{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:12:12Z","timestamp":1790345532883,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Northern Border University, Arar, Saudi Arabia","award":["NBU-FFR-2025-869-06"],"award-info":[{"award-number":["NBU-FFR-2025-869-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insects"],"abstract":"<jats:p>Mango fruits are one of the strategic fruit crops in different countries that are attacked by several serious pests such as Cryptoblabes gnidiella and Scirtothrips mangiferae. Natural extracts, especially essential oils, provide several promising insecticide agents to control different insects as an alternative to synthetic insecticides. Using Clevenger-type hydrodistillation, the essential oils of five thyme plants\u2014Thymus vulgaris, Origanum vulgare, Thymus argenteus, Thymus citriodorus, and Origanum syriacum\u2014from Saudi Arabia and Egypt were extracted, and GC\/MS analysis was performed. In addition, some chemical parameters of the five species were determined, such as chlorophyll a, chlorophyll b, \u03b2-carotene, total antioxidant capacity, total phenols, and total flavonoids. Two compounds, thymol and carvacrol, were identified in T. vulgaris and O. vulgare at ratios of 69.45 and 64.82%, respectively. These major compounds were isolated and identified using 1H NMR analysis. The insecticidal potentials of the five essential oils and their pure isolated compounds were evaluated on C. gnidiella and S. mangiferae on mango inflorescences. The results showed that T. vulgaris and O. vulgare oils were the most potent against C. gnidiella (LC50, 183.33 and 164.68 ppm, respectively) and S. mangiferae (18.93 and 16.93 ppm, respectively). Thymol and carvacrol had the highest effect on both insects. Furthermore, the effect of thymol and carvacrol at LC50 values on some biochemical parameters of C. gnidiella was determined. Therefore, thymol and carvacrol from Thymus species are promising compounds that could be used as insecticides against the harmful insects C. gnidiella and S. mangiferae on mango inflorescences.<\/jats:p>","DOI":"10.3390\/insects16090922","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:05:22Z","timestamp":1756829122000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical and Insecticidal Activity of Some Thyme Plants\u2019 Essential Oils Against Cryptoblabes gnidiella and Scirtothrips mangiferae on Mango Inflorescences"],"prefix":"10.3390","volume":"16","author":[{"given":"Mohammad M.","family":"Aljameeli","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, College of Science, Northern Border University, Arar 73213, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal Abdulaziz","family":"Alfuhaid","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1485-8425","authenticated-orcid":false,"given":"Ahmed Ramadan","family":"El-Rokh","sequence":"additional","affiliation":[{"name":"Plant Protection Research Institute, Agricultural Research Center, Giza 12618, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira A.","family":"El-Salam","sequence":"additional","affiliation":[{"name":"Plant Protection Research Institute, Agricultural Research Center, Giza 12618, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May A.","family":"Elhefni","sequence":"additional","affiliation":[{"name":"Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira S.","family":"El-Rahman","sequence":"additional","affiliation":[{"name":"Horticulture Department, Faculty of Agriculture, Benha University, Moshtohor, Toukh 13736, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa M.","family":"Hussein","sequence":"additional","affiliation":[{"name":"Horticulture Department, Faculty of Agriculture, Sohag University, Sohag 82524, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-4255","authenticated-orcid":false,"given":"Jazem A.","family":"Mahyoub","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-9271","authenticated-orcid":false,"given":"Hayam","family":"Elshazly","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences & Arts-Scientific, Qassim University, Buraidah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan S.","family":"Alyahya","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha I.","family":"Alqurashi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Collage of Science, University of Jeddah, Jeddah 23218, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-6089","authenticated-orcid":false,"given":"Mohamed A.","family":"Abdein","sequence":"additional","affiliation":[{"name":"Seeds Development Department, El-Nada Misr Scientific Research and Development Projects, Turrell, Mansoura 35511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EL-Sayed M.","family":"Qaoud","sequence":"additional","affiliation":[{"name":"Horticultural Department, Faculty of Agriculture, Suez Canal University, Ismailia 41522, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Mosallam","sequence":"additional","affiliation":[{"name":"Department of Plant Production, Faculty of Environmental Agricultural Science, Arish University, Al Arish 45516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"728065","DOI":"10.1155\/2012\/728065","article-title":"Essential Oils Composition and Antioxidant Properties of Three Thymus Species","volume":"2012","author":"Amiri","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Surburg, H., and Panten, J. (2006). Common Fragrance and Flavor Materials, Wiley. [5th ed.].","DOI":"10.1002\/3527608214"},{"key":"ref_3","first-page":"56","article-title":"Thymus vulgaris essential oil: Chemical composition and antimicrobial activity","volume":"7","author":"Jianu","year":"2014","journal-title":"J. Med. Life"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.indcrop.2015.09.046","article-title":"Chemical composition and antioxidant, antibacterial, allelopathic and insecticidal activities of essential oil of Thymus algeriensis Boiss. et Reut","volume":"77","author":"Ali","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_5","first-page":"756","article-title":"Chemical composition of essential oil from Thymus citriodorus and its toxic effect on liver cancer cells","volume":"36","author":"Wu","year":"2013","journal-title":"Zhong Yao Cai J. Chin. Med. Mater."},{"key":"ref_6","first-page":"6","article-title":"Analysis of the Essential Oil Compounds of Origanum syriacum L. Acta Fac","volume":"59","author":"Farhat","year":"2012","journal-title":"Pharm. Univ. Comen."},{"key":"ref_7","first-page":"116","article-title":"The essential oil and its main constituents of Origanum syriacum ssp. sinaicum grown wild in Saint Katherine Protectorate, South Sinai, Egypt","volume":"45","author":"Badawy","year":"2020","journal-title":"Al-Azhar J. Agric. Res."},{"key":"ref_8","unstructured":"Stahl-Biskup, E., and S\u00e1ez, F. (2002). Population structure and the spatial dynamics of genetic polymorphism in thyme. Thyme: The Genus Thymus, Taylor & Francis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1016\/j.chroma.2010.07.042","article-title":"Determination of polyphenolic compounds by liquid chromatography\u2013mass spectrometry in Thymus species","volume":"1217","author":"Boros","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/0972060X.2012.10644041","article-title":"Essential Oil Polymorphism of Thymus pannonicus All. (Lamiaceae) in Serbia","volume":"15","author":"Sostaric","year":"2012","journal-title":"J. Essent. Oil-Bear. Plants"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/boj.12034","article-title":"DNA barcoding to analyse taxonomically complex groups in plants: The case of Thymus (Lamiaceae)","volume":"171","author":"Federici","year":"2013","journal-title":"Bot. J. Linn. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12224-012-9126-0","article-title":"Geographical distribution of diploid and tetraploid cytotypes of Thymus sect. Mastichina (Lamiaceae) in the Iberian peninsula, genome size and evolutionary implications","volume":"47","author":"Giron","year":"2012","journal-title":"Folia Geobot."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.24154\/jhs.v7i1.406","article-title":"Record of Thrips on Mango","volume":"7","author":"Krishnamoorthy","year":"2012","journal-title":"J. Hortic. Sci."},{"key":"ref_14","first-page":"393","article-title":"Seasonal Activity, Natural Enemies and Life Table Parameters of Cryptoblabes gnidiella Mill. on Mango Inflorescences","volume":"9","author":"Kareim","year":"2018","journal-title":"J. Plant Prot. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.17660\/ActaHortic.1993.341.50","article-title":"The arthropod pests of mango in Israel","volume":"341","author":"Wysoki","year":"1993","journal-title":"Acta Hortic."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/pjen-2016-0010","article-title":"Honeydew Moth Cryptoblabes gnidiella (Milli\u00e8re, 1867) (Lepidoptera: Pyralidae): An adventive species frequently imported with fruit to Poland","volume":"85","author":"Dawidowicz","year":"2016","journal-title":"Pol. J. Entomol."},{"key":"ref_17","first-page":"149","article-title":"Phenology of the honeydew moth, Cryptoblabes gnidiella (Milliere) (Lepidoptera: Pyralidae), on avocado in Israel","volume":"25\u201326","author":"Wysoki","year":"1991","journal-title":"Isr. J. Entomol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/ps.1365","article-title":"Pest management programmes in vineyards using male mating disruption","volume":"63","author":"Harari","year":"2007","journal-title":"Pest Manag. Sci."},{"key":"ref_19","unstructured":"Grove, T. (1999). Thrips Management in Mango Orchards. [Ph.D. Thesis, Faculty of AgriSciences, Department of Conservation Ecology and Entomology, University of Stellenbosch]. Available online: http:\/\/hdl.handle.net\/10019.1\/51528."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.13005\/bbra\/2815","article-title":"Morphological and Molecular Genetic Assessment of Some Thymus Species","volume":"17","author":"Alqahtani","year":"2020","journal-title":"Biosci. Biotechnol. Res. Asia"},{"key":"ref_21","first-page":"105","article-title":"Toxicity, Phytochemical Analysis and Biochemical Responses of Some Selected Plant Essential Oils Against Cotton Mealybug, Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae)","volume":"16","author":"Mostafa","year":"2023","journal-title":"Acad. J. Entomol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3136\/nskkk1962.39.925","article-title":"Simple method for simultaneous determination of chlorophyll and carotenoids in tomato fruit","volume":"39","author":"Nagata","year":"1992","journal-title":"Nippon Shokuhin Kogyo Gakkaishi"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/abio.1999.4019","article-title":"Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E","volume":"269","author":"Prieto","year":"1999","journal-title":"Anal. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-Ciocalteu Reagent","volume":"299","author":"Singleton","year":"1999","journal-title":"Methods Enzymol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00218839.1998.11100961","article-title":"Analysis of propolis: Some parameters and procedures for chemical quality control","volume":"37","author":"Woisky","year":"1998","journal-title":"J. Apic. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ragab, A., Taher, M.A., El-Rafey, H.H., and El-Rokh, A.R. (2024). Bioactive compounds from Withania somnifera dun and their toxicity against some piercing sucking pests. Appl. Biol. Chem., 67.","DOI":"10.1186\/s13765-024-00880-z"},{"key":"ref_27","first-page":"67","article-title":"Efficacy of some compounds against Thrips tabaci Lind. infesting onion plants at Sohag Governorate, Egypt","volume":"5","author":"Allam","year":"2023","journal-title":"SVU-Int. J. Agric. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jee\/18.2.265a","article-title":"A method of computing the effectiveness of an insecticide","volume":"18","author":"Abbott","year":"1925","journal-title":"J. Econ. Entomol."},{"key":"ref_29","unstructured":"Finney, D.J. (1971). Probit Analysis: A Statistical Treatment of the Sigmoid Response Curve, Cambridge University Press. [7th ed.]."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jee\/43.1.45","article-title":"Toxicity index, an improved method of comparing the relative toxicity of insecticides","volume":"43","author":"Sun","year":"1950","journal-title":"J. Econ. Entomol."},{"key":"ref_31","first-page":"529","article-title":"Phytochemical Profiling and Isolation of Bioactive Polyphenols from Ipomoea carnea","volume":"66","author":"Elhefni","year":"2023","journal-title":"Egypt. J. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/clinchem\/32.4.717","article-title":"Textbook of Clinical Chemistry. N. W. Tietz, Ed., W. B. Saunders Co., Philadelphia, PA 19105, September 1985, xxvi + 1919 pp","volume":"32","author":"Bakerman","year":"1986","journal-title":"Clin. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/clinchem\/6.3.269","article-title":"Rapid Method for the Quantitative Determination of Serum Alkaline Phosphatase","volume":"6","author":"Klein","year":"1960","journal-title":"Clin. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"The First Enzymatic Step in Mercapturic Acid Formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/aesa\/57.3.367","article-title":"A Semimicro-technique for the Estimation of Cholinesterase Activity in Boll Weevils","volume":"57","author":"Simpson","year":"1964","journal-title":"Ann. Entomol. Soc. Am."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105206","DOI":"10.1016\/j.reactfunctpolym.2022.105206","article-title":"Green polymer synthesis and low dielectric properties obtained by oxidative polymerization of thymol with CuCl-2-(p-tolyl)pyridine catalyst","volume":"172","author":"Komaki","year":"2022","journal-title":"React. Funct. Polym."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s10600-020-03134-8","article-title":"Anti-inflammatory Constituents of Dichapetalum longipetalum","volume":"56","author":"Wang","year":"2020","journal-title":"Chem. Nat. Compd."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2298\/JSC0803307P","article-title":"Chemical composition of Thymus vulgaris L. (Thyme) essential oil from the Rio de Janeiro State, Brazil","volume":"73","author":"Porte","year":"2008","journal-title":"J. Serbian Chem. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Allahverdiyev, A.M., Bagirova, M., Yaman, S., Koc, R.C., Abamor, E.S., Ates, S.C., Baydar, S.Y., Elcicek, S., and Oztel, O.N. (2013). Chapter 17\u2014Development of New Antiherpetic Drugs Based on Plant Compounds. Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components, Elsevier.","DOI":"10.1016\/B978-0-12-398539-2.00017-3"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1631\/jzus.B1600377","article-title":"Chemical composition and antioxidant activities of essential oils from different parts of the oregano","volume":"18","author":"Han","year":"2017","journal-title":"J. Zhejiang Univ. B"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.apjtb.2016.11.023","article-title":"Chemical composition of essential oil of Thymus vulgaris collected from Saudi Arabian market","volume":"7","author":"Athar","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Walasek-Janusz, M., Grzegorczyk, A., Malm, A., Nurzy\u0144ska-Wierdak, R., and Zalewski, D. (2024). Chemical Composition, and Antioxidant and Antimicrobial Activity of Oregano Essential Oil. Molecules, 29.","DOI":"10.3390\/molecules29020435"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Martins, T., Barros, A.N., Rosa, E., and Antunes, L. (2023). Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review. Molecules, 28.","DOI":"10.3390\/molecules28145344"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Elvira-Torales, L.I., Garc\u00eda-Alonso, J., and Periago-Cast\u00f3n, M.J. (2019). Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review. Antioxidants, 8.","DOI":"10.3390\/antiox8070229"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ullah, A., Munir, S., Badshah, S.L., Khan, N., Ghani, L., Poulson, B.G., Emwas, A.-H., and Jaremko, M. (2020). Important Flavonoids and Their Role as a Therapeutic Agent. Molecules, 25.","DOI":"10.3390\/molecules25225243"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00436-009-1571-1","article-title":"Mosquitocidal activities of thyme oils (Thymus vulgaris L.) against Culex quinquefasciatus (Diptera: Culicidae)","volume":"105","author":"Pavela","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S589","DOI":"10.12980\/APJTB.4.2014APJTB-2014-0077","article-title":"Insecticidal activity of the essential oil of Thymus transcaspicus against Anopheles stephensi","volume":"4","author":"Dargahi","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ffj.1104","article-title":"Composition of the volatile oil of Thymus transcaspicus Klokov from Iran","volume":"17","author":"Miri","year":"2002","journal-title":"Flavour Fragr. J."},{"key":"ref_49","first-page":"129","article-title":"Insecticidal activities of Thymus vulgaris essential oil and its components (thymol and carvacrol) against larvae of lesser mealworm, Alphitobius diaperinus Panzer (Coleoptera: Tenebrionidae)","volume":"30","author":"Szczepanik","year":"2012","journal-title":"Allelopath. J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nation, J.L. (2022). Insect Physiology and Biochemistry, CRC Press. [4th ed.].","DOI":"10.1201\/9781003279822"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Goharrostami, M., Sendi, J.J., Hosseini, R., and Mahmoodi, N.O.A. (2022). Effect of thyme essential oil and its two components on toxicity and some physiological parameters in mulberry pyralid Glyphodes pyloalis Walker. Pestic. Biochem. Physiol., 188.","DOI":"10.1016\/j.pestbp.2022.105220"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.aspen.2017.04.004","article-title":"Screening for insecticidal potential and acetylcholinesterase activity inhibition of Urginea maritima bulbs extract for the control of Sitophilus oryzae (L.)","volume":"20","author":"Maazoun","year":"2017","journal-title":"J. Asia-Pacific \u00c8ntomol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/S2095-3119(14)60748-6","article-title":"Biochemical Mechanism of Chlorantraniliprole Resistance in the Diamondback Moth, Plutella xylostella Linnaeus","volume":"13","author":"Hu","year":"2014","journal-title":"J. Integr. Agric."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Al-Harbi, N.A., Al Attar, N.M., Hikal, D.M., Mohamed, S.E., Latef, A.A.H.A., Ibrahim, A.A., and Abdein, M.A. (2021). Evaluation of Insecticidal Effects of Plants Essential Oils Extracted from Basil, Black Seeds and Lavender against Sitophilus oryzae. Plants, 10.","DOI":"10.3390\/plants10050829"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Alhaithloul, H.A.S., Alqahtani, M.M., Ahmed, M.A.I., Hesham, A.E.-L., Aljameeli, M.M.E., Al Mozini, R.N., Gharsan, F.N., Hussien, S.M., and El-Amier, Y.A. (2023). Rosemary and neem methanolic extract: Antioxidant, cytotoxic, and larvicidal activities supported by chemical composition and molecular docking simulations. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1155698"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"720","DOI":"10.12693\/APhysPolA.132.720","article-title":"Effects of Thymol and Carvacrol on Acetylcholinesterase from Drosophila melanogaster","volume":"132","author":"Askin","year":"2017","journal-title":"Acta Phys. Pol. A"}],"container-title":["Insects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4450\/16\/9\/922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:38:02Z","timestamp":1760035082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4450\/16\/9\/922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["insects16090922"],"URL":"https:\/\/doi.org\/10.3390\/insects16090922","relation":{},"ISSN":["2075-4450"],"issn-type":[{"value":"2075-4450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}