{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:06:17Z","timestamp":1760148377848,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Post-transcatheter aortic valve replacement (TAVR) patient outcome is an important research topic. To accurately assess post-TAVR mortality, we examined a family of new echo parameters (augmented systolic blood pressure (AugSBP) and arterial mean pressure (AugMAP)) derived from blood pressure and aortic valve gradients. Methods: Patients in the Mayo Clinic National Cardiovascular Diseases Registry-TAVR database who underwent TAVR between 1 January 2012 and 30 June 2017 were identified to retrieve baseline clinical, echocardiographic and mortality data. AugSBP, AugMAP and valvulo-arterial impedance (Zva) (Zva) were evaluated using Cox regression. Receiver operating characteristic curve analysis and the c-index were used to assess the model performance against the Society of Thoracic Surgeons (STS) risk score. Results: The final cohort contained 974 patients with a mean age of 81.4 \u00b1 8.3 years old, and 56.6% were male. The mean STS risk score was 8.2 \u00b1 5.2. The median follow-up duration was 354 days, and the one-year all-cause mortality rate was 14.2%. Both univariate and multivariate Cox regression showed that AugSBP and AugMAP parameters were independent predictors for intermediate-term post-TAVR mortality (all p &lt; 0.0001). AugMAP1 &lt; 102.5 mmHg was associated with a 3-fold-increased risk of all-cause mortality 1-year post-TAVR (hazard ratio 3.0, 95%confidence interval 2.0\u20134.5, p &lt; 0.0001). A univariate model of AugMAP1 surpassed the STS score model in predicting intermediate-term post-TAVR mortality (area under the curve: 0.700 vs. 0.587, p = 0.005; c-index: 0.681 vs. 0.585, p = 0.001). Conclusions: Augmented mean arterial pressure provides clinicians with a simple but effective approach to quickly identify patients at risk and potentially improve post-TAVR prognosis.<\/jats:p>","DOI":"10.3390\/jcdd10050192","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T02:30:52Z","timestamp":1682476252000},"page":"192","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter Aortic Valve Replacement Prognostication with Augmented Mean Arterial Pressure"],"prefix":"10.3390","volume":"10","author":[{"given":"Chieh-Ju","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"},{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradyumna","family":"Agasthi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"},{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amith R.","family":"Seri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-2990","authenticated-orcid":false,"given":"Timothy","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anusha","family":"Shanbhag","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackram F.","family":"Eleid","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fortuin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Pollak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Florida, Jacksonville, FL 32224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah","family":"El Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Florida, Jacksonville, FL 32224, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Lester","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasneem Z.","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Appleton","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-4286","authenticated-orcid":false,"given":"Reza","family":"Arsanjani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N. 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