{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:58:38Z","timestamp":1761803918137,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Szeged Open Access Fund","award":["7786"],"award-info":[{"award-number":["7786"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNS"],"abstract":"<jats:p>Newborn screening (NBS), one of the most important public health care prevention programs, aims at the early identification of asymptomatic newborns at increased risk for inherited disorders, facilitating timely intervention to reduce morbidity and mortality. NBS in Hungary is celebrating the 50th anniversary of the nationwide implementation of screening for phenylketonuria and galactosemia, as well as the 40th anniversary of congenital hypothyroidism screening. The present paper reviews the early years, the present situation, and future perspectives for the Hungarian NBS program. Today, screening for 27 disorders (opt-out) plus spinal muscular atrophy (opt-in) is supported by two centralized and well-equipped laboratories in Budapest and Szeged, in-depth laboratory knowledge, a robust follow-up system, and governmental financial support. Since 1975, 3,289 patients have been confirmed with a screened condition from over 5.6 million newborns screened. The 50-year anniversary of the Hungarian NBS program highlights the dedication of both past and current professionals, ongoing advancements in analytical methods and laboratory information management systems, and alignment with international standards. The equitable provision of screening services continues to be prioritized for all newborns nationwide and within the broader Euro-regional context.<\/jats:p>","DOI":"10.3390\/ijns11040099","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:08:47Z","timestamp":1761800927000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Celebrating 50 Years of Nationwide Newborn Screening in Hungary\u2014Review, Current Situation, and Future Directions"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-6054","authenticated-orcid":false,"given":"P\u00e9ter","family":"Monostori","sequence":"first","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-145X","authenticated-orcid":false,"given":"Ildik\u00f3","family":"Szatm\u00e1ri","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Bar\u00e1th","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"B\u00f3kay","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Csenki","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Szeged, Sz\u0151kefalvi-Nagy B\u00e9la u. 4\/B, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-1212","authenticated-orcid":false,"given":"Zsolt","family":"Galla","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Gell\u00e9n","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Grecs\u00f3","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Gy\u00fcre","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Hal\u00e1sz","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Heged\u0171s","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Kincs","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Kiss","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-9882","authenticated-orcid":false,"given":"Magdolna","family":"K\u00f3sa","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"L\u00e9n\u00e1rt","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"P\u00e1lmay","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9na","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, 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J\u00f3zsef","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Metabolic Screening and Diagnostic Center, Department of Pediatrics, Semmelweis University, B\u00f3kay J\u00e1nos u. 53-54, H-1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Bereczki","sequence":"additional","affiliation":[{"name":"Metabolic and Newborn Screening Laboratory, Department of Pediatrics, University of Szeged, Kor\u00e1nyi Fasor 14-15, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Therrell, B.L., Padilla, C.D., Borrajo, G.J.C., Khneisser, I., Schielen, P.C.J.I., Knight-Madden, J., Malherbe, H.L., and Kase, M. 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