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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Zygophyllum xanthoxylum (Bunge) Maxim. is a dominant, deep-rooted shrub of the temperate deserts of north-western China whose leaflets range from comparatively flat and broad to slender and terete, but the molecular basis of this variation has rarely been reported. We compared three accessions from contrasting desert habitats\u2014one flat-leaved, from a shaded high-altitude valley, and two rod-leaved, from open full-sun sites. The accessions differed in the leaflet blade but not in the petiole, the flat-leaved accession bearing shorter and much wider leaflets with a width-to-length ratio almost four times greater. Leaf transcriptomes were assembled, and pairwise comparison identified several thousand differentially expressed genes. The leaf-form signal was defined as the genes that changed concordantly in both flat-versus-rod comparisons, placing the flat-leaved accession at one extreme of the series. This set contains a reciprocal leaf-development module: the YABBY lamina gene YAB2, the auxin\/polarity factors ARF3 and ARF18 and the expansin EXPA1 are higher in the flat-leaved accession, whereas the KNOX gene KNAT6, the class II TCP gene TCP12, ARF6, EXPA4 and ATHB7 are higher in both rod-leaved accessions. Photosynthesis genes are significantly concentrated in the expression clusters that peak in the flat-leaved accession, with light-harvesting antenna, photosystem II and Calvin-cycle transcripts highest there. The chlorophyll a-b binding protein CAB and the cytosolic phosphoglycerate kinase PGK are the most strongly flat-biased transcripts, and in each case, the bias holds for the gene family as a whole; quantitative RT-PCR confirmed the sequencing-based estimates. Flat- versus rod-leaved differentiation in Z. xanthoxylum is therefore accompanied by constitutive, coordinated differences in leaf-development and light-harvesting gene expression, CAB and PGK are proposed as candidate expression markers of the flat-leaved form.<\/jats:p>","DOI":"10.3390\/ijms27198537","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:11:23Z","timestamp":1790248283000},"page":"8537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Common-Garden Transcriptomes Distinguish Leaf-Form-Associated from Site-Associated Expression in Zygophyllum xanthoxylum"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-853X","authenticated-orcid":false,"given":"Xiaoyang","family":"Wang","sequence":"first","affiliation":[{"name":"Biological and Medical Metrology Laboratory, Beijing Institute of Metrology, Beijing 100029, China"},{"name":"College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Wenjing","family":"Shen","sequence":"additional","affiliation":[{"name":"Yunnan Open University, Kunming 650223, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"}]},{"given":"Xingshun","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Open University, Kunming 650223, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"}]},{"given":"Duanyang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Yunnan Open University, Kunming 650223, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Qin","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Highland Forest Science, Chinese Academy of Forestry, Kunming 650224, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Zhentao","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Yunnan Open University, Kunming 650223, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/nph.70597","article-title":"Leaf Evolution: Integrating Phylogenetics, Developmental Dynamics, and Genetic Insights across Land Plants","volume":"248","author":"Nakayama","year":"2025","journal-title":"New Phytol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R1215","DOI":"10.1016\/j.cub.2022.09.021","article-title":"From Genes to Shape in Leaf Development and Evolution","volume":"32","author":"Bhatia","year":"2022","journal-title":"Curr. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"eadd5667","DOI":"10.1126\/sciadv.add5667","article-title":"Leaf Economics Fundamentals Explained by Optimality Principles","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/pce.12857","article-title":"The Influence of Leaf Size and Shape on Leaf Thermal Dynamics: Does Theory Hold up under Natural Conditions?","volume":"40","author":"Leigh","year":"2017","journal-title":"Plant Cell Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1126\/science.aal4760","article-title":"Global Climatic Drivers of Leaf Size","volume":"357","author":"Wright","year":"2017","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1111\/nph.19702","article-title":"Variation in Leaf Carbon Economics, Energy Balance, and Heat Tolerance Traits Highlights Differing Timescales of Adaptation and Acclimation","volume":"242","author":"Bison","year":"2024","journal-title":"New Phytol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/s41477-023-01543-5","article-title":"The Global Biogeography of Tree Leaf Form and Habit","volume":"9","author":"Ma","year":"2023","journal-title":"Nat. Plants"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10265-024-01541-4","article-title":"Leaf Form Diversity and Evolution: A Never-Ending Story in Plant Biology","volume":"137","author":"Nakayama","year":"2024","journal-title":"J. Plant Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhao, L., Qin, F., and Dong, X. (2026). Study on Water Use Sources and Ecohydrological Niche Characteristics of Two Dominant Shrubs in the Tengger Desert. Front. Plant Sci., 17.","DOI":"10.3389\/fpls.2026.1755414"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1007\/s00344-021-10460-w","article-title":"RNAi-Based Transcriptome Suggests Candidate Genes Regulated by ZxNHX1 to Affect the Salt Tolerance of Zygophyllum Xanthoxylum","volume":"41","author":"Liu","year":"2022","journal-title":"J. Plant Growth Regul."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1111\/pbi.70163","article-title":"ZxNHX1 from a Xerophyte Outperforms AtNHX1 in Sequestering Na+ into Vacuoles to Enhance Plant Stress Resistance and Yield","volume":"23","author":"Liu","year":"2025","journal-title":"Plant Biotechnol. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100571","DOI":"10.1016\/j.xplc.2023.100571","article-title":"Chasing the Mechanisms of Ecologically Adaptive Salinity Tolerance","volume":"4","author":"Busoms","year":"2023","journal-title":"Plant Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/nph.18744","article-title":"Hidden Genetic Variation in Plasticity Provides the Potential for Rapid Adaptation to Novel Environments","volume":"239","author":"Walter","year":"2023","journal-title":"New Phytol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/plcell\/koac118","article-title":"Molecular Mechanisms Underlying Leaf Development, Morphological Diversification, and Beyond","volume":"34","author":"Nakayama","year":"2022","journal-title":"Plant Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.cub.2003.09.035","article-title":"Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes","volume":"13","author":"Emery","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/35079635","article-title":"Role of PHABULOSA and PHAVOLUTA in Determining Radial Patterning in Shoots","volume":"411","author":"McConnell","year":"2001","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"She, Z., Huang, X., Aslam, M., Wang, L., Yan, M., Qin, R., Chen, Y., Qin, Y., and Niu, X. (2022). Expression Characterization and Cross-Species Complementation Uncover the Functional Conservation of YABBY Genes for Leaf Abaxial Polarity and Carpel Polarity Establishment in Saccharum Spontaneum. BMC Plant Biol., 22.","DOI":"10.1186\/s12870-022-03501-3"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1093\/jxb\/erae118","article-title":"Shaping Leaves through TALE Homeodomain Transcription Factors","volume":"75","author":"Byrne","year":"2024","journal-title":"J. Exp. Bot."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1242\/dev.030049","article-title":"KNOX Genes: Versatile Regulators of Plant Development and Diversity","volume":"137","author":"Hay","year":"2010","journal-title":"Development"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41477-022-01111-3","article-title":"Specification of Leaf Dorsiventrality via a Prepatterned Binary Readout of a Uniform Auxin Input","volume":"8","author":"Burian","year":"2022","journal-title":"Nat. Plants"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1111\/nph.70631","article-title":"TCP3-Mediated Regulation of Cell Expansion in Arabidopsis Thaliana","volume":"248","author":"Koyama","year":"2025","journal-title":"New Phytol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev-cellbio-111822-115334","article-title":"Plant Cell Wall Loosening by Expansins","volume":"40","author":"Cosgrove","year":"2024","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41580-023-00691-y","article-title":"Structure and Growth of Plant Cell Walls","volume":"25","author":"Cosgrove","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jxb\/eraf421","article-title":"From Genes to Climate: A Perspective on the Importance of Leaf Shape","volume":"77","author":"Jessica","year":"2026","journal-title":"J. Exp. Bot."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.molp.2018.06.006","article-title":"Molecular Mechanisms of Leaf Morphogenesis","volume":"11","author":"Du","year":"2018","journal-title":"Mol. Plant"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/jipb.13323","article-title":"ERF4 Interacts with and Antagonizes TCP15 in Regulating Endoreduplication and Cell Growth in Arabidopsis","volume":"64","author":"Ding","year":"2022","journal-title":"J. Integr. Plant Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e70627","DOI":"10.1111\/ppl.70627","article-title":"A Review of Regulation of Leaf Margin Development: Integrating Genetic, Hormonal, and Environmental Controls","volume":"177","author":"Lu","year":"2025","journal-title":"Physiol. Plant."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/pce.70272","article-title":"TALE Homeodomain Proteins in Plant Reproductive Development and Environmental Stress Resilience","volume":"49","author":"Niu","year":"2025","journal-title":"Plant Cell Environ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1016\/j.cub.2024.07.068","article-title":"Age-Associated Growth Control Modifies Leaf Proximodistal Symmetry and Enabled Leaf Shape Diversification","volume":"34","author":"Li","year":"2024","journal-title":"Curr. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/jxb\/erae443","article-title":"WOX1 Controls Leaf Serration Development via Temporally Restricting BRASSINAZOLE RESISTANT 1 and CUP SHAPED COTYLEDON 3 Expression in Arabidopsis","volume":"76","author":"Xu","year":"2025","journal-title":"J. Exp. Bot."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/jxb\/eraf383","article-title":"A Unique Light-Harvesting Complex Protein Family, LHCE, Is Involved in Far-Red Absorption by Photosystems I and II in Euglena Gracilis","volume":"77","author":"Arshad","year":"2026","journal-title":"J. Exp. Bot."},{"key":"ref_32","first-page":"1","article-title":"Regulatory Mechanism of a Light-Dependent Protochlorophyllide Oxidoreductase in Chlorophyll Biosynthesis and Environmental Adaptation","volume":"4","author":"Wang","year":"2024","journal-title":"Technol. Agron."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/jipb.13837","article-title":"Regulatory and Retrograde Signaling Networks in the Chlorophyll Biosynthetic Pathway","volume":"67","author":"Li","year":"2025","journal-title":"J. Integr. Plant Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Roach, T., Kim, E., Tian, L., and Lepetit, B. (2022). Editorial: Regulation of Light-Harvesting Systems during Acclimation of Photosynthetic Organisms. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.914047"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.32615\/ps.2023.025","article-title":"LHCII\u2013A Protein like a \u201cSwiss Army Knife\u201d with Many Mechanisms and Functions","volume":"61","author":"Gruszecki","year":"2023","journal-title":"Photosynthetica"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Diop, M., and Gallois, J.-L. (2022). Exploring New Routes for Genetic Resistances to Potyviruses: The Case of the Arabidopsis Thaliana Phosphoglycerate Kinases (PGK) Metabolic Enzymes. Viruses, 14.","DOI":"10.3390\/v14061245"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/jipb.13908","article-title":"Advances in Photosynthesis Research: Unlocking the Potential for Food Security, Renewable Energy, and Environmental Sustainability","volume":"67","author":"Yang","year":"2025","journal-title":"J. Integr. Plant Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"21712","DOI":"10.1038\/s41598-024-72828-8","article-title":"Tissue-Specific Accumulation of PIP Aquaporins of a Particular Heteromeric Composition Is Part of the Maize Response to Mycorrhiza and Drought","volume":"14","author":"Polcyn","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6331","DOI":"10.1093\/jxb\/erae319","article-title":"Leucine-Rich Repeat Receptor Kinase BM41 Regulates Cuticular Wax Deposition in Sorghum","volume":"75","author":"Tian","year":"2024","journal-title":"J. Exp. Bot."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.48130\/FruRes-2023-0007","article-title":"Ectopic Expression of an Apple ABCG Transporter Gene MdABCG25 Increases Plant Cuticle Wax Accumulation and Abiotic Stress Tolerance","volume":"3","author":"Zhou","year":"2023","journal-title":"Fruit Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhu, Z., Quan, R., Chen, G., Yu, G., Li, X., Han, Z., Xu, W., Li, G., Shi, J., and Li, B. (2022). An R2R3-MYB Transcription Factor VyMYB24, Isolated from Wild Grape Vitis Yanshanesis J. X. Chen., Regulates the Plant Development and Confers the Tolerance to Drought. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.966641"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lv, K., Wei, H., and Liu, G. (2021). A R2R3-MYB Transcription Factor Gene, BpMYB123, Regulates BpLEA14 to Improve Drought Tolerance in Betula Platyphylla. Front. Plant Sci., 12.","DOI":"10.3389\/fpls.2021.791390"},{"key":"ref_43","first-page":"e023","article-title":"The Relationship between Plant Hormones and Cuticular Wax","volume":"1","author":"Gao","year":"2025","journal-title":"Plant Horm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1002\/joc.5086","article-title":"WorldClim 2: New 1-Km Spatial Resolution Climate Surfaces for Global Land Areas","volume":"37","author":"Fick","year":"2017","journal-title":"Int. J. Climatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A Flexible Trimmer for Illumina Sequence Data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_46","first-page":"410","article-title":"Corset: Enabling Differential Gene Expression Analysis for de Novo Assembled Transcriptomes","volume":"15","author":"Davidson","year":"2014","journal-title":"Genome Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Madritsch, S., Burg, A., and Sehr, E.M. (2021). Comparing de Novo Transcriptome Assembly Tools in Di- and Autotetraploid Non-Model Plant Species. BMC Bioinform., 22.","DOI":"10.1186\/s12859-021-04078-8"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1093\/bioinformatics\/btv351","article-title":"BUSCO: Assessing Genome Assembly and Annotation Completeness with Single-Copy Orthologs","volume":"31","author":"Waterhouse","year":"2015","journal-title":"Bioinformatics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and Sensitive Protein Alignment Using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Li, B., and Dewey, C.N. (2011). RSEM: Accurate Transcript Quantification from RNA-Seq Data with or without a Reference Genome. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-323"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-Seq Data with DESeq","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-ddCt Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8537\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:12:42Z","timestamp":1790248362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":53,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["ijms27198537"],"URL":"https:\/\/doi.org\/10.3390\/ijms27198537","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}