{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:55:39Z","timestamp":1790769339301,"version":"4.1.0"},"reference-count":66,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["RSF 22-16-00044"],"award-info":[{"award-number":["RSF 22-16-00044"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RSF 22-16-00044"],"award-info":[{"award-number":["RSF 22-16-00044"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"publisher"}]},{"name":"State Assignment of the Ministry of Science and Higher Education of the Russian Federation","award":["075-00264-26-00"],"award-info":[{"award-number":["075-00264-26-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Valeriana officinalis L. is a widely spread representative of the Eurasian flora. Preparations based on valerian extracts are recognized as sedatives, antidepressants, and anxiolytics by both traditional and modern medicine. Despite the extremely high interest in the biological and pharmacological properties of valerian extracts, the composition of biologically active substances and specific activities of their components are still not completely studied. Therefore, here we address the metabolic profiles of the valerian plants with a special emphasis on their major root constituents with pronounced neuroprotective activity. The following phytochemical analysis of the V. officinalis roots led to isolation of nine compounds, including two previously undescribed iridoids\u2014isovaltrate isovaleroyloxyisohydrin (1) and isovaltrate \u03b1-(isovaleroxy)isovaleroxyhydrin (2)\u2014together with one previously undescribed valerenic acid derivative\u20142-oxovalerenic acid (3). Three previously described iridoids\u2014iridoidvol A (4), isovaltrate isovaleroyloxyhydrin (5), and valtrate hydrine B1 (6)\u2014along with valerenic acid (7) and its metabolites\u2014hydroxyvalerenic (8) and acetoxyvalerenic acids (9)\u2014were isolated. Functional assays accomplished with the isolated compounds revealed moderate antioxidant activity characteristic for all of them. Moreover, a distinct neuroprotective potential was observed for the compound 3 (and, to a lesser extent, compound 8). This potential was manifested by a preliminary antineurodegenerative effect in the model of A\u03b225\u201335 induced cytotoxicity. In respect of thrombin-induced platelet aggregation, compounds 1, 4, and 7 demonstrated pronounced inhibitory activity, whereas compounds 2, 5, and 6 showed distinct potentiating activity. Valerenic acid showed activity on TRPV1 ion channels, manifested by both channel activation and potentiation of the capsaicin response in CHO cells expressing TRPV1. Moderate antioxidant activity was characteristic of all compounds.<\/jats:p>","DOI":"10.3390\/ijms27198756","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:59:25Z","timestamp":1790765965000},"page":"8756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A First Insight into the Biological Activity Profile of Individual Compounds of Valeriana officinalis L."],"prefix":"10.3390","volume":"27","author":[{"given":"Anastasia","family":"Orlova","sequence":"first","affiliation":[{"name":"Laboratory of Analytical Biochemistry and Biotechnology, K.A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, 127276 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-8628","authenticated-orcid":false,"given":"Alena","family":"Soboleva","sequence":"additional","affiliation":[{"name":"Laboratory of Bioanalytical Chemistry, Institute of Natural Sciences, Immanuel Kant Baltic Federal University, Universitetskaya 2, 236040 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Anastasiia O.","family":"Whaley","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Saint Petersburg State Chemical and Pharmaceutical University, 197376 St. Petersburg, Russia"},{"name":"Laboratory of Cellular Mechanisms of Blood Homeostasis, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Andrei K.","family":"Whaley","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Saint Petersburg State Chemical and Pharmaceutical University, 197376 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Darya","family":"Meshalkina","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Neurobiology, Sechenov Institute of Evolutional Physiology and Biochemistry, 194223 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-0791","authenticated-orcid":false,"given":"Stepan","family":"Gambaryan","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Mechanisms of Blood Homeostasis, Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-337X","authenticated-orcid":false,"given":"Sergey N.","family":"Smirnov","sequence":"additional","affiliation":[{"name":"Resource Center of Magnetic Resonance Research Methods, Saint Petersburg State University, 198504 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1511-1538","authenticated-orcid":false,"given":"Margarita M.","family":"Shamatova","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-5366","authenticated-orcid":false,"given":"Yuliya V.","family":"Korolkova","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-4240","authenticated-orcid":false,"given":"Sergey A.","family":"Kozlov","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-9547","authenticated-orcid":false,"given":"Eugene A.","family":"Rogozhin","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Toni","family":"Ditfe","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Stanislav","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Andrej","family":"Frolov","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Biochemistry and Biotechnology, K.A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, 127276 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5897\/AJAR2016.11677","article-title":"Plant secondary metabolites and its dynamical systems of induction in response to environmental factors: A review","volume":"12","author":"Olivoto","year":"2017","journal-title":"Afr. J. Agric. 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