{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:19:13Z","timestamp":1790615953556,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Ylang-ylang essential oil (YEO), obtained from Cananga odorata, contains chemically diverse constituents with potential anticancer activity that warrants further investigation. This study investigated the anti-breast-cancer potential of YEO through an integrated experimental and computational approach. The essential oil was chemically characterized by gas chromatography\u2013mass spectrometry, and its in vitro cytotoxic activity was evaluated against ER-positive MCF-7 and triple-negative MDA-MB-231 and MDA-MB-436 breast-cancer cell lines using the MTT assay. Peripheral blood mononuclear cells were included as a preliminary model for assessing cytotoxic selectivity toward non-tumoral cells. To generate hypotheses concerning possible molecular interactions, identified constituents were evaluated against three breast-cancer-relevant targets: estrogen receptor alpha (ER-\u03b1), epidermal growth factor receptor (EGFR), and poly(ADP-ribose) polymerase 1 (PARP1). The computational workflow included a structural confidence assessment based on AlphaFold 2, together with CNN-assisted Gnina docking, Glide docking, and in silico ADMET profiling. The in vitro experiments showed that YEO had biological activity against breast-cancer cells, and the computational analyses showed that the ligand profiles were dependent on the target. Gnina identified trans-geranylgeraniol, farnesyl-decanoate and linalool as the top candidates for ER-\u03b1, EGFR and PARP1, respectively, while Glide pointed out \u03b4-cadinene for ER-\u03b1, benzyl salicylate for EGFR and benzyl benzoate for PARP1. Both benzyl benzoate and \u03b1-cadinol also had potentially favorable multi-target binding profiles. The ADMET analysis found that several components had acceptable drug-likeness, but the high lipophilicity of some sesquiterpenes might limit their pharmacokinetic behavior. Overall, the results support the prioritization of selected YEO constituents as candidates for further investigation of potential multi-target anticancer activity. Nevertheless, the docking results remain predictive and do not demonstrate direct target inhibition or molecular synergy. Further biochemical, mechanistic, pharmacokinetic, and in vivo studies are needed to evaluate the biological relevance and translational potential of the prioritized constituents.<\/jats:p>","DOI":"10.3390\/ijms27198557","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:29:53Z","timestamp":1790267393000},"page":"8557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Anticancer Activity and Integrated Multi-Target Computational Analysis of Ylang-Ylang Essential Oil Against Breast Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6614-9594","authenticated-orcid":false,"given":"Mohamed","family":"Chebaibi","sequence":"first","affiliation":[{"name":"Higher Institute of Nursing Professions and Health Techniques, Fez 30000, Morocco"},{"name":"Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-8484","authenticated-orcid":false,"given":"Amine","family":"Elbouzidi","sequence":"additional","affiliation":[{"name":"Laboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-3538","authenticated-orcid":false,"given":"Mohamed","family":"Taibi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, and Sustainable Development (L2BD), Faculty of Sciences, Mohammed Premier University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4366-843X","authenticated-orcid":false,"given":"Mounir","family":"Haddou","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, and Sustainable Development (L2BD), Faculty of Sciences, Mohammed Premier University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Salah-Eddine","family":"Chebaibi","sequence":"additional","affiliation":[{"name":"Plant Biotechnology Team, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-7011","authenticated-orcid":false,"given":"Aziz","family":"Tikent","sequence":"additional","affiliation":[{"name":"Laboratory of Agricultural Production Improvement, Biotechnology and Environment (LAPABE), Faculty of Sciences, Mohammed Premier University, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-9033","authenticated-orcid":false,"given":"Aimad","family":"Allali","sequence":"additional","affiliation":[{"name":"Higher Institute of Nursing Professions and Health Techniques, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Tarik","family":"Moubchir","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, and Sustainable Development (L2BD), Faculty of Sciences, Mohammed Premier University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-6299","authenticated-orcid":false,"given":"Ibrahim","family":"Mssillou","sequence":"additional","affiliation":[{"name":"Euromed University of Fes, UEMF, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Chakib","family":"Nejjari","sequence":"additional","affiliation":[{"name":"Euromed University of Fes, UEMF, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-6738","authenticated-orcid":false,"given":"Abdellah","family":"Baraich","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, and Sustainable Development (L2BD), Faculty of Sciences, Mohammed Premier University, Boulevard Mohamed VI, B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-570X","authenticated-orcid":false,"given":"Abdelfattah El","family":"Moussaoui","sequence":"additional","affiliation":[{"name":"Plant Biotechnology Team, Faculty of Sciences, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Sanae","family":"Achour","sequence":"additional","affiliation":[{"name":"Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"896314","DOI":"10.1155\/2015\/896314","article-title":"Traditional Uses, Phytochemistry, and Bioactivities of Cananga odorata (Ylang-Ylang)","volume":"2015","author":"Tan","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med. eCAM"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sedky, N.K., Abdel-Kader, N.M., Issa, M.Y., Abdelhady, M.M.M., Shamma, S.N., Bakowsky, U., and Fahmy, S.A. (2023). Co-Delivery of Ylang Ylang Oil of Cananga odorata and Oxaliplatin Using Intelligent pH-Sensitive Lipid-Based Nanovesicles for the Effective Treatment of Triple-Negative Breast Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098392"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100214","DOI":"10.1016\/j.clcb.2026.100214","article-title":"Integrated green valorization of Cananga flower waste via microwave-assisted extraction and multifunctional residue utilization","volume":"14","author":"Mustafiah","year":"2026","journal-title":"Clean. Circ. Bioeconomy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"115362","DOI":"10.1016\/j.jep.2022.115362","article-title":"Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice","volume":"294","author":"Borgonetti","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Vella, F.M., Calandrelli, R., Cautela, D., Fiume, I., Pocsfalvi, G., and Laratta, B. (2020). Chemometric screening of fourteen essential oils for their composition and biological properties. Molecules, 25.","DOI":"10.3390\/molecules25215126"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.31436\/ijohs.v6i2.370","article-title":"Potential of Cananga odorata and Citrus limon essential oils in modulating NOTCH1 signalling for non-melanoma skin cancer treatment","volume":"6","author":"Muzamil","year":"2025","journal-title":"IIUM J. Orofac. Health Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/0972060X.2021.1957023","article-title":"Chemical Composition of Essential Oil of Cananga odorata (Lam.) Hook. F. & Thomson Leaves and Its Biological Activities","volume":"24","author":"Vimaladevi","year":"2021","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.26452\/ijrps.v11i4.3221","article-title":"Anticancer activity of ylang-ylang essential oil in Ehrlich Ascites Carcinoma cell-treated mice","volume":"11","author":"Malgi","year":"2020","journal-title":"Int. J. Res. Pharm. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13765-025-01005-w","article-title":"Anti-cancer activity of rose-geranium essential oil and its bioactive compound geraniol in colorectal cancer cells","volume":"68","author":"Kim","year":"2025","journal-title":"Appl. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"28169","DOI":"10.3390\/ijms161226089","article-title":"Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs","volume":"16","author":"Chang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"SM, S., Naveen, N.R., Rao, G.K., Gopan, G., Chopra, H., Park, M.N., Alshahrani, M.M., Jose, J., Emran, T.B., and Kim, B. (2022). A spotlight on alkaloid nanoformulations for the treatment of lung cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.994155"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ahmed, E.A. (2025). The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer. Molecules, 30.","DOI":"10.3390\/molecules30081751"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Botter, E., Caligiuri, I., Rizzolio, F., Visentin, F., and Scattolin, T. (2024). Liposomal formulations of metallodrugs for cancer therapy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179337"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mrani, S.A., Zejli, H., Azzouni, D., Fadili, D., Alanazi, M.M., Hassane, S.O.S., Sabbahi, R., Kabra, A., Moussaoui, A.E., and Hammouti, B. (2024). Chemical composition, antioxidant, antibacterial, and hemolytic properties of ylang-ylang (Cananga odorata) essential oil: Potential therapeutic applications in dermatology. Pharmaceuticals, 17.","DOI":"10.3390\/ph17101376"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e202401466","DOI":"10.1002\/cbdv.202401466","article-title":"Chemical compositions, molecular docking, anti-inflammatory, and anti-cancer effects of the leaf essential oils isolated from three species of the Rutaceae family in Vietnam","volume":"22","author":"Pham","year":"2025","journal-title":"Chem. Biodivers."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kasarci-Kavsara, G., Barak, T.H., Ertugrul, B., Senturk, T.B., Cakmakoglu, B., and Bireller, S. (2026). Ylang Ylang Essential Oil in Malignant and Non-Malignant Cells: Comparative Mitophagy-Related Transcriptional Responses. Pharmaceuticals, 19.","DOI":"10.3390\/ph19071002"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mustapa, M.A., Guswenrivo, I., Zuhrotun, A., Ikram, N.K.K., and Muchtaridi, M. (2022). Anti-Breast Cancer Activity of Essential Oil: A Systematic Review. Appl. Sci., 12.","DOI":"10.3390\/app122412738"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Madrid, A., Silva, V., Russo, A., Moller, A.C., S\u00e1nchez, E., Villena, J., Jara-Guti\u00e9rrez, C., and Montenegro, I. (2025). Selective cytotoxicity of Gomortega keule essential oil through a ROS-mediated pro-apoptotic mechanism. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1722619"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ptr.8054","article-title":"Essential oils and their nanoformulations for breast cancer therapy","volume":"38","author":"Thalappil","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e22223","DOI":"10.1002\/ddr.22223","article-title":"Validating linalool as a potential drug for breast cancer treatment based on machine learning and molecular docking","volume":"85","author":"Zhang","year":"2024","journal-title":"Drug Dev. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.6026\/97320630018697","article-title":"Molecular docking analysis of phytochemicals with estrogen receptor alpha","volume":"18","author":"Rafeeq","year":"2022","journal-title":"Bioinformation"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Reyes-Vidal, I., Tepale-Ledo, I., Rivera, G., Ortiz-Islas, E., P\u00e9rez-Mora, S., P\u00e9rez-Ishiwara, D.G., Flores-Martinez, Y.M., Lara-Rodr\u00edguez, M., and G\u00f3mez-Garc\u00eda, M.D.C. (2025). In Silico and In Vitro Evaluation of \u03b4-cadinene from Decatropis bicolor as a Selective Inhibitor of Human Cell Adhesion and Invasion Proteins. Cancers, 17.","DOI":"10.3390\/cancers17172839"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"133627","DOI":"10.1016\/j.molstruc.2022.133627","article-title":"Machine learning-based screening of MCF-7 human breast cancer cells and molecular docking analysis of essential oils from Ocimum basilicum against breast cancer","volume":"1268","author":"Nguyen","year":"2022","journal-title":"J. Mol. Struct."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1039\/D4RA00502C","article-title":"Anticancer evaluations of iodoquinazoline substituted with allyl and\/or benzyl as dual inhibitors of EGFRWT and EGFRT790M: Design, synthesis, ADMET and molecular docking","volume":"14","author":"Aljohani","year":"2024","journal-title":"RSC Adv."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Twala, C., Govender, P., and Govender, K. (2025). Compuational Chemistry Advances in the Development of PARP1 Inhibitors for Breast Cancer Therapy. Pharmaceuticals, 18.","DOI":"10.3390\/ph18111679"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Yan, F., Fu, Z., Li, G., and Wang, Z. (2023). In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers. Molecules, 28.","DOI":"10.3390\/molecules28041829"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Keung, M.Y., Wu, Y., Badar, F., and Vadgama, J.V. (2020). Response of breast cancer cells to PARP inhibitors is independent of BRCA status. J. Clin. Med., 9.","DOI":"10.3390\/jcm9040940"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1055\/a-2307-8183","article-title":"The Clinical Translation of \u03b1-humulene\u2014A Scoping Review","volume":"90","author":"Dalavaye","year":"2024","journal-title":"Planta Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bsharat, O., Salama, Y., Al-Hajj, N., and Al-Maharik, N. (2025). Chiliadenus iphionoides: From chemical profiling to anticancer, antioxidant, \u03b1-amylase, and \u03b1-glycosidase activities. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0327632"},{"key":"ref_31","first-page":"388","article-title":"Methods of endotoxin removal from biological preparations: A review","volume":"10","author":"Lopes","year":"2007","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_32","unstructured":"European Directorate for the Quality of Medicines (2017). European Pharmacopoeia, \u201cWater for Injections\u201d (0169), EDQM."},{"key":"ref_33","unstructured":"Adams, R.P. (2007). Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry, Allured Publishing Corporation."},{"key":"ref_34","first-page":"e03240","article-title":"Chemical composition and biological potential of Cedrus atlantica essential oil assessed through in vitro and in silico approaches","volume":"31","author":"Rabouj","year":"2026","journal-title":"Sci. Afr."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chaudhary, S., Chandrashekar, K.S., Pai, K.S.R., Setty, M.M., Devkar, R.A., Reddy, N.D., and Shoja, M.H. (2015). Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement. Altern. Med., 15.","DOI":"10.1186\/s12906-015-0563-1"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Elbouzidi, A., Ouassou, H., Aherkou, M., Kharchoufa, L., Meskali, N., Baraich, A., Mechchate, H., Bouhrim, M., Idir, A., and Hano, C. (2022). LC\u2013MS\/MS phytochemical profiling, antioxidant activity, and cytotoxicity of the ethanolic extract of Atriplex halimus L. Against breast cancer cell lines: Computational studies and experimental validation. Pharmaceuticals, 15.","DOI":"10.3390\/ph15091156"},{"key":"ref_37","unstructured":"Landrum, G. (2016). Rdkit: Open-Source Cheminformatics Software, Greg Landrum."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1021\/acs.jcim.5b00654","article-title":"Better informed distance geometry: Using what we know to improve conformation generation","volume":"55","author":"Riniker","year":"2015","journal-title":"J. Chem. Inf. Model."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/febs.12658","article-title":"Estrogen receptor \u03b1 mediates proliferation of breast cancer MCF\u20137 cells via a p21\/PCNA\/E 2 F 1-dependent pathway","volume":"281","author":"Liao","year":"2014","journal-title":"FEBS J."},{"key":"ref_40","first-page":"5475","article-title":"Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3\u2032-kinase and phospholipase C-dependent mechanism","volume":"59","author":"Price","year":"1999","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41598-016-0007-2","article-title":"Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13321-021-00522-2","article-title":"GNINA 1.0: Molecular docking with deep learning","volume":"13","author":"McNutt","year":"2021","journal-title":"J. Cheminform."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1021\/acs.jcim.0c00411","article-title":"Three-Dimensional Convolutional Neural Networks and a Cross-Docked Data Set for Structure-Based Drug Design","volume":"60","author":"Francoeur","year":"2020","journal-title":"J. Chem. Inf. Model."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Tikent, A., Laaraj, S., Bouddine, T., Chebaibi, M., Bouhrim, M., Elfazazi, K., Alqahtani, A.S., Noman, O.M., Hajji, L., and Rhazi, L. (2024). Antioxidant potential, antimicrobial activity, polyphenol profile analysis, and cytotoxicity against breast cancer cell lines of hydro-ethanolic extracts of leaves of (Ficus carica L.) from Eastern Morocco. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1505473"},{"key":"ref_46","first-page":"e03245","article-title":"Integrated In Vitro and Computational Assessment of Syzygium aromaticum Polyphenolic Extract: Bioactivities and Toxicity Profiling","volume":"31","author":"Chebaibi","year":"2026","journal-title":"Sci. Afr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"El Brahimi, R., El Barnossi, A., El Moussaoui, A., Chebaibi, M., Kachkoul, R., Baghouz, A., Nafidi, H.-A., Salamatullah, A.M., Bourhia, M., and Bari, A. (2023). Phytochemistry and biological activities of essential oils from Satureja calamintha Nepeta. Separations, 10.","DOI":"10.3390\/separations10060344"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ez-Zahra Amrati, F., Mssillou, I., Boukhira, S., Djiddi Bichara, M., El Abdali, Y., Galv\u00e3o de Azevedo, R., Mohamed, C., Slighoua, M., Conte, R., and Kiokias, S. (2024). Phenolic composition of Crataegus monogyna Jacq. extract and its anti-inflammatory, hepatoprotective, and antileukemia effects. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060786"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Chebaibi, M., Bourhia, M., Amrati, F.E.-Z., Slighoua, M., Mssillou, I., Aboul-Soud, M.A., Khalid, A., Hassani, R., Bousta, D., and Achour, S. (2024). Salsoline derivatives, genistein, semisynthetic derivative of kojic acid, and naringenin as inhibitors of A42R profilin-like protein of monkeypox virus: In silico studies. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1445606"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8557\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:05Z","timestamp":1790614325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/19\/8557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":49,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["ijms27198557"],"URL":"https:\/\/doi.org\/10.3390\/ijms27198557","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}