{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:07:22Z","timestamp":1764842842002,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNS"],"abstract":"<jats:p>It has been demonstrated that universal hearing neonatal screening (UHNS) is efficient at providing early diagnosis and rehabilitation for deafness. The risk factors of deafness in children have been identified, but less specifically in those diagnosed after UHNS. In this study, we aim to study these factors in infants who were referred after screening and to compare our experience to recent data. We studied infants referred to our department for diagnosis after screening between January 2018 and December 2021. Their medical history and neonatal hearing risk factors were assessed. Associations between factors were also analyzed. Sixty-six infants were included. A family history of deafness (47%), syndromic deafness (41%), intrauterine growth retardation or prematurity (19.7%), and prolonged NICU admission (18%) were the most observed factors. When analyzing according to these associations, family history of deafness and syndromic cases remained the most prevalent factors (74%), while only five cases (7.8%) presented with other neonatal risk factors only. The majority of congenital hearing loss cases are observed in infants with suspected genetic deafness. Parental counseling, the diagnostic pathway, as well as the healthcare system should be adapted according to these risk factors.<\/jats:p>","DOI":"10.3390\/ijns10010011","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T07:49:47Z","timestamp":1706600987000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leading Risk Factors for Congenital Deafness in the Context of Universal Neonatal Screening: Our Observations in a Four-Year Retrospective Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Antoine","family":"Paul","sequence":"first","affiliation":[{"name":"Otolaryngology Department\u2014Cochlear Implant Center, H\u00f4pital Bic\u00eatre, Assistance Publique\u2014H\u00f4pitaux de Paris, Paris-Saclay University, 94270 Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Bense","sequence":"additional","affiliation":[{"name":"Otolaryngology Department\u2014Cochlear Implant Center, H\u00f4pital Bic\u00eatre, Assistance Publique\u2014H\u00f4pitaux de Paris, Paris-Saclay University, 94270 Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Boithias Guerot","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Department, H\u00f4pital Bic\u00eatre, Assistance Publique\u2014H\u00f4pitaux de Paris, Paris-Saclay University, 94270 Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"De La Rubia","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit Department, H\u00f4pital Antoine B\u00e9cl\u00e8re, Assistance Publique\u2014H\u00f4pitaux de Paris, Paris-Saclay University, 92140 Clamart, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Lebeaux","sequence":"additional","affiliation":[{"name":"Center of Perinatal Care of Val-de-Marne Department, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Papon","sequence":"additional","affiliation":[{"name":"Otolaryngology Department\u2014Cochlear Implant Center, H\u00f4pital Bic\u00eatre, Assistance Publique\u2014H\u00f4pitaux de Paris, Paris-Saclay University, 94270 Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/pubmed\/fdi037","article-title":"Observed and expected prevalence of permanent childhood hearing impairment in Oldham","volume":"27","author":"Mytton","year":"2005","journal-title":"J. Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.ijporl.2014.08.032","article-title":"Sensorineural hearing loss in children: The association with Apgar score. A registry-based study of 392,371 children in Norway","volume":"78","author":"Kvestad","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111308","DOI":"10.1016\/j.ijporl.2022.111308","article-title":"The prevalence and risk factors for congenital hearing loss in neonates: A birth cohort study based on CHALLENGE study","volume":"162","author":"Zhou","year":"2022","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41372-020-00807-8","article-title":"Comprehensive evaluation of risk factors for neonatal hearing loss in a large Brazilian cohort","volume":"41","author":"Anastasio","year":"2021","journal-title":"J. Perinatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.anorl.2015.10.001","article-title":"Newborn hearing screening: Prevalence and medical and paramedical treatment of bilateral hearing loss in a neonatal series in the \u00cele-de-France region of France","volume":"133","author":"Antoni","year":"2016","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.ijporl.2014.07.005","article-title":"Unilateral hearing loss is associated with a negative effect on language scores in adolescents","volume":"78","author":"Fischer","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_7","unstructured":"JCIH (2019). Year 2019 Position Statement: Principles and Guidelines for Early Hearing Detection and Intervention Programs. J. Early Hear. Detect. Interv., 4, 1\u201344."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S1474-4422(16)00034-X","article-title":"Neurocognitive factors in sensory restoration of early deafness: A connectome model","volume":"15","author":"Kral","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_9","unstructured":"Adam, M.P., Mirzaa, G.M., Pagon, R.A., Wallace, S.E., Bean, L.J., Gripp, K.W., and Amemiya, A. (2023, August 28). Genetic Hearing Loss Overview, GeneReviews\u00ae, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1434\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1093\/brain\/awv270","article-title":"Pathophysiological mechanisms and functional hearing consequences of auditory neuropathy","volume":"138","author":"Rance","year":"2015","journal-title":"Brain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/jnr.23107","article-title":"Bilirubin induces auditory neuropathy in neonatal guinea pigs via auditory nerve fiber damage","volume":"90","author":"Ye","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1153123","DOI":"10.3389\/fped.2023.1153123","article-title":"Analysis of congenital hearing loss after neonatal hearing screening","volume":"11","author":"Verstappen","year":"2023","journal-title":"Front. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1080\/14992027.2021.1871975","article-title":"Predicting hearing loss from 10 years of universal newborn hearing screening results and risk factors","volume":"60","author":"Fitzgibbons","year":"2021","journal-title":"Int. J. Audiol."}],"container-title":["International Journal of Neonatal Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2409-515X\/10\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:51:48Z","timestamp":1760104308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2409-515X\/10\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,30]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["ijns10010011"],"URL":"https:\/\/doi.org\/10.3390\/ijns10010011","relation":{},"ISSN":["2409-515X"],"issn-type":[{"type":"electronic","value":"2409-515X"}],"subject":[],"published":{"date-parts":[[2024,1,30]]}}}