{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:43:47Z","timestamp":1789681427375,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medtronic"},{"name":"LivaNova"},{"name":"AtriCure"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Objective: The goal of this manuscript is to compare clinical and echocardiographic outcomes of patients undergoing aortic valve replacement (AVR) with Perceval sutureless bioprosthesis (SU-AVR) and sutured bioprosthesis (SB). Methods: Following the PRISMA statement, data were extracted from studies published after August 2022 and found in PubMed\/MEDLINE, EMBASE, CENTRAL\/CCTR, ClinicalTrials.gov, SciELO, LILACS, and Google Scholar. The primary outcome of interest was post-procedural permanent pacemaker implantation, and the secondary outcomes were new left bundle branch block (LBBB), moderate\/severe paravalvular leak (PVL), valve dislocation (pop-out), need for a second transcatheter heart valve, 30-day mortality, stroke, and echocardiographic outcomes. Results: Twenty-one studies were included in the analysis. When SU-AVR was compared to other SB, mortality ranged from 0 to 6.4% for Perceval and 0 to 5.9% for SB. Incidence of PVL (Perceval 1\u201319.4% vs. SB 0\u20131%), PPI (Perceval 2\u201310.7% vs. SB 1.8\u20138.5%), and MI (Perceval 0\u20137.8% vs. SB 0\u20134.3%) were comparable. In addition, the stroke rate was lower in the SU-AVR group when compared to SB (Perceval 0\u20133.7% vs. SB 1.8\u20137.3%). In patients with a bicuspid aortic valve, the mortality rate was 0\u20134% and PVL incidence was 0\u20132.3%. Long-term survival ranged between 96.7 and 98.6%. Valve cost analysis was lower for the Perceval valve and higher for sutured bioprosthesis. Conclusions: Compared to SB valves, Perceval bioprosthesis has proved to be a reliable prosthesis for surgical aortic valve replacement due to its non-inferior hemodynamics, implantation speed, reduced cardiopulmonary bypass time, reduced aortic cross-clamp time, and shorter length of stay.<\/jats:p>","DOI":"10.3390\/jcdd10050224","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T01:36:48Z","timestamp":1684805808000},"page":"224","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early and Long-Term Clinical and Echocardiographic Outcomes of Sutureless vs. Sutured Bioprosthesis for Aortic Valve Replacement"],"prefix":"10.3390","volume":"10","author":[{"given":"Aleksander","family":"Dokollari","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Wynnewood, PA 19096, USA"},{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Torregrossa","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Wynnewood, PA 19096, USA"},{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Bisleri","sequence":"additional","affiliation":[{"name":"St. Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Fatehi","family":"Hassanabad","sequence":"additional","affiliation":[{"name":"Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Pompeu","family":"Sa","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Sicouri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Wynnewood, PA 19096, USA"},{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altin","family":"Veshti","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Mother Teresa Hospital, University of Tirana, 1000 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvin","family":"Prifti","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Mother Teresa Hospital, University of Tirana, 1000 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Bacchi","sequence":"additional","affiliation":[{"name":"St. Michael\u2019s Hospital, Toronto, ON M5B 1W8, Canada"},{"name":"F.U. Clinical and Experimental Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cabrucci","sequence":"additional","affiliation":[{"name":"F.U. Clinical and Experimental Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel","family":"Ramlawi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lankenau Heart Institute, Wynnewood, PA 19096, USA"},{"name":"Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-7328","authenticated-orcid":false,"given":"Massimo","family":"Bonacchi","sequence":"additional","affiliation":[{"name":"F.U. Clinical and Experimental Medicine, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.athoracsur.2013.03.083","article-title":"The Perceval S aortic valve has the potential of shortening surgical time: Does it also result in improved outcome?","volume":"96","author":"Santarpino","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"789392","DOI":"10.3389\/fcvm.2021.789392","article-title":"Benefits and Pitfalls of the Perceval Sutureless Bioprosthesis","volume":"8","author":"Dokollari","year":"2022","journal-title":"Front. Cardiovasc. 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