{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:48:40Z","timestamp":1791953320649,"version":"4.3.4"},"reference-count":323,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondazione Don Carlo Gnocchi ETS","award":["Ricerca Corrente 2026; RRC-2026-23687902"],"award-info":[{"award-number":["Ricerca Corrente 2026; RRC-2026-23687902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Adult neurogenesis is impaired in Alzheimer\u2019s disease (AD) and contributes to neuronal and cognitive dysfunction. Furthermore, efficient neurogenesis promotes cognitive resilience. I recently proposed a theory suggesting that neurogenesis plays a more central role in the pathogenesis of AD. The main hypothesis posits that new neurons harboring tau seeds propagate tauopathy as they mature and integrate into the brain. The aim of this study is to demonstrate that the theory successfully predicts the distribution of the earliest foci of tauopathy in AD. To this end, I synthesized data from the literature regarding the earliest localizations of tauopathy in AD. I then indicated where one would expect to find the earliest seeds of tauopathy if the theory were true. Finally, I compared the localization data with the theory\u2019s predictions. Overall, the theory\u2019s predictions were entirely consistent with the initial localization of tauopathy. Specifically, the theory is consistent with the exclusively neuronal and somatodendritic involvement of tauopathy; the preference for layer II and the transentorhinal\/entorhinal complex; the early involvement of subcortical nuclei; phenotypic heterogeneity; differences between early- and late-onset AD; hemispheric asymmetries; and clinical-anatomical convergence. The theory demonstrates predictive power, economicity, compatibility with other theories, and generalizability to other diseases.<\/jats:p>","DOI":"10.3390\/ijms27198776","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:19:37Z","timestamp":1790777977000},"page":"8776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Adult Neurogenesis Theory of Alzheimer\u2019s Disease Predicts Where Tauopathy Develops in the Brain"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-3834","authenticated-orcid":false,"given":"Carlo","family":"Abbate","sequence":"first","affiliation":[{"name":"Fondazione Don Carlo Gnocchi ETS, Istituto Palazzolo, Via Don Luigi Palazzolo 21, 20149 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/bs.pmbts.2020.09.002","article-title":"Adult hippocampal neurogenesis in Alzheimer\u2019s disease","volume":"177","author":"Disouky","year":"2021","journal-title":"Prog. 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