{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:43:34Z","timestamp":1790275414279,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Left ventricular global longitudinal strain (LV GLS) is a superior predictor of adverse cardiac events in patients with myocardial infarction and heart failure. We investigated the ability of morphological features of infarcted myocardium to detect acute left ventricular (LV) dysfunction and predict LV functional recovery after three months in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods: Sixty-six STEMI patients were included in the C-reactive protein (CRP) apheresis in Acute Myocardial Infarction Study (CAMI-1). LV ejection fraction (LVEF), LV GLS, LV global circumferential strain (LV GCS), infarct size (IS), area-at-risk (AAR), and myocardial salvage index (MSI) were assessed by CMR 5 \u00b1 3 days (baseline) and 12 \u00b1 2 weeks after (follow-up) the diagnosis of first acute STEMI. Results: Significant changes in myocardial injury parameters were identified after 12 weeks of STEMI diagnosis. IS decreased from 23.59 \u00b1 11.69% at baseline to 18.29 \u00b1 8.32% at follow-up (p &lt; 0.001). AAR and MVO also significantly reduced after 12 weeks. At baseline, there were reasonably moderate correlations between IS and LVEF (r = \u22120.479, p &lt; 0.001), LV GLS (r = 0.441, p &lt; 0.001) and LV GCS (r = 0.396, p = 0.001) as well as between AAR and LVEF (r = \u22120.430, p = 0.003), LV GLS (r = 0.501, p &lt; 0.001) and weak with LV GCS (r = 0.342, p = 0.020). At follow-up, only MSI and change in LV GCS over time showed a weak but significant correlation (r = \u22120.347, p = 0.021). Patients with larger AAR at baseline improved more in LVEF (p = 0.019) and LV GLS (p = 0.020) but not in LV GCS. Conclusion: The CMR tissue characteristics of myocardial injury correlate with the magnitude of LV dysfunction during the acute stage of STEMI. AAR predicts improvement in LVEF and LV GLS, while MSI is a sensitive marker of LV GCS recovery at three months follow-up after STEMI.<\/jats:p>","DOI":"10.3390\/jcdd10070294","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T01:01:41Z","timestamp":1689123701000},"page":"294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Imaging Predictors of Left Ventricular Functional Recovery after Reperfusion Therapy of ST-Elevation Myocardial Infarction Assessed by Cardiac Magnetic Resonance"],"prefix":"10.3390","volume":"10","author":[{"given":"Agneta","family":"Virbickiene","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, German Heart Center Berlin, 13353 Berlin, Germany"},{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-6948","authenticated-orcid":false,"given":"Tomas","family":"Lapinskas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, German Heart Center Berlin, 13353 Berlin, Germany"},{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph D.","family":"Garlichs","sequence":"additional","affiliation":[{"name":"Medical Clinic, DIAKO Flensburg, 24939 Flensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1149-4075","authenticated-orcid":false,"given":"Stephan","family":"Mattecka","sequence":"additional","affiliation":[{"name":"Pentracor GmbH, 16761 Hennigsdorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Tanacli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, German Heart Center Berlin, 13353 Berlin, Germany"},{"name":"Department of Cardiology, Charit\u00e9 University Medicine Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Ries","sequence":"additional","affiliation":[{"name":"Medical Clinic, DIAKO Flensburg, 24939 Flensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-7293","authenticated-orcid":false,"given":"Jan","family":"Torzewski","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Oberallg\u00e4u-Kempten, 87439 Kempten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Heigl","sequence":"additional","affiliation":[{"name":"Medical Care Center Kempten-Allg\u00e4u, 87437 Kempten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-0435","authenticated-orcid":false,"given":"Christian","family":"Pfluecke","sequence":"additional","affiliation":[{"name":"Christian Pfluecke, Department of Internal Medicine I, St\u00e4dtisches Klinikum G\u00f6rlitz, Girbigsdorfer Stra\u00dfe 1-3, 02828 G\u00f6rlitz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Darius","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, Angiology, Nephrology, Intensive Care Medicine, Vivantes Clinic Neuk\u00f6lln, 12351 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hueseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Nephrology, Department of Internal Medicine, University Medicine Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-4068","authenticated-orcid":false,"given":"Peter","family":"Nordbeck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Heart Centre Brandenburg in Bernau, Brandenburg Medical School (MHB) Theodor Fontane, 16321 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schuster","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Department of Cardiology and Pneumology, Georg-August University, 37075 G\u00f6ttingen, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site G\u00f6ttingen, 10785 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Mitzner","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Nephrology, Department of Internal Medicine, University Medicine Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivija","family":"Dobiliene","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Sheriff","sequence":"additional","affiliation":[{"name":"Pentracor GmbH, 16761 Hennigsdorf, Germany"},{"name":"Gastroenterology\/Infectiology\/Rheumatology, Charit\u00e9 University Medicine Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kelle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, German Heart Center Berlin, 13353 Berlin, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, 10785 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. 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