{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:02:51Z","timestamp":1790330571505,"version":"4.1.0"},"reference-count":128,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Environmental pollution has emerged as a critical global health threat, with xenobiotic exposure increasingly linked to the pathogenesis of chronic liver diseases. The gut\u2013liver axis has been proposed as a potential mediator in the body\u2019s response to these insults. This review evaluates how selected environmental pollutants\u2014heavy metals, particulate matter (PM), and endocrine-disrupting chemicals (EDCs), particularly Bisphenol A (BPA)\u2014disrupt this homeostatic balance. Evidence indicates that environmental toxins induce gut dysbiosis and impair intestinal barrier integrity. This \u201cleaky gut\u201d phenomenon facilitates the translocation of endotoxins (LPS) into the portal circulation, where they trigger the TLR4\/NF-\u03baB signaling pathway in the liver. This leads to the activation of chronic inflammation, oxidative stress, and significant lipid accumulation in the liver. Furthermore, EDCs interfere with hepatic nuclear receptors, directly deregulating lipid metabolism and driving the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). By highlighting the gut\u2013liver axis as a key pathway affected by selected environmental contaminants, this review provides a mechanistic foundation to guide future research toward targeted preventive and therapeutic strategies.<\/jats:p>","DOI":"10.3390\/ijms27198581","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:23:01Z","timestamp":1790328181000},"page":"8581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of the Gut\u2013Liver Axis in the Development of Liver Diseases Induced by Selected Environmental Pollutants: A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-4744","authenticated-orcid":false,"given":"Sara","family":"Jarmakiewicz-Czaja","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"University Center for Research and Development in Health Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-1748","authenticated-orcid":false,"given":"K\u00fcbra","family":"Ergan","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul 34010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-8766","authenticated-orcid":false,"given":"Aneta","family":"Sokal-Dembowska","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"University Center for Research and Development in Health Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rojas-Rueda, D., Morales-Zamora, E., Alsufyani, W.A., Herbst, C.H., AlBalawi, S.M., Alsukait, R., and Alomran, M. 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