{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:09:49Z","timestamp":1790100589117,"version":"4.0.1"},"reference-count":129,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Insects"],"abstract":"<jats:p>This review summarizes the impact of insecticide resistance in urban pests and its implications for \u2018One Health\u2019 systems. Mosquitoes are the major vector of human disease via blood feeding, followed by houseflies and cockroaches via physical contact, and finally bed bugs, ants, and termites, which are not typically disease vectors. Besides overt disease, other impacts in the context of One Health include nuisance biting and resultant infections, as well as allergic reactions. Control of urban pests is still primarily achieved with insecticides, which have continually improved over time. However, their use has selected for the evolution of resistance to several compound classes across broad geographical areas and multiple species. Resistance results from several types of mechanisms: altered inherited behavioral repertoires that reduce chemical exposure, modified target sites, increased metabolism, and reduced penetration, which have recently been shown to have several specific underlying causes. Overall, the literature portrays a complex resistance landscape that highlights the importance of comprehensive, multifaceted approaches to maintain effective control. New technologies and approaches for resistance management are also discussed, with emphasis on improved chemical control measures via novel synergists and insecticides from both natural and synthetic sources.<\/jats:p>","DOI":"10.3390\/insects17090970","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:14:59Z","timestamp":1790097299000},"page":"970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring and Mitigating Insecticide Resistance in Urban Pests with New Synergists and Insecticides"],"prefix":"10.3390","volume":"17","author":[{"given":"Ayashaa","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Research and Development, Vestacy (E.H. Entomology India Pvt. Ltd.), D-30, Infocity II, Sector 33, Gurgaon 122001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartul","family":"Panhalkar","sequence":"additional","affiliation":[{"name":"Germ Protection\u2014Bar Soap Delivery, Research & Development, Reckitt Benckiser India Pvt. Ltd., Infocity II, Sector 33, Gurgaon 122001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Vestacy (E.H. Entomology India Pvt. Ltd.), D-30, Infocity II, Sector 33, Gurgaon 122001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bloomquist","sequence":"additional","affiliation":[{"name":"Emerging Pathogens Institute, Entomology and Nematology Department, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","unstructured":"US CDC (2026, August 07). About One Health, Available online: https:\/\/www.cdc.gov\/one-health\/about\/index.html."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Khamesipour, F., Lankarani, K.B., Honarvar, B., and Kwenti, T.E. (2018). A systematic review of human pathogens carried by the housefly (Musca domestica L.). 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