{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:50:32Z","timestamp":1791978632554,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation","award":["24-13-00370"],"award-info":[{"award-number":["24-13-00370"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"crossref"}]},{"award":["24-13-00370"],"award-info":[{"award-number":["24-13-00370"]}],"id":[{"id":"https:\/\/ror.org\/03y2gwe85","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The study investigates the effect of cerium dioxide (CeO2) nanoparticles on ribosomal DNA (rDNA) transcriptional activity and the status of ribosomal genes in human skin fibroblasts. Nano-CeO2 has attracted attention due to its antioxidant and redox properties; however, its impact on rDNA has so far remained virtually unexplored. Fibroblasts from ten adult donors were incubated with nano-CeO2 for 3 and 24 h, and the copy number of ribosomal genes and their functional state were assessed using real-time quantitative PCR and non-radioactive quantitative hybridization; the interaction of the nanoparticles with the cells was also assessed by fluorescence microscopy. It was shown that exposure to CeO2 nanoparticles leads to functional changes in rDNA transcription and rRNA abundance, indicating modulation of ribosomal biogenesis and consistent with a model of altered balance between transcriptionally active and inactive rDNA copies, although this study did not directly measure ribosome content or rDNA fraction distribution. The observed effects are likely mediated by the antioxidant and redox properties of the nanoparticles. Thus, nano-CeO2 can be considered a compound capable of modulating the functional state of ribosomal genes in normal human cells.<\/jats:p>","DOI":"10.3390\/ijms27198913","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:40:17Z","timestamp":1791596417000},"page":"8913","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerium Dioxide Nanoparticles Modulate Ribosomal DNA Transcriptional Activity in Cultured Human Skin Fibroblasts"],"prefix":"10.3390","volume":"27","author":[{"given":"Natalia N.","family":"Veiko","sequence":"first","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, Institute of Biology of Aging and Healthy Longevity Medicine with Clinic of Predictive Medicine, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-5832","authenticated-orcid":false,"given":"Elizaveta S.","family":"Ershova","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, Institute of Biology of Aging and Healthy Longevity Medicine with Clinic of Predictive Medicine, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5868-4746","authenticated-orcid":false,"given":"Madina M.","family":"Sozarukova","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Science, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-6339","authenticated-orcid":false,"given":"Elena V.","family":"Proskurnina","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Science, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Larisa V.","family":"Kameneva","sequence":"additional","affiliation":[{"name":"Petrovsky Russian Scientific Center of Surgery, Institute of Biology of Aging and Healthy Longevity Medicine with Clinic of Predictive Medicine, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Edmund V.","family":"Kostyuk","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Science, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Rozhnova","sequence":"additional","affiliation":[{"name":"Center of Digital Health and AI in Medicine, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-1609","authenticated-orcid":false,"given":"Yuriy L.","family":"Orlov","sequence":"additional","affiliation":[{"name":"Center of Digital Health and AI in Medicine, I.M. 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