{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:10:59Z","timestamp":1788876659706,"version":"build-2803163510"},"reference-count":220,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Overseas High-Level Talent Program-Taishan Scholar title","award":["tshw20091015"],"award-info":[{"award-number":["tshw20091015"]}]},{"name":"Ministry of Science and Technology of China-National Expert title","award":["G2022023033L"],"award-info":[{"award-number":["G2022023033L"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insects"],"abstract":"<jats:p>The gut, brain, fat body, and various glands, although rich in \u201cCSPs\u201d, are not involved in chemosensory functions. We propose renaming the \u201cCSPs\u201d to \u201c4CSPs\u201d (4-Cysteine Soluble Proteins) to clarify their role, avoiding confusion with proteins also found in wings, hemolymph, and eggs. This report highlights studies related to insecticide resistance and lipid transport and expands on potential intracellular functions, strongly indicating non-chemosensory features of 4CSPs. Additionally, we show a significant correlation between 4CSPs and mucins, translation initiation factors, and actin complex proteins, reinforcing the proposal to rename \u201cCSPs\u201d and consider developmental pattern, tissue distribution, and intracellular localization.<\/jats:p>","DOI":"10.3390\/insects17090940","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:46:33Z","timestamp":1788875193000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renaming the \u2018OS-D\/CSP\u2019 Family (Part 2): \u20184-Cysteine Soluble Proteins\u2019 (4CSPs)\u2014Intracellular Functions"],"prefix":"10.3390","volume":"17","author":[{"given":"Guoxia","family":"Liu","sequence":"first","affiliation":[{"name":"Shandong Academy of Agricultural Sciences, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botong","family":"Sun","sequence":"additional","affiliation":[{"name":"Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Shandong Academy of Sciences, Jinan 250103, China"},{"name":"Shandong Institute for Product Quality Inspection, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Shandong Academy of Sciences, Jinan 250103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shousong","family":"Yue","sequence":"additional","affiliation":[{"name":"Shandong Academy of Agricultural Sciences, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"He","sequence":"additional","affiliation":[{"name":"Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Shandong Academy of Sciences, Jinan 250103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-4772","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Picimbon","sequence":"additional","affiliation":[{"name":"Shandong Academy of Agricultural Sciences, Jinan 250100, China"},{"name":"Science and Technology Service Platform of Shandong Academy of Sciences, Shandong Academy of Sciences Foreign Students Pioneer Park, Shandong Academy of Sciences, Jinan 250103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, G., Sun, B., Fan, W., Yue, S., He, Q., and Picimbon, J.F. 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