{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:51Z","timestamp":1792789491999,"version":"4.5.0"},"reference-count":67,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia","award":["BNW-1-137\/K\/3\/I"],"award-info":[{"award-number":["BNW-1-137\/K\/3\/I"]}],"id":[{"id":"https:\/\/ror.org\/005k7hp45","id-type":"ROR","asserted-by":"crossref"}]},{"award":["BNW-1-137\/K\/3\/I"],"award-info":[{"award-number":["BNW-1-137\/K\/3\/I"]}],"id":[{"id":"https:\/\/ror.org\/005k7hp45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Diagnosis and management of pediatric cardiac arrhythmias is challenging due to heterogeneous clinical presentation and limited availability of validated biomarkers. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a well-established marker of myocardial stress; its role in pediatric arrhythmias has not been fully elucidated. This pilot study included 26 children and adolescents with a history of idiopathic ventricular arrhythmias (VAs, n = 17) or supraventricular tachycardia (SVT, n = 9) and 20 hospital-based controls without arrhythmias. Serum NT-proBNP was measured by ELISA. Group differences were tested with the Mann\u2013Whitney U test and correlations with Spearman\u2019s coefficient. NT-proBNP concentrations were significantly higher in pediatric patients with a history of cardiac arrhythmias than in controls, with the difference remaining statistically significant for the VAs subgroup. The treated patients had significantly lower levels than the untreated individuals. NT-proBNP showed no significant associations with age, sex, echocardiography, or other laboratory parameters. In the VAs subgroup, NT-proBNP was moderately negatively correlated with baseline QRS duration. Given a limited patient population, these findings represent a pilot exploratory analysis. NT-proBNP should be considered a supportive biomarker reflecting functional myocardial strain rather than a stand-alone diagnostic tool for pediatric arrhythmia classification.<\/jats:p>","DOI":"10.3390\/ijms27198559","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:29:53Z","timestamp":1790267393000},"page":"8559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum NT-proBNP Concentrations in Pediatric Patients with a History of Idiopathic Cardiac Arrhythmias: A Pilot Study"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-2824","authenticated-orcid":false,"given":"Ewa","family":"Moric-Janiszewska","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8A, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-3342","authenticated-orcid":false,"given":"Joanna","family":"Wawszczyk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8A, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-1171","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Kapral","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedno\u015bci 8A, 41-200 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41569-021-00520-9","article-title":"Electroimmunology and Cardiac Arrhythmia","volume":"18","author":"Grune","year":"2021","journal-title":"Nat. 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