{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:37:18Z","timestamp":1785530238593,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2021YFC2701004"],"award-info":[{"award-number":["2021YFC2701004"]}]},{"name":"National Key Research and Development Project of China","award":["2016YFC1000506"],"award-info":[{"award-number":["2016YFC1000506"]}]},{"name":"National Key Research and Development Project of China","award":["23DZ2203000"],"award-info":[{"award-number":["23DZ2203000"]}]},{"name":"National Key Research and Development Project of China","award":["2019-I2M-5-002"],"award-info":[{"award-number":["2019-I2M-5-002"]}]},{"name":"Shanghai Municipal Science and Technology Commission","award":["2021YFC2701004"],"award-info":[{"award-number":["2021YFC2701004"]}]},{"name":"Shanghai Municipal Science and Technology Commission","award":["2016YFC1000506"],"award-info":[{"award-number":["2016YFC1000506"]}]},{"name":"Shanghai Municipal Science and Technology Commission","award":["23DZ2203000"],"award-info":[{"award-number":["23DZ2203000"]}]},{"name":"Shanghai Municipal Science and Technology Commission","award":["2019-I2M-5-002"],"award-info":[{"award-number":["2019-I2M-5-002"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2021YFC2701004"],"award-info":[{"award-number":["2021YFC2701004"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2016YFC1000506"],"award-info":[{"award-number":["2016YFC1000506"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["23DZ2203000"],"award-info":[{"award-number":["23DZ2203000"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-002"],"award-info":[{"award-number":["2019-I2M-5-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNS"],"abstract":"<jats:p>Background: This study aimed to enhance the scope of neonatal congenital heart disease (CHD) screening by evaluating the effectiveness of training personnel in CHD screening using the \u201cdual-index\u201d method, combining pulse oximetry with cardiac murmur auscultation. Methods: From 2019 to 2022, a total of 2374 screening personnel from the Xinjiang, Yunnan, Hainan, Fujian, and Anhui provinces underwent training in neonatal CHD screening using the \u201cdual-index\u201d method, which involves pulse oximetry and cardiac murmur auscultation. Pre- and post-training assessments were conducted using a neonatal CHD screening knowledge questionnaire, distributed through the Questionnaire Star platform, to evaluate the impact of the training. The annual neonatal CHD screening rates were consistently recorded in these five provinces during the same period to assess the increase in screening coverage. Results: After the training, the screening personnel exhibited a significantly improved understanding of the neonatal CHD screening method (p &lt; 0.001). Additionally, the professional background (t = \u22128.007, p &lt; 0.001) and years of experience (t = 2.839, p = 0.005) of the screening personnel were identified as independent factors influencing their screening knowledge. During the same period, there was consistent linear growth in the screening coverage rate for neonatal CHD across the five provinces (\u03c72 = 121065.416, p &lt; 0.001). Conclusion: Standardized training in the \u201cdual-index\u201d method, incorporating pulse oximetry and cardiac murmur auscultation, for screening personnel significantly enhances their screening knowledge, thereby playing a critical role in expanding the coverage of neonatal CHD screening.<\/jats:p>","DOI":"10.3390\/ijns11010008","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T11:28:31Z","timestamp":1736854111000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Training and Evaluation of the \u201cDual-Index\u201d Screening Method for Neonatal Congenital Heart Disease: A Multi-Center Study in China"],"prefix":"10.3390","volume":"11","author":[{"given":"Panpan","family":"Huang","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"},{"name":"Xiamen Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"},{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gu","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-2938","authenticated-orcid":false,"given":"Ijaz ul","family":"Haq","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Li","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Hu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"},{"name":"Xiamen Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"},{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"},{"name":"National Management Office of Neonatal Screening Project for CHD, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"},{"name":"Xiamen Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"},{"name":"Children\u2019s Hospital of Fudan University, Shanghai 201102, China"},{"name":"National Management Office of Neonatal Screening Project for CHD, Shanghai 201102, China"},{"name":"Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China"},{"name":"Innovation Unit of Early Prevention and Control of Genetically Related Cardiovascular Diseases in Children, Chinese Academy of Medical Science (2018RU002), Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000311216","article-title":"It is time for routine neonatal screening by pulse oximetry","volume":"99","author":"Hoffman","year":"2011","journal-title":"Neonatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"F176","DOI":"10.1136\/adc.2006.107656","article-title":"Accuracy of pulse oximetry in screening for congenital heart disease in asymptomatic newborns: A systematic review","volume":"92","author":"Thangaratinam","year":"2007","journal-title":"Arch. 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