{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:11Z","timestamp":1787028611120,"version":"build-2736575974"},"reference-count":14,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPMA"],"abstract":"<jats:p>Daptomycin is widely used for serious methicillin-resistant Staphylococcus aureus (MRSA) infections, but it can cause eosinophilic pneumonia, an uncommon and potentially severe adverse drug reaction. We report probable daptomycin-induced eosinophilic pneumonia (DIEP) in a 77-year-old woman receiving intravenous daptomycin with rifampin for a postoperative MRSA foot infection with concern for orthopedic-device involvement and osteomyelitis. Daptomycin had been initiated 10 days before admission, when she developed acute hypoxemic respiratory failure with bilateral ground-glass and consolidative opacities on chest computed tomography and a negative evaluation for infection. Daptomycin was discontinued on the day of admission, yet respiratory failure progressed, requiring mechanical ventilation. Bronchoalveolar lavage performed after corticosteroid exposure demonstrated eosinophilia (9%), and she improved with systemic corticosteroids and supportive care. Although she did not meet strict FDA \u201cmost likely\/definite\u201d criteria, the temporal association, compatible imaging, exclusion of alternative etiologies, abnormal lavage eosinophilia, and clinical response following drug withdrawal support \u201cprobable\u201d DIEP criteria. Clinicians managing complex foot infections should consider DIEP when new respiratory symptoms and infiltrates develop during daptomycin therapy, even early in the treatment course and even when peripheral eosinophilia is absent or minimal.<\/jats:p>","DOI":"10.3390\/japma116040049","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:27:31Z","timestamp":1783531651000},"page":"49","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daptomycin-Induced Eosinophilic Pneumonia in a Patient Treated for MRSA Foot Infection: A Case Report"],"prefix":"10.3390","volume":"116","author":[{"given":"Ogechi","family":"Okafor","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The University of Texas at San Antonio, San Antonio, TX 78249, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius Rey Angelo R.","family":"Agorilla","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The University of Texas at San Antonio, San Antonio, TX 78249, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7374-5700","authenticated-orcid":false,"given":"Lee C.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The University of Texas at San Antonio, San Antonio, TX 78249, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","unstructured":"U.S. Food and Drug Administration (2010). FDA Drug Safety Communication: Eosinophilic Pneumonia Associated with the Use of Cubicin (Daptomycin)."},{"key":"ref_2","unstructured":"(2026, June 10). Daptomycin for Injection, for Intravenous Use [Prescribing Information]. DailyMed. National Library of Medicine, Available online: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=548f3559-0531-4c95-9e1d-81f81a3801f1."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2165\/11597460-000000000-00000","article-title":"Eosinophilic pneumonia in patients treated with daptomycin: Review of the literature and US FDA adverse event reporting system reports","volume":"35","author":"Kim","year":"2012","journal-title":"Drug Saf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13756-016-0158-8","article-title":"Daptomycin-induced eosinophilic pneumonia: A systematic review","volume":"5","author":"Uppal","year":"2016","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s15010-024-02349-z","article-title":"Daptomycin eosinophilic pneumonia, a systematic review of the literature and case series","volume":"52","author":"Gidari","year":"2024","journal-title":"Infection"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"ofac577","DOI":"10.1093\/ofid\/ofac577","article-title":"Seventeen cases of daptomycin-induced eosinophilic pneumonia in a cohort of patients treated for bone and joint infections: Proposal for a new algorithm","volume":"9","author":"Pham","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1398-9995.2005.00812.x","article-title":"Eosinophilic pneumonias","volume":"60","author":"Cottin","year":"2005","journal-title":"Allergy"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2169\/internalmedicine.52.8997","article-title":"Pneumonitis induced by rifampicin: A case report and literature review","volume":"52","author":"Koma","year":"2013","journal-title":"Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijantimicag.2016.02.014","article-title":"Possible daptomycin-induced acute eosinophilic pneumonia in a patient with diabetic foot infection","volume":"47","author":"Hatipoglu","year":"2016","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_10","first-page":"199","article-title":"Daptomycin-induced acute eosinophilic pneumonia","volume":"113","author":"Patel","year":"2014","journal-title":"WMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e266295","DOI":"10.1136\/bcr-2025-266295","article-title":"Daptomycin and acute lung injury: Recognising drug-induced eosinophilic pneumonia","volume":"18","author":"Utley","year":"2025","journal-title":"BMJ Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Soldevila-Boixader, L., Villanueva, B., Ulldemolins, M., Benavent, E., Padulles, A., Ribera, A., Borras, I., Ariza, J., and Murillo, O. (2021). Risk factors of daptomycin-induced eosinophilic pneumonia in a population with osteoarticular infection. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040446"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciy745","article-title":"2018 Infectious Diseases Society of America clinical practice guideline for the management of outpatient parenteral antimicrobial therapy","volume":"68","author":"Norris","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"ofac065","DOI":"10.1093\/ofid\/ofac065","article-title":"Eosinophilic syndromes associated with daptomycin use: Re-exposure hypersensitivity pneumonitis and prior peripheral eosinophilia","volume":"9","author":"West","year":"2022","journal-title":"Open Forum Infect. Dis."}],"container-title":["Journal of the American Podiatric Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1930-8264\/116\/4\/49\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:07:31Z","timestamp":1783534051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1930-8264\/116\/4\/49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["japma116040049"],"URL":"https:\/\/doi.org\/10.3390\/japma116040049","relation":{},"ISSN":["1930-8264"],"issn-type":[{"value":"1930-8264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]}}}