article-title":"Ablation of \u03b12\u03b4-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo","volume":"115","author":"Ramgoolam","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12856","DOI":"10.1523\/JNEUROSCI.2700-10.2010","article-title":"The \u03b12\u03b4 ligand gabapentin inhibits the Rab11-dependent recycling of the calcium channel subunit \u03b12\u03b4-2","volume":"30","author":"Dolphin","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"zqac058","DOI":"10.1093\/function\/zqac058","article-title":"Capsaicin-Induced Endocytosis of Endogenous Presynaptic CaV2.2 in DRG-Spinal Cord Co-Cultures Inhibits Presynaptic Function","volume":"4","author":"Ramgoolam","year":"2023","journal-title":"Function"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.expneurol.2012.12.007","article-title":"The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection","volume":"241","author":"Wei","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbi.2014.08.003","article-title":"Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons","volume":"44","author":"Zang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3892\/etm.2017.4071","article-title":"Impact of gabapentin on neuronal high voltage-activated Ca2+ channel properties of injured-side axotomized and adjacent uninjured dorsal root ganglions in a rat model of spinal nerve ligation","volume":"13","author":"Zhu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Won, Y.J., Ono, F., and Ikeda, S.R. (2012). Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042602"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1523\/JNEUROSCI.12-05-01789.1992","article-title":"Multiple Ca2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons","volume":"12","author":"Scroggs","year":"1992","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/brain\/awaf214","article-title":"Functional expression of the T-type Cav3.2 calcium channel in female and male human dorsal root ganglion neurons","volume":"149","author":"Chemin","year":"2026","journal-title":"Brain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.celrep.2014.12.042","article-title":"The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function","volume":"10","author":"Francois","year":"2015","journal-title":"Cell Rep."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wu, J., Peng, S., Xiao, L., Cheng, X., Kuang, H., Zhu, M., Zhang, D., Jiang, C., and Liu, T. (2018). Cell-Type Specific Distribution of T-Type Calcium Currents in Lamina II Neurons of the Rat Spinal Cord. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00370"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1038\/s41598-019-39703-3","article-title":"Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons","volume":"9","author":"Candelas","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1073\/pnas.86.17.6802","article-title":"Transient low-threshold Ca2+ current triggers burst firing through an afterdepolarizing potential in an adult mammalian neuron","volume":"86","author":"White","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4161\/chan.4.6.14106","article-title":"Contributions of T-type calcium channel isoforms to neuronal firing","volume":"4","author":"Cain","year":"2010","journal-title":"Channels"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1523\/JNEUROSCI.0068-12.2012","article-title":"Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons","volume":"32","author":"Jacus","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.emboj.7600515","article-title":"Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception","volume":"24","author":"Bourinet","year":"2005","journal-title":"EMBO J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pain.2009.06.012","article-title":"In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy","volume":"145","author":"Messinger","year":"2009","journal-title":"Pain"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1601-183X.2006.00268.x","article-title":"Attenuated pain responses in mice lacking CaV3.2 T-type channels","volume":"6","author":"Choi","year":"2007","journal-title":"Genes Brain Behav."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13705","DOI":"10.1073\/pnas.1511740112","article-title":"Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties","volume":"112","author":"Blesneac","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00424-013-1259-3","article-title":"Surface expression and function of Cav3.2 T-type calcium channels are controlled by asparagine-linked glycosylation","volume":"465","author":"Weiss","year":"2013","journal-title":"Pfl\u00fcg. Arch.\u2014Eur. J. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.neuron.2014.07.036","article-title":"The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity","volume":"83","author":"Gadotti","year":"2014","journal-title":"Neuron"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"15489","DOI":"10.1074\/jbc.M111.310763","article-title":"Transcriptional regulation of T-type calcium channel CaV3.2: Bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)","volume":"287","author":"Schaub","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bcp.2015.08.005","article-title":"Functional upregulation of the H2S\/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells","volume":"97","author":"Fukami","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1744806916642444","DOI":"10.1177\/1744806916642444","article-title":"A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain","volume":"12","author":"Gadotti","year":"2016","journal-title":"Mol. Pain"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12990-015-0011-8","article-title":"Small organic molecule disruptors of Cav3.2\u2014USP5 interactions reverse inflammatory and neuropathic pain","volume":"11","author":"Gadotti","year":"2015","journal-title":"Mol. Pain"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1152\/jn.1994.72.1.466","article-title":"Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy","volume":"72","author":"Waxman","year":"1994","journal-title":"J. Neurophysiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1002\/j.1460-2075.1989.tb08534.x","article-title":"Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development","volume":"8","author":"Beckh","year":"1989","journal-title":"EMBO J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0304-3959(99)00169-4","article-title":"Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain","volume":"83","author":"Fjell","year":"1999","journal-title":"Pain"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1152\/jn.1999.82.5.2776","article-title":"Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons","volume":"82","author":"Black","year":"1999","journal-title":"J. Neurophysiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pain.2005.05.027","article-title":"Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats","volume":"117","author":"Lindia","year":"2005","journal-title":"Pain"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2010.09.048","article-title":"Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro","volume":"1363","author":"Zang","year":"2010","journal-title":"Brain Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1523\/JNEUROSCI.21-16-05952.2001","article-title":"Nav1.3 sodium channels: Rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons","volume":"21","author":"Cummins","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0962-8924(01)02064-5","article-title":"Signal transduction by tumor necrosis factor and its relatives","volume":"11","author":"Baud","year":"2001","journal-title":"Trends Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/379257a0","article-title":"A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons","volume":"379","author":"Akopian","year":"1996","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1074\/jbc.271.11.5953","article-title":"Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons","volume":"271","author":"Sangameswaran","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1152\/jn.00113.2015","article-title":"Human Nav1.8: Enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons","volume":"113","author":"Han","year":"2015","journal-title":"J. Neurophysiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17360","DOI":"10.1038\/s41598-024-67793-1","article-title":"Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner","volume":"14","author":"Kimourtzis","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.mcn.2007.09.007","article-title":"Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain","volume":"37","author":"Berta","year":"2008","journal-title":"Mol. Cell Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1097\/j.pain.0000000000001018","article-title":"Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C","volume":"158","author":"Xie","year":"2017","journal-title":"Pain"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3959(95)00096-8","article-title":"Contributions of injured and intact afferents to neuropathic pain in an experimental rat model","volume":"64","author":"Yoon","year":"1996","journal-title":"Pain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0304-3959(01)00391-8","article-title":"Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8","volume":"95","author":"Lai","year":"2002","journal-title":"Pain"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.290.5489.124","article-title":"Potent analgesic effects of GDNF in neuropathic pain states","volume":"290","author":"Boucher","year":"2000","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1152\/jn.2001.85.2.630","article-title":"Axotomy- and autotomy-induced changes in the excitability of rat dorsal root ganglion neurons","volume":"85","author":"Abdulla","year":"2001","journal-title":"J. Neurophysiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1152\/jn.1994.72.1.349","article-title":"Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels","volume":"72","author":"Matzner","year":"1994","journal-title":"J. Neurophysiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1016\/S0304-3959(99)00147-5","article-title":"The molecular pathophysiology of pain: Abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons","volume":"82","author":"Waxman","year":"1999","journal-title":"Pain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1523\/JNEUROSCI.22-17-07746.2002","article-title":"Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents","volume":"22","author":"Wu","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.expneurol.2010.11.017","article-title":"TNF-\u03b1 enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury","volume":"227","author":"Chen","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/224285a0","article-title":"Abnormal electroretinogram from a Drosophila mutant","volume":"224","author":"Cosens","year":"1969","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0304-3940(98)00475-3","article-title":"Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia","volume":"250","author":"Helliwell","year":"1998","journal-title":"Neurosci. Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1523\/JNEUROSCI.19-05-01844.1999","article-title":"Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy","volume":"19","author":"Michael","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: A heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pain.2005.07.016","article-title":"TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator","volume":"118","author":"Joseph","year":"2005","journal-title":"Pain"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1744-8069-3-31","article-title":"Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4\u2212\/\u2212 mice","volume":"3","author":"Chen","year":"2007","journal-title":"Mol. Pain"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-3959(00)00354-7","article-title":"Partial sciatic nerve transection as a model of neuropathic pain: A qualitative and quantitative neuropathological study","volume":"89","author":"Lindenlaub","year":"2000","journal-title":"Pain"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(90)91074-S","article-title":"A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury","volume":"43","author":"Seltzer","year":"1990","journal-title":"Pain"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/35050121","article-title":"Induction of vanilloid receptor channel activity by protein kinase C","volume":"408","author":"Premkumar","year":"2000","journal-title":"Nature"},{"key":"ref_97","first-page":"128","article-title":"[Effect of electroacupuncture with different frequencies on neuropathic pain in a rat model]","volume":"18","author":"Sun","year":"2002","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1213\/ANE.0b013e31826f0a4a","article-title":"The effects of electroacupuncture on the extracellular signal-regulated kinase 1\/2\/P2X3 signal pathway in the spinal cord of rats with chronic constriction injury","volume":"116","author":"Yu","year":"2013","journal-title":"Anesth. Analg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1007\/s00125-011-2117-5","article-title":"Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats","volume":"54","author":"Manni","year":"2011","journal-title":"Diabetologia"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1523\/JNEUROSCI.11-10-03165.1991","article-title":"Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: Comparison of Schwann cells with other cell types","volume":"11","author":"Matsuoka","year":"1991","journal-title":"J. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nature"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"19564","DOI":"10.1073\/pnas.0609598103","article-title":"TRP channel activation by reversible covalent modification","volume":"103","author":"Hinman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1523\/JNEUROSCI.1822-09.2009","article-title":"A key role for gp130 expressed on peripheral sensory nerves in pathological pain","volume":"29","author":"Andratsch","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"14805","DOI":"10.1074\/jbc.272.23.14805","article-title":"A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia","volume":"272","author":"Sangameswaran","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"E1670","DOI":"10.1002\/humu.21325","article-title":"Congenital insensitivity to pain: Novel SCN9A missense and in-frame deletion mutations","volume":"31","author":"Cox","year":"2010","journal-title":"Hum. Mutat."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/cne.21786","article-title":"Comparative study of the distribution of the \u03b1-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons","volume":"510","author":"Fukuoka","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/jcp.20846","article-title":"Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line","volume":"210","author":"Brackenbury","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"24316","DOI":"10.1074\/jbc.M113.474924","article-title":"CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking","volume":"288","author":"Dustrude","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"E8443","DOI":"10.1073\/pnas.1610531113","article-title":"Hierarchical CRMP2 posttranslational modifications control NaV1.7 function","volume":"113","author":"Dustrude","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/mp.2017.117","article-title":"Blocking CRMP2 SUMOylation reverses neuropathic pain","volume":"23","author":"Moutal","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1097\/j.pain.0000000000001951","article-title":"Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain","volume":"161","author":"Moutal","year":"2020","journal-title":"Pain"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s40122-024-00697-0","article-title":"Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain","volume":"14","author":"Osteen","year":"2025","journal-title":"Pain Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1021\/acs.jmedchem.7b00598","article-title":"Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7","volume":"60","author":"Swain","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"eabh1314","DOI":"10.1126\/scitranslmed.abh1314","article-title":"Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents","volume":"13","author":"Cai","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e2217800120","DOI":"10.1073\/pnas.2217800120","article-title":"Identification and targeting of a unique NaV1.7 domain driving chronic pain","volume":"120","author":"Gomez","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bbrc.2004.05.026","article-title":"Role of auxiliary \u03b21-, \u03b22-, and \u03b23-subunits and their interaction with Nav1.8 voltage-gated sodium channel","volume":"319","author":"Vijayaragavan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tips.2005.08.002","article-title":"Regulation of Nav channels in sensory neurons","volume":"26","author":"Chahine","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1073\/pnas.030362197","article-title":"\u03b23: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics","volume":"97","author":"Morgan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1523\/JNEUROSCI.23-20-07577.2003","article-title":"Sodium channel \u03b24, a new disulfide-linked auxiliary subunit with similarity to \u03b22","volume":"23","author":"Yu","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0092-8674(86)90664-1","article-title":"Biosynthesis and processing of the \u03b1 subunit of the voltage-sensitive sodium channel in rat brain neurons","volume":"46","author":"Schmidt","year":"1986","journal-title":"Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"17072","DOI":"10.1073\/pnas.212638099","article-title":"Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel \u03b22-subunits","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/jn.00184.2021","article-title":"A novel gain-of-function sodium channel \u03b22 subunit mutation in idiopathic small fiber neuropathy","volume":"126","author":"Alsaloum","year":"2021","journal-title":"J. Neurophysiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1172\/JCI41084","article-title":"The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl\u2212 channels","volume":"120","author":"Liu","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-10-5","article-title":"Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity","volume":"10","author":"Lee","year":"2014","journal-title":"Mol. Pain"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1007\/s12035-021-02520-9","article-title":"The Role of TMEM16A\/ERK\/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI)","volume":"58","author":"Chen","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.4103\/1673-5374.250631","article-title":"Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury","volume":"14","author":"Chen","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/hmg\/7.9.1517","article-title":"Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best\u2019s disease)","volume":"7","author":"Marquardt","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/915","article-title":"Identification of the gene responsible for Best macular dystrophy","volume":"19","author":"Petrukhin","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5607\/en.2017.26.3.113","article-title":"Distribution and Function of the Bestrophin-1 (Best1) Channel in the Brain","volume":"26","author":"Oh","year":"2017","journal-title":"Exp. Neurobiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"10063","DOI":"10.1523\/JNEUROSCI.1312-09.2009","article-title":"Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl\u2212 current expression in axotomized sensory neurons","volume":"29","author":"Boudes","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/377428a0","article-title":"A P2X purinoceptor expressed by a subset of sensory neurons","volume":"377","author":"Chen","year":"1995","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/377432a0","article-title":"Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons","volume":"377","author":"Lewis","year":"1995","journal-title":"Nature"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuropharm.2008.06.067","article-title":"ATP-gated P2X cation-channels","volume":"56","author":"Jarvis","year":"2009","journal-title":"Neuropharmacology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/mcne.1998.0719","article-title":"The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor","volume":"12","author":"Bradbury","year":"1998","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0304-3959(00)00456-5","article-title":"Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia","volume":"91","author":"Tsuzuki","year":"2001","journal-title":"Pain"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/(SICI)1097-4598(199904)22:4<502::AID-MUS12>3.0.CO;2-K","article-title":"Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy","volume":"22","author":"Ishikawa","year":"1999","journal-title":"Muscle Nerve"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0169-328X(02)00388-1","article-title":"Downregulation of voltage-gated potassium channel \u03b1 gene expression in dorsal root ganglia following chronic constriction injury of the rat sciatic nerve","volume":"105","author":"Kim","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2009.12.021","article-title":"Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury","volume":"166","author":"Uchida","year":"2010","journal-title":"Neuroscience"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"13373","DOI":"10.1073\/pnas.231376298","article-title":"Distinct potassium channels on pain-sensing neurons","volume":"98","author":"Rasband","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.pain.2008.06.015","article-title":"Activation of interleukin-1\u03b2 receptor suppresses the voltage-gated potassium currents in the small-diameter trigeminal ganglion neurons following peripheral inflammation","volume":"139","author":"Takeda","year":"2008","journal-title":"Pain"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1471-4159.2010.06863.x","article-title":"Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: Role of brain-derived neurotrophic factor","volume":"114","author":"Cao","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1523\/JNEUROSCI.3503-08.2009","article-title":"p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents","volume":"29","author":"Luther","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2015.03.041","article-title":"Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats","volume":"295","author":"Smith","year":"2015","journal-title":"Neuroscience"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1085\/jgp.118.3.237","article-title":"Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions","volume":"118","author":"Wang","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1097\/j.pain.0000000000001224","article-title":"Hyperpolarization-activated cyclic nucleotide-gated channels contribute to spontaneous activity in L4 C-fiber nociceptors, but not A\u03b2-non-nociceptors, after axotomy of L5-spinal nerve in the rat in vivo","volume":"159","author":"Djouhri","year":"2018","journal-title":"Pain"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pain.2004.01.029","article-title":"Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy","volume":"109","author":"Flatters","year":"2004","journal-title":"Pain"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(03)00177-5","article-title":"Reversal of experimental neuropathic pain by T-type calcium channel blockers","volume":"105","author":"Dogrul","year":"2003","journal-title":"Pain"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e013530","DOI":"10.1136\/bmjopen-2016-013530","article-title":"Assessment of the effectiveness and safety of Ethosuximide in the Treatment of non-Diabetic Peripheral Neuropathic Pain: EDONOT-protocol of a randomised, parallel, controlled, double-blinded and multicentre clinical trial","volume":"6","author":"Kerckhove","year":"2016","journal-title":"BMJ Open"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/ejp.1221","article-title":"Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial","volume":"22","author":"Kerckhove","year":"2018","journal-title":"Eur. J. Pain"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1111\/jns.12080_2","article-title":"Z944: A first in class T-type calcium channel modulator for the treatment of pain","volume":"19","author":"Lee","year":"2014","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bcp.2014.03.015","article-title":"A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats","volume":"89","author":"Jarvis","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/pm\/pnv068","article-title":"A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the T-Type Calcium Channel Blocker ABT-639 in an Intradermal Capsaicin Experimental Pain Model in Healthy Adults","volume":"17","author":"Wallace","year":"2016","journal-title":"Pain Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/j.pain.0000000000000263","article-title":"A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain","volume":"156","author":"Ziegler","year":"2015","journal-title":"Pain"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/brain\/aws225","article-title":"Neurological perspectives on voltage-gated sodium channels","volume":"135","author":"Eijkelkamp","year":"2012","journal-title":"Brain"},{"key":"ref_158","first-page":"682","article-title":"Future potential and status of selective sodium channel blockers for the treatment of pain","volume":"12","author":"Priest","year":"2009","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"ref_159","first-page":"CD005451","article-title":"Carbamazepine for chronic neuropathic pain and fibromyalgia in adults","volume":"2014","author":"Wiffen","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/15360288.2026.2624502","article-title":"The Clinical Application of Suzetrigine","volume":"40","author":"Yuan","year":"2026","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMoa2602910","article-title":"Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain","volume":"395","author":"Singla","year":"2026","journal-title":"N. Engl. J. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"101971","DOI":"10.1016\/j.eclinm.2023.101971","article-title":"Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): A phase 2 placebo-controlled enriched-enrolment randomised withdrawal study","volume":"59","author":"Faber","year":"2023","journal-title":"eClinicalMedicine"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.2147\/JPR.S247182","article-title":"Design of Phase 3 Studies Evaluating Vixotrigine for Treatment of Trigeminal Neuralgia","volume":"13","author":"Kotecha","year":"2020","journal-title":"J. Pain Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/j.pain.0000000000001227","article-title":"Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy","volume":"159","author":"McDonnell","year":"2018","journal-title":"Pain"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3959(99)00007-X","article-title":"Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation","volume":"81","author":"Nolano","year":"1999","journal-title":"Pain"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/bja\/aer260","article-title":"Topical capsaicin for pain management: Therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch","volume":"107","author":"Anand","year":"2011","journal-title":"Br. J. Anaesth."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e738","DOI":"10.1097\/j.pain.0000000000002470","article-title":"Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: Impact of preserved small nerve fiber function","volume":"163","author":"Jain","year":"2022","journal-title":"Pain"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/13543776.2020.1797679","article-title":"Transient receptor potential ankyrin 1 (TRPA1) antagonists: A patent review (2015\u20132019)","volume":"30","author":"Chen","year":"2020","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"O\u2019Driscoll, K.E., Pipe, R.A., and Britton, F.C. (2011). Increased complexity of Tmem16a\/Anoctamin 1 transcript alternative splicing. BMC Mol. Biol., 12.","DOI":"10.1186\/1471-2199-12-35"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"19877","DOI":"10.1038\/s41598-021-99177-0","article-title":"Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers","volume":"11","author":"Davenport","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/j.pain.0000000000003085","article-title":"Efficacy and safety of eliapixant in diabetic neuropathic pain and prediction of placebo responders with an exploratory novel algorithm: Results from the randomized controlled phase 2a PUCCINI study","volume":"165","author":"Bouhassira","year":"2024","journal-title":"Pain"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: Multiple explanations of a controversial phenomenon","volume":"13","author":"Mogil","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Guan, L.C., Liu, J., Luo, Z., Jiang, M., Zhang, J.M., and Zheng, Q. (2026). In vivo GCaMP imaging reveals distinct subsets of dorsal root ganglion neurons driving spontaneous pain after nerve injury in mice. Pain, online ahead of printing.","DOI":"10.1097\/j.pain.0000000000004084"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8365\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:17:24Z","timestamp":1790914644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/18\/8365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":173,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27188365"],"URL":"https:\/\/doi.org\/10.3390\/ijms27188365","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]}}}