{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:56:21Z","timestamp":1791100581946,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Thoracic aortic aneurysms (TAA) may be associated with complications such as rupture and dissection, which can lead to a fatal outcome. Increased central arterial stiffness has been proposed to be present in patients with TAA compared to unmatched controls. We aimed to assess whether wall properties in patients with TAA are also altered when compared to a matched control group. Applanation tonometry was performed in 74 adults with TAA and 74 sex, age, weight, height, and left ventricular ejection fraction matched controls. Subsequently analysis of the pulse wave was done using the SphygmoCor System. For comparing the two groups, AIx was adjusted to a heart rate of 75\/min (AIx@75). 148 1-to-1 matched participants were included in the final model. There was no significant difference in the Alx@75 between the TAA group and the matched control group [mean (SD) of 24.7 (11.2) % and 22.8 (11.2) %, p = 0.240]. Adjusted for known cardiovascular risk factors, there was no association between TAA and AIx@75. Patients with TAA showed comparable arterial wall properties to cardiovascular risk factor matched controls. Since higher arterial stiffness is associated with TAA progression, it remains to be investigated if increased central arterial stiffness is a relevant factor of TAA emergence.<\/jats:p>","DOI":"10.3390\/jcdd10010006","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:26:25Z","timestamp":1671765985000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Augmentation Index in Patients with Thoracic Aortic Aneurysm: A Matched Case-Control Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Patrick","family":"Baumgartner","sequence":"first","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-5466","authenticated-orcid":false,"given":"Protazy","family":"Rejmer","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Osswald","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Malesevic","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1758-4586","authenticated-orcid":false,"given":"Noriane A.","family":"Sievi","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Roeder","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Herth","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-8216","authenticated-orcid":false,"given":"Simon F.","family":"St\u00e4mpfli","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-2321","authenticated-orcid":false,"given":"Christian F.","family":"Clarenbach","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix C.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-6143","authenticated-orcid":false,"given":"Thomas","family":"Gaisl","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Kohler","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich (USZ), University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1001\/jama.280.22.1926","article-title":"Improved prognosis of thoracic aortic aneurysms: A population-based study","volume":"280","author":"Clouse","year":"1998","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.CIR.85.1.205","article-title":"Are aortic aneurysms caused by atherosclerosis?","volume":"85","author":"Reed","year":"1992","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCRESAHA.118.312436","article-title":"Genetics of Thoracic and Abdominal Aortic Diseases","volume":"124","author":"Pinard","year":"2019","journal-title":"Circ. 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