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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Plant essential oils (EOs) exhibit promising anxiolytic activity, but their application may be constrained by adverse motor effects arising from interactions with neural circuits controlling movement. Here, we investigated the anxiolytic-like effects and motor impairment liability of EOs from Pimenta pseudocaryophyllus, Melissa officinalis, Matricaria chamomilla, Lippia alba, Salvia rosmarinus, Ocimum basilicum, Spiranthera odoratissima, and Cymbopogon citratus, integrating computational target prediction with behavioral pharmacology. Prioritized EO constituents were subjected to target prediction, molecular docking, and 100-ns molecular dynamics simulations to identify molecular mechanisms potentially associated with motor impairment. Male and female Swiss mice received oral vehicle 10 mL\/kg, EOs (10, 100, or 500 mg\/kg) or diazepam (DZP 1 or 5 mg\/kg), followed by the evaluation of anxiolytic-like behavior and motor coordination in the elevated plus maze and rotarod test, respectively. In silico analyses involving docking and molecular dynamics simulations of computationally prioritized EO constituents identified candidate targets within M1 and M2 receptors. All EOs exhibited anxiolytic-like activity at the intermediate dose. Motor impairment varied markedly among EOs. Integrating computational target prediction with behavioral assessment identified distinct motor liability profiles among EOs.<\/jats:p>","DOI":"10.3390\/ijms27198786","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:20:59Z","timestamp":1790781659000},"page":"8786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anxiolytic Potential of Selected Essential Oils and Their Impact on Motor Function"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-4231","authenticated-orcid":false,"given":"Alberto Souza","family":"S\u00e1 Filho","sequence":"first","affiliation":[{"name":"Graduate Program in Pharmaceutical Sciences, Evangelical University of Goi\u00e1s, An\u00e1polis 75083-515, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-9945","authenticated-orcid":false,"given":"John Ihayi","family":"Ogbu","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Ayobami J.","family":"Olusola","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, Federal University of Goi\u00e1s, Goi\u00e2nia 74690-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Saheed Olanrewaju","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin 240003, 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Ingenier\u00eda de Construcci\u00f3n y Transporte, Pontif\u00edcia Universidad Cat\u00f3lica de Valpara\u00edso, Avda Brasil 2147, Valpara\u00edso 2362804, Chile"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-3427","authenticated-orcid":false,"given":"Ren\u00ea Oliveira","family":"do Couto","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Development (LADEF), Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis 35501-296, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-7196","authenticated-orcid":false,"given":"Lucas Barbosa Ribeiro de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"School of Medical and Life Sciences, Pontifical Catholic University of Goi\u00e1s, Goi\u00e2nia 74605-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Leonardo Luiz","family":"Borges","sequence":"additional","affiliation":[{"name":"School of Medical and Life Sciences, Pontifical Catholic University of Goi\u00e1s, Goi\u00e2nia 74605-010, Brazil"},{"name":"Laboratory for Research, Development & Innovation of Biodiversity Products, State University of Goi\u00e1s, An\u00e1polis 75132-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-9794","authenticated-orcid":false,"given":"Mirely Vit\u00f3ria Farias","family":"da Silva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC Sim\u00f5es Campus, Macei\u00f3 57072-970, 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