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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Individuals with rheumatoid arthritis (RA) experience increased risk of heart failure. Malondialdehyde\u2013acetaldehyde (MAA) adducts are overexpressed and co-localize with citrullinated (CIT) proteins in RA myocardium. This study investigated whether reactive aldehyde species (RASP) inhibitors prevent MAA formation in vitro and attenuate cardiac dysfunction in a collagen-induced arthritis (CIA) mouse model. Among eight RASP inhibitors screened, ADX-246 demonstrated the greatest inhibition of MAA formation in vitro. Mice with early CIA (week 5) exhibited elevated levels of myocardial MAA adducts, myocardial inflammation, and reduced ejection fraction, but normal cardiac collagen deposition and diastolic function vs. control. By weeks 10\u201312, mice with chronic CIA demonstrated increased levels of myocardial MAA and CIT adducts, perivascular collagen deposition, and diastolic dysfunction. ADX-246 treatment reduced myocardial levels of MAA and CIT adducts, inflammation, fibrosis, and cardiac dysfunction in CIA. While ADX-246 reduced weight loss and attenuated arthritis severity, it did not reduce serum autoantibody levels or serum markers of inflammation or fibrosis. Indices of diastolic dysfunction significantly correlated with myocardial MAA and CIT levels, collagen deposition, arthritis severity, and weight loss. These findings support the hypothesis that targeting myocardial RASP and MAA formation may represent a novel therapeutic approach for preventing cardiac dysfunction in RA.<\/jats:p>","DOI":"10.3390\/ijms27198478","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:20:46Z","timestamp":1790155246000},"page":"8478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuation of Cardiac Dysfunction in the Collagen-Induced Arthritis Mouse Model Mediated by a Reactive Aldehyde Species Inhibitor"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-9286","authenticated-orcid":false,"given":"Wenxian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology & Immunology, University of Nebraska Medical Center, Omaha, NE 68198, 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J. Rheumatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/art.27425","article-title":"Is the Incidence of Rheumatoid Arthritis Rising?: Results from Olmsted County, Minnesota, 1955\u20132007","volume":"62","author":"Myasoedova","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00296-017-3726-1","article-title":"Prevalence of Rheumatoid Arthritis in the United States Adult Population in Healthcare Claims Databases, 2004\u20132014","volume":"37","author":"Hunter","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chen, J., Norling, L.V., and Cooper, D. (2021). Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation. 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Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1186\/ar1149","article-title":"Rheumatoid Arthritis Specific Anti-Sa Antibodies Target Citrullinated Vimentin","volume":"6","author":"Vossenaar","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/s10165-006-0498-y","article-title":"Autoimmunity to Citrullinated Type II Collagen in Rheumatoid Arthritis","volume":"16","author":"Yoshida","year":"2006","journal-title":"Mod. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/art.27349","article-title":"Left Ventricular Structure and Function in Patients with Rheumatoid Arthritis, as Assessed by Cardiac Magnetic Resonance Imaging","volume":"62","author":"Giles","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_15","first-page":"79","article-title":"Left Ventricular Function in Treatment-Naive Early Rheumatoid Arthritis","volume":"4","author":"Deibjerg","year":"2014","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"ref_16","first-page":"534","article-title":"Association of Anti-Citrullinated Protein or Peptide Antibodies with Left Ventricular Structure and Function in Rheumatoid Arthritis","volume":"56","author":"Russo","year":"2017","journal-title":"Rheumatology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Norouzi, S., Javinani, A., Aminorroaya, A., and Masoumi, M. (2020). Anti-Modified Citrullinated Vimentin Antibody: A Novel Biomarker Associated with Cardiac Systolic Dysfunction in Patients with Rheumatoid Arthritis. BMC Cardiovasc. Disord., 20.","DOI":"10.1186\/s12872-020-01676-x"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e13869","DOI":"10.1111\/apha.13869","article-title":"Citrullination Is Linked to Reduced Ca2+ Sensitivity in Hearts of a Murine Model of Rheumatoid Arthritis","volume":"236","author":"Pironti","year":"2022","journal-title":"Acta Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1186\/ar3752","article-title":"Myocardial Citrullination in Rheumatoid Arthritis: A Correlative Histopathologic Study","volume":"14","author":"Giles","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhou, W., Johnson, H.J., Duryee, M.J., Aripova, N., Sharp, E.E., Hunter, C.D., Sinanan, K., Drvol, H.C., Feely, M.G., and Johnson, T.M. (2025). Citrullinated and Malondialdehyde-Acetaldehyde-Modified Fibrinogen Activates Macrophages and Promotes Coronary Endothelial Cell Inflammation. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47110943"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhou, W., Aripova, N., Johnson, H.J., England, B.R., Schmidt, C.M., Anderson, D.R., Poole, J.A., Johnson, T.M., Duryee, M.J., and Thiele, G.M. (2025). Malondialdehyde-Acetaldehyde Modified Macromolecules and Resulting Autoantibodies in Rheumatoid Arthritis Pathogenesis: A Systematic Literature Review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1648290"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Duryee, M.J., Clemens, D.L., Opperman, P.J., Thiele, G.M., Duryee, L.M., Garvin, R.P., and Anderson, D.R. (2021). Malondialdehyde-Acetaldehyde Modified (MAA) Proteins Differentially Effect the Inflammatory Response in Macrophage, Endothelial Cells and Animal Models of Cardiovascular Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312948"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/art.38969","article-title":"Malondialdehyde-Acetaldehyde Adducts and Anti-Malondialdehyde-Acetaldehyde Antibodies in Rheumatoid Arthritis","volume":"67","author":"Thiele","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/art.42916","article-title":"Antibodies to Malondialdehyde-Acetaldehyde Adduct Are Associated with Prevalent and Incident Rheumatoid Arthritis-Associated Interstitial Lung Disease in US Veterans","volume":"76","author":"Aripova","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10547","DOI":"10.1038\/s41598-022-14954-9","article-title":"Serum Anti-Malondialdehyde-Acetaldehyde IgA Antibody Concentration Improves Prediction of Coronary Atherosclerosis beyond Traditional Risk Factors in Patients with Rheumatoid Arthritis","volume":"12","author":"Lomzenski","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e202302055","DOI":"10.26508\/lsa.202302055","article-title":"Inhibition of Protein Arginine Deiminase 4 Prevents Inflammation-Mediated Heart Failure in Arthritis","volume":"6","author":"Heger","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s40123-026-01379-0","article-title":"Phase 3 Randomized Clinical Trial Evaluating the Safety of Reproxalap in Patients with Dry Eye Disease","volume":"15","author":"Radcliffe","year":"2026","journal-title":"Ophthalmol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ochoa, C.A., Nissen, C.G., Mosley, D.D., Bauer, C.D., Jordan, D.L., Bailey, K.L., and Wyatt, T.A. (2022). Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules, 12.","DOI":"10.3390\/biom12030393"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109400","DOI":"10.1016\/j.intimp.2022.109400","article-title":"A Novel Reactive Aldehyde Species Inhibitor Prevents the Deleterious Effects of Ethanol in an Animal Model of Alcoholic Liver Disease","volume":"113","author":"Duryee","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_30","first-page":"100839","article-title":"Sj\u00f6gren-Larsson Syndrome: A Biochemical Rationale for Using Aldehyde-Reactive Therapeutic Agents","volume":"30","author":"Rizzo","year":"2022","journal-title":"Mol. Genet. Metab. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/heartjnl-2012-301961","article-title":"Echo-Doppler Assessment of Diastole: Flow, Function and Haemodynamics","volume":"99","author":"Gillebert","year":"2013","journal-title":"Heart"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Villalba-Orero, M., Garcia-Pavia, P., and Lara-Pezzi, E. (2022). Non-Invasive Assessment of HFpEF in Mouse Models: Current Gaps and Future Directions. BMC Med., 20.","DOI":"10.1186\/s12916-022-02546-3"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1084\/jem.20180049","article-title":"Interleukin-10 Stiffens the Heart","volume":"215","author":"Cihakova","year":"2018","journal-title":"J. Exp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1152\/physiol.00004.2023","article-title":"Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction","volume":"38","author":"Daou","year":"2023","journal-title":"Physiology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e10865","DOI":"10.15252\/emmm.201910865","article-title":"Targeting Cardiac Fibrosis in Heart Failure with Preserved Ejection Fraction: Mirage or Miracle?","volume":"12","author":"Sweeney","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/s41401-023-01099-2","article-title":"Chronic \u03b2-Adrenergic Stress Contributes to Cardiomyopathy in Rodents with Collagen-Induced Arthritis","volume":"44","author":"Zhu","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"114709","DOI":"10.1016\/j.intimp.2025.114709","article-title":"GRK2-Facilitated TLR4 Signaling Promotes Cardiac Fibrosis in Rheumatic Mice","volume":"157","author":"Wang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1248\/cpb.c22-00684","article-title":"Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice","volume":"71","author":"Ning","year":"2023","journal-title":"Chem. Pharm. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.55563\/clinexprheumatol\/6kxs1o","article-title":"Identifying a Marked Inflammation Mediated Cardiac Dysfunction during the Development of Arthritis in Collagen-Induced Arthritis Mice","volume":"38","author":"Zhou","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/acr.24804","article-title":"Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients with Rheumatoid Arthritis","volume":"75","author":"Huang","year":"2023","journal-title":"Arthritis Care Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/acr.25481","article-title":"Risk of Incident Heart Failure and Heart Failure Subtypes in Patients with Rheumatoid Arthritis","volume":"77","author":"Kawano","year":"2025","journal-title":"Arthritis Care Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109010","DOI":"10.1016\/j.intimp.2022.109010","article-title":"Peptidyl Arginine Deiminase Expression and Macrophage Polarization Following Stimulation with Citrullinated and Malondialdehyde-Acetaldehyde Modified Fibrinogen","volume":"110","author":"Aripova","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/art.27264","article-title":"Cardiovascular Disease in Patients with Inflammatory Rheumatic Disease Is Associated with Up-Regulation of Markers of Inflammation in Cardiac Microvessels and Cardiomyocytes","volume":"62","author":"Grundtman","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"107711","DOI":"10.1016\/j.carpath.2024.107711","article-title":"Tocilizumab Does Not Ameliorate Inflammation-Induced Left Ventricular Dysfunction in a Collagen-Induced Arthritis Rat Model","volume":"75","author":"Manilall","year":"2025","journal-title":"Cardiovasc. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.55563\/clinexprheumatol\/l4nnv0","article-title":"TNF-\u03b1 Inhibitors Reduce Inflammation-Induced Concentric Remodelling, but Not Diastolic Dysfunction in Collagen-Induced Arthritis","volume":"40","author":"Mokotedi","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/FJC.0000000000001428","article-title":"Tumor Necrosis Factor-\u03b1 Mediates Inflammation-Induced Early-Stage Left Ventricular Systolic Dysfunction","volume":"81","author":"Manilall","year":"2023","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","article-title":"IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling after Myocardial Infarction via Activation of STAT3 and Suppression of HuR","volume":"104","author":"Krishnamurthy","year":"2009","journal-title":"Circ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, J.J., Rizk, R., Li, X., Lee, B.G., Matthies, M.L., Bietz, K.A., Kim, K., Huard, J., Wang, Y., and Chen, W.C.W. (2025). Interleukin-10 Exhibit Dose-Dependent Effects on Macrophage Phenotypes and Cardiac Remodeling after Myocardial Infarction. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1481460"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"I233","DOI":"10.1161\/hc37t1.094872","article-title":"Quantitative Myocardial Cytokine Expression and Activation of the Apoptotic Pathway in Patients Who Require Left Ventricular Assist Devices","volume":"104","author":"Birks","year":"2001","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1161\/01.CIR.102.14.1690","article-title":"Cardiac-Specific Overexpression of Tumor Necrosis Factor-\u03b1 Causes Oxidative Stress and Contractile Dysfunction in Mouse Diaphragm","volume":"102","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.RES.81.4.627","article-title":"Dilated Cardiomyopathy in Transgenic Mice with Cardiac-Specific Overexpression of Tumor Necrosis Factor-\u03b1","volume":"81","author":"Kubota","year":"1997","journal-title":"Circ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1073\/pnas.86.17.6753","article-title":"Interleukin 1 and Tumor Necrosis Factor Inhibit Cardiac Myocyte Beta-Adrenergic Responsiveness","volume":"86","author":"Gulick","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00011-013-0625-0","article-title":"Interleukin-1\u03b2 Induces a Reversible Cardiomyopathy in the Mouse","volume":"62","author":"Seropian","year":"2013","journal-title":"Inflamm. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FJC.0000000000000106","article-title":"Interleukin-1\u03b2 Blockade Improves Left Ventricular Systolic\/Diastolic Function and Restores Contractility Reserve in Severe Ischemic Cardiomyopathy in the Mouse","volume":"64","author":"Toldo","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/CIRCRESAHA.121.318159","article-title":"From Systemic Inflammation to Myocardial Fibrosis: The Heart Failure with Preserved Ejection Fraction Paradigm Revisited","volume":"128","author":"Paulus","year":"2021","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/CIRCULATIONAHA.114.013215","article-title":"Myocardial Stiffness in Patients with Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin","volume":"131","author":"Zile","year":"2015","journal-title":"Circulation"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.33549\/physiolres.935575","article-title":"Myocardial Fibrosis, The Silent Instigator of Diastolic Dysfunction in Patients with Rheumatoid Arthritis","volume":"74","author":"Jalali","year":"2025","journal-title":"Physiol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Bonanni, A., Vinci, R., d\u2019Aiello, A., Grimaldi, M.C., Di Sario, M., Tarquini, D., Proto, L., Severino, A., Pedicino, D., and Liuzzo, G. (2023). Targeting Collagen Pathways as an HFpEF Therapeutic Strategy. J. Clin. Med., 12.","DOI":"10.3390\/jcm12185862"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jcsm.12280","article-title":"Collagen-induced Arthritis as an Animal Model of Rheumatoid Cachexia","volume":"9","author":"Alabarse","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e70229","DOI":"10.1002\/jcsm.70229","article-title":"Loss of Lean Mass in Rheumatoid Arthritis Is Associated with Loss of Total and Visceral Fat","volume":"17","author":"Baker","year":"2026","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Masuko, K. (2014). Rheumatoid Cachexia Revisited: A Metabolic Co-Morbidity in Rheumatoid Arthritis. Front. Nutr., 1.","DOI":"10.3389\/fnut.2014.00020"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31138\/mjr.33.3.271","article-title":"Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management","volume":"33","author":"Efthymiou","year":"2022","journal-title":"Mediterr. J. Rheumatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/annrheumdis-2016-210997","article-title":"Low Disease Activity (DAS28\u22643.2) Reduces the Risk of First Cardiovascular Event in Rheumatoid Arthritis: A Time-Dependent Cox Regression Analysis in a Large Cohort Study","volume":"76","author":"Arts","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Tarjanyi, Z., Szabo, L., Mong, N., Mahmood, A., Dohy, Z., Drobni, Z.D., Panajotu, A., Tothfalusi, L., Szappanos, A., and Raisi-Estabragh, Z. (2025). Subclinical Myocardial Changes in Rheumatoid Arthritis: Cardiovascular Magnetic Resonance Evidence of Immuno-Inflammatory Remodeling. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1607018"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/art.40900","article-title":"Malondialdehyde-Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis-Associated Interstitial Lung Disease","volume":"71","author":"England","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1080\/14789450.2021.2018303","article-title":"Role of Protein Deimination in Cardiovascular Diseases: Potential New Avenues for Diagnostic and Prognostic Biomarkers","volume":"18","author":"Mao","year":"2021","journal-title":"Expert Rev. Proteom."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2017.06.004","article-title":"Autoreactivity to Malondialdehyde-Modifications in Rheumatoid Arthritis Is Linked to Disease Activity and Synovial Pathogenesis","volume":"84","author":"Amara","year":"2017","journal-title":"J. Autoimmun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"eaba2927","DOI":"10.1126\/scitranslmed.aba2927","article-title":"Citrullinated Vimentin Mediates Development and Progression of Lung Fibrosis","volume":"13","author":"Li","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/03009742.2012.670263","article-title":"Citrullinated Vimentin Stimulates Proliferation, pro-Inflammatory Cytokine Secretion, and PADI4 and RANKL Expression of Fibroblast-like Synoviocytes in Rheumatoid Arthritis","volume":"41","author":"Fan","year":"2012","journal-title":"Scand. J. Rheumatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"L134","DOI":"10.1152\/ajplung.00153.2024","article-title":"Citrullinated and Malondialdehyde-Acetaldehyde Modified Fibrinogen Activates Macrophages and Promotes Profibrotic Responses in Human Lung Fibroblasts","volume":"328","author":"Aripova","year":"2024","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Alomar, F.A., Dash, P.K., Ramasamy, M., Venn, Z.L., Bidasee, S.R., Zhang, C., Hackfort, B.T., Gorantla, S., and Bidasee, K.R. (2025). Diastolic Dysfunction with Vascular Deficits in HIV-1-Infected Female Humanized Mice Treated with Antiretroviral Drugs. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083801"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1038\/s41598-020-65943-9","article-title":"HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice","volume":"10","author":"Dash","year":"2020","journal-title":"Sci. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8478\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:20:14Z","timestamp":1790310014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":72,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["ijms27198478"],"URL":"https:\/\/doi.org\/10.3390\/ijms27198478","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}