{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:26:14Z","timestamp":1760145974438,"version":"build-2065373602"},"reference-count":80,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["2020\/01018-4","2022\/11113-0","2011\/50877-0","Code 01"],"award-info":[{"award-number":["2020\/01018-4","2022\/11113-0","2011\/50877-0","Code 01"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","doi-asserted-by":"publisher","award":["2020\/01018-4","2022\/11113-0","2011\/50877-0","Code 01"],"award-info":[{"award-number":["2020\/01018-4","2022\/11113-0","2011\/50877-0","Code 01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insects"],"abstract":"<jats:p>The Streptomyces genus has long been recognized as a prolific and valuable source of diverse secondary metabolites. These metabolites contribute significantly to the intricate chemical diversity exhibited by Streptomyces, making them an indispensable reservoir for drug discovery, agricultural applications, and industrial processes. Exploiting the potential of these natural compounds holds the promise of ushering in a new era in insect pest management, reducing reliance on synthetic chemicals and fostering ecologically sustainable solutions. This study dives into the realm of chemo diversity within isolates of Streptomyces nojiriensis and Streptomyces novaecaesareae, with a specific focus on the production of insecticidal compounds. We explored chromatographic techniques for the identification and isolation of insecticidal compounds, and two bioactive compounds were identified in extracts of S. novaecaesareae. Valinomycin was identified from hexanic extracts of strain Asp59, while naphthomycin from ethyl acetate extracts of strain Asp58. These compounds showed insecticidal activity against first instars of Spodoptera frugiperda (Asp59: LC50 = 10.82 \u00b5g\/\u00b5L, LC90 = 26.25 \u00b5g\/\u00b5L; Asp58: LC50 = 15.05 \u00b5g\/\u00b5L, LC90 = 38.84 \u00b5g\/\u00b5L). Notably, this is the first report of naphthomycin as an insecticidal compound. The present study suggests that valinomycin and naphthomycin may be a novel biological source for the control of Spodoptera frugiperda in early stages.<\/jats:p>","DOI":"10.3390\/insects15090707","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T01:16:10Z","timestamp":1726622170000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactive Insecticides from Chemometric Diverse Ant-Associated Symbionts Streptomyces novaecaesareae and Streptomyces nojiriensis against the Fall Armyworm Larvae"],"prefix":"10.3390","volume":"15","author":[{"given":"Cec\u00edlia Beatriz Nascimento","family":"Lima","sequence":"first","affiliation":[{"name":"Insect Interactions Laboratory, Luiz de Queiroz College of Agriculture, University of S\u00e3o Paulo, Piracicaba 13418-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Montini","family":"Joly","sequence":"additional","affiliation":[{"name":"Insect Interactions Laboratory, Luiz de Queiroz College of Agriculture, University of S\u00e3o Paulo, Piracicaba 13418-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-1944","authenticated-orcid":false,"given":"Luiz Alberto Beraldo","family":"Moraes","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Philosophy, Sciences and Letters, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Lu\u00eds","family":"C\u00f4nsoli","sequence":"additional","affiliation":[{"name":"Insect Interactions Laboratory, Luiz de Queiroz College of Agriculture, University of S\u00e3o Paulo, Piracicaba 13418-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Goergen, G., Kumar, P.L., Sankung, S.B., Togola, A., and Tam\u00f2, M. 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