{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:15:03Z","timestamp":1767831303543,"version":"3.49.0"},"reference-count":22,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNS"],"abstract":"<jats:p>This study sought to assess the current state of screening for congenital cytomegalovirus infection in newborns among birth hospitals and newborn nurseries in the state of Massachusetts. A survey assessing hospital protocols for cytomegalovirus testing in newborns was distributed to all birth hospitals and newborn nurseries in Massachusetts from November 2020 to February 2021. 73.3% of hospitals responded to at least one survey question. Of these, fewer than half (48.5%) had any established approach for neonatal cytomegalovirus screening. Salivary polymerase chain reaction was the most common testing modality. Most hospitals did not perform confirmatory testing for positive test results. Most respondents (87.9%) did not know or did not answer how results of cCMV screening were reported to families and who was responsible for coordinating care for cCMV-infected infants. We conclude that congenital cytomegalovirus screening protocols are absent or incomplete in most Massachusetts birth hospitals and newborn nurseries. A cohesive strategy involving standardized education and screening guidelines is needed to reduce the incidence and burden of congenital cytomegalovirus disease on children and their families.<\/jats:p>","DOI":"10.3390\/ijns8040065","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T03:32:32Z","timestamp":1670902352000},"page":"65","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Congenital Cytomegalovirus Screening in Massachusetts Birth Hospitals: A Statewide Survey"],"prefix":"10.3390","volume":"8","author":[{"given":"Cheryl K.","family":"Glovsky","sequence":"first","affiliation":[{"name":"Department of Audiology, Massachusetts Eye and Ear, Boston, MA 02114, USA"},{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendall","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Audiology, Massachusetts Eye and Ear, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Clark","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Colleran","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Colleran","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayne","family":"Gaffney","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Kenna","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"},{"name":"Department of Otolaryngology and Communication Enhancement, Children\u2019s Hospital Boston, Boston, MA 02115, USA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Kuhns-Rankin","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy Evans","family":"Luiselli","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"},{"name":"New England Consortium on Deafblindness, Watertown, MA 02472, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia","family":"Mango","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"},{"name":"New England Consortium on Deafblindness, Watertown, MA 02472, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Morris","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Mullen","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"},{"name":"Department of Otolaryngology and Communication Enhancement, Children\u2019s Hospital Boston, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-3581","authenticated-orcid":false,"given":"Matthew","family":"Stenerson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gibson","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"},{"name":"Infectious Diseases and Immunology, Department of Medicine and Pediatrics, UMass Memorial Medical Center, Worcester, MA 01605, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1877-8668","authenticated-orcid":false,"given":"Michael S.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Massachusetts CMV Coalition, Boston, MA 02115, USA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection","volume":"17","author":"Kenneson","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpeds.2018.04.043","article-title":"Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection","volume":"200","author":"Fowler","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s10995-013-1275-0","article-title":"Congenital cytomegalovirus reference material: A content analysis of coverage and accuracy","volume":"18","author":"Thackeray","year":"2013","journal-title":"Matern. Child Health J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMra050700","article-title":"Newborn hearing screening\u2014A silent revolution","volume":"354","author":"Morton","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"Dollard","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1016\/S1473-3099(17)30143-3","article-title":"Congenital cytomegalovirus infection in pregnancy and the neonate: Consensus recommendations for prevention, diagnosis, and therapy","volume":"17","author":"Rawlinson","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e20160789","DOI":"10.1542\/peds.2016-0789","article-title":"Outcomes from a Hearing-Targeted Cytomegalovirus Screening Program","volume":"139","author":"Diener","year":"2017","journal-title":"Pediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0022-3476(03)00192-6","article-title":"Effect of ganciclovir therapy on hearing in symptomatic congenital cytomeg-alovirus disease involving the central nervous system: A randomized, controlled trial","volume":"143","author":"Kimberlin","year":"2003","journal-title":"J. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1835","DOI":"10.1097\/MD.0000000000001835","article-title":"Outcome of preterm infants with postnatal cytomegalovirus infection via breast milk: A two-year prospective follow-up study","volume":"94","author":"Jim","year":"2015","journal-title":"Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/pch\/pxaa083","article-title":"Update on congenital cytomegalovirus infection: Prenatal prevention, newborn diagnosis, and management","volume":"25","author":"Barton","year":"2020","journal-title":"Paediatr. Child Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1001\/jama.286.16.2000","article-title":"Universal newborn hearing screening: Summary of evidence","volume":"286","author":"Thompson","year":"2001","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/mrdd.10088","article-title":"Early intervention after universal neonatal hearing screening: Impact on outcomes","volume":"9","year":"2003","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tastad, K.J., Schleiss, M.R., Lammert, S.M., and Basta, N.E. (2019). Awareness of congenital cytomegalovirus and acceptance of maternal and newborn screening. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221725"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijporl.2018.12.027","article-title":"Long-term hearing outcomes of children with symptomatic congenital CMV treated with valganciclovir","volume":"118","author":"McCrary","year":"2018","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jpeds.2018.02.028","article-title":"Valganciclovir Is Beneficial in Children with Congenital Cytomegalovirus and Isolated Hearing Loss","volume":"199","author":"Pasternak","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e20171517","DOI":"10.1542\/peds.2017-1517","article-title":"Intelligence and academic achievement with asymptomatic congenital cy-tomegalovirus infection","volume":"140","author":"Lopez","year":"2017","journal-title":"Pediatrics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00431-019-03558-7","article-title":"Treatment of congenital cytomegalovirus beyond the neonatal period: An ob-servational study","volume":"179","author":"Dorfman","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/INF.0000000000002079","article-title":"Hematologic Adverse Events Associated With Prolonged Valganciclovir Treatment in Congenital Cytomegalovirus Infection","volume":"38","author":"Ziv","year":"2019","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.ijporl.2015.09.019","article-title":"Cost\u2013benefit analysis of targeted hearing directed early testing for congenital cytomegalovirus infection","volume":"79","author":"Bergevin","year":"2015","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/jamapediatrics.2016.2016","article-title":"Cost-effectiveness of Universal and Targeted Newborn Screening for Congenital Cytomegalovirus Infection","volume":"170","author":"Gantt","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e20162128","DOI":"10.1542\/peds.2016-2128","article-title":"A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening","volume":"139","author":"Fowler","year":"2017","journal-title":"Pediatrics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"151393","DOI":"10.1016\/j.semperi.2021.151393","article-title":"Economic assessments of the burden of congenital cytomegalovirus infection and the cost-effectiveness of prevention strategies","volume":"45","author":"Grosse","year":"2021","journal-title":"Semin. Perinatol."}],"container-title":["International Journal of Neonatal Screening"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2409-515X\/8\/4\/65\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:13Z","timestamp":1760146813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2409-515X\/8\/4\/65"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ijns8040065"],"URL":"https:\/\/doi.org\/10.3390\/ijns8040065","relation":{},"ISSN":["2409-515X"],"issn-type":[{"value":"2409-515X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]}}}