{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:01:11Z","timestamp":1792112471466,"version":"4.4.0"},"reference-count":67,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Inflammation plays on important role in plaque instability and acute coronary syndromes. The anti-inflammatory effects of B-regulatory lymphocytes (B-regs) in atherosclerosis was tested mainly in animal models with inconclusive results. Herein, we studied for the first time, levels of circulating B-regs in patients with acute myocardial infarction (MI). Methods: We examined circulating levels of B-regs by flow cytometry in 29 patients with recent ST-segment elevation MI and 18 patients with stable angina pectoris (SAP) and coronary artery disease. We re-assessed B-reg levels on average 4 months later. Results: The mean level of CD20+ cells was similar in patients with MI and patients with SAP (p = 0.60). The levels of CD24hiCD38hi cells among CD20+ cells were 5.7 \u00b1 4% and 11.6 \u00b1 6% in patients with MI and SAP, respectively, (p &lt; 0.001). The level of CD24hiCD38hi B-regs remained related to acute MI after correcting for age, gender, and risk factors. Circulating levels of CD24hiCD38hi B-regs in patients with MI did not change significantly at follow-up in a small patient groups (p = 0.408). Conclusions: Circulating B-regs are reduced in patients with MI compared to patients with SAP. This finding may shed further light on the inflammatory pathophysiologic factors related to plaque rupture.<\/jats:p>","DOI":"10.3390\/jcdd10010002","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:09:03Z","timestamp":1671761343000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating Regulatory B-Lymphocytes in Patients with Acute Myocardial Infarction: A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Igor","family":"Volodarsky","sequence":"first","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Shimoni","sequence":"additional","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"},{"name":"Hadassah Medical School, the Hebrew University, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-8919","authenticated-orcid":false,"given":"Dan","family":"Haberman","sequence":"additional","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Mirkin","sequence":"additional","affiliation":[{"name":"The Hematology Institute, Kaplan Medical Center, Rehovot 7661041, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakov","family":"Fabrikant","sequence":"additional","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Yoskovich Mashriki","sequence":"additional","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Zalik","sequence":"additional","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"The Heart Institute, Kaplan Medical Center, Rehovot 7661041, Israel"},{"name":"Hadassah Medical School, the Hebrew University, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/2048872612441582","article-title":"Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease","volume":"1","author":"Badimon","year":"2012","journal-title":"Eur. 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