{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:55:55Z","timestamp":1777100155660,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heart Research Australia","award":["2014-02"],"award-info":[{"award-number":["2014-02"]}]},{"name":"Heart Research Australia","award":["G180904"],"award-info":[{"award-number":["G180904"]}]},{"name":"Heart Research Australia","award":["G151106"],"award-info":[{"award-number":["G151106"]}]},{"name":"Bushell Foundation","award":["2014-02"],"award-info":[{"award-number":["2014-02"]}]},{"name":"Bushell Foundation","award":["G180904"],"award-info":[{"award-number":["G180904"]}]},{"name":"Bushell Foundation","award":["G151106"],"award-info":[{"award-number":["G151106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Peripartum cardiomyopathy (PPCM) is a rare form of acute onset heart failure that presents in otherwise healthy pregnant women around the time of delivery. While most of these women respond to early intervention, about 20% progress to end-stage heart failure that symptomatically resembles dilated cardiomyopathy (DCM). In this study, we examined two independent RNAseq datasets from the left ventricle of end-stage PPCM patients and compared gene expression profiles to female DCM and non-failing donors. Differential gene expression, enrichment analysis and cellular deconvolution were performed to identify key processes in disease pathology. PPCM and DCM display similar enrichment in metabolic pathways and extracellular matrix remodeling suggesting these are similar processes across end-stage systolic heart failure. Genes involved in golgi vesicles biogenesis and budding were enriched in PPCM left ventricles compared to healthy donors but were not found in DCM. Furthermore, changes in immune cell populations are evident in PPCM but to a lesser extent compared to DCM, where the latter is associated with pronounced pro-inflammatory and cytotoxic T cell activity. This study reveals several pathways that are common to end-stage heart failure but also identifies potential targets of disease that may be unique to PPCM and DCM.<\/jats:p>","DOI":"10.3390\/jcdd10050188","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T02:06:11Z","timestamp":1682301971000},"page":"188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways"],"prefix":"10.3390","volume":"10","author":[{"given":"Jude","family":"Taylor","sequence":"first","affiliation":[{"name":"Centre for Healthy Futures, Torrens University Australia, Surrey Hills, NSW 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C. Y.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Respiratory Bioinformatics and Molecular Biology, School of Life Sciences, The University of Technology Sydney (UTS), Sydney, NSW 2007, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-1566","authenticated-orcid":false,"given":"Anthony","family":"Ashton","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alen","family":"Faiz","sequence":"additional","affiliation":[{"name":"Respiratory Bioinformatics and Molecular Biology, School of Life Sciences, The University of Technology Sydney (UTS), Sydney, NSW 2007, Australia"},{"name":"Groningen Research Institute for Asthma and COPD (GRIAC), The University of Groningen, 9700 Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-6022","authenticated-orcid":false,"given":"Victor","family":"Guryev","sequence":"additional","affiliation":[{"name":"Groningen Research Institute for Asthma and COPD (GRIAC), The University of Groningen, 9700 Groningen, The Netherlands"},{"name":"Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing (ERIBA), University Medical Centre Groningen, The University of Groningen, 9713 Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Fang","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia"},{"name":"School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Lal","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia"},{"name":"School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia"},{"name":"Department of Cardiology, The Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia"},{"name":"Sydney Heart Bank, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-5369","authenticated-orcid":false,"given":"Mark","family":"Grosser","sequence":"additional","affiliation":[{"name":"23Strands, Pyrmont, NSW 2009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristobal G.","family":"dos Remedios","sequence":"additional","affiliation":[{"name":"Sydney Heart Bank, The University of Sydney, Sydney, NSW 2006, Australia"},{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5222-0895","authenticated-orcid":false,"given":"Filip","family":"Braet","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia"},{"name":"Australian Centre for Microscopy & Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-8980","authenticated-orcid":false,"given":"Craig S.","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Centre for Healthy Futures, Torrens University Australia, Surrey Hills, NSW 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5413-3771","authenticated-orcid":false,"given":"Amy","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Healthy Futures, Torrens University Australia, Surrey Hills, NSW 2010, Australia"},{"name":"Sydney Heart Bank, The University of Sydney, Sydney, NSW 2006, Australia"},{"name":"Department of Pharmacy & Biomedical Sciences, La Trobe University, Bendigo, VIC 3550, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/CIRCULATIONAHA.115.020491","article-title":"Peripartum Cardiomyopathy","volume":"133","author":"Arany","year":"2016","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12551-022-00930-0","article-title":"Peripartum cardiomyopathy: A global effort to find the cause and cure for the rare and little understood disease","volume":"14","author":"Li","year":"2022","journal-title":"Biophys. 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