{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:34:10Z","timestamp":1787081650644,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fisabio foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Introduction: It is a matter of controversy whether the therapeutic strategy for severe aortic stenosis (AS) differs according to gender. Methods: Retrospective study of patients diagnosed with severe AS (transvalvular mean gradient \u2265 40 mmHg and\/or aortic valvular area &lt; 1 cm2) between 2009 and 2019. Our aim was to assess the association of sex on AVR or medical management and outcomes in patients with severe AS. Results: 452 patients were included. Women (51.1%) were older than men (80 \u00b1 8.4 vs. 75.8 \u00b1 9.9 years; p &lt; 0.001). Aortic valve replacement (AVR) was performed less frequently in women (43.4% vs. 53.2%; p = 0.03), but multivariate analyses showed that sex was not an independent predictor factor for AVR. Age, Charlson index and symptoms were predictive factors (OR 0.81 [0.82\u20130.89], OR 0.81 [0.71\u20130.93], OR 22.02 [6.77\u201371.64]). Survival analysis revealed no significant association of sex within all-cause and cardiovascular mortalities (log-rank p = 0.63 and p = 0.07). Cox proportional hazards analyses showed AVR (HR: 0.1 [0.06\u20130.15]), Charlson index (HR: 1.13 [1.06\u20131.21]) and reduced LVEF (HR: 1.9 [1.32\u20132.73]) to be independent cardiovascular mortality predictors. Conclusions: Gender is not associated with AVR or long-term prognosis. Cardiovascular mortality was associated with older age, more comorbidity and worse LVEF.<\/jats:p>","DOI":"10.3390\/jcdd10020038","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T03:26:41Z","timestamp":1674444401000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does Gender Influence the Indication of Treatment and Long-Term Prognosis in Severe Aortic Stenosis?"],"prefix":"10.3390","volume":"10","author":[{"given":"Celia","family":"Gil Llopis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-429X","authenticated-orcid":false,"given":"Amparo","family":"Valls Serral","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-0785","authenticated-orcid":false,"given":"Ildefonso","family":"Rold\u00e1n Torres","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8882-6725","authenticated-orcid":false,"given":"Maria Bel\u00e9n","family":"Contreras Tornero","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-2332","authenticated-orcid":false,"given":"Ana","family":"Cuevas Vilaplana","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Sorribes Alonso","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Escribano Escribano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Gimeno Tio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Galiana Talavera","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-1383","authenticated-orcid":false,"given":"Juan","family":"Geraldo Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Gramage Sanchis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Hidalgo","family":"Mateos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-6854","authenticated-orcid":false,"given":"Vicente","family":"Mora Llabata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Dr Peset, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary Presentation and Management of Valvular Heart Disease","volume":"140","author":"Lung","year":"2019","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/heartjnl-2019-315407","article-title":"Aortic stenosis in women","volume":"106","author":"Shan","year":"2020","journal-title":"Heart"},{"key":"ref_3","first-page":"129","article-title":"Sex Differences in the Pathophysiology, Diagnosis, and Management of Aortic Stenosis","volume":"38","author":"Clavel","year":"2019","journal-title":"Cardiol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/14779072.2020.1732209","article-title":"Sex differences in aortic stenosis: From pathophysiology to treatment","volume":"18","author":"Saeed","year":"2020","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","article-title":"The evolving epidemiology of valvular aortic stenosis. The Troms\u00f8 Study","volume":"99","author":"Eveborn","year":"2013","journal-title":"Heart"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/CIRCRESAHA.116.309306","article-title":"Sex-related discordance between aortic valve calcification and hemodynamic severity of aortic stenosis: Is valvular fibrosis the explanation?","volume":"120","author":"Simard","year":"2017","journal-title":"Circ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/01.CIR.86.4.1099","article-title":"Sex-associated differences in left ventricular function in aortic stenosis of the elderly","volume":"86","author":"Carroll","year":"1992","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/oxfordjournals.eurheartj.a060749","article-title":"Sex-dependent differences in left ventricular function and structure in chronic pressure overload","volume":"16","author":"Villari","year":"1995","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jcmg.2017.09.019","article-title":"Symptom Onset in Aortic Stenosis","volume":"12","author":"Singh","year":"2017","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e006370","DOI":"10.1161\/JAHA.117.006370","article-title":"Sex Differences in the Utilization and Outcomes of Surgical Aortic Valve Replacement for Severe Aortic Stenosis","volume":"6","author":"Chaker","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/j.jacc.2016.10.041","article-title":"Sex-based differences in outcomes with transcatheter aortic valve therapy: TVT registry from 2011 to 2014","volume":"68","author":"Chandrasekhar","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/hrt.2009.186650","article-title":"Gender differences in clinical presentation and surgical outcome of aortic stenosis","volume":"96","author":"Fuchs","year":"2010","journal-title":"Heart"},{"key":"ref_14","first-page":"483","article-title":"Cardiovascular risk factors as predictors of early and late survival after bioprosthetic valve replacement for aortic stenosis","volume":"16","author":"Marechaux","year":"2007","journal-title":"J. Heart Valve Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.carcor.2015.10.004","article-title":"Diferencias en la presentaci\u00f3n cl\u00ednica y manejo terap\u00e9utico de la estenosis a\u00f3rtica severa en mujeres en un centro de tercer nivel","volume":"51","year":"2016","journal-title":"Cardiocore"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/eurheartj\/ehab242","article-title":"Impact of sex on the management and outcome of aortic stenosis patients","volume":"42","author":"Fleury","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jacc.2015.05.024","article-title":"Revisiting sex equality with transcatheter aortic valve replacement outcomes: A collaborative, patient-level meta-analysis of 11,310 patients","volume":"66","author":"Morice","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00392-014-0690-6","article-title":"Effect of gender differences on 1-year mortality after transcatheter aortic valve implantation for severe aortic stenosis: Results from a multicenter real-world registry","volume":"103","author":"Sherif","year":"2014","journal-title":"Clin. Res. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jacc.2011.10.877","article-title":"Sex-Related Differences in Clinical Presentation and Outcome of Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis","volume":"59","author":"Hayashida","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.echo.2008.11.029","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"22","author":"Baumgartner","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: A report from the American Society of Echocardiography\u2019s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","author":"Lang","year":"2005","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/eurheartj\/ehl428","article-title":"Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology","volume":"28","author":"Vahanian","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the management of valvular heart disease (version 2012)","volume":"33","author":"Vahanian","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1053\/j.jvca.2018.08.196","article-title":"Impact of Sex on the Outcome of Isolated Aortic Valve Replacement and the Role of Different Preoperative Profiles","volume":"33","author":"Hoff","year":"2019","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"831179","DOI":"10.3389\/fphys.2022.831179","article-title":"Sex Matters: A Comprehensive Comparison of Female and Male Hearts","volume":"13","author":"Pierre","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/HCO.0000000000000612","article-title":"Sex differences in hypertrophic cardiomyopathy","volume":"34","author":"Nijenkamp","year":"2019","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e012307","DOI":"10.1161\/JAHA.119.012307","article-title":"Presenting Symptoms in Men and Women Diagnosed with Myocardial Infarction Using Sex-Specific Criteria","volume":"8","author":"Ferry","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13293-018-0201-y","article-title":"Sex differences in ischemic heart disease and heart failure biomarkers","volume":"9","author":"Sobhani","year":"2018","journal-title":"Biol. Sex Differ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.amjmed.2005.08.006","article-title":"Gender and perceived severity of cardiac disease: Evidence that women are \u201ctougher\u201d","volume":"118","author":"Nau","year":"2005","journal-title":"Am. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCOUTCOMES.109.848259","article-title":"Evaluation of patients with severe symptomatic aortic stenosis who do not undergo aortic valve replacement: The potential role of subjectively overestimated operative risk","volume":"2","author":"Bach","year":"2009","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_32","first-page":"284","article-title":"Prevalence and characteristics of unoperated patients with severe aortic stenosis","volume":"20","author":"Bach","year":"2011","journal-title":"J. Heart Valve Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.amjcard.2009.12.056","article-title":"Reasons for Nonadherence to Guidelines for Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Potential Solutions","volume":"105","author":"Freed","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jcmg.2017.05.008","article-title":"Lower Transaortic Flow Rate Is Associated with Increased Mortality in Aortic Valve Stenosis","volume":"10","author":"Saeed","year":"2017","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2014.11.047","article-title":"Impact of classic and paradoxical low flow on survival after aortic valve replacement for severe aortic stenosis","volume":"65","author":"Clavel","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/NRL.0000000000000151","article-title":"Perioperative Stroke and Mortality After Surgical Aortic Valve Replacement","volume":"22","author":"Thiagarajan","year":"2017","journal-title":"Neurologist"},{"key":"ref_37","first-page":"394","article-title":"Impact of gender on outcomes after transcatheter aortic valve implantation","volume":"15","author":"Yousif","year":"2018","journal-title":"J. Geriatr. Cardiol."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/10\/2\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:13:34Z","timestamp":1760120014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/10\/2\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,22]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcdd10020038"],"URL":"https:\/\/doi.org\/10.3390\/jcdd10020038","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,22]]}}}