{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:18:30Z","timestamp":1792858710537,"version":"4.5.0"},"reference-count":55,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Agriculture and Rural Affairs of Guangdong Province","award":["2024-XDY-00014"],"award-info":[{"award-number":["2024-XDY-00014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insects"],"abstract":"<jats:p>Apis cerana is widely managed in apiculture in Southern China but experiences substantial colony losses during prolonged summer heat. Developing effective strategies to support colony over-summering is therefore critical. This study demonstrates that dietary supplementation with melatonin significantly enhances thermal tolerance and extends worker lifespan in A. cerana under heat stress. Laboratory bioassays revealed that melatonin supplementation (20 \u00b5g\/mL) markedly improved worker survival at both 35 \u00b0C and 37 \u00b0C, with the most pronounced effect at 37 \u00b0C, where mortality was significantly reduced. Consistently, field trials demonstrated that melatonin supplemented colonies gained significantly more weight during summer heatwaves than colonies without melatonin supplementation. Mechanistically, melatonin orchestrates a biphasic adaptive response. In an early phase (day 4), melatonin rapidly upregulates heat shock proteins (HSC70-4, CRYAA, l(2)efl) and detoxification enzymes (GST-like), accompanied by reduced reactive oxygen species (ROS) accumulation and enhanced proboscis extension response (PER), indicative of preserved sensory function. This is followed by a later maintenance phase (day 11), characterized by sustained upregulation of fatty acyl-CoA reductases (FAR1, FAR11-like, FARwat) and peroxisomal components (PMP34), which promote lipid remodeling and membrane stabilization. RNA-seq analysis identified differentially expressed genes (DEGs) significantly enriched in pathways related to redox homeostasis, lipid metabolism, detoxification (GSTs, CarEs, CYP450s), and longevity. These molecular responses were associated with enhanced antioxidant capacity, reduced oxidative damage, and sustained foraging activity under thermal stress. Collectively, these results indicate that melatonin serves as a potent nutritional intervention that reprograms redox metabolic networks to mitigate heat-induced damage, extend worker longevity, and enhance colony productivity under climate warming. These findings highlight melatonin\u2019s potential as a practical tool to reduce summer colony losses in apiculture.<\/jats:p>","DOI":"10.3390\/insects17040379","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:09:21Z","timestamp":1775038161000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Melatonin Enhances Thermal Resilience and Extends Worker Lifespan in Apis cerana via Redox\u2013Metabolic Reprogramming"],"prefix":"10.3390","volume":"17","author":[{"given":"Ke","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfu","family":"Xiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglian","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-6009","authenticated-orcid":false,"given":"Wenfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richou","family":"Han","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical 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(2019). Tolerance and response of two honeybee species Apis cerana and Apis mellifera to high temperature and relative humidity. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217921"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12192-022-01255-3","article-title":"Cloning and expression studies on glutathione S-transferase like-gene in honey bee for its role in oxidative stress","volume":"27","author":"Shan","year":"2021","journal-title":"Cell Stress Chaperones"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lin, Z., Page, P., Li, L., Qin, Y., Zhang, Y., Hu, F., Neumann, P., Zheng, H., and Dietemann, V. (2016). Go East for Better Honey Bee Health: Apis cerana Is Faster at Hygienic Behavior than A. mellifera. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162647"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Li, G., Zhao, H., Liu, Z., Wang, H., Xu, B., and Guo, X. (2018). The Wisdom of Honeybee Defenses Against Environmental Stresses. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00722"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fang, F., Chen, X., Lv, J., Shi, X., Feng, X., Wang, Z., and Li, X. (2022). Population Structure and Genetic Diversity of Chinese Honeybee (Apis Cerana Cerana) in Central China. Genes, 13.","DOI":"10.3390\/genes13061007"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"White, S.A., and Dillon, M.E. (2023). Climate warming and bumble bee declines: The need to consider sub-lethal heat, carry-over effects, and colony compensation. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1251235"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sagastume, S., Cilia, G., Henriques, D., Yadro, C., Corona, M., Higes, M., Pinto, M.A., Nanetti, A., and Martin-Hernandez, R. (2025). Climate change-induced stress in the honey bee Apis mellifera L.\u2014a genetic review. Front. Physiol., 16.","DOI":"10.3389\/fphys.2025.1623705"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"20230290","DOI":"10.1098\/rsif.2023.0290","article-title":"How honeybees respond to heat stress from the individual to colony level","volume":"20","author":"Jhawar","year":"2023","journal-title":"J. R. Soc. Interface"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102541","DOI":"10.1016\/j.jtherbio.2020.102541","article-title":"Heat stress during development affects immunocompetence in workers, queens and drones of Africanized honey bees (Apis mellifera L.) (Hymenoptera: Apidae)","volume":"89","author":"Medina","year":"2020","journal-title":"J. Therm. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3390\/insects3041271","article-title":"General Stress Responses in the Honey Bee","volume":"3","author":"Even","year":"2012","journal-title":"Insects"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104870","DOI":"10.1016\/j.jinsphys.2025.104870","article-title":"Stress response of the honey bee exposed to warming, starvation and neonicotinoids","volume":"165","author":"Dattilo","year":"2025","journal-title":"J. Insect Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s13592-020-00830-w","article-title":"Response mechanisms to heat stress in bees","volume":"52","author":"Zhao","year":"2021","journal-title":"Apidologie"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103784","DOI":"10.1016\/j.jtherbio.2024.103784","article-title":"The response of heat shock proteins in honey bees to abiotic and biotic stressors","volume":"119","year":"2024","journal-title":"J. Therm. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0531-5565(01)00229-7","article-title":"Extension of Life Span and Stress Resistance of Drosophila Melanogaster by Long-Term Supplementation with Melatonin","volume":"37","author":"Bonilla","year":"2002","journal-title":"Exp. Gerontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20061352","article-title":"Metabolite transport across the peroxisomal membrane","volume":"401","author":"Visser","year":"2007","journal-title":"Biochem. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ajhg.2014.10.003","article-title":"A Peroxisomal Disorder of Severe Intellectual Disability, Epilepsy, and Cataracts Due to Fatty Acyl-CoA Reductase 1 Deficiency","volume":"95","author":"Buchert","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/s12964-024-01862-w","article-title":"Peroxisomal homeostasis in metabolic diseases and its implication in ferroptosis","volume":"22","author":"Han","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s12276-020-00503-9","article-title":"Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases","volume":"52","author":"Jo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12192-020-01095-z","article-title":"Small Heat-Shock Proteins and Their Role in Mechanical Stress","volume":"25","author":"Collier","year":"2020","journal-title":"Cell Stress Chaperones"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev-ento-112408-085356","article-title":"Insect Fat Body: Energy, Metabolism, and Regulation","volume":"55","author":"Arrese","year":"2010","journal-title":"Annu. Rev. Entomol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhang, B., Li, X., Jiang, Y., Liu, J., Zhang, J., and Ma, W. (2023). Comparative transcriptome analysis of adult worker bees under short-term heat stress. Front. Ecol. Evol., 11.","DOI":"10.3389\/fevo.2023.1099015"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: One of evolution\u2019s best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1021\/ja01543a060","article-title":"Isolation of melatonin, the pineal gland factor that lightens melanocytes","volume":"1","author":"Lerner","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neurol.2019.07.025","article-title":"Melatonin: A review of its potential functions and effects on neurological diseases","volume":"176","author":"Gunata","year":"2020","journal-title":"Rev. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e12839","DOI":"10.1111\/jpi.12839","article-title":"Melatonin functions as a broad-spectrum antifungal by targeting a conserved pathogen protein kinase","volume":"74","author":"Li","year":"2023","journal-title":"J. Pineal Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Joseph, T.T., Schuch, V., Hossack, D.J., Chakraborty, R., and Johnson, E.L. (2024). Melatonin: The placental antioxidant and anti-inflammatory. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1339304"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: Under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"113622","DOI":"10.1016\/j.ecoenv.2022.113622","article-title":"Melatonin enhances the antioxidant capacity to rescue the honey bee Apis mellifera from the ecotoxicological effects caused by environmental imidacloprid","volume":"239","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s12640-021-00397-z","article-title":"Melatonin Increases Life Span, Restores the Locomotor Activity, and Reduces Lipid Peroxidation (LPO) in Transgenic Knockdown Parkin Drosophila melanogaster Exposed to Paraquat or Paraquat\/Iron","volume":"39","year":"2021","journal-title":"Neurotox. Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wang, J., Wang, X.Q., Liu, R.P., Li, Y.H., Yao, X.R., Kim, N.H., and Xu, Y.N. (2023). Melatonin Supplementation during In Vitro Maturation of Porcine Oocytes Alleviates Oxidative Stress and Endoplasmic Reticulum Stress Induced by Imidacloprid Exposure. Animals, 13.","DOI":"10.3390\/ani13162596"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Contreras-Correa, Z.E., Messman, R.D., Swanson, R.M., and Lemley, C.O. (2023). Melatonin in Health and Disease: A Perspective for Livestock Production. Biomolecules, 13.","DOI":"10.3390\/biom13030490"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1093\/jxb\/erac224","article-title":"Melatonin as a regulator of plant ionic homeostasis: Implications for abiotic stress tolerance","volume":"73","author":"Huang","year":"2022","journal-title":"J. Exp. Bot."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104180","DOI":"10.1016\/j.jinsphys.2020.104180","article-title":"The role of melatonin and Tryptophan-5-hydroxylase-1 in different abiotic stressors in Apis cerana cerana","volume":"128","author":"Fan","year":"2021","journal-title":"J. Insect Physiol."},{"key":"ref_35","first-page":"2282","article-title":"Behavioural Pharmacology in Classical Conditioning of the Proboscis Extension Response in Honeybees (Apis mellifera)","volume":"47","author":"Felsenberg","year":"2011","journal-title":"Jove-J. Vis. Exp."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Decros, G., Baldet, P., Beauvoit, B., Stevens, R., Flandin, A., Colombie, S., Gibon, Y., and Petriacq, P. (2019). Get the Balance Right: ROS Homeostasis and Redox Signalling in Fruit. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.01091"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1134\/S0006297917020031","article-title":"alpha-Crystallins Are Small Heat Shock Proteins: Functional and Structural Properties","volume":"82","author":"Tikhomirova","year":"2017","journal-title":"Biochem. -Mosc"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Runtuwene, L.R., Kawashima, S., Pijoh, V.D., Tuda, J.S.B., Hayashida, K., Yamagishi, J., Sugimoto, C., Nishiyama, S., Sasaki, M., and Orba, Y. (2020). The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207520"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"108538","DOI":"10.1016\/j.jbc.2025.108538","article-title":"Fatty acyl-CoA reductase FAR1 is essential for the testicular seminolipid synthesis required for spermatogenesis and male fertility","volume":"301","author":"Tamazawa","year":"2025","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ibmb.2010.06.004","article-title":"A fatty acyl-CoA reductase highly expressed in the head of honey bee (Apis mellifera) involves biosynthesis of a wide range of aliphatic fatty alcohols","volume":"40","author":"Teerawanichpan","year":"2010","journal-title":"Insect Biochem. Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/s42003-022-03956-y","article-title":"Fatty acyl-CoA reductase influences wax biosynthesis in the cotton mealybug, Phenacoccus solenopsis Tinsley","volume":"5","author":"Tong","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1083\/jcb.153.6.1141","article-title":"Multiple Distinct Targeting Signals in Integral Peroxisomal Membrane Proteins","volume":"153","author":"Jones","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00484-024-02824-0","article-title":"A review of short-term weather impacts on honey production","volume":"69","author":"Vincze","year":"2025","journal-title":"Int. J. Biometeorol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"van Beest, F.M., and Milner, J.M. (2013). Behavioural responses to thermal conditions affect seasonal mass change in a heat-sensitive northern ungulate. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065972"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Picimbon, J.-F. (2019). Olfactory Concepts of Insect Control\u2014Alternative to Insecticides, Springer.","DOI":"10.1007\/978-3-030-05165-5"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Hardeland, R. (2019). Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051223"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Adamiak, K., Gaida, V.A., Schafer, J., Bosse, L., Diemer, C., Reiter, R.J., Slominski, A.T., Steinbrink, K., Sionkowska, A., and Kleszczynski, K. (2024). Melatonin\/Sericin Wound Healing Patches: Implications for Melanoma Therapy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094858"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrm2941","article-title":"The HSP70 chaperone machinery: J proteins as drivers of functional specificity","volume":"11","author":"Kampinga","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling mechanisms of Malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/jisesa\/iead074","article-title":"Based proteomics analyses reveal response mechanisms of Apis mellifera against the heat stress","volume":"24","author":"Li","year":"2024","journal-title":"J. Insect Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/15548627.2023.2259732","article-title":"The lipid basis of cell death and autophagy","volume":"20","author":"Lin","year":"2024","journal-title":"Autophagy"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/03602532.2011.558092","article-title":"Interactions of glutathione transferases with 4-hydroxynonenal","volume":"43","author":"Balogh","year":"2011","journal-title":"Drug Metab. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbamcr.2015.09.016","article-title":"No peroxisome is an island\u2014Peroxisome contact sites","volume":"1863","author":"Shai","year":"2016","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/BJ20111420","article-title":"The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+","volume":"443","author":"Agrimi","year":"2012","journal-title":"Biochem. J."}],"container-title":["Insects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4450\/17\/4\/379\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:26:04Z","timestamp":1775039164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4450\/17\/4\/379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["insects17040379"],"URL":"https:\/\/doi.org\/10.3390\/insects17040379","relation":{},"ISSN":["2075-4450"],"issn-type":[{"value":"2075-4450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}