{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:52Z","timestamp":1792789492940,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","award":["280-CN-2022"],"award-info":[{"award-number":["280-CN-2022"]}],"id":[{"id":"https:\/\/ror.org\/01fh86n78","id-type":"ROR","asserted-by":"crossref"}]},{"award":["280-CN-2022"],"award-info":[{"award-number":["280-CN-2022"]}],"id":[{"id":"https:\/\/ror.org\/01fh86n78","id-type":"ROR","asserted-by":"publisher"}]},{"name":"National Council for Science and Technology","award":["809161"],"award-info":[{"award-number":["809161"]}],"id":[{"id":"https:\/\/ror.org\/05qk3dq04","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Renal ischemia\u2013reperfusion (I\/R) injury is a major cause of graft dysfunction. Flourensia cernua possesses antioxidant properties that may protect against this injury. This study evaluated its antioxidant capacity and nephroprotective effects in a renal I\/R model in Wistar rats. The extract was characterized by phytochemical analysis, total phenolic content, and ABTS, DPPH, and FRAP assays. Hemolytic activity was assessed, and rats were assigned to Sham, Non-Tox, I\/R, and I\/R + F. cernua groups (200 mg\/kg\/day for 7 days before I\/R). Biochemical parameters, renal oxidative stress markers, and Gpx, Rela, and Mpo expression were evaluated. The extract contained several secondary metabolites, showed radical-scavenging and reducing capacity, and had low hemolytic activity. Pretreatment reduced serum creatinine and renal malondialdehyde levels, restored glutathione and superoxide dismutase activity, and downregulated Gpx expression compared with I\/R. Pretreatment with F. cernua partially attenuated I\/R-induced renal injury and was associated with reduced lipid peroxidation and preservation of endogenous antioxidant defenses; however, these findings do not establish a causal molecular mechanism.<\/jats:p>","DOI":"10.3390\/ijms27198912","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:40:17Z","timestamp":1791596417000},"page":"8912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nephroprotective Effect of the Methanolic Extract of Flourensia cernua Against Renal Ischemia\u2013Reperfusion Injury Associated with Modulation of Oxidative Stress in Wistar Rats"],"prefix":"10.3390","volume":"27","author":[{"given":"Catalina","family":"Leos-Rivas","sequence":"first","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, School of Biological Sciences, Department of Analytical Chemistry, San Nicolas de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Carlos Humberto","family":"Andrade-Ordaz","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, School of Biological Sciences, Department of Analytical Chemistry, San Nicolas de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Diana Patricia","family":"Moreno-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, University Hospital \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d Department of Internal Medicine, Liver Unit Monterrey 66460, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-4953","authenticated-orcid":false,"given":"Catalina","family":"Rivas-Morales","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, School of Biological Sciences, Department of Analytical Chemistry, San Nicolas de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-8376","authenticated-orcid":false,"given":"Liliana","family":"Torres-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, University Hospital \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d Department of Internal Medicine, Liver Unit Monterrey 66460, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5751-9848","authenticated-orcid":false,"given":"Eduardo","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, School of Biological Sciences, Department of Analytical Chemistry, San Nicolas de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3176-9571","authenticated-orcid":false,"given":"Diana Raquel","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, University Hospital \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d Department of Internal Medicine, Liver Unit Monterrey 66460, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-3200","authenticated-orcid":false,"given":"Sandra Loruhama","family":"Castillo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, School of Biological Sciences, Department of Analytical Chemistry, San Nicolas de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda E.","family":"Mu\u00f1oz-Espinosa","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, University Hospital \u201cDr. Jos\u00e9 E. Gonz\u00e1lez\u201d Department of Internal Medicine, Liver Unit Monterrey 66460, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-7246","authenticated-orcid":false,"given":"Sergio Arturo","family":"Galindo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, School of Biological Sciences, Department of Analytical Chemistry, San Nicolas de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Cordero-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon, University Hospital \u201cDr. Jos\u00e9 E. 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