{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:10:54Z","timestamp":1790097054267,"version":"4.0.1"},"reference-count":53,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Division of Intramural Research of NIAID"},{"DOI":"10.13039\/501100001691","name":"JSPS Fellowship for Japanese Biomedical and Behavioral Research in NIH and JSPS KAKENHI","doi-asserted-by":"publisher","award":["19K16881"],"award-info":[{"award-number":["19K16881"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS Fellowship for Japanese Biomedical and Behavioral Research in NIH and JSPS KAKENHI","doi-asserted-by":"publisher","award":["24K10092"],"award-info":[{"award-number":["24K10092"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Here we report that Dectin-1-stimulated dendritic cells (DCs) induce unique IL-10-producing T cells with strong regulatory function during fungal infection or experimental asthma. These T cells, which we call Dect-10 T cells, are induced by DC-initiated signaling that sets in motion two complementary mechanisms of IL-10-producing T cell differentiation. The first involves induction of nascent Dect-10 T cell IL-4 synthesis and attendant GATA3 production, the latter being a factor that exerts canonical and epigenetic transcriptional function at separate IL-10 promoter sites. The second involves TGF\u03b2 superfamily signaling associated with induction of glutaminolysis and generation of alpha-ketoglutarate, a factor that induces rapamycin-sensitive TORC1 activation; in turn, such activation causes the translation of the LIP isoform of C\/EBP\u03b2 and the formation of a CREB1-LIP complex that binds to adjacent sites on the IL-10 promoter to facilitate the transactivation of the IL10 gene. Dect-10 T cell regulatory function is manifested through its capacity to down-regulate normally protective immune responses to hyphal C. albicans renal infection. In addition, Dect-10 T cells, in accord with their IL-4-dependent genesis, suppress dust mite-induced experimental asthma.<\/jats:p>","DOI":"10.3390\/ijms27198447","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:32:12Z","timestamp":1790083932000},"page":"8447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glutaminolysis and mTOR-C\/EBP\u03b2 Signaling Drives the Differentiation of Novel IL-10-Producing Regulatory T Cells"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-0229","authenticated-orcid":false,"given":"Masaki","family":"Tajima","sequence":"first","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"},{"name":"Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"},{"name":"Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Ivan J.","family":"Fuss","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Liming","family":"Mao","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-5906","authenticated-orcid":false,"given":"Timothy G.","family":"Myers","sequence":"additional","affiliation":[{"name":"Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Gardina","sequence":"additional","affiliation":[{"name":"Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-1716","authenticated-orcid":false,"given":"Atsushi","family":"Kitani","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Warren","family":"Strober","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of the IL-10 family of cytokines in inflammation and disease","volume":"29","author":"Ouyang","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Carlini, V., Noonan, D.M., Abdalalem, E., Goletti, D., Sansone, C., Calabrone, L., and Albini, A. (2023). The multifaceted nature of IL-10: Regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1161067"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/eji.200636385","article-title":"Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3","volume":"37","author":"Chang","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.4049\/jimmunol.176.6.3470","article-title":"GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells","volume":"176","author":"Shoemaker","year":"2006","journal-title":"J. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.immuni.2010.06.003","article-title":"Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation","volume":"32","author":"Wei","year":"2010","journal-title":"Immunity"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.4049\/jimmunol.1201521","article-title":"beta-glucan curdlan induces IL-10-producing CD4+ T cells and inhibits allergic airway inflammation","volume":"189","author":"Kawashima","year":"2012","journal-title":"J. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.immuni.2009.05.012","article-title":"Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose","volume":"31","author":"Saraiva","year":"2009","journal-title":"Immunity"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.4049\/jimmunol.0803302","article-title":"IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines","volume":"183","author":"Ahyi","year":"2009","journal-title":"J. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.4049\/jimmunol.1600801","article-title":"Etv5 Regulates IL-10 Production in Th Cells","volume":"198","author":"Koh","year":"2017","journal-title":"J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/ni.1912","article-title":"The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27","volume":"11","author":"Apetoh","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/ni1541","article-title":"A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells","volume":"8","author":"Awasthi","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaut.2012.07.009","article-title":"Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation","volume":"40","author":"Jin","year":"2013","journal-title":"J. Autoimmun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.4049\/jimmunol.166.9.5530","article-title":"IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells","volume":"166","author":"Levings","year":"2001","journal-title":"J. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.4049\/jimmunol.0900123","article-title":"c-Maf regulates IL-10 expression during Th17 polarization","volume":"182","author":"Xu","year":"2009","journal-title":"J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.4049\/jimmunol.174.5.2720","article-title":"IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation","volume":"174","author":"Yang","year":"2005","journal-title":"J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.immuni.2015.01.008","article-title":"Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation","volume":"42","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune defence against Candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","first-page":"39","article-title":"Tr1 cells and the counter-regulation of immunity: Natural mechanisms and therapeutic applications","volume":"380","author":"Roncarolo","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cyto.2010.12.019","article-title":"The CCAAT\/enhancer (C\/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation","volume":"54","author":"Tsukada","year":"2011","journal-title":"Cytokine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1074\/jbc.M207448200","article-title":"cAMP-induced Interleukin-10 promoter activation depends on CCAAT\/enhancer-binding protein expression and monocytic differentiation","volume":"278","author":"Brenner","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/gad.557910","article-title":"C\/EBP\u03b2\u0394uORF mice\u2014A genetic model for uORF-mediated translational control in mammals","volume":"24","author":"Wethmar","year":"2010","journal-title":"Genes Dev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1084\/jem.20101563","article-title":"Inflammatory dendritic cells\u2014Not basophils\u2014Are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen","volume":"207","author":"Hammad","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"Kishton","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nmeth.4512","article-title":"Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics","volume":"15","author":"Lai","year":"2018","journal-title":"Nat. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41587-020-0531-2","article-title":"A lipidome atlas in MS-DIAL 4","volume":"38","author":"Tsugawa","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.molcel.2012.05.043","article-title":"Glutaminolysis activates Rag-mTORC1 signaling","volume":"47","author":"Duran","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.immuni.2014.04.007","article-title":"Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation","volume":"40","author":"Nakaya","year":"2014","journal-title":"Immunity"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.cell.2018.10.001","article-title":"Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism","volume":"175","author":"Johnson","year":"2018","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1172\/JCI129269","article-title":"GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis","volume":"130","author":"Xia","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1074\/jbc.RA117.000444","article-title":"Glutaminolysis is required for transforming growth factor-beta1-induced myofibroblast differentiation and activation","volume":"293","author":"Bernard","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110367","DOI":"10.18632\/oncotarget.22775","article-title":"Resminostat induces changes in epithelial plasticity of hepatocellular carcinoma cells and sensitizes them to sorafenib-induced apoptosis","volume":"8","author":"Soukupova","year":"2017","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"a021881","DOI":"10.1101\/cshperspect.a021881","article-title":"Activins and Inhibins: Roles in Development, Physiology, and Disease","volume":"8","author":"Namwanje","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1021\/jm500115w","article-title":"Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A highly potent, selective, and orally bioavailable inhibitor of TGF-beta type I receptor kinase as cancer immunotherapeutic\/antifibrotic agent","volume":"57","author":"Jin","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1210\/en.2006-0089","article-title":"Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins","volume":"147","author":"Sidis","year":"2006","journal-title":"Endocrinology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Briard, B., Malireddi, R.K.S., and Kanneganti, T.D. (2021). Role of inflammasomes\/pyroptosis and PANoptosis during fungal infection. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009358"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15871","DOI":"10.1038\/ncomms15871","article-title":"ITK signalling via the Ras\/IRF4 pathway regulates the development and function of Tr1 cells","volume":"8","author":"Huang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.1259472","article-title":"Differential regulation of mTORC1 by leucine and glutamine","volume":"347","author":"Jewell","year":"2015","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"16390","DOI":"10.1074\/jbc.RA118.004972","article-title":"Phospholipase D-dependent mTOR complex 1 (mTORC1) activation by glutamine","volume":"293","author":"Bernfeld","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11427-020-1703-2","article-title":"Glutamine metabolism in Th17\/Treg cell fate: Applications in Th17 cell-associated diseases","volume":"64","author":"Yang","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9288","DOI":"10.1073\/pnas.1805717115","article-title":"Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation","volume":"115","author":"Kono","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature23475","article-title":"Metabolic control of T(H)17 and induced T(reg) cell balance by an epigenetic mechanism","volume":"548","author":"Xu","year":"2017","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/eji.202149387","article-title":"Glutamine promotes the generation of B10(+) cells via the mTOR\/GSK3 pathway","volume":"52","author":"Mielle","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4049\/jimmunol.1001473","article-title":"The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production","volume":"186","author":"Wang","year":"2011","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zong, Y., Deng, K., and Chong, W.P. (2024). Regulation of Treg cells by cytokine signaling and co-stimulatory molecules. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1387975"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E2891","DOI":"10.1073\/pnas.1616942114","article-title":"Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses","volume":"114","author":"Tousa","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.chom.2015.07.004","article-title":"Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra","volume":"18","author":"Borghi","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12931-016-0352-5","article-title":"Beta-glucan exacerbates allergic airway responses to house dust mite allergen","volume":"17","author":"Hadebe","year":"2016","journal-title":"Respir. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1186\/s40064-016-2501-1","article-title":"Orally administered beta-glucan attenuates the Th2 response in a model of airway hypersensitivity","volume":"5","author":"Burg","year":"2016","journal-title":"SpringerPlus"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.aller.2012.08.008","article-title":"Beta-glucans in the treatment and prevention of allergic diseases","volume":"42","author":"Jesenak","year":"2014","journal-title":"Allergol. Immunopathol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gu, C., Upchurch, K., Horton, J., Wiest, M., Zurawski, S., Millard, M., Kane, R.R., Joo, H., Miller, L.A., and Oh, S. (2021). Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.678036"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8447\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:46:04Z","timestamp":1790095564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":53,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["ijms27198447"],"URL":"https:\/\/doi.org\/10.3390\/ijms27198447","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}