{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:06Z","timestamp":1790618226505,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00342230"],"award-info":[{"award-number":["RS-2024-00342230"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00345119"],"award-info":[{"award-number":["RS-2024-00345119"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2024-00342230"],"award-info":[{"award-number":["RS-2024-00342230"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RS-2024-00345119"],"award-info":[{"award-number":["RS-2024-00345119"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Basic Science Research Program (Host-Directed Antiviral Research Center","doi-asserted-by":"publisher","award":["RS-2023-00219517"],"award-info":[{"award-number":["RS-2023-00219517"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mid-Career Researcher Program","award":["RS-2023-00208589"],"award-info":[{"award-number":["RS-2023-00208589"]}]},{"name":"Global Learning & Academic Research Institute for Master\u2019s and PhD students and Postdocs (LAMP) Program","award":["RS-2024-00445180"],"award-info":[{"award-number":["RS-2024-00445180"]}]},{"DOI":"10.13039\/501100001459","name":"Anchor Program through the Gwangju Anchor Center","doi-asserted-by":"publisher","award":["2026-ANCHOR-05-011"],"award-info":[{"award-number":["2026-ANCHOR-05-011"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The genus Peucedanum (Apiaceae) contains diverse coumarins and related secondary metabolites with a wide range of pharmacological activities; however, the antiviral potential of Korean taxa remains largely unexplored. In this study, we evaluated the cytotoxicity and anti-influenza activity of aerial-part extracts from Korean Peucedanum taxa and the allied species Sillaphyton podagraria. Twenty-six ethanol extracts, comprising 24 accessions representing eight identified taxa and two unidentified Peucedanum samples, were screened against influenza A\/Puerto Rico\/8\/34 (H1N1) virus in MDCK cells. Cytotoxicity and antiviral activity were assessed using MTT-based assays, and the half-maximal inhibitory concentration (IC50), half-maximal cytotoxic concentration (CC50), and selectivity index (SI) were determined. Most extracts showed low cytotoxicity, with CC50 values &gt; 100 \u03bcg\/mL. P. terebinthaceum var. deltoideum showed the strongest and most consistent activity across all three accessions, with IC50 values of 6.42 to 12.18 \u03bcg\/mL and SI values ranging from &gt;8.21 to &gt;15.57. One P. japonicum extract (Pj2) was also active (IC50 = 15.52 \u03bcg\/mL; SI &gt; 6.44). Comparative chromatographic profiling further revealed taxon-specific chemical patterns. Collectively, these findings identify P. terebinthaceum var. deltoideum as a promising source of antiviral compounds and highlight the utility of a taxonomy-guided approach for bioprospecting and natural-product-based antiviral discovery.<\/jats:p>","DOI":"10.3390\/ijms27198676","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:50:54Z","timestamp":1790614254000},"page":"8676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae)"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5545-4464","authenticated-orcid":false,"given":"Gun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Kyeonghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6808-0524","authenticated-orcid":false,"given":"Seung Mok","family":"Ryu","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Heewon","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Biology, Chungbuk National University, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Hyun Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0943-9297","authenticated-orcid":false,"given":"Hyeon Jeong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1029-5669","authenticated-orcid":false,"given":"Chung-Do","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6049-049X","authenticated-orcid":false,"given":"Jaewoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of 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Korea"},{"name":"Animal Medical Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2180-4860","authenticated-orcid":false,"given":"Joong-Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Animal Medical Institute, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Department of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-3591","authenticated-orcid":false,"given":"Jun-Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"},{"name":"Animal Medical 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