{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:13:02Z","timestamp":1791346382339,"version":"4.3.1"},"reference-count":2,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNS"],"abstract":"<jats:p>Part of the vision of the ISNS is \u2018to enhance the quality of neonatal screening and medical services through dissemination of information, guidelines and best practices.\u2019 Although newborn screening encompasses testing in the newborn period for critical congenital heart disease, hearing impairment, birth defects, and congenital biochemical disorders (usually on bloodspots), this guideline is specifically about bloodspot screening. The ISNS has provided neonatal screening guidelines for many years and here presents the renewed 2025 General Guidelines for Neonatal Bloodspot Screening. They are intended to provide a framework for screening programs to develop specific policies around all aspects of the newborn screening system, offering the basic set of items for consideration. These guidelines provide trusted anchors to build, expand, or maintain robustly organized neonatal or newborn screening (NBS) programs and a checklist to evaluate and improve the essential elements of those programs. For starting or developing programs, it is a set of elements for which provisions need to be in place and a checklist of items that the screening program should at a minimum have provisions for. The publication of these guidelines is meant as a starting point for interactive discussion, to further improve this document and expand where necessary.<\/jats:p>","DOI":"10.3390\/ijns11020045","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T06:40:27Z","timestamp":1750056027000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["ISNS General Guidelines for Neonatal Bloodspot Screening 2025"],"prefix":"10.3390","volume":"11","author":[{"given":"Dianne","family":"Webster","sequence":"first","affiliation":[{"name":"National Newborn Screening Laboratory, LabPlus, Health New Zealand Te Whatu Ora, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-3820","authenticated-orcid":false,"given":"Amy","family":"Gaviglio","sequence":"additional","affiliation":[{"name":"Connetics Consulting, LLC, Minneapolis, MN 55417, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7693-5740","authenticated-orcid":false,"given":"Aysha Habib","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, Aga Khan University, Karachi 74800, Pakistan"},{"name":"Department of Medicine, Aga Khan University, Karachi 74800, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-1834","authenticated-orcid":false,"given":"Mei","family":"Baker","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-2567","authenticated-orcid":false,"given":"David","family":"Cheillan","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de D\u00e9pistage N\u00e9onatal Auvergne Rh\u00f4ne-Alpes (CRDN AuRA), 69003 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layachi","family":"Chabraoui","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University Mohammed V of Rabat, Rabat 10100, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Abdoh","sequence":"additional","affiliation":[{"name":"Newborn Screening\/Neonatal Intensive Care Unit, Pediatrics Department, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-9724","authenticated-orcid":false,"given":"Juan","family":"Cabello","sequence":"additional","affiliation":[{"name":"Instituto de Nutrici\u00f3n y Tecnolog\u00eda de los Alimentos (INTA), University of Chile, Santiago 7830489, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9655-3686","authenticated-orcid":false,"given":"Roberto","family":"Giugliani","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics and Molecular Biology UFRGS, Medical Genetics Service HCPA, Dasa Genomica, and Casa dos Raros, Porto Alegre 90610-261, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Platis","sequence":"additional","affiliation":[{"name":"Department of Newborn Screening, Institute of Child Health, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"\u00d8strup","sequence":"additional","affiliation":[{"name":"International Society for Neonatal Screening, Reigerskamp 273, 3607 HP Maarssen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-9123","authenticated-orcid":false,"given":"R. Rodney","family":"Howell","sequence":"additional","affiliation":[{"name":"Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-7322","authenticated-orcid":false,"given":"Peter C. J. I.","family":"Schielen","sequence":"additional","affiliation":[{"name":"International Society for Neonatal Screening, Reigerskamp 273, 3607 HP Maarssen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9485-6754","authenticated-orcid":false,"given":"James R.","family":"Bonham","sequence":"additional","affiliation":[{"name":"International Society for Neonatal Screening, Reigerskamp 273, 3607 HP Maarssen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1754","DOI":"10.1016\/S2214-109X(24)00335-8","article-title":"The 77th World Health Assembly resolution calling for newborn screening, diagnosis, and management of birth defects: Moving towards action in low-income and middle-income countries","volume":"12","author":"Tam","year":"2024","journal-title":"Lancet Glob. Health"},{"key":"ref_2","unstructured":"World Health Organization (2025, May 20). Regional Office for Europe. Screening programmes: A short guide. Increase effectiveness, maximize benefits and minimize harm. World Health Organization. Regional Office for Europe. Available online: https:\/\/iris.who.int\/handle\/10665\/330829."}],"container-title":["International Journal of Neonatal Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2409-515X\/11\/2\/45\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:52:14Z","timestamp":1760032334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2409-515X\/11\/2\/45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,14]]},"references-count":2,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijns11020045"],"URL":"https:\/\/doi.org\/10.3390\/ijns11020045","relation":{},"ISSN":["2409-515X"],"issn-type":[{"value":"2409-515X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,14]]}}}