{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:55:17Z","timestamp":1790769317175,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u0130lko \u0130la\u00e7 Sanayi ve Ticaret A.\u015e.","award":["430011792"],"award-info":[{"award-number":["430011792"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is an important comorbidity in people living with HIV (PLWH), yet most data derive from individuals receiving antiretroviral therapy (ART). In the baseline cross-sectional analysis of the prospective multicentre MASHIV-TR cohort (nine centres, T\u00fcrkiye), we compared 250 newly diagnosed, ART-na\u00efve PLWH and 161 HIV-negative controls. Hepatic steatosis and liver stiffness were assessed by vibration-controlled transient elastography; MASLD was defined as hepatic steatosis, indicated by CAP \u2265 248 dB\/m together with at least one cardiometabolic risk factor. MASLD prevalence was similar in the two groups (25.2% vs. 30.4%; p = 0.245), and HIV status was not independently associated with MASLD. Triglyceride level was independently associated with CAP in PLWH (+10.69 dB\/m per 50 mg\/dL) and in controls (+9.26 dB\/m), whereas CD4 and CD8 counts, the CD4\/CD8 ratio and HIV-RNA were not associated with the liver outcomes. Before ART, hepatic steatosis tracked metabolic rather than HIV-specific markers.<\/jats:p>","DOI":"10.3390\/ijms27198672","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:50:54Z","timestamp":1790614254000},"page":"8672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline Liver Metabolic Health in Newly Diagnosed People Living with HIV Compared with HIV-Negative Controls: Cross-Sectional Findings from the Prospective MASHIV-TR Cohort"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-6281","authenticated-orcid":false,"given":"\u00c7i\u011fdem","family":"Mermutluo\u011flu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dicle University, Diyarbak\u0131r 21280, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u015fim","family":"Ta\u015fova","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, \u00c7ukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe \u00d6zlem","family":"Mete","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep 27310, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkay","family":"Karao\u011flan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep 27310, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcsn\u00fc","family":"Pulluk\u00e7u","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, \u0130zmir 35100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meliha \u00c7a\u011fla","family":"S\u00f6nmezer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara 06100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya 07070, 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T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-838X","authenticated-orcid":false,"given":"\u0130smail","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Faculty of Medicine, Dicle University, Diyarbak\u0131r 21280, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behice","family":"Kurtaran","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ac\u0131badem Adana Hospital, Adana 01130, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-2727","authenticated-orcid":false,"given":"M\u00fcge","family":"Toygar Deniz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli 41380, 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Mol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3350\/cmh.2022.0239","article-title":"Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach","volume":"28","author":"Le","year":"2022","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"ofz509","DOI":"10.1093\/ofid\/ofz509","article-title":"Presumed Nonalcoholic Fatty Liver Disease Among Medicare Beneficiaries with HIV, 2006\u20132016","volume":"7","author":"Paik","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/COH.0000000000000866","article-title":"Deciphering HIV-associated inflammation: Microbiome\u2019s influence and experimental insights","volume":"19","author":"Lippincott","year":"2024","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_5","unstructured":"(2026, September 11). Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV: Initiation of Antiretroviral Therapy, Available online: https:\/\/clinicalinfo.hiv.gov\/en\/guidelines."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"INSIGHT START Study Group (2015). Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N. Engl. J. Med., 373, 795\u2013807.","DOI":"10.1056\/NEJMoa1506816"},{"key":"ref_7","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases (2026, June 18). Stavudine, LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548694\/."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/cc2162","article-title":"Bench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors","volume":"7","author":"Claessens","year":"2003","journal-title":"Crit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/pcad.2003.3","article-title":"Dyslipidemia in the era of HIV protease inhibitors","volume":"45","author":"Stein","year":"2003","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/COH.0b013e3283139134","article-title":"HIV protease inhibitors and insulin resistance: Lessons from in-vitro, rodent and healthy human volunteer models","volume":"3","author":"Hruz","year":"2008","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"ofab542","DOI":"10.1093\/ofid\/ofab542","article-title":"Excess Weight Gain with Integrase Inhibitors and Tenofovir Alafenamide: What Is the Mechanism and Does It Matter?","volume":"8","author":"Wood","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11904-024-00708-x","article-title":"Metabolic Complications Associated with Use of Integrase Strand Transfer Inhibitors (InSTI) for the Treatment of HIV-1 Infection: Focus on Weight Changes, Lipids, Glucose and Bone Metabolism","volume":"21","author":"Savinelli","year":"2024","journal-title":"Curr. HIV AIDS Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/COH.0000000000000680","article-title":"Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV","volume":"16","author":"Lake","year":"2021","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.cgh.2023.01.001","article-title":"Prevalence and Characteristics of Nonalcoholic Fatty Liver Disease and Fibrosis in People Living with HIV Monoinfection: A Systematic Review and Meta-analysis","volume":"21","author":"Kalligeros","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1038\/s41598-023-32965-y","article-title":"Metabolic dysfunction-associated fatty liver disease in people living with HIV","volume":"13","author":"Michel","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/apt.17849","article-title":"Prevalence of steatotic liver disease, MASLD, MetALD and significant fibrosis in people with HIV in the United States","volume":"59","author":"Gawrieh","year":"2024","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jahagirdar, V., Parajuli, P., Hargrove, S., and Sterling, R.K. (2026). Metabolic dysfunction-associated steatotic liver disease in people living with HIV: A scoping review. Livers, 6.","DOI":"10.3390\/livers6010012"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/hep4.1958","article-title":"Effect of hepatic steatosis and associated metabolic comorbidities on health-related quality of life in people living with HIV","volume":"6","author":"Michel","year":"2022","journal-title":"Hepatol. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100966","DOI":"10.1016\/j.gastha.2026.100966","article-title":"Metabolic dysfunction-associated steatotic liver disease is associated with impaired health-related quality of life in people with HIV","volume":"5","author":"Cinque","year":"2026","journal-title":"Gastro Hep Adv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease","volume":"77","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL\u2013EASD\u2013EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jhep.2017.11.013","article-title":"Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers","volume":"68","author":"Chalasani","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/hep.23312","article-title":"Diagnosis of Fibrosis and Cirrhosis Using Liver Stiffness Measurement in Nonalcoholic Fatty Liver Disease","volume":"51","author":"Wong","year":"2010","journal-title":"Hepatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S2468-1253(19)30383-8","article-title":"FibroScan-AST (FAST) score for the noninvasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: A prospective derivation and global validation study","volume":"5","author":"Newsome","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jhep.2016.06.005","article-title":"MRI and MRE for noninvasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: Clinical trials to clinical practice","volume":"65","author":"Dulai","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1053\/j.gastro.2016.10.026","article-title":"Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease","volume":"152","author":"Park","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Dogay Us, G., Innocenti, F., Koc, O.M., Yumuk, V.D., Gungor, Z.B., and Koek, G.H. (2026). Prevalence of MASLD and fibrosis in Turkey: Results from a multicenter study of at-risk populations. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0341214"},{"key":"ref_28","first-page":"37","article-title":"The prevalence of metabolic-associated fatty liver disease in the Turkish population: A multicenter study","volume":"2","author":"Yilmaz","year":"2021","journal-title":"Hepatol. Forum"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ergenc, I., Kara, E., Yilmaz, M.E., Demirtas, C.O., Keklikkiran, C., Das, T., Buyuk, Y., Celikel, C., Asliyuksek, H., and Yilmaz, Y. (2024). Prevalence of metabolic dysfunction-associated steatotic liver disease and steatohepatitis in T\u00fcrkiye: A forensic autopsy study. Heliyon, 10.","DOI":"10.1016\/j.heliyon.2024.e34915"},{"key":"ref_30","unstructured":"Republic of T\u00fcrkiye Ministry of Health, General Directorate of Public Health (2026, September 22). HIV\/AIDS Statistics, Version of 7 November 2024, Available online: https:\/\/hsgm.saglik.gov.tr\/depo\/birimler\/bulasici-hastaliklar-ve-erken-uyari-db\/Dokumanlar\/Istatistikler\/HIV_AIDS_Istatistikleri.pdf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/01621459.2016.1260466","article-title":"Balancing covariates via propensity score weighting","volume":"113","author":"Li","year":"2018","journal-title":"J. Am. Stat. Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wei, J., Hui, W., Fang, Y., Jia, H., Yang, Y., Zhang, T., Wu, H., Su, B., and Jiang, T. (2025). The prevalence of nonalcoholic fatty liver disease in people living with HIV: A systematic review and meta-analysis. BMC Infect. Dis., 25.","DOI":"10.1186\/s12879-025-10455-y"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cgh.2022.03.048","article-title":"Screening HIV Patients at Risk for NAFLD Using MRI-PDFF and Transient Elastography: A European Multicenter Prospective Study","volume":"21","author":"Lemoine","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ajg.2014.32","article-title":"Risk Factors for Fatty Liver in the Multicenter AIDS Cohort Study","volume":"109","author":"Price","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2184","DOI":"10.1093\/cid\/ciaa1302","article-title":"Increased Body Mass Index and Type 2 Diabetes Are the Main Predictors of Nonalcoholic Fatty Liver Disease and Advanced Fibrosis in Liver Biopsies of Patients with Human Immunodeficiency Virus Monoinfection","volume":"73","author":"Maurice","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"ofag236","DOI":"10.1093\/ofid\/ofag236","article-title":"Predicting MASLD in People with HIV Using Anthropometric Measures: A Multicenter Cross-Sectional Study","volume":"13","author":"Slim","year":"2026","journal-title":"Open Forum Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jin, D., Jin, S., Zhou, T., Cui, Z., Guo, B., Li, G., and Zhang, C. (2024). Regional variation in NAFLD prevalence and risk factors among people living with HIV in Europe: A meta-analysis. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1295165"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/hiv.12384","article-title":"Changes in liver steatosis evaluated by transient elastography with the controlled attenuation parameter in HIV-infected patients","volume":"17","author":"Real","year":"2016","journal-title":"HIV Med."},{"key":"ref_39","first-page":"16","article-title":"Lipid Profile Differences in HIV-Infected Populations with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis","volume":"12","author":"Hartantri","year":"2026","journal-title":"Chronic Dis. Transl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12944-024-02317-4","article-title":"MASLD in persons with HIV is associated with high cardiometabolic risk as evidenced by altered advanced lipoprotein profiles and targeted metabolomics","volume":"23","author":"Lin","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101185","DOI":"10.1016\/j.jhepr.2024.101185","article-title":"Lipid metabolism in MASLD and MASH: From mechanism to the clinic","volume":"6","author":"Carli","year":"2024","journal-title":"JHEP Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI134165","article-title":"Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease","volume":"130","author":"Smith","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/135965350701200203","article-title":"Liver triglyceride content in HIV-1-infected patients on combination antiretroviral therapy studied with 1H-MR spectroscopy","volume":"12","author":"Domingo","year":"2007","journal-title":"Antivir. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/infdis\/jiaa246","article-title":"Prevalence and Risk Factors of Moderate-to-Severe Hepatic Steatosis in Human Immunodeficiency Virus Infection: The Copenhagen Co-morbidity Liver Study","volume":"222","author":"Fuchs","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/hiv.13697","article-title":"Metabolic dysfunction-associated steatohepatitis exhibits sex differences in people with HIV","volume":"25","author":"Kablawi","year":"2024","journal-title":"HIV Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"ofaf637","DOI":"10.1093\/ofid\/ofaf637","article-title":"Female sex is protective against MASLD with clinically significant fibrosis in a large cross-sectional cohort of persons with HIV","volume":"12","author":"Wegermann","year":"2025","journal-title":"Open Forum Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.molmed.2024.05.013","article-title":"Sexual dimorphism of metabolic dysfunction-associated steatotic liver disease","volume":"30","author":"Cherubini","year":"2024","journal-title":"Trends Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mu, W., Patankar, V., Kitchen, S., and Zhen, A. (2024). Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection. Viruses, 16.","DOI":"10.3390\/v16020219"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Tao, M., Xia, M., Yu, T., Li, B., Peng, J., Cai, S., and Xu, X. (2026). Longitudinal analysis of metabolic changes in people with HIV on integrase inhibitor-based versus efavirenz-based therapy: A prospective real-world cohort study in China. BMC Infect. Dis., 26.","DOI":"10.1186\/s12879-026-12553-x"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/09564624241287886","article-title":"Incidence of non-alcoholic fatty liver disease in antiretroviral therapy-na\u00efve people with human immunodeficiency virus who start DTG\/ABC\/3TC compared to BIC\/FTC\/TAF at 48-week follow-up","volume":"36","author":"Mauss","year":"2025","journal-title":"Int. J. STD AIDS"},{"key":"ref_51","unstructured":"World Health Organization (2000). Obesity: Preventing and Managing the Global Epidemic, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/42330."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/diacare.23.1.57","article-title":"Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity","volume":"23","author":"Bonora","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.20920","article-title":"Insulin Resistance: A Metabolic Pathway to Chronic Liver Disease","volume":"42","author":"Bugianesi","year":"2005","journal-title":"Hepatology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.ultrasmedbio.2024.03.013","article-title":"WFUMB Guideline\/Guidance on Liver Multiparametric Ultrasound: Part 1. Update to 2018 Guidelines on Liver Ultrasound Elastography","volume":"50","author":"Ferraioli","year":"2024","journal-title":"Ultrasound Med. 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