{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:47:34Z","timestamp":1791348454269,"version":"4.3.1"},"reference-count":136,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32220103009"],"award-info":[{"award-number":["32220103009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["32220103009"],"award-info":[{"award-number":["32220103009"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"China Agriculture Research System of MOF and MARA","award":["CARS-26"],"award-info":[{"award-number":["CARS-26"]}]},{"award":["CARS-26"],"award-info":[{"award-number":["CARS-26"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Hubei Hongshan Laboratory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insects"],"abstract":"<jats:p>The gut microbiota influences host health, development, nutrition, and behavior, positioning it as a frontier research area in life sciences. Bactrocera dorsalis is a major agricultural pest, with a short life cycle, ease of laboratory rearing, and the availability of germ-free larvae. The gut microbiota of B. dorsalis is complex and relatively insensitive to environmental influences. Due to these advantages, B. dorsalis has emerged as a promising model organism for gut microbiota research. This review synthesizes the advantages of B. dorsalis as a model organism, detailing its gut structure and the composition of its microbiota across developmental stages, sexes, diets, and geographical populations\u2014highlighting the dominance of Enterobacteriaceae as a core component. Key functional roles of gut microbiota in B. dorsalis are elucidated, including nutrient provisioning, regulation of development and reproduction, enhancement of environmental adaptability, behavioral modulation, pesticide resistance, and immune interactions. The mechanisms underpinning gut microbiota homeostasis, involving the host Duox\/ROS system, NOX enzymes, and the Imd pathway, are also discussed. Limitations are addressed, alongside future directions for leveraging genetic tools to dissect host\u2013microbe interplay. Furthermore, the potential applications of gut microbiota research\u2014including probiotics for Sterile Insect Technique optimization, microbial-based attractants, and paratransgenesis for pest control\u2014are emphasized. Collectively, B. dorsalis offers a platform for understanding intricate host\u2013microbe interplay and inspires novel pest management strategies.<\/jats:p>","DOI":"10.3390\/insects17070662","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:14:12Z","timestamp":1782375252000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bactrocera dorsalis and Its Gut Microbiota: An Emerging Insect Model"],"prefix":"10.3390","volume":"17","author":[{"given":"Qi","family":"Zhou","sequence":"first","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops, Hubei Hongshan Laboratory, Institute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops, Hubei Hongshan Laboratory, Institute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops, Hubei Hongshan Laboratory, Institute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-5903","authenticated-orcid":false,"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops, Hubei Hongshan Laboratory, Institute of Urban and Horticultural Entomology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00248-016-0789-6","article-title":"Microbial Ecology of the Human Skin","volume":"76","author":"Cundell","year":"2018","journal-title":"Microb. Ecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/sj.bdj.2018.217","article-title":"The Oral Microbiota\u2014A Mechanistic Role for Systemic Diseases","volume":"224","author":"Jia","year":"2018","journal-title":"Br. Dent. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Li, Y., Chang, L., Xu, K., Zhang, S., Gao, F., and Fan, Y. (2023). Research Progresses on the Function and Detection Methods of Insect Gut Microbes. Microorganisms, 11.","DOI":"10.3390\/microorganisms11051208"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/1744-7917.12183","article-title":"Genitalia-associated Microbes in Insects","volume":"22","author":"Otti","year":"2015","journal-title":"Insect Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut Biogeography of the Bacterial Microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-ento-121423-013513","article-title":"Nutritional Symbiosis Between Ants and Their Symbiotic Microbes","volume":"71","author":"Hu","year":"2025","journal-title":"Annu. Rev. Entomol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110941","DOI":"10.1016\/j.ygeno.2024.110941","article-title":"Impairment of Oocyte Quality Caused by Gut Microbiota Dysbiosis in Obesity","volume":"116","author":"Shan","year":"2024","journal-title":"Genomics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2016.10.027","article-title":"The Central Nervous System and the Gut Microbiome","volume":"167","author":"Sharon","year":"2016","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-025-08990-4","article-title":"Targeting Symbionts by Apolipoprotein L Proteins Modulates Gut Immunity","volume":"643","author":"Yang","year":"2025","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12672-025-04248-7","article-title":"Applications and Challenges of Drosophila melanogaster as a Laboratory Model in Human Cancer Research: A Narrative Review","volume":"17","author":"Abdullateef","year":"2025","journal-title":"Discov. Onc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1104\/pp.125.1.15","article-title":"Prehistory and History of Arabidopsis Research","volume":"125","author":"Meyerowitz","year":"2001","journal-title":"Plant Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jprot.2010.08.002","article-title":"Model Organisms\u2014A Historical Perspective","volume":"73","author":"Grossniklaus","year":"2010","journal-title":"J. Proteom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41684-018-0173-x","article-title":"Honey Bees as Models for Gut Microbiota Research","volume":"47","author":"Zheng","year":"2018","journal-title":"Lab. Anim."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cho, K.H., and Kang, S.O. (2025). The Gut Microbiota of Drosophila melanogaster: A Model for Host\u2013Microbe Interactions in Metabolism, Immunity, Behavior, and Disease. Microorganisms, 13.","DOI":"10.3390\/microorganisms13112515"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e01117-14","DOI":"10.1128\/mBio.01117-14","article-title":"Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology","volume":"5","author":"Broderick","year":"2014","journal-title":"mBio"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pais, I.S., Valente, R.S., Sporniak, M., and Teixeira, L. (2018). Drosophila melanogaster Establishes a Species-Specific Mutualistic Interaction with Stable Gut-Colonizing Bacteria. PLoS Biol., 16.","DOI":"10.1101\/265991"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ympev.2009.01.003","article-title":"African Dacus (Diptera: Tephritidae: Molecular Data and Host Plant Associations Do Not Corroborate Morphology Based Classifications","volume":"51","author":"Virgilio","year":"2009","journal-title":"Mol. Phylogenet. Evol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1017\/S0007485319000853","article-title":"Tephritidae Fruit Fly Gut Microbiome Diversity, Function and Potential for Applications","volume":"110","author":"Raza","year":"2020","journal-title":"Bull. Entomol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00203-022-03207-y","article-title":"The Gut Microbiome Analysis of Anastrepha obliqua Reveals Inter-Kingdom Diversity: Bacteria, Fungi, and Archaea","volume":"204","author":"Amores","year":"2022","journal-title":"Arch. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Akami, M., Andongma, A.A., Zhengzhong, C., Nan, J., Khaeso, K., Jurkevitch, E., Niu, C.-Y., and Yuval, B. (2019). Intestinal Bacteria Modulate the Foraging Behavior of the Oriental Fruit Fly Bactrocera dorsalis (Diptera: Tephritidae). PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210109"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wang, A., Yao, Z., Zheng, W., and Zhang, H. (2014). Bacterial Communities in the Gut and Reproductive Organs of Bactrocera minax (Diptera: Tephritidae) Based on 454 Pyrosequencing. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106988"},{"key":"ref_22","first-page":"285","article-title":"Assessment of the Bacteria Community Structure across Life Stages of the Chinese Citrus Fly, Bactrocera minax (Diptera: Tephritidae)","volume":"19","author":"Andongma","year":"2019","journal-title":"Scand. J. Trauma. Resusc. Emerg. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yao, Z., Ma, Q., Cai, Z., Raza, M.F., Bai, S., Wang, Y., Zhang, P., Ma, H., and Zhang, H. (2019). Similar Shift Patterns in Gut Bacterial and Fungal Communities Across the Life Stages of Bactrocera minax Larvae from Two Field Populations. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02262"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1038\/s41598-019-50602-5","article-title":"Next-Generation Sequencing Reveals Relationship between the Larval Microbiome and Food Substrate in the Polyphagous Queensland Fruit Fly","volume":"9","author":"Majumder","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Woruba, D.N., Morrow, J.L., Reynolds, O.L., Chapman, T.A., Collins, D.P., and Riegler, M. (2019). Diet and Irradiation Effects on the Bacterial Community Composition and Structure in the Gut of Domesticated Teneral and Mature Queensland Fruit Fly, Bactrocera tryoni (Diptera: Tephritidae). BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1649-6"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Malacrin\u00f2, A., Campolo, O., Medina, R.F., and Palmeri, V. (2018). Instar- and Host-Associated Differentiation of Bacterial Communities in the Mediterranean Fruit Fly Ceratitis capitata. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194131"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"13723","DOI":"10.1038\/s41598-023-40562-2","article-title":"Gut Bacterial Population and Community Dynamics Following Adult Emergence in Pest Tephritid Fruit Flies","volume":"13","author":"Mason","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/1744-7917.12768","article-title":"Diversity of Bacteria in Different Life Stages and Their Impact on the Development and Reproduction of Zeugodacus tau (Diptera: Tephritidae)","volume":"28","author":"Noman","year":"2021","journal-title":"Insect Sci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hadapad, A.B., Shettigar, S.K.G., and Hire, R.S. (2019). Bacterial Communities in the Gut of Wild and Mass-Reared Zeugodacus cucurbitae and Bactrocera dorsalis Revealed by Metagenomic Sequencing. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1647-8"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00284-020-02327-2","article-title":"High Taxonomic and Functional Diversity of Bacterial Communities Associated with Melon Fly, Zeugodacus cucurbitae (Diptera: Tephritidae)","volume":"78","author":"Choudhary","year":"2021","journal-title":"Curr. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jisesa\/iez128","article-title":"Assessment of Bactrocera dorsalis (Diptera: Tephritidae) Diets on Adult Fecundity and Larval Development: Insights into Employing the Sterile Insect Technique","volume":"20","author":"Hou","year":"2020","journal-title":"J. Insect Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102877","DOI":"10.1016\/j.jtherbio.2021.102877","article-title":"Temperature-Based Phenology Model to Predict the Development, Survival, and Reproduction of the Oriental Fruit Fly Bactrocera dorsalis","volume":"97","author":"Michel","year":"2021","journal-title":"J. Therm. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S2095-3119(18)62015-5","article-title":"Invasion, Expansion, and Control of Bactrocera dorsalis (Hendel) in China","volume":"18","author":"Liu","year":"2019","journal-title":"J. Integr. Agric."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-ento-012723-102658","article-title":"The Global Epidemic of Bactrocera Pests: Mixed-Species Invasions and Risk Assessment","volume":"69","author":"Zhao","year":"2024","journal-title":"Annu. Rev. Entomol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nugnes, F., Russo, E., Viggiani, G., and Bernardo, U. (2018). First Record of an Invasive Fruit Fly Belonging to Bactrocera dorsalis Complex (Diptera: Tephritidae) in Europe. Insects, 9.","DOI":"10.3390\/insects9040182"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1007\/s00253-017-8551-7","article-title":"Transmission Modes of a Pesticide-Degrading Symbiont of the Oriental Fruit Fly Bactrocera dorsalis (Hendel)","volume":"101","author":"Guo","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s40168-024-01931-9","article-title":"Intestinal Commensal Bacteria Promote Bactrocera dorsalis Larval Development through the Vitamin B6 Synthesis Pathway","volume":"12","author":"Gu","year":"2024","journal-title":"Microbiome"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/1744-7917.12986","article-title":"Gut Fungal Community and Its Probiotic Effect on Bactrocera dorsalis","volume":"29","author":"Guo","year":"2022","journal-title":"Insect Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"10861","DOI":"10.1038\/s41467-025-65870-1","article-title":"Telomere-to-Telomere Genome Assembly of the Dipteran Bactrocera dorsalis from a Single Individual","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00248-024-02352-9","article-title":"Impact of Larval Food Source on the Stability of the Bactrocera dorsalis Microbiome","volume":"87","author":"Kempraj","year":"2024","journal-title":"Microb. Ecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/imb.12540","article-title":"CRISPR\/Cas9-Mediated Mutagenesis of the Mew Gene Induces Muscle Weakness and Flightlessness in Bactrocera dorsalis (Diptera: Tephritidae)","volume":"28","author":"Zheng","year":"2019","journal-title":"Insect Mol. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"fuag001","DOI":"10.1093\/femsre\/fuag001","article-title":"The Honeybee Gut Microbiome: A Novel Multidimensional Model of Antimicrobial Resistance Transmission and Immune Homeostasis from Environmental Interactions to Health Regulation","volume":"50","author":"Hai","year":"2026","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Liu, H., Yin, J., Huang, X., Zang, C., Zhang, Y., Cao, J., and Gong, M. (2024). Mosquito Gut Microbiota: A Review. Pathogens, 13.","DOI":"10.3390\/pathogens13080691"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cois.2018.05.008","article-title":"Composition and Functional Roles of the Gut Microbiota in Mosquitoes","volume":"28","author":"Strand","year":"2018","journal-title":"Curr. Opin. Insect Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1574-6976.12025","article-title":"The Gut Microbiota of Insects\u2014Diversity in Structure and Function","volume":"37","author":"Engel","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111523","DOI":"10.1016\/j.celrep.2022.111523","article-title":"Compartmentalized PGRP Expression along the Dipteran Bactrocera dorsalis Gut Forms a Zone of Protection for Symbiotic Bacteria","volume":"41","author":"Yao","year":"2022","journal-title":"Cell Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF00384954","article-title":"Bacteria Associated with Four Species of Dacus (Diptera: Tephritidae) and Their Role in the Nutrition of the Larvae","volume":"67","author":"Fitt","year":"1985","journal-title":"Oecologia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1534\/genetics.118.300224","article-title":"Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster","volume":"210","author":"Jasper","year":"2018","journal-title":"Genetics"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e11723","DOI":"10.1002\/advs.202511723","article-title":"Alkaline\u2013Acid Intestine Environment Controlled by A Carbonic Anhydrase Gene Influences Synthesis of Sex Pheromone by Symbionts","volume":"12","author":"Gui","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1017\/S0007485318000834","article-title":"The Influence of Antibiotics on Gut Bacteria Diversity Associated with Laboratory-Reared Bactrocera dorsalis","volume":"109","author":"Bai","year":"2019","journal-title":"Bull. Entomol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/j.1365-2672.2011.05001.x","article-title":"Comparison of the Diversity of the Bacterial Communities in the Intestinal Tract of Adult Bactrocera dorsalis from Three Different Populations: Bacterial Communities in B. dorsalis Gut","volume":"110","author":"Wang","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9470","DOI":"10.1038\/srep09470","article-title":"Pyrosequencing Reveals a Shift in Symbiotic Bacteria Populations across Life Stages of Bactrocera dorsalis","volume":"5","author":"Andongma","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1017\/S0007485316000390","article-title":"Bacterial Communities Associated with Invasive Populations of Bactrocera dorsalis (Diptera: Tephritidae) in China","volume":"106","author":"Liu","year":"2016","journal-title":"Bull. Entomol. Res."},{"key":"ref_54","first-page":"2861","article-title":"Diversity of Bacterial Communities in the Intestinal Tracts of Two Geographically Distant Populations of Bactrocera dorsalis (Diptera: Tephritidae)","volume":"111","author":"Liu","year":"2018","journal-title":"J. Econ. Entomol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Han, R., Zhang, T., Yang, J., Teng, Z., Fan, Y., Sun, P., Lu, Y., Ren, Y., and Wan, F. (2024). The Food Source and Gut Bacteria Show Effects on the Invasion of Alien Pests\u2014A Case of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). Insects, 15.","DOI":"10.3390\/insects15070530"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Nikolouli, K., Augustinos, A.A., Stathopoulou, P., Asimakis, E., Mintzas, A., Bourtzis, K., and Tsiamis, G. (2020). Genetic Structure and Symbiotic Profile of Worldwide Natural Populations of the Mediterranean Fruit Fly, Ceratitis capitata. BMC Genet., 21.","DOI":"10.1186\/s12863-020-00946-z"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1007\/s11033-019-04818-3","article-title":"Differential Abundance and Core Members of the Bacterial Community Associated with Wild Male Zeugodacus cucurbitae Fruit Flies (Insecta: Tephritidae) from Three Geographical Regions of Southeast Asia","volume":"46","author":"Yong","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.es.11.110180.001003","article-title":"Herbivory in Relation to Plant Nitrogen Content","volume":"11","author":"Mattson","year":"1980","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/s41467-018-03357-y","article-title":"Herbivorous Turtle Ants Obtain Essential Nutrients from a Conserved Nitrogen-Recycling Gut Microbiome","volume":"9","author":"Hu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41396-023-01415-y","article-title":"Cuticle Supplementation and Nitrogen Recycling by a Dual Bacterial Symbiosis in a Family of Xylophagous Beetles","volume":"17","author":"Kiefer","year":"2023","journal-title":"ISME J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00248-021-01930-5","article-title":"Nitrogen Fixation and Diazotrophic Community in Plastic-Eating Mealworms Tenebrio molitor L.","volume":"85","author":"Yang","year":"2023","journal-title":"Microb. Ecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/AEM.02761-12","article-title":"Phylogenetic, Metabolic, and Taxonomic Diversities Shape Mediterranean Fruit Fly Microbiotas during Ontogeny","volume":"79","author":"Aharon","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1111\/jeb.12527","article-title":"Symbiotic Bacteria Enable Olive Flies (Bactrocera oleae) to Exploit Intractable Sources of Nitrogen","volume":"27","author":"Pasternak","year":"2014","journal-title":"J. Evol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ren, X., Cao, S., Akami, M., Mansour, A., Yang, Y., Jiang, N., Wang, H., Zhang, G., Qi, X., and Xu, P. (2022). Gut Symbiotic Bacteria Are Involved in Nitrogen Recycling in the Tephritid Fruit Fly Bactrocera dorsalis. BMC Biol., 20.","DOI":"10.1186\/s12915-022-01399-9"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev-ento-112408-085319","article-title":"Cellulolytic Systems in Insects","volume":"55","author":"Watanabe","year":"2010","journal-title":"Annu. Rev. Entomol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e00091-20","DOI":"10.1128\/AEM.00091-20","article-title":"Cultivable, Host-Specific Bacteroidetes Symbionts Exhibit Diverse Polysaccharolytic Strategies","volume":"86","author":"Jahnes","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"25909","DOI":"10.1073\/pnas.1916224116","article-title":"Division of Labor in Honey Bee Gut Microbiota for Plant Polysaccharide Digestion","volume":"116","author":"Zheng","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","first-page":"122","article-title":"Production of Polysaccharide Degrading Enzymes by the Gut Microbiota of Leucinodes orbonalis and Bactrocera dorsalis","volume":"3","author":"Saha","year":"2015","journal-title":"J. Entomol. Zool. Stud."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e02225-22","DOI":"10.1128\/mbio.02225-22","article-title":"Involvement of Microbiota in Insect Physiology: Focus on B Vitamins","volume":"14","author":"Gendrin","year":"2023","journal-title":"mBio"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10255","DOI":"10.1073\/pnas.1423305112","article-title":"Signatures of Host\/Symbiont Genome Coevolution in Insect Nutritional Endosymbioses","volume":"112","author":"Wilson","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Cai, Z., Guo, Q., Yao, Z., Zheng, W., Xie, J., Bai, S., and Zhang, H. (2020). Comparative Genomics of Klebsiella michiganensis BD177 and Related Members of Klebsiella Sp. Reveal the Symbiotic Relationship with Bactrocera dorsalis. BMC Genet., 21.","DOI":"10.1186\/s12863-020-00945-0"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1111\/mec.12771","article-title":"Mosquitoes Rely on Their Gut Microbiota for Development","volume":"23","author":"Coon","year":"2014","journal-title":"Mol. Ecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12866-019-1648-7","article-title":"Commensal Microbiota Modulates Larval Foraging Behaviour, Development Rate and Pupal Production in Bactrocera tryoni","volume":"19","author":"Morimoto","year":"2019","journal-title":"BMC Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1212782","article-title":"Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling","volume":"334","author":"Shin","year":"2011","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1073\/pnas.1701819114","article-title":"Honeybee Gut Microbiota Promotes Host Weight Gain via Bacterial Metabolism and Hormonal Signaling","volume":"114","author":"Zheng","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Hassan, B., Siddiqui, J.A., and Xu, Y. (2020). Vertically Transmitted Gut Bacteria and Nutrition Influence the Immunity and Fitness of Bactrocera dorsalis Larvae. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.596352"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Gichuhi, J., Khamis, F., Van Den Berg, J., Mohamed, S., Ekesi, S., and Herren, J.K. (2020). Influence of Inoculated Gut Bacteria on the Development of Bactrocera dorsalis and on Its Susceptibility to the Entomopathogenic Fungus, Metarhizium anisopliae. BMC Microbiol., 20.","DOI":"10.1186\/s12866-020-02015-y"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s40168-025-02121-x","article-title":"Gut Symbiotic Bacteria Enhance Reproduction in Spodoptera frugiperda (J.E. Smith) by Regulating Juvenile Hormone III and 20-Hydroxyecdysone Pathways","volume":"13","author":"Chu","year":"2025","journal-title":"Microbiome"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"112102","DOI":"10.1016\/j.celrep.2023.112102","article-title":"A Bacteriocyte Symbiont Determines Whitefly Sex Ratio by Regulating Mitochondrial Function","volume":"42","author":"Yao","year":"2023","journal-title":"Cell Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rspb.2009.2102","article-title":"Give Us the Tools and We Will Do the Job: Symbiotic Bacteria Affect Olive Fly Fitness in a Diet-Dependent Fashion","volume":"277","author":"Aharon","year":"2010","journal-title":"Proc. R. Soc. B."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"104396","DOI":"10.1016\/j.jinsphys.2022.104396","article-title":"Antibiotic Treatment Reduces Fecundity and Nutrient Content in Females of Anastrepha fraterculus (Diptera: Tephritidae) in a Diet Dependent Way","volume":"139","author":"Goane","year":"2022","journal-title":"J. Insect Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"115911","DOI":"10.1016\/j.celrep.2025.115911","article-title":"Gut Commensal Bacteria-Derived Methionine Is Required for Host Reproduction by Modulating RNA m6A Methylation of the Insulin Receptor","volume":"44","author":"Zhang","year":"2024","journal-title":"Cell Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1038\/s41467-026-69021-y","article-title":"The Lolal-Dpp Axis Mediates the Regulation of Host Reproduction by Gut Symbionts in Insects","volume":"17","author":"Qiao","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Msaad Guerfali, M., Charaabi, K., Hamden, H., Zidi, O., Hamdi, M., Fadhl, S., Kouidhi, S., Cherif, A., and Mosbah, A. (2024). Exploring the Metabolic Changes of Ceratitis capitata Vienna 8 Strain across Three Developmental Stages through Probiotic Larval Diet Supplementation. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0313894"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Shuttleworth, L.A., Khan, M.A.M., Osborne, T., Collins, D., Srivastava, M., and Reynolds, O.L. (2019). A Walk on the Wild Side: Gut Bacteria Fed to Mass-Reared Larvae of Queensland Fruit Fly [Bactrocera tryoni (Froggatt)] Influence Development. BMC Biotechnol., 19.","DOI":"10.1186\/s12896-019-0579-6"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1111\/eva.12698","article-title":"Intestinal Probiotics Restore the Ecological Fitness Decline of Bactrocera dorsalis by Irradiation","volume":"11","author":"Cai","year":"2018","journal-title":"Evol. Appl."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e70158","DOI":"10.1111\/eva.70158","article-title":"Effects of X-Ray Irradiation on the Biological Parameters, Gut Microbiota, and Gene Expression of Bactrocera dorsalis: Implications for the Sterile Insect Technique","volume":"18","author":"Lin","year":"2025","journal-title":"Evol. Appl."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/jee\/toaa294","article-title":"Manipulation of Gut Symbionts for Improving the Sterile Insect Technique: Quality Parameters of Bactrocera dorsalis (Diptera: Tephritidae) Genetic Sexing Strain Males After Feeding on Bacteria-Enriched Diets","volume":"114","author":"Zhang","year":"2021","journal-title":"J. Econ. Entomol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Khan, M., Seheli, K., Bari, M.A., Sultana, N., Khan, S.A., Sultana, K.F., and Hossain, M.A. (2019). Potential of a Fly Gut Microbiota Incorporated Gel-Based Larval Diet for Rearing Bactrocera dorsalis (Hendel). BMC Biotechnol., 19.","DOI":"10.1186\/s12896-019-0580-0"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1038\/ncomms8618","article-title":"Gut Microbiota Mediate Caffeine Detoxification in the Primary Insect Pest of Coffee","volume":"6","author":"Vega","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/s42003-024-06779-1","article-title":"The Symbiont Acinetobacter baumannii Enhances the Insect Host Resistance to Entomopathogenic Fungus Metarhizium anisopliae","volume":"7","author":"Tang","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1002\/ps.8096","article-title":"Gut Microbiota Metagenomics and Mediation of Phenol Degradation in Bactrocera minax (Diptera, Tephritidae)","volume":"80","author":"Cao","year":"2024","journal-title":"Pest Manag. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"35096","DOI":"10.1038\/s41598-025-18890-2","article-title":"Predicting the Invasion Risk of Bactrocera dorsalis in Italy under Climate and Land Cover Change","volume":"15","author":"Bernardo","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00248-021-01682-2","article-title":"Endosymbiotic Bacteria Aid to Overcome Temperature Induced Stress in the Oriental Fruit Fly, Bactrocera dorsalis","volume":"82","author":"Ayyasamy","year":"2021","journal-title":"Microb. Ecol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Raza, M.F., Wang, Y., Cai, Z., Bai, S., Yao, Z., Awan, U.A., Zhang, Z., Zheng, W., and Zhang, H. (2020). Gut Microbiota Promotes Host Resistance to Low-Temperature Stress by Stimulating Its Arginine and Proline Metabolism Pathway in Adult Bactrocera dorsalis. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008441"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s40168-023-01664-1","article-title":"Population Mixing Mediates the Intestinal Flora Composition and Facilitates Invasiveness in a Globally Invasive Fruit Fly","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","article-title":"Gastrointestinal and Brain Barriers: Unlocking Gates of Communication across the Microbiota\u2013Gut\u2013Brain Axis","volume":"21","author":"Aburto","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1016\/j.cub.2021.02.046","article-title":"Rectal Bacteria Produce Sex Pheromones in the Male Oriental Fruit Fly","volume":"31","author":"Ren","year":"2021","journal-title":"Curr. Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00248-016-0819-4","article-title":"Commensal Bacteria Aid Mate-Selection in the Fruit Fly, Bactrocera dorsalis","volume":"72","author":"Damodaram","year":"2016","journal-title":"Microb. Ecol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/s42003-022-03947-z","article-title":"Gut Bacteria Induce Oviposition Preference through Ovipositor Recognition in Fruit Fly","volume":"5","author":"He","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1016\/j.cub.2020.08.080","article-title":"Egg-Surface Bacteria Are Indirectly Associated with Oviposition Aversion in Bactrocera dorsalis","volume":"30","author":"Li","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Akami, M., Ren, X.-M., Qi, X., Mansour, A., Gao, B., Cao, S., and Niu, C.-Y. (2019). Symbiotic Bacteria Motivate the Foraging Decision and Promote Fecundity and Survival of Bactrocera dorsalis (Diptera: Tephritidae). BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1607-3"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"RP100870","DOI":"10.7554\/eLife.100870","article-title":"The Neuropeptide Sulfakinin, a Peripheral Regulator of Insect Behavioral Switch between Mating and Foraging","volume":"13","author":"Li","year":"2024","journal-title":"eLife"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1603\/022.038.0114","article-title":"Association and Attraction of Blueberry Maggot Fly Curran (Diptera: Tephritidae) to Pantoea (Enterobacter) agglomerans","volume":"38","author":"Maccollom","year":"2009","journal-title":"Environ. Entomol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s10886-017-0877-1","article-title":"Two Gut-Associated Yeasts in a Tephritid Fruit Fly Have Contrasting Effects on Adult Attraction and Larval Survival","volume":"43","author":"Piper","year":"2017","journal-title":"J. Chem. Ecol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/ps.3528","article-title":"Identification of Cultivable Bacteria in the Intestinal Tract of Bactrocera dorsalis from Three Different Populations and Determination of Their Attractive Potential: Bacterial Communities and Function in B. dorsalis Gut","volume":"70","author":"Wang","year":"2014","journal-title":"Pest Manag. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Duan, Y., Li, A., Zhang, L., Yin, C., Li, Z., and Liu, L. (2024). Attractant Potential of Enterobacter cloacae and Its Metabolites to Bactrocera dorsalis (Hendel). Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1465946"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40168-017-0236-z","article-title":"Gut Symbiont Enhances Insecticide Resistance in a Significant Pest, the Oriental Fruit Fly Bactrocera dorsalis (Hendel)","volume":"5","author":"Cheng","year":"2017","journal-title":"Microbiome"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"wrae058","DOI":"10.1093\/ismejo\/wrae058","article-title":"Lactic Acid Bacteria Modulate the CncC Pathway to Enhance Resistance to \u03b2-Cypermethrin in the Oriental Fruit Fly","volume":"18","author":"Zeng","year":"2024","journal-title":"ISME J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"wrae194","DOI":"10.1093\/ismejo\/wrae194","article-title":"Insecticide Susceptibility in a Planthopper Pest Increases Following Inoculation with Cultured Arsenophonus","volume":"18","author":"Cai","year":"2024","journal-title":"ISME J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1073\/pnas.1200231109","article-title":"Symbiont-Mediated Insecticide Resistance","volume":"109","author":"Kikuchi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1016\/j.cub.2025.08.004","article-title":"Symbiotic Bacteria Mediate Chemical-Insecticide Resistance but Enhance the Efficacy of a Biological Insecticide in Diamondback Moth","volume":"35","author":"Li","year":"2025","journal-title":"Curr. Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/1744-7917.12868","article-title":"Regulatory Mechanisms of Microbial Homeostasis in Insect Gut","volume":"28","author":"Bai","year":"2021","journal-title":"Insect Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"115404","DOI":"10.1016\/j.celrep.2025.115404","article-title":"Bacterial-Induced Duox-ROS Regulates the Imd Immune Pathway in the Gut by Modulating the Peritrophic Matrix","volume":"44","author":"Bai","year":"2025","journal-title":"Cell Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.tree.2012.08.013","article-title":"Insect Symbionts as Hidden Players in Insect\u2013Plant Interactions","volume":"27","author":"Frago","year":"2012","journal-title":"Trends Ecol. Evol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/s41467-017-01935-0","article-title":"Symbionts Protect Aphids from Parasitic Wasps by Attenuating Herbivore-Induced Plant Volatiles","volume":"8","author":"Frago","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1073\/pnas.0335320100","article-title":"Facultative Bacterial Symbionts in Aphids Confer Resistance to Parasitic Wasps","volume":"100","author":"Oliver","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Gwokyalya, R., Weldon, C.W., Herren, J.K., Gichuhi, J., Makhulu, E.E., Ndlela, S., and Mohamed, S.A. (2023). Friend or Foe: Symbiotic Bacteria in Bactrocera dorsalis\u2013Parasitoid Associations. Biology, 12.","DOI":"10.3390\/biology12020274"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1117311","article-title":"A Direct Role for Dual Oxidase in Drosophila Gut Immunity","volume":"310","author":"Ha","year":"2005","journal-title":"Scinece"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1209678","article-title":"Epithelial Nitration by a Peroxidase\/NOX5 System Mediates Mosquito Antiplasmodial Immunity","volume":"335","author":"Oliveira","year":"2012","journal-title":"Science"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.dci.2009.11.010","article-title":"Innate Immunity and Gut\u2013Microbe Mutualism in Drosophila","volume":"34","author":"Ryu","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/ismej.2015.202","article-title":"The Dual Oxidase Gene BdDuox Regulates the Intestinal Bacterial Community Homeostasis of Bactrocera dorsalis","volume":"10","author":"Yao","year":"2016","journal-title":"ISME J."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zeng, T., Su, H., Liu, Y., Li, J., Jiang, D., Lu, Y., and Qi, Y. (2022). Serotonin Modulates Insect Gut Bacterial Community Homeostasis. BMC Biol., 20.","DOI":"10.1186\/s12915-022-01319-x"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"wrae221","DOI":"10.1093\/ismejo\/wrae221","article-title":"Pathobiont and Symbiont Contribute to Microbiota Homeostasis through Malpighian Tubules\u2013Gut Countercurrent Flow in Bactrocera dorsalis","volume":"18","author":"Liu","year":"2024","journal-title":"ISME J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1002\/ps.70506","article-title":"BdNOX5 Mediates Gut Microbiota Homeostasis via ROS Regulation in Bactrocera dorsalis","volume":"82","author":"Zeng","year":"2026","journal-title":"Pest Manag. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Zhang, P., Yao, Z., Bai, S., and Zhang, H. (2022). The Negative Regulative Roles of BdPGRPs in the Imd Signaling Pathway of Bactrocera dorsalis. Cells, 11.","DOI":"10.3390\/cells11010152"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e00803-19","DOI":"10.1128\/AEM.00803-19","article-title":"Microbial Communities in Different Developmental Stages of the Oriental Fruit Fly, Bactrocera dorsalis, Are Associated with Differentially Expressed Peptidoglycan Recognition Protein-Encoding Genes","volume":"85","author":"Huang","year":"2019","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Gu, J., Zhang, P., Yao, Z., Li, X., and Zhang, H. (2023). BdNub is Essential for Maintaining Gut Immunity and Microbiome Homeostasis in Bactrocera dorsalis. Insects, 14.","DOI":"10.3390\/insects14020178"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.tim.2023.02.007","article-title":"Axenic and Gnotobiotic Insect Technologies in Research on Host\u2013Microbiota Interactions","volume":"31","author":"Wu","year":"2023","journal-title":"Trends Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1038\/srep08700","article-title":"Endocytic Pathway Mediates Refractoriness of Insect Bactrocera dorsalis to RNA Interference","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41467-020-14622-4","article-title":"miRNA-1-3p Is an Early Embryonic Male Sex-Determining Factor in the Oriental Fruit Fly Bactrocera dorsalis","volume":"11","author":"Peng","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/1744-7917.13311","article-title":"Identification and Functional Verification of Y-chromosome-specific Gene Typo-gyf in Bactrocera dorsalis","volume":"31","author":"Liu","year":"2024","journal-title":"Insect Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/s41564-021-00899-8","article-title":"A Natural Symbiotic Bacterium Drives Mosquito Refractoriness to Plasmodium Infection via Secretion of an Antimalarial Lipase","volume":"6","author":"Gao","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1038\/s41467-023-38498-2","article-title":"Engineered Symbiotic Bacteria Interfering Nosema Redox System Inhibit Microsporidia Parasitism in Honeybees","volume":"14","author":"Lang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.aan5478","article-title":"Driving Mosquito Refractoriness to Plasmodium falciparum with Engineered Symbiotic Bacteria","volume":"357","author":"Wang","year":"2017","journal-title":"Science"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"eadn9524","DOI":"10.1126\/science.adn9524","article-title":"A Naturally Isolated Symbiotic Bacterium Suppresses Flavivirus Transmission by Aedes Mosquitoes","volume":"384","author":"Zhang","year":"2024","journal-title":"Science"}],"container-title":["Insects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4450\/17\/7\/662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:10:11Z","timestamp":1782537011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4450\/17\/7\/662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":136,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["insects17070662"],"URL":"https:\/\/doi.org\/10.3390\/insects17070662","relation":{},"ISSN":["2075-4450"],"issn-type":[{"value":"2075-4450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}