{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:50:34Z","timestamp":1791435034879,"version":"4.3.3"},"reference-count":78,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro Universitario de los Valles, Universidad de Guadalajara","award":["FI2025-18"],"award-info":[{"award-number":["FI2025-18"]}],"id":[{"id":"https:\/\/ror.org\/043xj7k26","id-type":"ROR","asserted-by":"crossref"}]},{"award":["FI2025-18"],"award-info":[{"award-number":["FI2025-18"]}],"id":[{"id":"https:\/\/ror.org\/043xj7k26","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Quercetin (QUE) and resveratrol (RES) have complementary bioactivities but limited aqueous solubility and oral bioavailability. This study developed dual-loaded quercetin\u2013resveratrol niosomes (QR-NIOs) for incorporation into hummus and screened quercetin:resveratrol molar ratios using antioxidant, erythroprotective, and enzyme-inhibition assays. The 50:50 formulation showed the broadest activity profile and produced vesicles with 90.63 \u00b1 3.63% overall encapsulation efficiency, 149 \u00b1 13 nm diameter, 0.21 \u00b1 0.02 polydispersity index, and \u221234 \u00b1 2 mV \u03b6-potential. After 24 h, dialysis passage was 51.63%, compared with 80.35% for the unencapsulated mixture. Following simulated intestinal digestion, enriched hummus yielded 5.8 milligrams of gallic acid equivalents per gram of dry weight (mg GAE\/g D.W.) and 4.7 milligrams of quercetin equivalents per gram of dry weight (mg QE\/g D.W.) in the dialyzable phenolic and flavonoid fractions, respectively, exceeding both controls while retaining antioxidant and enzyme-inhibitory activities. Over 28 days at 4 \u00b0C, microbial counts remained below detection limits and the tested pathogens were absent. Overall acceptability (8.23\/9) did not differ significantly from commercial hummus. QR-NIO-enriched hummus represents a sensory-compatible functional-food prototype with sustained apparent release and increased intestinal recovery of assay-reactive phenolic and flavonoid compounds; compound-specific and in vivo validation remains necessary.<\/jats:p>","DOI":"10.3390\/ijms27198686","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:50:54Z","timestamp":1790614254000},"page":"8686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-Loaded Quercetin\u2013Resveratrol Niosomes: Sustained In Vitro Release and Retained Bioactivity in Hummus During Simulated Gastrointestinal Digestion"],"prefix":"10.3390","volume":"27","author":[{"given":"Jade Alejandra","family":"Miramontes-Piedra","sequence":"first","affiliation":[{"name":"Departamento de Ciencias de la Salud, Centro Universitario de los Valles (CUValles), Universidad de Guadalajara, Carretera a Guadalajara Km 45.5, Ameca 46600, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-5088","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Robles-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas y de la Vida, Centro Universitario de la Ci\u00e9nega (CUCI\u00c9NEGA), Universidad de Guadalajara, Av. Universidad 1115, Lindavista, Ocotl\u00e1n 47820, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"V\u00e1zquez-Aguilar","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos (DIPA), Universidad de Sonora, Blvd. Luis Encinas y Rosales S\/N, Col. 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Centro, Hermosillo 83000, Sonora, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-5087","authenticated-orcid":false,"given":"Fridha Viridiana","family":"Villalpando-Vargas","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Centro Universitario de los Valles (CUValles), Universidad de Guadalajara, Carretera a Guadalajara Km 45.5, Ameca 46600, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8612-2855","authenticated-orcid":false,"given":"Sergio Yair","family":"Rodr\u00edguez-Preciado","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Centro Universitario de los Valles (CUValles), Universidad de Guadalajara, Carretera a Guadalajara Km 45.5, Ameca 46600, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7427-5865","authenticated-orcid":false,"given":"Mariana","family":"D\u00edaz-Zaragoza","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Centro Universitario de los Valles (CUValles), Universidad de Guadalajara, Carretera a Guadalajara Km 45.5, Ameca 46600, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Barrera-de-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Centro Universitario de los Valles (CUValles), Universidad de Guadalajara, Carretera a Guadalajara Km 45.5, Ameca 46600, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-2542","authenticated-orcid":false,"given":"Ernesto","family":"Ram\u00edrez-Briones","sequence":"additional","affiliation":[{"name":"Departamento de Ecolog\u00eda Aplicada, Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Camino Ing. 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